Clinical trials: Migraine Disorders, Brain
Migraine
Research Study to Determine Sensitivity to Gentle Touch and Pressure During an Active Migraine Attack.
Cutaneous allodynia (pronounced q-tane-ee-us all-o-din-ee-a) is common in migraine. It is a heightened skin sensitivity during an active migraine attack.
- Trial name
- NCT00329771
- Testing
- No intervention: We are testing for the presence of allodynia
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Thomas Jefferson University
Migraine, Fibromyalgia
The Effect of Remote Electrical Neuromodulation (REN) on Conditioned Pain Modulation (CPM) in Migraine and Fibromyalgia
Migraine and Fibromyalgia (FM) are chronic pain disorders characterized by altered central pain processing and impaired endogenous pain inhibition.
- Conditions
- Migraine, Fibromyalgia, Conditioned Pain Modulation
- Trial name
- NCT07841509
- Testing
- Remote Electrical Neuromodulation (REN) device
- Where
- 2 sites in United States, Israel
- Volunteers
- 120 people
- Sponsor
- Theranica
Migraine, With or Without Aura
An Extension Study to Evaluate the Long-Term Safety and Tolerability of Ubrogepant in the Treatment of Migraine
This study will evaluate the long-term safety and tolerability of intermittent treatment with ubrogepant for the acute treatment of migraine over 1 year.
- Trial name
- NCT02873221
- Testing
- Ubrogepant, Usual Care
- Where
- 177 sites in United States
- Volunteers
- 1,254 people
- Sponsor
- Allergan
Migraine
Effects Of Dry Needling On Sternocleidomastoid Muscle For Pain And Disability In Migraine
To determine the effects, sequel of dry needling in migraine by resolving MTrPs in sternocleidomastoid muscle. To determine the possession of dry needling technique to mitigate the frequency, intensity and duration of headache.
- Trial name
- NCT05285852
- Testing
- Dry Needling
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Migraine
An Open Label Extension of a Study Comparing Topiramate and Amitriptyline in Migraine Prevention.
The purpose of this study is to assess the long-term safety and effectiveness of topiramate for the prevention of migraine headaches in adults. Topiramate has been approved to prevent migraine headaches in adults.
- Trial name
- NCT00210860
- Testing
- topiramate
- Volunteers
- 142 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Migraine
Efficacy and Tolerability of Rimegepant for the Prevention of Migraine in Adults With History of Inadequate Response to Oral Preventive Medications
This study is being conducted to evaluate the efficacy and tolerability of rimegepant for migraine prophylaxis in adults with a history of inadequate response to oral preventive medications
- Trial name
- NCT05518123
- Testing
- Rimegepant
- Where
- 111 sites in United States, Australia and 12 more
- Volunteers
- 962 people
- Sponsor
- Pfizer
Migraine
An Exploratory Prospective Trial of Rescue Acupuncture for the Treatment of Acute Migraine
This will be an exploratory observational trial of rescue acupuncture for the treatment of acute migraine in military beneficiaries to gain information to inform the power analysis of a larger, more definitive trial.
- Trial name
- NCT02764996
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Mike O'Callaghan Military Hospital
Migraine
Migraine Characteristics and Associated Factors
This cross-sectional study aims to evaluate the clinical characteristics of migraine and factors associated with migraine-related disability and impact in adults diagnosed with primary migraine.
- Trial name
- NCT07822386
- Testing
- Observational assessment
- Volunteers
- 100 people
- Sponsor
- Lokman Hekim University
Migraine, Rosacea
Deep Phenotyping of Rosacea and Migraine
This study aims to deep phenotype patients with rosacea and migraine
- Trial name
- NCT03872050
- Testing
- No intervention apart from tests, including interview
- Where
- Denmark
- Volunteers
- 613 people
- Sponsor
- Danish Headache Center
PFO, Cognitive
Multimodal Brain Function in Migraine Patients With Patent Foramen Ovale
This investigator-initiated, single-center prospective study is designed to clarify how patent foramen ovale (PFO) relates to brain function abnormalities in patients with drug-refractory migraine with aura (MA), and whether…
- Conditions
- PFO, Cognitive, Cognitive Functions, Migraine
- Trial name
- NEURO-PFO (NCT07343154)
- Volunteers
- 45 people
- Sponsor
- Second Xiangya Hospital of Central South University
Migraine
Chronology and Sequence of Premonitory Symptoms
The purpose of this study is to prospectively investigate the temporal sequence of premonitory symptoms across multiple migraine attacks.
- Trial name
- CHRONOpS (NCT07681466)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Roma La Sapienza
Migrainous Headache
Treatment of Acute Migraine Headache in Children
Migraine is common in children and is one of the most common etiologies of headache leading to emergency room presentation in children.
- Trial name
- NCT00355394
- Testing
- Metoclopramide
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Children's Hospital of Philadelphia
Migraine, Episodic Migraine
A Study of Galcanezumab (LY2951742) in Adult Participants With Episodic Migraine
The purpose of this study is to assess whether galcanezumab is superior to rimegepant in the prevention of migraine in participants with episodic migraine. The study duration will be approximately 6 months.
- Trial name
- CHALLENGE-MIG (NCT05127486)
- Testing
- Galcanezumab, Rimegepant
- Where
- 77 sites in United States
- Volunteers
- 580 people
- Sponsor
- Eli Lilly and Company
Migraine Disorders
Effects of tDCS and Physical Therapy in Chronic Migraine
The aim of this clinical study is to compare the effects of tDCS, physiotherapy, and their association with the intensity in women with Chronic Migraine.
- Trial name
- NCT05706077
- Testing
- active tDCS, real Physical Therapy
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba
Migraine With Aura, Migraine Without Aura
Migraine With and Without Aura Characteristics and Response to Remote Electrical Neuromodulation (REN) Treatment
This is a Post-marketing, real-world evidence study investigating the safety and efficacy of the acute treatment of migraine with a Remote Electrical Neuromodulation (REN) device (Nerivio) in migraine patients with and without…
- Trial name
- NCT06023953
- Testing
- Nerivio device
- Where
- Israel
- Volunteers
- 31,715 people
- Sponsor
- Theranica
Migraine
A Study of M207 With Intranasal Zolmitriptan in Healthy Volunteers
This is a single-center, open-label, randomized, four-way crossover study. Each subject will receive each of the four study treatments once, followed by in-clinic monitoring and extensive blood sample collection for…
- Trial name
- NCT03708744
- Testing
- A: M207 3.8mg, 30 min, upper arm, B: M207 3.8 mg, 30 min, thigh, C: M207 3.8 mg, 1 hr, upper arm
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Zosano Pharma Corporation
Migraine
Evaluation of a New Treatment for Migraine Attacks
The purpose of this study is to evaluate the efficacy of a novel therapy for treatment of migraine, pain reduction and relief of associated symptoms during ongoing migraine attacks, and presence of a preventive effect post…
- Trial name
- NCT01880671
- Testing
- Inactive Migraine Medical Device, Migraine Medical Device
- Where
- Sweden
- Volunteers
- 36 people
- Sponsor
- Karolinska University Hospital
Headache, Migraine
Migraines Accepted Laser Acupuncture Compared in Blood Test of MMP2 and CGRP
Aims: To investigate the efficacy of laser-acupuncture for the severity of primary headache and comorbidities, and the Lab data examination.
- Trial name
- NCT06584409
- Testing
- Laser Pen, Observation
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taichung Veterans General Hospital
Migraine
Efficacy of Zolmitriptan (Zomig) in the Treatment of Migraines in Adolescents
The purpose of this study is to evaluate the effectiveness and safety of Zolmitriptan (Zomig) nasal spray, 5.0 mg, compared with placebo (inactive drug) for 2 migraine headaches over a 3-month period in adolescent patients (aged…
- Trial name
- NCT00617695
- Testing
- Zolmitriptan
- Volunteers
- 247 people
- Sponsor
- Impax Laboratories, LLC
Migraine, Migraine With Aura
Oxygenation and Perfusion in Patients With Acute Migraine Attacks
The aim of the study is to retrospectively evaluate brain perfusion and oxygenation in acute migraine attacks. Magnetic resonance perfusion and susceptibility weighted imaging are the technics to measure perfusion and oxygenation…
- Conditions
- Migraine, Migraine With Aura, Migraine; Status
- Trial name
- OPAMA (NCT03536936)
- Volunteers
- 1,000 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern