Clinical trials: Migraines
Migraine, Headache
Ticagrelor Therapy for RefrACTORy Migraine Study
This is a prospective, open-label, single-arm pilot study treating 40 subjects to assess the hypothesis that P2Y, G protein-coupled 12 (P2Y12) inhibition with Brilinta/ticagrelor (90 mg by mouth (PO) twice a day) reduces episodic…
- Conditions
- Migraine, Headache, Migraine Headache
- Trial name
- TRACTOR (NCT02518464)
- Testing
- Ticagrelor 90 mg twice per day
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Columbia University
Migraine
Prospective Survey of Menstrual Migraine & Prevention With Eletriptan
Women are followed prospectively for 3 months, recording headaches, other symptoms, and menstrual periods. Those with menstrual migraine are treated perimenstrually with eletriptan for 3 months.
- Trial name
- NCT00259649
- Testing
- eletriptan
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Migraine
Ictal and Interictal Inflammatory Markers in Migraine
The purpose of this study is to evaluate blood levels of several proteins that may be altered in the inflammation associated with migraine headaches.
- Trial name
- NCT01138150
- Testing
- Treximet
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Johns Hopkins University
Migraine
Study to Evaluate the Efficacy and Safety of Erenumab (AMG 334) Compared to Placebo in Migraine Prevention
To evaluate the effect of erenumab compared to placebo on the change from baseline in monthly migraine days, in adults with episodic migraine.
- Trial name
- ARISE (NCT02483585)
- Testing
- Erenumab
- Where
- 76 sites in United States, Denmark and 6 more
- Volunteers
- 577 people
- Sponsor
- Amgen
Migraine
Comparison of Therapeutic Effects of Greater Occipital Nerve Block, Topiramate, and Flunarizine on Episodic Migraine
Background: Preventive drug therapy in migraine aims to reduce the attack frequency, severity and duration of headache. Flunarizine and topiramate are widely used in the prevention of migraine attacks.
- Trial name
- NCT03712917
- Testing
- Greater Occipital Nerve Block, Topiramate, Flunarizine
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ataturk University
Migraine
Study of Telcagepant (MK-0974) in Participants With Moderate to Severe Acute Migraine With or Without Aura (MK-0974-011)
The purpose of this study is to investigate the efficacy and safety of telcagepant (MK-0974) compared to an approved medication for acute migraine.
- Trial name
- NCT00442936
- Testing
- Telcagepant potassium 150 mg, Telcagepant potassium 300 mg, Zolmitriptan 5 mg
- Volunteers
- 1,380 people
- Sponsor
- Merck Sharp & Dohme LLC
Migraine
A Study to Learn About the Benefit of Rimegepant Versus Triptans in Migraine Buddy App Users.
The purpose of this study is to collect information of the US users from the Migraine Buddy app between 20 October 2023 and 20 May 2024.
- Trial name
- NCT06532357
- Where
- United States
- Volunteers
- 1,536 people
- Sponsor
- Pfizer
Migraine
A Safety and Efficacy Study to Evaluate AMG 334 in Migraine Prevention
Randomized, double-blind, placebo-controlled, parallel-group, multicenter study followed by an open-label treatment phase (OLTP).
- Trial name
- NCT02630459
- Testing
- Erenumab
- Where
- 44 sites in Japan
- Volunteers
- 475 people
- Sponsor
- Amgen
Migraine Headache
Electrical Stimulation of the Sphenopalatine Ganglion for the Treatment of Migraine Headaches
This investigation will gather information about a procedure called sphenopalatine ganglion (SPG) stimulation, and its appropriateness, safety, and efficacy as a treatment for those who suffer migraine headaches which may result…
- Trial name
- NCT01294046
- Testing
- Deep Brain Stimulation of SPG for Migraine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- The Cleveland Clinic
Migraine, Pregnancy Related
Safety of Nerivio in Pregnant Women With Migraine
This is a retrospective controlled survey study to assess the safety of treating migraine with Nerivio during pregnancy and 3 months postpartum.
- Trial name
- NCT05464069
- Testing
- Nerivio, Migraine Relief
- Where
- 2 sites in United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Theranica
Migraine Disorders, Stress
Mindfulness During COVID-19
The objective of this study is to provide remote mindfulness session(s) to help during the COVID-19 pandemic.
- Conditions
- Migraine Disorders, Stress, Anxiety
- Trial name
- NCT04319445
- Testing
- Mindfulness session(s)
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Migraine
AMG 334 20160172 Pediatric Migraine PK Study.
AMG 334 20160172 Pediatric Migraine PK Study.
- Trial name
- NCT03499119
- Testing
- AMG 334 Dose 1, AMG 334 Dose 2, AMG 334 Dose 3
- Where
- 14 sites in United States
- Volunteers
- 53 people
- Sponsor
- Amgen
Migraine
Timolol Eye Drops in the Treatment of Acute Migraine Headache
The goal of this study is to determine whether timolol eye drops are effective in alleviating acute migraine headaches. Subjects will be randomized to receive either timolol eye drops or placebo (tears) to use as a migraine…
- Trial name
- NCT02630719
- Testing
- Timolol eye drops, Artificial tears
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Missouri, Kansas City
Migraine, Headache
STOPAIN in the Treatment of a Single Migraine Attack
This is an open label pilot study of 25 subjects with a diagnosis of episodic migraine with or without aura. STOPAIN is an over-the-counter product that is used for the temporary relief of minor aches and pains of muscles and…
- Trial name
- NCT01687101
- Testing
- STOPAIN topical gel
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Thomas Jefferson University
Headache Disorders, Primary, Migraine With Aura
IndoProCaf Effervescent Tablets Effectiveness in Acute Treatment of Migraine and/or Episodic Tension-type Headache and Patients' Satisfaction With the Treatment in Routine Clinical Practice
Headaches are a common medical problem that physicians frequently encounter in their practice. One of key findings of The Atlas of Headache Disorders prepared by World Health Organization (WHO) is: headache disorders, including…
- Conditions
- Headache Disorders, Primary, Migraine With Aura, Migraine Without Aura, Tension-Type Headache
- Trial name
- PRESTO (NCT02115269)
- Where
- 30 sites in Kazakhstan, Ukraine
- Volunteers
- 759 people
- Sponsor
- Abbott
Migraine
Comparative Study of Oral Atogepant Versus Oral Topiramate to Assess Adverse Events in Adult Participants With Migraine
A migraine is a moderate to severe headache on one side of the head that may be accompanied by throbbing, nausea, vomiting, sensitivity to light and sound, or other symptoms.
- Trial name
- ATO-TOPIRAMATE (NCT05748483)
- Testing
- Atogepant, Topiramate
- Where
- 81 sites in Austria, Belgium and 10 more
- Volunteers
- 545 people
- Sponsor
- AbbVie
Migraine, Acute Treatment of Migraine
Dose Ranging Study of Rimegepant (BMS-927711) for the Acute Treatment of Migraine
The primary purpose of this study is to evaluate the efficacy of rimegepant (BMS-927711) compared with placebo in the acute treatment of migraine as measured by Pain Freedom (headache pain intensity level reported as "no pain")…
- Trial name
- NCT01430442
- Testing
- Rimegepant, Sumatriptan
- Where
- 41 sites in United States
- Volunteers
- 1,026 people
- Sponsor
- Pfizer
Migraine
Oral Dexamethasone for the Treatment of Acute Migraine Recurrence in the Pediatric Emergency Department
Migraine recurrence is common amongst pediatric patients being discharged from the emergency department after treatment for migraine.
- Trial name
- NCT02794441
- Testing
- Dexamethasone
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Children's Hospital of Eastern Ontario
Acute Migraine
Lasmiditan Compared to Placebo in the Acute Treatment of Migraine:
This is a prospective randomized, double-blind, placebo-controlled study in participants with disabling migraine (Migraine Disability Assessment (MIDAS) score ≥ 11).
- Trial name
- SAMURAI (NCT02439320)
- Testing
- Lasmiditan 100 mg, Lasmiditan 200 mg
- Where
- 92 sites in United States
- Volunteers
- 2,231 people
- Sponsor
- Eli Lilly and Company
Migraine
Efficacy and Safety of Intranasal Ketorolac for the Acute Treatment of Migraine
The study evaluates the efficacy and safety of using ketorolac as a nasal spray for the acute treatment of migraine.
- Trial name
- NCT00483717
- Testing
- Ketorolac tromethamine
- Where
- Germany
- Volunteers
- 173 people
- Sponsor
- Egalet Ltd