Clinical trials: Migraines
Episodic Migraine
The Effects of Expectation and Knowledge on Rizatriptan and Placebo Treatment of Acute Migraine Headache
Evidence-based medicine depends on distinguishing between pharmacological effects and placebo effects in randomized controlled trials (RCT).
- Trial name
- NCT00719134
- Testing
- Maxalt
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Beth Israel Deaconess Medical Center
Migraine in Adolescence
Real-world Data Analysis of REN Treatment in Adolescence With Migraine
This is a Post-marketing study investigating the safety and efficacy of the REN device (Nerivio by Theranica, Israel) in adolescents with migraine.
- Trial name
- NCT05443659
- Testing
- Nerivio
- Where
- 2 sites in United States, Israel
- Volunteers
- 1,629 people
- Sponsor
- Theranica
Migraine, With or Without Aura
Open Label Safety Study in Acute Treatment of Migraine
The purpose of this study is to evaluate safety and tolerability of BHV-3000 (rimegepant).
- Trial name
- NCT03266588
- Testing
- Rimegepant
- Where
- 98 sites in United States
- Volunteers
- 3,019 people
- Sponsor
- Pfizer
Migraine
Greater Occipital Nerve Block Versus Metoclopramide
We are comparing a type of nerve block called greater occipital nerve block versus standard therapy among patients who present to an emergency department for acute migraine. This is a randomized, double-blind, double dummy study.
- Trial name
- NCT03269435
- Testing
- Greater occipital nerve block with bupivacaine, Metoclopramide
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Montefiore Medical Center
Migraine, Major Depressive Disorder
A Study to Evaluate the Efficacy and Safety of Fremanezumab for Preventive Treatment of Migraine in Patients With Major Depressive Disorder
The primary objective is to evaluate the efficacy of monthly 225 mg sc fremanezumab in adult participants with migraine and major depressive disorder (MDD) The secondary objectives are to evaluate the efficacy of monthly 225 mg…
- Trial name
- NCT04041284
- Testing
- Fremanezumab
- Where
- 64 sites in United States, Czechia and 11 more
- Volunteers
- 353 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Migraine Disorders
Biomarker Study in Participants With Migraine
This is a study of participants with a diagnosis of migraine who completed another clinical trial NCT02163993. The participants received either LY2951742 or placebo.
- Trial name
- NCT02766517
- Testing
- Capsaicin
- Where
- 14 sites in United States
- Volunteers
- 37 people
- Sponsor
- Eli Lilly and Company
Migraine
An Efficacy and Tolerability Study of Topiramate in Participants With Migraine
The purpose of this study is to investigate the adequacy (reasonably good) of topiramate therapy (medicine or medical care given to a participant for a disease or condition) in prevention of migraine (type of severe headache that…
- Trial name
- NCT01060111
- Testing
- Topiramate Standard, Topiramate Slow, Propranolol booster
- Where
- 6 sites in South Korea
- Volunteers
- 250 people
- Sponsor
- Janssen Korea, Ltd., Korea
Migraine
A Research Study Examining the Use of Olanzapine for the Prevention of Migraine
Olanzapine (o-lan-zah-peen) is a medication that has been approved by the Food and Drug Administration (FDA) for the treatment of patients with schizophrenia and/ or bipolar disorder. The trade name for this drug is Zyprexa®.
- Trial name
- NCT00203307
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Thomas Jefferson University
Migraine Disorders
Chronic Migraine Epidemiology and Outcomes Study
This is a population internet-based study to characterize migraine clinical course and impact on family.
- Trial name
- NCT01648530
- Testing
- No Treatment
- Volunteers
- 16,789 people
- Sponsor
- Allergan
Acute Migraine
Migraine Treatment With Nerivio Migra Neurostimulation Device
This is a prospective, randomized, double-blind, sham controlled multi-center trial. Ratio between treatment and control groups will be 1:1, stratified by center and use of preventive medications.
- Trial name
- NCT03076515
- Testing
- Nerivio Migra neurostimulation
- Where
- 8 sites in United States, Israel
- Volunteers
- 120 people
- Sponsor
- Theranica
Migraine
Metoclopramide for Migraine: A Dose Finding Study
Metoclopramide is an effective intravenous treatment for acute migraine attacks, but we do not know the best dose to administer. This study compares three different doses of metoclorpamide.
- Trial name
- MDFS (NCT00682734)
- Testing
- metoclopramide, Diphenhydramine 25mg
- Where
- United States
- Volunteers
- 349 people
- Sponsor
- Montefiore Medical Center
Migraine
Omega-3 Supplementation for Pediatric Migraine
The purpose of the study is to assess the biochemical and clinical effects of omega-3 polyunsaturated fatty acid (PUFA) supplementation in youth suffering from migraine, including its effects on migraine disability, psychological…
- Trial name
- NCT06899074
- Testing
- Omega 3 Polyunsaturated Fats
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of North Carolina, Chapel Hill
Headache
The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine
This study compares the efficacy of low dose Ketamine versus Compazine for the control of headache in patients presenting to the Emergency Department.
- Trial name
- NCT02657031
- Testing
- Prochlorperazine, Ketamine, Diphenhydramine
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University Medical Center of Southern Nevada
Migraine
Efficacy and Safety Study of Rimegepant in Episodic Migraine Prevention With Multiple Dosing Regimens
The purpose of this study is to compare the efficacy and safety of daily and every other day dosing of rimegepant to placebo as a preventive treatment for episodic migraine.
- Trial name
- NCT05217927
- Testing
- Rimegepant 75mg daily dosing, Rimegepant 75mg every other day dosing
- Where
- 107 sites in United States, Austria and 8 more
- Volunteers
- 1,415 people
- Sponsor
- Pfizer
Migraine, Depression
Treatment for Migraine and Mood (Team-M)
The researchers propose a two-arm pilot study of telephone and video delivered Mindfulness-based Cognitive Therapy (MBCT-T and MBCT-V) in people with migraine and depressive symptoms.
- Trial name
- TEAM-M (NCT04992494)
- Testing
- MBCT-Telephone, MBCT-Video
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- NYU Langone Health
Migraine
A Research Study Examining Migranal and Skin Sensitivity in Subjects With Migraine
This is a research study looking at Migranal (study drug) in the treatment of two migraine attacks in patients who have a history of cutaneous allodynia (pronounced q-tay-nee-us al-o-din-ee-a).
- Trial name
- NCT00335777
- Testing
- Migranal nasal spray at 1 hour, Migranal nasal spray at 4 hour
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Thomas Jefferson University
Migraine Disorders, Chronic Disease
"Follow the Sutures". A New Procedure for Injection of Botulinum Toxin for Chronic Migraine
There is no doubt that chronic migraine is a large public health problem, which is both disabling and costly. Many patients and headache doctors see Botulinum toxin (Botox) treatment as a big stride forward, but it is a problem…
- Trial name
- NCT03543254
- Testing
- BoNT-A
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Norwegian University of Science and Technology
Migraine
Acute Treatment of Migraine With e-TNS
The main objective of this study is to assess the efficacy of the Cefaly® device as an acute treatment of migraine attack in adult patients.
- Trial name
- ACME (NCT02590939)
- Testing
- CEFALY Active
- Where
- 3 sites in United States
- Volunteers
- 106 people
- Sponsor
- Cefaly Technology
Migraine
Investigation and Modulation of the Mu-Opioid Mechanisms in Migraine (in Vivo)
This study investigates whether non-invasive brain stimulation, given for 20 minutes/once per day for ten days (M-F) can reduce migraine pain.
- Trial name
- NCT02964741
- Testing
- Active Comparator
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Migraine, With or Without Aura
Efficacy, Safety, and Tolerability Study of Oral Ubrogepant in the Acute Treatment of Migraine
This study will evaluate the efficacy, safety, and tolerability of 2 doses of ubrogepant (50 and 100 mg) compared to placebo for the acute treatment of a single migraine attack.
- Trial name
- ACHIEVE I (NCT02828020)
- Testing
- Ubrogepant
- Where
- 90 sites in United States
- Volunteers
- 1,672 people
- Sponsor
- Allergan