Clinical trials: Mild Behavioral Impairment
Mild Cognitive Impairment
Exercise Training to Improve Cognitive Function
This project is assessing the feasibility of a novel home-based exercise intervention to improve episodic memory in individuals with mild cognitive impairment.
- Trial name
- NCT03824639
- Testing
- Structured exercise, Health Education
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Mild Cognitive Impairment, Adherence, Patient
MI-CBT Adherence Program for Lifestyle Interventions in Older Adults
Objective 1: Assess feasibility and acceptability of all protocol components of a pilot trial testing a 6-week telehealth Mediterranean ketogenic nutrition adherence (KNA) program using motivational interviewing and cognitive…
- Conditions
- Mild Cognitive Impairment, Adherence, Patient, Ketosis
- Trial name
- MI-CBT KNAP (NCT04817176)
- Testing
- Motivational Interviewing-Cognitive Behavioral Therapy Ketogenic Nutrition Adherence Program, Ketogenic Nutrition Program
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Florida State University
Cognitive Dysfunction, Insomnia
Sleep Disturbance in MCI: A Study of a Cognitive Behavioural Therapy Digital Intervention
This study aims to determine the feasibility of a randomized-controlled trial of digital cognitive behavioural therapy for insomnia (CBT-I) for sleep and cognitive performance in older adults with MCI and insomnia symptoms (50-80…
- Conditions
- Cognitive Dysfunction, Insomnia, Mild Cognitive Impairment, Cognitive Disorder
- Trial name
- SUCCEED (NCT05568381)
- Testing
- digital CBT-I, Online Sleep Health Education package
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- University of Sydney
Subjective Cognitive Decline, Alzheimer Disease
Using Artificial Intelligence to Detect Early Signs of Alzheimer's Disease in People With Memory Concerns
AHEAD is a prospective, longitudinal, risk-stratified single-arm interventional study enrolling 300 patients with Subjective Cognitive Decline (SCD) at IRCCS San Raffaele Hospital, Milan, Italy.
- Conditions
- Subjective Cognitive Decline, Alzheimer Disease, Mild Cognitive Impairment, Cognitive Decline
- Trial name
- AHEAD (NCT07652931)
- Testing
- High-frequency Transcranial Magnetic Stimulation (TMS), Digital Cognitive Training, Structured Physical Exercise
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS San Raffaele
Traumatic Brain Injury, Insomnia
CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms
This study is a prospective two-arm, single blind randomized controlled trial design to compare the clinical effectiveness of telemedicine-delivered, 6-session, standardized cognitive behavioral therapy for insomnia (CBT-I) and…
- Conditions
- Traumatic Brain Injury, Insomnia, Depression, Post-traumatic Stress
- Trial name
- NCT05663034
- Testing
- Mindfulness-based treatment for insomnia (MBTI), Cognitive behavioral therapy for insomnia (CBT-I)
- Where
- 5 sites in United States
- Volunteers
- 360 people
- Sponsor
- Johns Hopkins University
Exercise, Gait
Rhythmically Entrained Exercise in Community-Dwelling Older Adults
Researchers at the University of North Carolina at Greensboro conduct a single-arm intervention trial to investigate the efficacy of a music-based group exercise program for community-dwelling older adults.
- Conditions
- Exercise, Gait, Cognitive Decline, Caregiver Burden
- Trial name
- REECO (NCT05462977)
- Testing
- Group exercise program
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Greensboro
Cancer, Advanced, Cognitive Impairment, Mild
Study of a Behavioral Intervention for Older Advanced Cancer Patients and Their Caregivers
The purpose of this study is to test the feasibility of a telehealth Dyadic Life Review (DLR), adapted from individual Life Review Therapy, with patients and caregivers of older adults with advanced cancer, including those with…
- Trial name
- DLR Pilot (NCT05200572)
- Testing
- Dyadic Life Review (DLR)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Rochester
Memory Disorders, Alzheimer Disease
Impact of Covid-19 on Frequent Social Interaction Through Communication Technologies in the Cognitive Status of Socially-isolated Older Adults
The current study will examine the impact of frequent social interaction through communication technologies during COVID-19 pandemic in the cognitive status of socially-isolated older adults with and without cognitive impairment.
- Conditions
- Memory Disorders, Alzheimer Disease, Mild Cognitive Impairment
- Trial name
- NCT04480112
- Testing
- Technology based social interactions, No research related technology based social interactions
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- Boston University
Mild Cognitive Impairment, Alzheimer's Disease
Effect of Cerefolin®/CerefolinNAC® on Biomarker Measurements
In a retrospective analysis of data from 1100 patients, disease-delaying effects of Cerefolin®/CerefolinNAC® were examined in terms of cognition.
- Conditions
- Mild Cognitive Impairment, Alzheimer's Disease, Alzheimer's Disease Related Disorders
- Trial name
- NCT01745198
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Pamlab, Inc.
TMS Protocols in the Treatment of PD
Standardization and Optimization of TMS Protocols for the Treatment of PD With Depression or Cognitive Impairment
The goal of this study is to determine whether transcranial magnetic stimulation (TMS) is an effective treatment in Parkinson's disease patients with depression or cognitive impairment.
- Trial name
- NCT03552861
- Testing
- repetitive transcranial magnetic stimulation(rTMS)
- Where
- 10 sites in China
- Volunteers
- 252 people
- Sponsor
- Guangdong Provincial People's Hospital
Mild Cognitive Impairment in Middle-aged Adults
Deafness and Cognition in Middle-aged Adults
A mild cognitive impairment was observed in 50% of cochlear implant candidates aged 65 years and over, compared to 5-19% in general population. No studies analysed cognition in patients younger than 65 years.
- Trial name
- SURDICOG (NCT05149742)
- Testing
- Cognitive and audiometry evaluation
- Where
- France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alzheimer Disease
CBT for African Americans With Cognitive Impairment
The aim of the study is to test the feasibility and acceptability of a six-month cognitive-behavioral therapy (CBT) program (group based and phone-based) compared with usual care, and to determine if the intervention can improve…
- Trial name
- NCT03384069
- Testing
- Group-based Cognitive Behavioral Therapy (CBT), Phone-based Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Emory University
Alzheimer Disease, Preclinical Alzheimer's Disease
Amyloid Prediction in Early Stage Alzheimer's Disease From Acoustic and Linguistic Patterns of Speech
The primary objective of the study is to evaluate whether a set of algorithms analysing acoustic and linguistic patterns of speech can detect amyloid-specific cognitive impairment in early stage Alzheimer's disease, as measured…
- Conditions
- Alzheimer Disease, Preclinical Alzheimer's Disease, Prodromal Alzheimer's Disease, Alzheimer's Disease (Incl Subtypes)
- Trial name
- AMYPRED (NCT04828122)
- Where
- 4 sites in United Kingdom
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Novoic Limited
Depression, Mild Cognitive Impairment
The Rapid Diagnosis of MCI and Depression in Patients Ages 60 and Over
Mild cognitive impairment (MCI) leading to Alzheimer's disease and related disorders (ADRD) represents a significant health and economic burden of the rapidly expanding senior population.
- Trial name
- NCT06011681
- Where
- 2 sites in United States
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Miro Health
Multiple Sclerosis, Fatigue
The Impact of Exercise Training on Living Quality in Multiple Sclerosis Individuals
The most common symptom displayed in patients with multiple sclerosis (MS) is a pronounced sense of fatigue that can have negative effect on functional ability and quality of life (QOL).
- Conditions
- Multiple Sclerosis, Fatigue, Mental Status Change, Physical Disability
- Trial name
- NCT03222596
- Testing
- Exercise training
- Where
- Croatia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Rijeka
Mental Health, Non Communicable Diseases
Adapting Behavioral Interventions for Dementia to Address NCDs and Mental Health
This pilot study aims to adapt the BEhavioral Community-based COmbined Intervention for MEntal Health and Noncommunicable Diseases (BECOME) to address the unique needs of individuals with dementia or mild cognitive impairment…
- Conditions
- Mental Health, Non Communicable Diseases, Dementia
- Trial name
- BECOME-D (NCT07543341)
- Testing
- BECOME-D Intervention
- Where
- Nepal
- Volunteers
- 12 people
- Sponsor
- Possible
Mild Cognitive Impairment
Reducing Sedentary Behaviour and Cognition in Older People
Introduction Sedentary behaviour refers to activities of low energy expenditure in lying and sitting positions. Examples include driving, watching television, playing cards, puzzles and working on a computer.
- Trial name
- NCT04464538
- Testing
- WALC-R, Information leaflet
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Anglia Ruskin University
Insomnia, Cognitive Dysfunction
Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND)
This randomized controlled trial will evaluate the impact of an Internet-delivered cognitive behavioral therapy for insomnia (CBT-I) intervention on sleep and the extent to which it contributes to cognitive health in individuals…
- Conditions
- Insomnia, Cognitive Dysfunction, Mild Cognitive Impairment, Sleep Initiation and Maintenance Disorders
- Trial name
- NCT05565833
- Testing
- SHUTi OASIS, Patient Education
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of Virginia
Dementia, Mild Cognitive Impairment (MCI)
Predictors Of Cognitive Decline Using Digital Devices
The overall aim of this study is to find out if people with cognitive difficulties will wear and use different types of digital technology, and if they will allow data from that technology and their clinical profile to be…
- Conditions
- Dementia, Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), Rapid Eye Movement Sleep Behavior Disorder
- Trial name
- CODEC-II (NCT07051408)
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University College, London
Mild Cognitive Impairment, Cognitive Function
Binaural Beats for Cognitive Function in Older Adults With Mild Cognitive Impairment in Nursing Homes
This study will evaluate whether binaural beats can improve cognitive function in older adults with mild cognitive impairment living in nursing homes.
- Trial name
- BB-MCI (NCT07735910)
- Testing
- Binaural Beats Embedded in Old Songs, Old Songs
- Where
- 3 sites in China
- Volunteers
- 60 people
- Sponsor
- China Medical University, China