Clinical trials: Mild Cognitive Impairment (MCI)
Mild Cognitive Impairment, Mild Alzheimer's Disease
Early Detection of Mild Cognitive Impairment in Individual Patients
Our central hypothesis is that the early metabolic lesions of MCI can be reliably detected in individual subjects by objective analysis of [18]F-fluorodeoxyglucose (FDG) positron-emission tomography (PET) brain images, earlier…
- Trial name
- NCT00243451
- Testing
- PET scan & fMRI
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Cognitive Decline, Alzheimer Disease
Effects of Real vs. Soundless Acoustic Stimulation During Deep Sleep on Brain Activity, Memory, and Blood Biomarkers in Older Adults (60-85) With Mild Memory Impairment
This study aims to explore a non-invasive way to improve memory and slow cognitive decline in older adults by enhancing sleep quality.
- Conditions
- Cognitive Decline, Alzheimer Disease, Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI)
- Trial name
- NCT06669546
- Testing
- Phase-locked auditory stimulation (PLAS)
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Bern
Alzheimer Disease
CBT for African Americans With Cognitive Impairment
The aim of the study is to test the feasibility and acceptability of a six-month cognitive-behavioral therapy (CBT) program (group based and phone-based) compared with usual care, and to determine if the intervention can improve…
- Trial name
- NCT03384069
- Testing
- Group-based Cognitive Behavioral Therapy (CBT), Phone-based Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Emory University
Mild Cognitive Impairment, Dementia
Dementia Patient's Behavior Evaluation Using Noninvasive Ambient Sensor
This study is an observational study that uses daily activity and environmental sensing techniques to establish behavioral models of early dementia patients and cognitive healthy function to assess their daily behavior and…
- Trial name
- NCT03120741
- Where
- Taiwan
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Mild Cognitive Impairment
Study of Neurobiological Predictors of Response to Non-invasive Neurostimulation and Genetic Susceptibility to Dementia in Patients With Amnestic Mild Cognitive Impairment
Transcranial Direct Current Stimulation is a non-invasive neuromodulatory technique that results in the clinical improvement of patients with Mild Cognitive Impairment, a prodromal condition for the onset of dementia.
- Trial name
- NCT04943003
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Suellen Marinho Andrade
Parkinson's Disease, Mild Cognitive Impairment
Combined STN and NBM Deep Brain Stimulation for Mild Cognitive Impairment in Parkinson's Disease
The goal of this clinical trial is to evaluate the safety and tolerability of a novel deep brain stimulation (DBS) of the Subthalamic Nucleus (STN) and Nucleus Basalis of Meynert (NBM) to treat cognitive and cognitive-motor…
- Trial name
- NCT05968703
- Testing
- Combined STN+NBM DBS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Helen M. Bronte-Stewart
Mild Cognitive Impairment
Effects of SUDOKU Mind Activation & Revitalizing Training on Cognitive Function in People With Mild Cognitive Impairment
This study aims to implement a SUDOKU Mind Activation and Revitalization Training (SMART) Program to promote cognitive health among patients with mild cognitive impairment (MCI), and the use of active mind strategy in preventing…
- Trial name
- SMART (NCT04913857)
- Testing
- 24-week SUDOKU Training Programme, Control Arm (wait-list)
- Where
- Hong Kong
- Volunteers
- 262 people
- Sponsor
- The University of Hong Kong
Cognitive Changes Due to Organic Disorder (Finding), Dementia
Gerontology Research Programme: The Singapore Longitudinal Ageing Studies (SLAS I & II)
The Gerontology Research Programme (GRP) in the National University Singapore's Department of Psychological Medicine, was formed to coordinate and facilitate the conduct of multi-disciplinary research on in a wide range of…
- Conditions
- Cognitive Changes Due to Organic Disorder (Finding), Dementia, Mild Cognitive Impairment, Frailty
- Trial name
- SLAS (NCT03405675)
- Testing
- SLAS 1, SLAS 2
- Where
- Singapore
- Volunteers
- 6,183 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Mild Cognitive Impairment (MCI)
The Effects of Single Baduanjin and Elastic Band Exercises on VSWM in Elderly Individuals With MCI
Previous studies have confirmed that both acute (single) and long-term various exercise interventions can significantly improve the cognitive function of individuals with MCI.
- Trial name
- NCT07656480
- Testing
- baduanjin exercise, elastic band exercises
- Volunteers
- 60 people
- Sponsor
- qiu chen
Alzheimer Disease, Mild Cognitive Impairment
Applying Non-invasive Brain Stimulation in Alzheimer's Rehabilitation
Presently, few studies have evaluated the clinical impact of rTMS in Alzheimer's disease. Though some studies have demonstrated an improvement, there have been conflicting results, as others do not seem to demonstrate beneficial…
- Trial name
- StimoLaMente (NCT04866979)
- Testing
- Experimental: Continuous TBS (cTBS), Intermittent TBS (iTBS), Cognitive training (CT).
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Università degli Studi di Trento
Mild Cognitive Impairment, Dementia
A Study of CST-2032 and CST-107 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's or Alzheimer's Disease
This is a Phase 2a, randomized, placebo-controlled, double-blind, crossover study to evaluate the effects CST-2032 administered with CST-107 on cognition in participants with Mild Cognitive Impairment (MCI) or mild dementia.
- Trial name
- NCT05104463
- Where
- 15 sites in United States, New Zealand
- Volunteers
- 64 people
- Sponsor
- CuraSen Therapeutics, Inc.
Early Alzheimer's Disease
A Study to Confirm Safety and Efficacy of Lecanemab in Participants With Early Alzheimer's Disease
This study will be conducted to evaluate the efficacy of lecanemab in participants with early Alzheimer's disease (EAD) by determining the superiority of lecanemab compared with placebo on the change from baseline in the Clinical…
- Trial name
- Clarity AD (NCT03887455)
- Testing
- Lecanemab IV, Lecanemab SC
- Where
- 247 sites in United States, Australia and 12 more
- Volunteers
- 1,906 people
- Sponsor
- Eisai Inc.
Colorectal Cancer
Developing Risk Prediction Model and Testing the Effect of Dual Task Walking on Improving Cognitive Function in Patients With Colorectal Cancer
The aims of this three-year study are to explore cognitive function under different stages of colorectal cancer (CRC) and its related factors; and understand its disturbance and coping process caused by cancer-induced cognitive…
- Trial name
- NCT04490733
- Testing
- dual-task walking
- Where
- Taiwan
- Volunteers
- 355 people
- Sponsor
- National Taiwan University Hospital
Mild Cognitive Impairment, Dementia; Alzheimer's Type (Etiology)
STIM+: PET Biomarker Education & Disclosure
When dementia is caused by AD, we refer to it as dementia of the Alzheimer's Type (DAT). The greatest risk factor for Alzheimer's Disease (AD) and DAT is advancing age, but DAT is not a normal part of aging.
- Trial name
- STIM+ (NCT04818255)
- Testing
- PET Biomarker Disclosure
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- University of Michigan
Mild Cognitive Impairment (MCI)
Assessment of Motor Reserve in the Preclinical Stages of Dementia
Mild Cognitive Impairment (MCI) is a clinical condition associated with an increased risk of progression to dementia. Although cognitive alterations have traditionally been the main focus of investigation, growing evidence…
- Trial name
- NCT07634055
- Testing
- Sensor-based medical device for kinematic assessment: Hand Test System (HTS)
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
Mild Cognitive Impairment, TTM
Non-pharmacological Interventions on Cognitive Functions in Older People With Mild Cognitive Impairment
This project is proposed to be a three-year project. The purposes of this project are to develop and examine physical activity program, cognitive rehabilitation training, and new life-style (combination of exercise and cognitive)…
- Conditions
- Mild Cognitive Impairment, TTM, Physical Activity, Cognitive Rehabilitation
- Trial name
- NCT03545152
- Testing
- Exercise, Cognitive training, New life-style
- Volunteers
- 192 people
- Sponsor
- Tzu-Ting Huang
Mild Cognitive Impairment
Mild Cognitive Impairment, Use of qEEG as a Prognostic Marker
Multi center study of six Memory Clinics in four Nordic countries in validating a prognostic diagnostic investigation of qEEG in Mild Cognitive Impairment (MCI).
- Trial name
- NCT03659643
- Testing
- EEG with SPR analysis
- Where
- Iceland
- Volunteers
- 300 people
- Sponsor
- Jon Snaedal
Alzheimer's Disease
Biomarkers and Early Alzheimer's Disease
The main goal of this project is to use imaging and biomarkers to identify cognitively normal elderly people who are at increased risk for developing mild cognitive impairment (MCI).
- Trial name
- NCT00094952
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Mild Cognitive Impairment
Feasibility Study of Virtual Sail 3D in Cognitive Functions
This research project will assess the feasibility and preliminary effectiveness of a 6-week intervention to improve cognitive functions using the 3D immersive virtual reality software "CEREBRUM" with virtual sailing scenarios…
- Trial name
- NCT06579378
- Testing
- VSail 3D, WEB-Health
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Cagliari
Alzheimer´s Disease
Safety, Tolerability and Biomarker-based Efficacy of NPI-001 (AT-001) in Subjects With MCI or Alzheimer's Disease (AD)
The study aims to measure safety, tolerability and biomarker-based efficacy of NPI-001 (AT-001) in Subjects with MCI or Alzheimer's Disease (AD).
- Trial name
- AD Biomarker (NCT07741526)
- Testing
- NPI-001
- Where
- 4 sites in Denmark, Iceland
- Volunteers
- 33 people
- Sponsor
- Arctic Therapeutics
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