Clinical trials: Mild Depression, open to volunteers
Mild Cognitive Impairment (MCI), Dementia Alzheimer Type
Global Collaborative Research on Establishing a Korean Cognitive Aging Cohort
The goal of this observational study is to learn how daily emotional stress affects cognitive function and inflammation in community-dwelling older adults aged 60 and older in Seoul, Republic of Korea.
- Conditions
- Mild Cognitive Impairment (MCI), Dementia Alzheimer Type, Chronic Pain, Depression - Major Depressive Disorder
- Trial name
- KoCoA cohort (NCT07485387)
- Where
- South Korea
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Korea University
Mild Depression
Prefrontal Glutamatergic Modulation by NAC and MBCT for Depression in Youth
The primary goal is to investigate to what extent changes in glutamate and glutathione modulation and functional integration between brain networks associated with emotion and attention regulation are associated with treatment…
- Trial name
- NAC+MIND (NCT07464886)
- Testing
- N-acetylcysteine, Mindfulness-based cognitive therapy
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Cincinnati
Neurocognitive Disorders, Mild, Cognitive Impairment, Mild
Effects of Personalized Digital Reminiscence Therapy on Patients With Neurocognitive Disorders
This study aims to observe the effects of daily personalized digital reminiscence sessions, conducted with the help of a digital conversational agent, and to determine whether these sessions lead to improvements in symptoms such…
- Conditions
- Neurocognitive Disorders, Mild, Cognitive Impairment, Mild, Depression Mild, Apathy
- Trial name
- NCT07237009
- Where
- 5 sites in France
- Volunteers
- 80 people
- Sponsor
- KompanionCare SAS
Post-Concussion Syndrome, Concussion, Brain
Personalized Brain Stimulation to Treat Chronic Concussive Symptoms
The goal of this study is to investigate a new treatment for chronic symptoms after concussion or mild traumatic brain injury in people aged 18-65 years old.
- Conditions
- Post-Concussion Syndrome, Concussion, Brain, Mild Traumatic Brain Injury, Head Injury
- Trial name
- NCT06073886
- Testing
- Active cTBS, Imaginal exposure
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of California, Los Angeles
Depression Mild, Depression Moderate
Treating Major Depression With Yoga Mono-therapy
The goal of this single-center, single-blind, randomized, controlled, parallel group, interventional trial is to evaluate antidepressant efficacy of yoga monotherapy of 12-weeks duration in 180 adults meeting diagnostic criteria…
- Trial name
- NCT06091527
- Testing
- Yoga practice, Education
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of California, San Francisco
Major Depressive Disorder, Alzheimer Disease
Deep TMS for Comorbid Depression and Cognitive Impairment in Older Adults
In this study, the investigators will be examining the effects of the deep repetitive transcranial magnetic stimulation (rTMS) using the H1 coil in patients over the age of 60 diagnosed with mild to early-moderate Alzheimer's…
- Conditions
- Major Depressive Disorder, Alzheimer Disease, Mild Cognitive Impairment
- Trial name
- NCT03665831
- Testing
- Brainsway H1-Coil Deep TMS System
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- Rotman Research Institute at Baycrest
Stress, Psychological, Depression and/or Anxiety in the Mild-to-moderate Range
Testing Adapted Self-Help Plus (SH+) for Stress and Well-Being in International Students at a U.S. University
The goal of this clinical trial is to learn if an adapted version of Self-Help Plus (SH+), a stress management program developed by the World Health Organization, can reduce stress and improve well-being in international students…
- Conditions
- Stress, Psychological, Depression and/or Anxiety in the Mild-to-moderate Range, Loneliness, Adjustment, Psychological
- Trial name
- NCT07188467
- Testing
- Digitized SH+
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The New School
Mild Cognitive Impairment in Middle-aged Adults
Deafness and Cognition in Middle-aged Adults
A mild cognitive impairment was observed in 50% of cochlear implant candidates aged 65 years and over, compared to 5-19% in general population. No studies analysed cognition in patients younger than 65 years.
- Trial name
- SURDICOG (NCT05149742)
- Testing
- Cognitive and audiometry evaluation
- Where
- France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depressive Symptoms Mild to Moderate in Severity, Major Depressive Disorder
Adolescent Interpersonal Counseling in Primary Care
The demand for prevention and treatment of adolescent depression has rapidly increased over years. A national project to improve treatment of adolescent depression in primary care has taken place in Finland starting 2020.
- Trial name
- NCT06390462
- Testing
- Interpersonal counseling, Treatment as usual, No support, intervention or other treatment
- Where
- 4 sites in Finland
- Volunteers
- 9,000 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Generalised Anxiety Disorder, Anxiety Disorders
CBT and the Neural Circuits of Anxiety
This study will aim to test whether specific neural circuitry changes, proposed on the basis of a neurocognitive model of anxiety, are a mechanism of action for Cognitive Behavioural Therapy (CBT) interventions.
- Conditions
- Generalised Anxiety Disorder, Anxiety Disorders, CBT, Anxiety Depression
- Trial name
- NCT05549102
- Testing
- Cognitive Behavioural Therapy, Waiting List
- Where
- United Kingdom
- Volunteers
- 174 people
- Sponsor
- UCLH/UCL Joint Research Office
Mild to Moderate Anxiety and Depression
Digital Positive Affect Intervention Study
Anxiety and depression are highly prevalent mental health disorders that impose a significant burden on individuals and public health systems worldwide (GBD 2019 Mental Disorders Collaborators, 2022).
- Trial name
- NCT06978257
- Testing
- Digital positive affect intervention (PAI), Self-monitoring intervention
- Where
- Singapore
- Volunteers
- 2,400 people
- Sponsor
- National University of Singapore
Depressive Symptoms Mild to Moderate in Severity, Anxiety
Effects of Intranasal Ketamine on Depression and Anxiety in Palliative Care Cancer Patients
With progression of cancer, patients and their caregivers experience challenging emotional distress, which can make them feel depressed and very anxious. Patients with advanced cancer often do not have long to live.
- Conditions
- Depressive Symptoms Mild to Moderate in Severity, Anxiety, Quality of Life (QOL), Caregiver Burden
- Trial name
- Keta-Care (NCT06665568)
- Testing
- Intranasal ketamine hydrochloride
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Mild Cognitive Impairment
WAVE: AudioVisual Stimulation Enhances Cognitive, Mental and Physical Health in Elderly
The goal of this randomized controlled trial is to 1) carry out a screening of cognitive function, depressive symptoms, agility and functional balance and chronic inflammatory conditions in older adults; 2) analyze the influence…
- Trial name
- NCT06686563
- Testing
- Intervention Group: Gamma stimulation, Control Group: Theta stimulation
- Where
- Portugal
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maria Paço
Dementia, Bipolar Disorder (BD)
Lithium for Prevention of Cognitive Declining in Mood Illnesses
INTRODUCTION: Mood disorders, bipolar disorder and recurrent unipolar depression, are among the most common mental health conditions worldwide.
- Conditions
- Dementia, Bipolar Disorder (BD), Depression - Major Depressive Disorder, Mild Cognitive Impairment (MCI)
- Trial name
- NCT06662526
- Testing
- Trace lithium dose plus treatment as usual
- Where
- 2 sites in Chile
- Volunteers
- 250 people
- Sponsor
- University of Chile