Clinical trials: Mild Hypertension
Uncontrolled Hypertension
A Phase I Trial of QLS1410 in Healthy Chinese Adults and Participants With Mild Essential Hypertension
The goal of this clinical trial is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and food effect of single and multiple ascending doses of QLS1410 in healthy Chinese adults and participants with mild…
- Trial name
- NCT07152444
- Testing
- QLS1410 (CYP11B2 inhibitor)
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Hypertension
A Study of the Safety and Efficacy of Nebivolol in Hypertensive Patients
A study to determine the safety, efficacy and superiority of nebivolol to placebo for the treatment of elevated blood pressure in patients with mild to moderate hypertension.
- Trial name
- NCT00200473
- Testing
- Nebivolol
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Mylan Bertek Pharmaceuticals
Hypertension, Essential
Study of Nifedipine GITS and Candesartan Combination Compared to Monotherapy in Patients With Essential Hypertension
The purpose of this study is to determine the blood pressure lowering responses of various dose combinations of nifedipine GITS and candesartan as compared to treatment with each component on their own (monotherapy) and placebo…
- Trial name
- DISTINCT (NCT01303783)
- Testing
- Candesartan cilexetil (Atacand), 4 mg, Candesartan cilexetil (Atacand), 8 mg, Nifedipine GITS (Adalat, BAYA1040), 20 mg
- Where
- 157 sites in United States, Argentina and 11 more
- Volunteers
- 1,381 people
- Sponsor
- Bayer
Diabetes Mellitus
Effects of Valsartan and Aliskiren on Hemostatic Indices in Hypertensive Diabetics
People with both hypertension and diabetes have a higher chance of developing heart and arterial problems that could be reduced with anti-coagulant therapy.
- Trial name
- NCT01095822
- Testing
- Aliskiren + Valsartan
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- HeartDrug Research LLC
Hypertension, Type 2 Diabetes Mellitus
Antiproteinuric Effect of Imidapril Versus Ramipril in Type 2 Diabetic and Hypertensive Patients With Microalbuminuria
Numerous clinical and experimental data show that the elective treatment of diabetic nephropathy should be based on drugs that inhibit the renin-angiotensin system (RAS).
- Conditions
- Hypertension, Type 2 Diabetes Mellitus, Microalbuminuria
- Trial name
- NCT01230034
- Testing
- Ramipril, Imidapril
- Where
- Italy
- Volunteers
- 206 people
- Sponsor
- University of Pavia
Mild Cognitive Impairment, Hypertension
Hypertension, Brain Clearance, and Markers of Neurodegeneration
The purpose of this research study is to measure cerebrospinal fluid (CSF) clearance in subjects with and without high blood pressure.
- Trial name
- NCT05785871
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Coronary Artery Disease, Non-significant Coronary Artery Disease
TweeSteden Mild Stenosis Study
Psychosocial factors have been found to be associated with an increased risk for coronary artery disease incidence, progression and worse clinical outcomes.
- Conditions
- Coronary Artery Disease, Non-significant Coronary Artery Disease, Mild Stenosis, Vascular Irregularities
- Trial name
- TWIST (NCT01788241)
- Where
- Netherlands
- Volunteers
- 547 people
- Sponsor
- Tilburg University
Hypertension
Hypertension Study: Multinational Torasemide Trial in Mild to Moderate Hypertension.
Primary objective:To demonstrate the no-inferiority in efficacy of treatment with Torsemide-PR in relation to Torsemide-IR in patients with mild and/or moderate hypertension.
- Trial name
- NCT00334386
- Testing
- Torasemide Prolonged Release (loop diuretic), Torasemide Immediate Release (loop diuretic)
- Volunteers
- 388 people
- Sponsor
- Ferrer Internacional S.A.
Essential Hypertension, Renal Impairment
Olmesartan Medoxomil in Hypertension and Renal Impairment
This is a study in hypertensive patients with mild to moderate renal impairment. The antihypertensive efficacy of olmesartan medoxomil is compared to losartan.
- Trial name
- NCT00151827
- Testing
- Olmesartan medoxomil, Losartan, Furosemide oral tablets
- Where
- Germany
- Volunteers
- 393 people
- Sponsor
- Sankyo Pharma Gmbh
Hypertension,Essential
Safety and Efficacy of SPH3127 on Treating Mild-moderate Essential Hypertension Patients
SPH3127 tablet is a of renin inhibitor. It is expected to be a new drug for essential hypertension. This is a phase IIa trial which designed to evaluate its efficacy and safety on treating mild-moderate essential hypertension…
- Trial name
- NCT03756103
- Testing
- SPH3127 tablet Dose 1, SPH3127 tablet Dose 2, SPH3127 tablet Dose 3
- Where
- 10 sites in China
- Volunteers
- 120 people
- Sponsor
- Shanghai Pharmaceuticals Holding Co., Ltd
Glaucoma, Ocular Hypertension
Evaluation of the Safety, Efficacy, Dose Response of the Bimatoprost Drug Ring System (BIM-DRS) in Pseudophakic Patients Diagnosed With Open Angle Glaucoma or Ocular Hypertension
The goal of this clinical trial is to learn if two different doses of the SpyGlass Bimatoprost-Drug Ring System (BIM-DRS) work to treat adult pseudophakic patients with either glaucoma or ocular hypertension.
- Trial name
- NCT07641296
- Testing
- BIM-DRS Low Dose, BIM-DRS High Dose, SpyGlass IOL with silicone pads (no drug)
- Volunteers
- 24 people
- Sponsor
- SpyGlass Pharma, Inc.
Hypertension
Effects of Aliskiren/Amlodipine Versus Amlodipine Monotherapy on Ankle-foot Volume in Hypertensive Patients
Comparison between the effect of aliskiren/amlodipine combination with amlodipine monotherapy on ankle-foot volume in hypertensive patients. It will be enrolled male or female outpatients, aged 18-65 years.
- Trial name
- NCT01048047
- Testing
- aliskiren/amlodipine
- Where
- 2 sites in Italy
- Volunteers
- 88 people
- Sponsor
- University of Pavia
Glaucoma
Comparison of Two OCT Device RNFL and GCIPL Measurements in Mild, Moderate, and Severe Glaucoma
This research study was designed to evaluate how consistently two different imaging devices measure the thickness of retinal layers in patients with glaucoma.
- Trial name
- NCT07350304
- Testing
- Optical Coherence Tomography
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Twin Cities Eye Consultants
Hypertension
A Study of the Efficacy and Safety of Nebivolol Added to Existing Antihypertensive Treatment in Patients With Hypertension
The purpose of this study was to contrast the efficacy and safety of 3 dose levels of nebivolol vs. placebo, when added to a patient's existing antihypertensive medication(s) for 3 months, in patients with mild to moderate…
- Trial name
- NCT00200434
- Testing
- Nebivolol
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Mylan Bertek Pharmaceuticals
Cardiovascular Diseases, Heart Diseases
Treatment of Mild Hypertension Study (TOMHS)
To compare the effects of nonpharmacologic therapy alone with those of one of five active drug regimens combined with non-pharmacologic therapy, for long- term management of patients with mild hypertension.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Vascular Diseases
- Trial name
- NCT00000522
- Testing
- diet, sodium-restricted, diet, reducing, exercise
- Sponsor
- University of Minnesota
Hypertension
Comparison of the Antihypertensive Efficacy of Valsartan and Enalapril After Missing One Dose
This study was designed in order to evaluate the blood pressure lowering effect of valsartan compared to enalapril over 24 hours after skipping one daily dose.
- Trial name
- NCT00302705
- Testing
- Valsartan, Enalapril, Ambulatory blood pressure monitoring, Missing one dose
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- University of Vigo
Renal Disorder
Antiproteinuric Efficacy of Losartan Potassium in Patients With Non-Diabetic Proteinuric Renal Diseases (0954-213)
Antiproteinuric Efficacy of Losartan Potassium in Patients with Non-Diabetic Proteinuric Renal Diseases.
- Trial name
- NCT00140985
- Testing
- MK0954, losartan potassium/Duration of Treatment: 20 weeks, Comparator: amlodipine / Duration of Treatment: 20 weeks
- Volunteers
- 97 people
- Sponsor
- Organon and Co
Gestational Hypertension, Mild Pre-eclampsia
Labor Characteristics and Outcomes in Women With Gestational Hypertension or Preeclampsia Who Underwent Labor Induction
Comparison of Labor Characteristics and Maternal-Neonatal Outcomes in Induced Labor Between Women with Gestational Hypertension/Mild Preeclampsia and Normotensive Controls
- Trial name
- NCT06907576
- Where
- China
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Essential Hypertension
Olmesartan Medoxomil Versus Losartan in Patients With Hypertension
The purpose of this study is to determine the efficacy and safety of oral administration of olmesartan medoxomil compared to losartan in subjects with mild to moderate hypertension.
- Trial name
- NCT00857285
- Testing
- olmesartan medoxomil, losartan potassium
- Where
- 3 sites in Taiwan
- Volunteers
- 130 people
- Sponsor
- Daiichi Sankyo
Hypertension
Efficacy/Safety of Valsartan Plus Amlodipine and Amlodipine Alone in Patients With Hypertension
This study will evaluate the safety and efficacy of the fixed combination of valsartan/amlodipine in adult patients with mild to moderate hypertension
- Trial name
- NCT00413049
- Testing
- Valsartan/amlodipine 80/5 mg, Amlodipine 5 mg
- Where
- 12 sites in China
- Volunteers
- 698 people
- Sponsor
- Novartis