Clinical trials: Mild Hypertension
Diabetic Nephropathies, Hypertension
Adalat XL vs Diltiazem on Proteinuria and Blood Pressure in Hypertensive Diabetic Patients
The study consists of a 12 week run-in period when all subjects are stabilized on a single dose of Avalide (300 mg/12.5 mg or 300mg/25mg dose) per day.
- Trial name
- CARDINAL (NCT00713011)
- Testing
- Adalat XL, Tiazac XC
- Sponsor
- Bayer
Prediabetic State, Insulin Resistance
Macronutrient Effects on Alzheimer's Disease (MEAL-2)
This study compares the effects of a one-month diet high in saturated fat (SF), glycemic index (GI), and salt (Na+) to a diet low in these nutritional parameters on memory and other cognitive functions, on MRI measures of brain…
- Conditions
- Prediabetic State, Insulin Resistance, Middle Age, Prehypertension
- Trial name
- MEAL-2 (NCT02463084)
- Testing
- Low Diet, High Diet
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Hypertension
Telmisartan vs. Valsartan in Patients With Mild to Moderate Hypertension Following a Missed Dose
The primary objectives are to demonstrate that MICARDIS® (telmisartan) is statistically superior to Diovan® (valsartan) in reducing diastolic blood pressure (DBP) following a missed dose at the end of a 6 to 8-week treatment…
- Trial name
- NCT00034840
- Testing
- telmisartan, valsartan
- Where
- 35 sites in United States, Canada
- Volunteers
- 490 people
- Sponsor
- Boehringer Ingelheim
Mild Essential Hypertension, Moderate Essential Hypertension
Safety, Tolerability and Efficacy of a Vaccine Against Essential Hypertension
The study medication CYT006-AngQb is a vaccine, consisting of angiotensin II (Ang II), the naturally occurring octapeptide coupled onto the surface of virus-like particles (VLP).
- Trial name
- NCT00710372
- Testing
- CYT006-AngQb
- Where
- Switzerland
- Volunteers
- 83 people
- Sponsor
- Cytos Biotechnology AG
Hypertension
Telmisartan and Hydrochlorothiazide Antihypertensive Treatment Study in High Sodium Intake Population
In this research, the investigators aim to compare the antihypertensive efficacy and safety of monotherapy of routine dose angiotensin receptor antagonist telmisartan (ARB) and diuretic Hydrochlorothiazide (HCTZ) in high sodium…
- Trial name
- NCT02255253
- Testing
- Telmisartan, Hydrochlorothiazide
- Where
- 14 sites in China
- Volunteers
- 1,410 people
- Sponsor
- The George Institute for Global Health, China
Hypertensive Disorder of Pregnancy, Pre-Eclampsia, Severe
Low-Sodium Diet for Postpartum Blood Pressure Control
The goal of this randomized controlled trial is to learn if a low-sodium diet improves postpartum blood pressure control in adults who were diagnosed with a late-onset hypertensive disorder of pregnancy.
- Conditions
- Hypertensive Disorder of Pregnancy, Pre-Eclampsia, Severe, Pre-Eclampsia; Mild, Postpartum
- Trial name
- NCT07752056
- Testing
- Low Sodium Diet
- Volunteers
- 110 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Hypertension
Irbesartan/Hydrochlorothiazide National Taiwan University Hospital Listing
Primary: 1. To compare the change in forearm vascular resistance following a 12-week regimen of irbesartan/hydrochlorothiazide versus irbesartan 2.
- Trial name
- NCT00443612
- Testing
- Irbesartan/Hydrochlorothiazide, Irbesartan
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Sanofi
Hypertension
Efficacy and Safety Study of S-Amlodipine Gentisate Compared to Amlodipine Besylate to Treat Mild-to-Moderate Hypertension
The goal of this study is to compare the antihypertensive effect and tolerability of S-amlodipine gentisate with those of amlodipine besylate in patients with mild to moderate hypertension.
- Trial name
- NCT00289406
- Testing
- S-amlodipine gentisate, Amlodipine besylate
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- SK Chemicals Co., Ltd.
Hypertension
Natriuretic Effect of Telmisartan Versus Placebo in Patients With Mild-to-Moderate Hypertension
Study to compare the natriuretic effect of telmisartan to placebo in mild-to-moderate hypertensive patients on a controlled sodium diet as well as to explore the effects of telmisartan on norepinephrine, plasma renin activity…
- Trial name
- NCT02176499
- Testing
- Telmisartan, low dose, Telmisartan, high dose
- Volunteers
- 26 people
- Sponsor
- Boehringer Ingelheim
Hypertension
Efficacy and Safety of Aliskiren in Patients With Mild to Moderate Hypertension During Exercise
This study compared the blunting effect of aliskiren and valsartan monotherapies on exercise-induced rises in systolic blood pressure in patients with mild to moderate essential hypertension.
- Trial name
- NCT00819767
- Testing
- Aliskiren, Valsartan
- Where
- 8 sites in Czechia, Hungary and 2 more
- Volunteers
- 68 people
- Sponsor
- Novartis
Hypertension
Effectiveness and Safety of Combination of Nebivolol and Amlodipine in Hypertensive Patients Versus Each Monotherapy
Study to assess the anti-hypertensive efficacy and safety of the extemporaneous combination of Nebivolol 5 mg in combination with Amlodipine 5 mg or AML 10 mg in lowering the sitting diastolic BP after 8 weeks of treatment…
- Trial name
- Botticelli (NCT05513937)
- Testing
- Nebivolol, Amlodipine
- Where
- Bulgaria
- Volunteers
- 301 people
- Sponsor
- Menarini International Operations Luxembourg SA
Hypertension
Efficacy and Safety of Chronic Administration of Telmisartan as Monotherapy or in Combination With Hydrochlorothiazide or Other Antihypertensive Medications in Patients With Mild to Moderate Hypertension
The primary objective of this trial was to assess the efficacy and safety of telmisartan 80 mg during open-label, long-term treatment.
- Trial name
- NCT02177422
- Testing
- Telmisartan, Hydrochlorothiazide
- Volunteers
- 489 people
- Sponsor
- Boehringer Ingelheim
Hypertension
Evaluate the Safety and Anti-Hypertensive Efficacy of Hyzaar(R) In Patients With Mild To Moderate Essential Hypertension (0954A-323)
Evaluate the safety and anti-hypertensive efficacy of hyzaar(R) in patients with mild to moderate essential hypertension.
- Trial name
- NCT00400218
- Testing
- MK0954A, hydrochlorothiazide (+) losartan potassium / Duration of Treatment: 12 Weeks
- Volunteers
- 62 people
- Sponsor
- Organon and Co
Essential Hypertension
Dose-finding Study With ACT-132577 (Aprocitentan) in Participants With Essential Hypertension
The main objective will be to evaluate the dose-response of ACT-132577 (aprocitentan) on diastolic blood pressure (DBP) in participants with grade 1 or 2 essential hypertension.
- Trial name
- NCT02603809
- Testing
- Aprocitentan 5 mg, Aprocitentan 10 mg, Aprocitentan 25 mg
- Where
- 90 sites in United States, Canada and 2 more
- Volunteers
- 1,659 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Systolic Hypertension
An 8-week Study to Evaluate the Dose Response of AHU377 in Combination With Valsartan 320 mg in Patients With Mild-to-moderate Systolic Hypertension
The purpose of the study is to evaluate dose response of blood pressure lowering for 4 doses of AHU377, given once daily (50 mg, 100 mg, 200 mg and 400 mg) in combination with a fixed dose of valsartan (320 mg).
- Trial name
- NCT01281306
- Testing
- LCZ696, Valsartan, AHU377
- Where
- 90 sites in United States, Argentina and 7 more
- Volunteers
- 910 people
- Sponsor
- Novartis Pharmaceuticals
Hypertension, Type 2 Diabetes Mellitus
A Comparison of Indapamide SR 1.5 mg With HCTZ 25 mg, in Combination With an ACE-inhibitor, in Patients With Mild to Moderate AHT and Type 2 DM
The aim of this study is to evaluate the effects of indapamide SR 1.5 mg on blood pressure, blood tests (glucose metabolism, lipids, minerals, and uric acid), cardiac function, endothelial and arterial function, by comparison…
- Trial name
- AISHA (NCT00980187)
- Testing
- Hydrochlorothiazide, Indapamide
- Where
- Romania
- Volunteers
- 56 people
- Sponsor
- LaborMed Pharma S.A.
GLAUCOMA 1, OPEN ANGLE, D (Disorder), Cataract
Comparison of Visual Outcomes and Patient Satisfaction in Mild to Moderate Glaucoma Patients Undergoing Cataract Surgery With EDOF Versus Monofocal IOLs
Cataract is the leading cause of reversible vision loss, while glaucoma remains the primary cause of irreversible blindness, often impairing contrast sensitivity (CS), glare tolerance, and dark adaptation.
- Trial name
- NCT07436871
- Testing
- Cataract surgery (Monofocal intraocular lens implantation), cataract surgery (Extended depht of focus intraocular lens implantation)
- Volunteers
- 74 people
- Sponsor
- OMIQ Research
Hypertension
Safety Evaluation of Telmisartan Plus Hydrochlorothiazide in Patients With Mild-to-Moderate Hypertension
Study to assess the safety of six month of open-label, treatment with the fixed dose combination of telmisartan 80 mg plus hydrochlorothiazide 12.5 mg in a subset of patients with mild-to-moderate hypertension who completed the…
- Trial name
- NCT02177487
- Testing
- Telmisartan/hydrochlorothiazide
- Volunteers
- 100 people
- Sponsor
- Boehringer Ingelheim
Hypertension
Efficacy and Safety of Telmisartan in Hypertensive Patients With Mild/Moderate or Severe Renal Impairment or Requiring Hemodialysis
To evaluate the safety and efficacy, in particular with regard to renal function of telmisartan at the doses of 40 mg and 80 mg in hypertensive patients with moderate to endstage renal impairment after 12 weeks of treatment
- Trial name
- ESPRIT (NCT02178306)
- Testing
- Telmisartan low dose, Telmisartan high dose
- Volunteers
- 82 people
- Sponsor
- Boehringer Ingelheim
Mild to Moderate Hypertension
Acupuncture Therapy and Hypertension
Acupuncture therapy will be provided to reduce blood pressure in hypertensive patients. The mild to moderate hypertensive patients will be either on or off hypertensive medications.
- Trial name
- NCT05530512
- Testing
- electroacupuncture
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- University of California, Irvine