Clinical trials: Milk Intolerance
Lactose Intolerance
Does Daily Supplementation of Lactobacillus Acidophilus MPH734, for One Week, Affect Acute (Immediate), Subacute (7 Days), and Post-treatment Discontinuation Lactose Metabolism, Gastrointestinal Symptoms, and Clinical Markers of Inflammation and Safety Compared to a Placebo
The purpose of this study is to determine if twice or three times daily supplementation of Lactobacillus acidophilus MPH734 (Lacto-FreedomTM, or LF), for one week, affects acute (immediate), subacute (7 days), and post-treatment…
- Trial name
- LF (NCT04531033)
- Testing
- Lactobacillus acidophilus MPH734
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lemuel W. Taylor IV
Protein Intolerance
Evaluation of Infants Fed an Extensively Hydrolyzed Infant Formula
This is a single group, non-randomized, multicenter study to assess the effects of a hypoallergenic casein hydrolysate powdered infant formula on gastrointestinal (GI) tolerance, growth and compliance in an intended use infant…
- Trial name
- NCT03884309
- Testing
- Experimental Hydrolyzed Protein Infant Formula
- Where
- 6 sites in United States
- Volunteers
- 48 people
- Sponsor
- Abbott Nutrition
Lactose Intolerance
Comparing the Adaptation of Commercial Milk and A2 Milk in Lactose Maldigesters
Cow's milk contains two types of β-casein: A1 and A2. It is evident from human clinical trials that milk with A1 protein produces more hydrogen and symptoms of lactose intolerance.
- Trial name
- NCT05669274
- Testing
- Milk containing A1 and A2 beta-casein, Milk containing only A2 beta-casein
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Purdue University
Feeding; Difficult, Newborn
Source of Human Milk Fortifier and Intestinal Oxygenation in Preterm Infants <30 Weeks Gestation
Preterm infants require higher nutritional intakes during the neonatal phase than they do at any other stage of their development. Standard volumes of human milk alone do not offer sufficient nourishment to these infants.
- Trial name
- NCT06336668
- Testing
- Human milk-based HMF
- Volunteers
- 18 people
- Sponsor
- University of Calgary
Pre Diabetes
Impact of Whey and Leucine on Glycaemia in Adults Without Diabetes
Higher than average blood sugar (glucose) levels are linked to an increased risk of developing type 2 diabetes. As such, there is interest in identifying dietary factors that could lower blood glucose to help reduce the number of…
- Trial name
- Whey2Glo (NCT03785951)
- Testing
- Whey Protein Isolate, Wheat Protein, Wheat Protein with Leucine
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Reading
Milk Intolerance
Effects of A2 Milk on Gastrointestinal Function in Non-lactose Milk Intolerance
There is increasing evidence that a number of people experience moderate milk intolerance characterised by increased gas production, bloating and abdominal cramp, which can neither be attributed to lactose intolerance, nor to…
- Trial name
- NCT03060395
- Testing
- A2 milk 100, A2 milk 150, A2 milk 200
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Reading
Growth, Necrotizing Enterocolitis
Bovine Colostrum as a Fortifier Added to Human Milk for Preterm Infants
Very preterm infants (<32 weeks gestation) with very low birth weight (VLBW, <1500 g) show immaturity of organs and have high nutrient requirements forgrowth and development.
- Conditions
- Growth, Necrotizing Enterocolitis, Late-Onset Sepsis, Feeding Intolerance
- Trial name
- FortiColos (NCT03537365)
- Testing
- Bovine Colostrum (BC) / intervention group, FM85 / control group
- Where
- 7 sites in Denmark
- Volunteers
- 252 people
- Sponsor
- Per Torp Sangild
Low Milk Supply, Pre-diabetes
Metformin to Augment Low Milk Supply (MALMS) Study
Most new mothers in the United States will start off breastfeeding. For some mothers, despite following best practices, they are not able to meet their breastfeeding goals due to unexplained low milk supply.
- Conditions
- Low Milk Supply, Pre-diabetes, Insulin Resistance, Suppressed Lactation
- Trial name
- MALMS (NCT02179788)
- Testing
- Standard care, Metformin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Non-celiac Wheat Sensitivity
Lactose Intolerance and Cow's Milk Protein Allergy in Non-celiac Wheat Sensitivity Patients
In the last few years a new clinical entity has emerged which includes patients who consider themselves to be suffering from problems caused by wheat and/or gluten ingestion, even though they do not have celiac disease (CD) or…
- Trial name
- NCT03008252
- Testing
- Lactose breath test, DBPC cow's milk protein challenge
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- University of Palermo
Gastrointestinal Diseases, Cow's Milk Intolerance
Goat Milk Infant Formula Comfort Study
In this study, the investigators aim to assess that infants with mild symptoms have significantly less (severe) symptoms after 14 days goat milk-based formula use compared to infants using cow's milk-based formula supplemented…
- Trial name
- NCT06301139
- Testing
- Goat milk-based infant formula, Cow's milk-based infant formula with probiotic drops
- Where
- Spain
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ausnutria Hyproca B.V.
Lactose Intolerance
Amount of Lactose Causing Symptoms in Lactose Intolerant People
The hypothesis underlying this study is that failure to recognise the role of lactose intolerance among patients has led to inappropriate dietary advice and treatment with drugs that contain lactose as a filler.
- Trial name
- NCT00395954
- Volunteers
- 48 people
- Sponsor
- University Hospitals, Leicester
Lactose Intolerance
Effect of I31 Probiotic on Lactose Intolerance
This randomized study evaluates the usefulness of the I31 probiotic formula, against placebo, in the treatment of symptoms of lactose intolerance.
- Trial name
- NCT04164394
- Testing
- I31 Probiotic
- Where
- Mexico
- Volunteers
- 48 people
- Sponsor
- Hospital Juarez de Mexico
Lactose Intolerance
Efficacy, Safety, and Tolerability Study of RP-G28 in Subjects With Lactose Intolerance
RP-G28 is being investigated for treatment of moderate to severe lactose intolerance and its potential to improve the tolerance of lactose (dairy products).
- Trial name
- NCT02673749
- Testing
- RP-G28
- Where
- United States
- Volunteers
- 377 people
- Sponsor
- Ritter Pharmaceuticals, Inc.
Lactose Intolerance
Comparing the Inflammation, Maldigestion and Symptoms Due to Commercial Milk and A2 Milk
Cow's milk contains two types of β-casein: A1 and A2. It is evident from human clinical trials that milk with A1 protein produces more hydrogen and symptoms of lactose intolerance.
- Trial name
- NCT05660278
- Testing
- Milk containing A1 and A2 beta-casein, Milk containing only A2 beta-casein
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Purdue University
Lactose Intolerance
Effects of Raw Versus Other Milk Sources on Lactose Digestion
The purpose of this small, short pilot study is to determine the feasibility (e.g., recruitment, dose acceptance, retention) of a future longer trial comparing the effects of different types of milk (raw milk, cow's milk…
- Trial name
- NCT01129791
- Testing
- Raw Milk, Pasteurized Milk, Non-dairy milk
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Stanford University
Lactose Malabsorption, Cardiovascular Disease
Whole Milk Intake and Cardio-metabolic Risk Factors
Milk is the source of high-quality protein, calcium, and other vitamins and minerals. Epidemiologic studies have linked high consumption of milk with risk of metabolic syndrome, T2DM, hypertension and obesity, which are…
- Trial name
- NCT02798718
- Testing
- full-fat milk
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Premature; Infant, Enteral Nutrition
Human Milk Fortification in Very Low Birth Neonates
The purpose of this study to find out how safely we can add extra nutrients to human milk at different feeding volume.
- Conditions
- Premature; Infant, Enteral Nutrition, Human Milk, Fortification
- Trial name
- NCT01988792
- Testing
- Human milk fortifiers
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Tennessee
Pre-Diabetes
Full-fat Yogurt and Glucose Tolerance
This study determines if substituting full-fat yogurt (i.e., whole, 3.25% fat) for non-fat yogurt in the diet can reduce the risk of type 2 diabetes and inflammation in association with changes in the composition of the…
- Trial name
- NCT03577119
- Testing
- Full-fat yogurt, Non-fat yogurt
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Vermont Medical Center
Small Intestinal Bacterial Overgrowth, Lactose Intolerance
Clinical Utility of Breath Tests in GI
Bloating, gas, pain and diarrhea are common complaints. Routine investigations are negative; these patients are labeled as IBS. In these patients, whether testing for carbohydrate malabsorption or small intestinal bacterial…
- Conditions
- Small Intestinal Bacterial Overgrowth, Lactose Intolerance, Fructose Intolerance, Glucose Intolerance
- Trial name
- NCT03261856
- Where
- United States
- Volunteers
- 1,080 people
- Sponsor
- Augusta University
Ell-nourished Pediatric Patients, Nutritional Management in Diarrhea
Dietary Management of Well Nourished Children With Persistent Diarrhea and Secondary Lactose Intolerance With Different Feeding Formulas.( Hospital-Originated Modified Feeding HOMF)
Interventional, treatment based study randomized control trial 32O Well nourished children allocated in 2 groups 160 each group ,Group A on lactose free commercial formula already in use,Group B ,ON Rice based feeding recipe .
- Trial name
- HOMF (NCT07114796)
- Testing
- Standard Commercial Lactose-Free Formula, Rice based recipe method feeding formula
- Where
- 2 sites in Pakistan
- Volunteers
- 320 people
- Sponsor
- Children's Hospital and Institute of Child Health, Multan