Clinical trials: Mineralocorticoid Excess
Primary Aldosteronism, Adrenal Adenoma
Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism
The aim of the study is to evaluate the novel use of adrenal radiofrequency ablation on a prospective cohort of patients with primary aldosteronism and unilateral adrenal adenoma concerning the efficacy on blood pressure control.
- Trial name
- ADERADHTA (NCT02756754)
- Testing
- Radiofrequency ablation
- Where
- 2 sites in France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Toulouse
Hyperaldosteronism, Hypertension
The Therapeutic Effect of Bromocriptin in Patients With Primary Aldosteronism
we propose that bromocriptine may be an alternative treatment of primary aldosteronism, both APA and BAH.
- Trial name
- NCT00451672
- Testing
- bromocriptine
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- National Taiwan University Hospital
Cardiovascular Diseases, Hypertension
Diagnosis/Pathophysiology of Glucocorticoid Remediable Aldosteronism Hypertension
To identify and study a large cohort of glucocorticoid remediable aldosteronism (GRA) patients.
- Conditions
- Cardiovascular Diseases, Hypertension, Heart Diseases
- Trial name
- NCT00005394
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypertension, Mineralocorticoid Excess
MR Antagonist and LSD1
Lysine specific demethylase-1 (LSD1) is an epigenetic regulator of gene transcription involved in the pathophysiology of elevated blood pressure and likely renal damage in Blacks.
- Trial name
- NCT04840342
- Testing
- Eplerenone, Amlodipine
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Brigham and Women's Hospital
Primary Hyperaldosteronism Due to Adrenal Adenoma
Unilateral Primary Aldosteronism, Mineralocorticoid Antagonists Versus Surgical Treatment
This is a prospective randomized controlled trial where quality of life and the effectiveness of treatment will be evaluated in 80 patients with confirmed unilateral primary aldosteronism ,randomly assigned to be either treated…
- Trial name
- UPA-MEST (NCT05797558)
- Testing
- Unilateral adrenalectomy, Medical treatment (eplerenone)
- Where
- 3 sites in Sweden
- Volunteers
- 80 people
- Sponsor
- Göteborg University
Hypertension, Primary Aldosteronism
Tissue Sodium Quantification in Patients With Primary Aldosteronism: See Sodium to Treat
The study aims to provide quantitative facts on the pathophysiological changes in tissue Na+ content during Na+/K+ redistribution disorders in patients with PA in response to standard therapy.
- Conditions
- Hypertension, Primary Aldosteronism, Hypokalemia
- Trial name
- SSTT (NCT06569589)
- Testing
- 23NaMRI Scan, Potassium Chloride (KCl)
- Where
- 4 sites in Singapore
- Volunteers
- 80 people
- Sponsor
- Jens Titze
Hyperaldosteronism
Study of Prevalence and Clinical Phenotype in Patients With Glucocorticoid-Remediable Aldosteronism
OBJECTIVES: I. Determine the prevalence of glucocorticoid-remediable aldosteronism (GRA) in various hypertensive populations and screen at risk members of GRA pedigrees. II.
- Trial name
- NCT00004354
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism
11C-Metomidate PET/CT for Endocrine Hypertension and Characterisation of Adrenal Tumours
10% of patients with hypertension potentially have the treatable condition - primary aldosteronism (PA). This is caused by either bilateral adrenal disease (~40%), managed with lifelong medications; or unilateral disease (~60%)…
- Conditions
- Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism, Adrenal Tumors
- Trial name
- NCT06100367
- Testing
- 11C-Metomidate PET/CT imaging at Clinical Imaging Research Centre
- Where
- 7 sites in Singapore
- Volunteers
- 97 people
- Sponsor
- Changi General Hospital
Primary Aldosteronism
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism.
The objective of this observational study is to utilize the advantages of 68Ga-Pentixafor subtyping diagnosis and the diagnostic ability of 68Ga-FAPI-04 for cardiovascular disease to identify primary aldosterone patients in need…
- Trial name
- NCT06756737
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai East Hospital
Hyperaldosteronism, Renal Insufficiency
The Water Intake Trail and Primary Aldosteronism Postoperation(WIT-PAP)
To investigate whether increasing water intake has renal protective effect on PA patients after surgical treatment.
- Trial name
- NCT04150666
- Testing
- Hydration
- Where
- China
- Sponsor
- Qifu Li
Primary Aldosteronism, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)
Calcium Channel Blockade in Primary Aldosteronism
This pilot study explore whether the calcium channel blocker amlodipine can lower aldosterone levels in people with primary aldosteronism.
- Trial name
- CCB-PA (NCT04179019)
- Testing
- Amlodipine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Brigham and Women's Hospital
Primary Hyperaldosteronism
Proof-of-concept for the Aldosterone Synthase Inhibitor LCI699 in Patients With Primary Hyperaldosteronism
The purpose of this study is to determine if LCI699, thorough reductions in aldosterone, can lower BP in patients with Primary hyperaldosteronism.
- Trial name
- NCT00732771
- Testing
- LCI699
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Novartis
Primary Aldosteronism
The Effect of Disease-specific Treatment on Bone Turnover Markers in Patients With Primary Aldosteronism
Primary aldosteronism (PA) is a disorder of the adrenal gland causing an autonomous overproduction of mineralocorticoids, leading to arterial hypertension. Although rare, it is the most frequent cause of secondary hypertension.
- Trial name
- NCT02216721
- Where
- Malaysia
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Malaysia Sarawak
Sleep Apnea, Arrhythmias, Cardiac
Sleep Apnea Diagnosis Using a Novel Pacemaker Algorithm and Link With Aldosterone Plasma Level in Patients Presenting With Diastolic Dysfunction
Little is known about potential relationships between sleep apnea, plasma aldosterone and diastolic dysfunction which is a very frequent finding among patients requiring permanent cardiac pacing.
- Conditions
- Sleep Apnea, Arrhythmias, Cardiac, Cardiac Diastolic Function, Hyperaldosteronism
- Trial name
- SAPAAD (NCT02751021)
- Testing
- pacemaker diagnostic algorithm, Attended cardiorespiratory sleep study
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Caen
Hypocalcemia, Hypercalcemia
Parathyroid Hormone (PTH) Homeostasis in Bartter Syndrome
Parathyroid hormone (PTH) gland calcium sensing receptor (CASR) regulates PTH secretion. CASR is also expressed in nephron thick ascending limb (TAL).
- Trial name
- NCT01021280
- Where
- Israel
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Primary Aldosteronism Due to Conn Adenoma, Radiofrequency Ablation Treatment
Radiofrequency Ablation Versus Adrenalectomy for Adenoma in Patients With Primary Aldosteronism and Hypertension
Primary aldosteronism (PA) is characterized by hypertension, frequent hypokalaemia, and an inappropriately high aldosterone-to-renin ratio (ARR).
- Conditions
- Primary Aldosteronism Due to Conn Adenoma, Radiofrequency Ablation Treatment, Adrenalectomy
- Trial name
- ADERADHTA2 (NCT07470580)
- Testing
- RFA -radiofrequency ablation, Adrenalectomy
- Where
- France
- Volunteers
- 134 people
- Sponsor
- University Hospital, Toulouse
Cushing Syndrome, Pheochromocytoma
Metabolic Myopathy in Endocrinopathy
Endocrine diseases including Cushing's syndrome and phaeochromocytoma/paraganglioma (PPGL) but not Conn's syndrome are associated with muscle wasting and weakness.
- Conditions
- Cushing Syndrome, Pheochromocytoma, Conns Syndrome, Metabolic Myopathy
- Trial name
- LYDIA (NCT05456997)
- Testing
- Muscle biopsy
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- Barts & The London NHS Trust