Clinical trials: Minimal Hepatic Encephalopathy
Hepatic Encephalopathy
Flicker App for Minimal Hepatic Encephalopathy
There is a great unmet clinical need for improved screening for MHE in patients with cirrhosis. We will demonstrate that the Flicker-App can be used in clinic as well as at home by patients with cirrhosis to measure CFF, a proven…
- Trial name
- NCT04415294
- Testing
- Critical flicker frequency
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Washington
Hepatic Encephalopathy, Decompensated Cirrhosis
BCAA vs. Rifaximin in Patients With Cirrhosis for Secondary Prophylaxis of HE
Rationale Patients who recover from an episode of overt HE(OHE) are at risk of recurrent episodes of HE and persistent minimal hepatic encephalopathy, impacting their daily functioning and mental health.
- Conditions
- Hepatic Encephalopathy, Decompensated Cirrhosis, Minimal Hepatic Encephalopathy
- Trial name
- HERB (NCT06538077)
- Testing
- Oral Branched chain Amino acid, Rifaximin 550 MG, Lactulose
- Where
- India
- Volunteers
- 336 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Hepatic Encephalopathy, Liver Cirrhosis
Efficacy and Safety of E.Coli Nissle 1917 in Patients With Mild (Stage 1-2) or Minimal Hepatic Encephalopathy
The purpose of study to assess the short-term efficacy and safety of probiotic E.coli Nissle 1917 strain comparing to lactulose and rifaximin in patients with mild (Stage 1-2) or minimal hepatic encephalopathy
- Conditions
- Hepatic Encephalopathy, Liver Cirrhosis, End Stage Liver DIsease
- Trial name
- NCT04787276
- Testing
- E.coli Nissle 1917, Lactulose, Rifaximin
- Volunteers
- 42 people
- Sponsor
- Bogomolets National Medical University
Hepatic Encephalopathy, Liver Cirrhosis
Effect of Lactose in Patients With Chronic Liver Disease and Minimal Hepatic Encephalopathy
Two groups of patients with minimal hepatic encephalopathy will be studied. The treatment group (n=17) will receive whole milk (24 g lactose) and the control group (n=17) will receive "lactose-free" milk (3.5 g of lactose) two…
- Trial name
- NCT01113567
- Testing
- Lactose-free milk, Whole milk
- Where
- Mexico
- Volunteers
- 18 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Cirrhosis, Hepatic Encephalopathy
HEAL STUDY (Hepatic Encephalopathy and Albumin Study)
Patients with continued cognitive impairment after episodes of HE have few options beyond lactulose and rifaximin in the US. Therefore using IV albumin in a randomized, double-blind, placebo-controlled trial, which could…
- Conditions
- Cirrhosis, Hepatic Encephalopathy, Minimal Hepatic Encephalopathy, Covert Hepatic Encephalopathy
- Trial name
- HEAL (NCT03585257)
- Testing
- 25% IV albumin
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Minimal Hepatic Encephalopathy
Psychometric Hepatic Encephalopathy Score in Prediction of Minimal Hepatic Encephalopathy in Compensated Cirrhotic Patients
Minimal hepatic encephalopathy (MHE) is a covert form of hepatic encephalopathy associated with cognitive and psychomotor impairment in patients with compensated liver cirrhosis.
- Trial name
- PHES-MHE (NCT07272707)
- Testing
- Psychometric Hepatic Encephalopathy Score (PHES)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Sohag University
Hepatic Encephalopathy
ETOS: Minimal Hepatic Encephalopathy in Childhood and Young Adult: epidemiOlogical Study and Pilot Interventional Study
The aim of the study is: Epidemiological/observational: investigating the presence of neuropsychological and electrophysiological alterations, suggesting a condition of minimal hepatic encephalopathy(and its behavioral…
- Trial name
- ETOS (NCT01798329)
- Testing
- probiotic VSL#3
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Depression in Chronic Hepatitis C
Effects of Direct-acting Antiviral Agents on HCV Cognitive Function, and Depression in HCV Related Cirrhosis: A Prospective Clinical Trial
Minimal hepatic encephalopathy (MHE) is an important clinical variant of hepatic encephalopathy (HE), which occurs in up to 60-70% of patients with cirrhosis.
- Trial name
- NCT04330508
- Testing
- Depression and Cognitive Tests
- Where
- India
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Hepatic Encephalopathy, Liver Cirrhosis
Prediction of Post-TIPS Hepatic Encephalopathy in Patients With Liver Cirrhosis
Prediction of hepatic encephalopathy after insertion of a transjugular intrahepatic portosystemic stent shunt (post-TIPS HE) are critical for patient selection prior to TIPS insertion, and a currently unmet, clinically highly…
- Trial name
- NCT05466669
- Where
- 2 sites in Germany
- Volunteers
- 83 people
- Sponsor
- Johannes Gutenberg University Mainz
Cirrhosis, Liver, Minimal Hepatic Encephalopathy
Rifaximin's Effect on Covert Hepatic Encephalopathy With SIBO and Gastrointestinal Dysmotility
Small Intestinal Bacterial Overgrowth (SIBO) is a common and increasingly recognized disorder in cirrhosis (30% to 73%). One of the most important predisposing factors of SIBO is small bowel dysmotility.
- Conditions
- Cirrhosis, Liver, Minimal Hepatic Encephalopathy, Small Intestinal Bacterial Overgrowth, Gastrointestinal Motility Disorder
- Trial name
- NCT04244877
- Testing
- Rifaximin
- Sponsor
- MetroHealth Medical Center
Liver Cirrhosis
Fructans, Lactitol and Lactose in Minimal Hepatic Encephalopathy
As an alternative for the treatment of Minimal Hepatic Encephalopathy (MHE) Agave fructans have shown prebiotic effects, and have shown to improve function of the digestive system, control and induce glycemic effect satiety.
- Trial name
- NCT02022137
- Testing
- Red cereal bar, Green cereal bar, White cereal bar
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Hepatic Encephalopathy
S. Endotoxin, Inflammatory Mediators and MRS Before and After Treatment in MHE
The purpose of this study is to examine S.endotoxins , inflammatory mediators and Magnetic Resonance Spectroscopy (MRS) before and after treatment in patients of cirrhosis and minimal hepatic encephalopathy.
- Trial name
- endtxninHE (NCT01446523)
- Testing
- Lactulose
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Govind Ballabh Pant Hospital
Minimal Hepatic Encephalopathy
Reversibility of Minimal Hepatic Encephalopathy Following Liver Transplantation
This study included 20 patients listed for liver transplantation in addition to 20 age- and sex- matched controls. Neurological, psychiatric, laboratory and radiological examinations were performed for both patients and controls…
- Trial name
- NCT02767622
- Testing
- Liver transplantation
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Minimal Hepatic Encephalopathy
Probiotic Lactobacillus GG (LGG) in Patients With Minimal Hepatic Encephalopathy
This research proposes to find whether the probiotic lactobacillus GG is safe and well tolerated in patients with minimal hepatic encephalopathy. We also want to get insight into the mechanisms of action of LGG.
- Trial name
- NCT00992290
- Testing
- Lactobacillus GG
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Virginia Commonwealth University
Hepatic Encephalopathy, Liver Cirrhosis
Diagnosing Minimal Hepatic Encephalopathy
Our purpose is to 1. Examine the correlation between MDF in a resting EEG, recorded just before the CRT test, and the variance in reaction times indicated by the CRT index 2.
- Trial name
- MindTheLiver (NCT05433948)
- Testing
- Simultaneous EEG and CRT
- Where
- Denmark
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Cirrhosis, Portal Hypertension
Evaluation of Minimal Hepatic Encephalopathy in Patients With Cirrhosis and Portal Hypertension
Minimal hepatic encephalopathy (MHE) is a subclinical cognitive impairment and represents the mildest type of hepatic encephalopathy (HE).
- Trial name
- Evencipor (NCT04807803)
- Testing
- Assessment of Minimal hepatic encephalopathy (MHE)
- Where
- 2 sites in France
- Volunteers
- 82 people
- Sponsor
- IHU Strasbourg
Hepatic Encephalopathy.
Efficacy of Sildenafil in the Improvement of Cognition and Quality of Life in Patients With Cirrhosis of Liver. A Proof of Concept Study.
The study is being conducted to evaluate the efficacy of Sildenafil (a 5-phosphodiesterase inhibitor) as a means to improve the cognitive impairment encountered in patients of minimal hepatic encephalopathy (MHE) as proposed in…
- Trial name
- NCT02028429
- Testing
- Sildenafil.
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Minimal Hepatic Encephalopathy
A Nutritional Approach to Minimal Hepatic Encephalopathy
This trial will study a possible effect of standard Israeli breakfast (30% of caloric value and 21 gram protein) on cognitive and executive functions (working memory, visual memory, concentration and coordination), on patients…
- Trial name
- NCT01083446
- Testing
- Nutritional Intervention
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Hepatic Encephalopathy, Minimal Hepatic Encephalopathy
Brain Muscle Axis During Treatment of Hepatic Encephalopathy With L-ornithine L-aspartate
Patients with cirrhosis of the liver may suffer from a condition called hepatic encephalopathy which in its mildest form as mental slowing and impaired reaction times in driving and machinery operation.
- Conditions
- Hepatic Encephalopathy, Minimal Hepatic Encephalopathy, Cirrhosis
- Trial name
- NCT01847651
- Testing
- Vastus Muscle Biopsy, Cognitive assessment (PHES), Cognitive Assessement (Cogstate)
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- Imperial College London
Hepatic Encephalopathy
Therapeutic Efficacy of Oral L-Ornithine-L-Aspartate on Minimal Encephalopathy
The study aimed to assess the effectiveness and safety of L-ornithine-L-aspartate in the management of hepatic encephalopathy.
- Trial name
- PORTOALEGRE (NCT00896831)
- Testing
- L-ornithine-L-aspartate
- Where
- Brazil
- Volunteers
- 96 people
- Sponsor
- Hospital de Clinicas de Porto Alegre