Clinical trials: Minimally Invasive Techniques
Osteoarthritis Knee, Chronic Pain
Comparison of Denervation Techniques for the Treatment of Knee Osteoarthritis: Continuous Ablative Radiofrequency Vs. Chemical Denervation with Absolute Alcohol
This randomized clinical trial compares two minimally invasive treatments for knee osteoarthritis pain that has not responded to conventional therapies.
- Trial name
- NCT06858228
- Testing
- Continuous Ablative Radiofrequency, Chemical Denervation with Absolute Alcohol
- Where
- Brazil
- Volunteers
- 288 people
- Sponsor
- Federal University of São Paulo
Periodontitis, Intrabony Periodontal Defect
Clinical Evaluation of Nano-Hydroxyapatite as an Adjunctive to Minimally Invasive Non-Surgical Technique in the Treatment of Deep Intra-bony Defects
This randomized controlled clinical trial aims to evaluate the effectiveness of using nano-hydroxyapatite (nHA) gel alongside a minimally invasive non-surgical technique (MINST) to treat deep intra-bony defects in patients with…
- Trial name
- MINST (NCT07608783)
- Testing
- Minimally invasive non-surgical technique (MINST), nano-hydroxyapatite
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Cairo University
Dental Caries
Traditional vs. Minimally Invasive Decay Treatments in Primary Molars: An 18-month Split-mouth Randomized Study
The goal of this clinical trial is to compare the 18-month clinical success rates of three caries management approaches in primary molars of 60 healthy children aged 4-8 years attending the Department of Pediatric Dentistry at…
- Trial name
- MiCRO-PM (NCT07447583)
- Testing
- Hall Technique, Silver diamine Fluoride 38%, Compomer Restoration
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Osteoarthritis, Knee
Comparison of Pinless Navigation and Conventional Method in Total Knee Arthroplasty
The purpose of this study is to conduct a prospective randomized clinical trial to compare the accuracy of prosthesis, radiographic alignment, total blood loss, the risk of venous thromboembolism between pinless-navigated total…
- Trial name
- NCT04235283
- Testing
- Primary total knee replacement by pinless navigation (Orthomap Express,Stryker, Michigan), Primary total knee replacement by traditional jig and minimally invasive technique
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
Periodontal Regeneration, Minimally Invasive Surgical Technique
Efficacy of the Entire Papilla Preservation Technique With and Without the Use of L-PRF as a Regenerative Material for the Treatment of Infrabony Defects
The goal of this clinical trial is to evaluate the efficacy of using L-PRF (leukocyte and platelet rich fibrin clot) as an autologous filling material in conjunction with the EPP (entire papilla preservation) technique for the…
- Conditions
- Periodontal Regeneration, Minimally Invasive Surgical Technique, Platelet Rich Fibrin, Microsurgery
- Trial name
- NCT06694168
- Testing
- Periodontal Regeneration, clinical and radiographic results, modified minimal invasive surgery, REGEND001 Autologous Therapy Product
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Universidad de los Andes, Chile
Hallux Valgus Deformity, Hallux Valgus (Bunion) Resection
Fourth Generation Percutaneous Transverse Osteotomies for Hallux Valgus
The goal of this observational study is to learn if percutaneous transverse osteotomies for hallux valgus deformity are safe and effective. The main questions it aims to answer are: 1.
- Conditions
- Hallux Valgus Deformity, Hallux Valgus (Bunion) Resection, Hallux Valgus Surgery, Hallux Deformity
- Trial name
- NCT06625229
- Where
- Australia
- Volunteers
- 483 people
- Sponsor
- Orthopaedic and Arthritis Specialist Centre
Temporomandibular Disorder
Pterygomaxillary Disjunction With Interpositional Y-shape Plate in Patients With Temporomandibular Joint Derangement
Temporomandibular joint internal derangement (TMJ ID) is the most frequent type of temporomandibular disorder (TMDs)which is managed by different therapeutic modalities.
- Trial name
- NCT05561465
- Testing
- Pterygomaxillary disjunction with interposition Y-shape plate
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- Hams Hamed Abdelrahman
Injectable Platelet-Rich Fibrin, Minimally Invasive
Injectable Platelet-Rich Fibrin With Minimally Invasive Non-Surgical Technique in Treatment of Grade II Furcation Defects
This study aims to compare the clinical and radiographic effectiveness of injectable platelet-rich fibrin (i-PRF) combined with minimally invasive non-surgical therapy (MINST) versus MINST alone in the management of class II…
- Conditions
- Injectable Platelet-Rich Fibrin, Minimally Invasive, Non-Surgical Technique, Grade II Furcation Defects
- Trial name
- NCT07787949
- Testing
- Minimally invasive non-surgical technique (MINST), Minimally invasive non-surgical technique (MINST) + injectable platelet-rich fibrin (i-PRF) injection
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- October 6 University
Periodontal Diseases
Minimally Invasive Surgical Technique in Management of Intrabony Defects
In the fast-growing era of contemporary periodontology, the understanding of biological concepts in wound healing together with the evolution of the flap design and biomaterials applied in periodontal regeneration allowed for…
- Trial name
- NCT06591416
- Testing
- minimally invasive surgical technique, minimally invasive surgical technique with granulation tissue preservation
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Aesthetic Procedures, Complication of Treatment
Complications in Minimally Invasive Aesthetic Dermatological Procedures in Switzerland
The aim of this retrospective study is to describe cases of complications from minimally invasive aesthetic procedures treated at a university reference centre in Switzerland between 2021 and 2024.
- Trial name
- NCT06864871
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Basel, Switzerland
Healthy Participants
Monitoring Changes in Blood Circulating Metabolites Using Minimally Invasive Techniques
This study investigates short-term intra- and inter-individual variability in human blood metabolism under real-life conditions.
- Trial name
- MicroFastFood (NCT07527793)
- Testing
- Burger, Daily blood microsampling, Daily glucose monitoring
- Where
- Sweden
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Enhanced Recovery After Surgery
Comparison of Postoperative Recovery Between TIVA and Inhalation Agent
This prospective, randomized, single-blinded study is designed to compare the postoperative quality of recovery between propofol based total intravenous anesthesia and desflurane in patients undergoing minimally invasive…
- Trial name
- NCT04447105
- Testing
- total intravenous anesthesia with propofol, inhalation anesthesia with desflurane
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Seoul National University Hospital
Osteoarthritis, Rheumatoid Arthritis
Minimally Invasive Versus Conventional Approaches in Navigated Total Knee Arthroplasty (TKA)
50 patients are randomized to two groups who receive a navigated knee prosthesis. Aim of the study is a comparison between a minimally invasive and a conventional approach.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis
- Trial name
- NCT00839020
- Testing
- Navigated TKA with a minimally invasive approach, Navigated TKA with a conventional approach
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Aesculap AG
Lung Disease, Lung Cancer
Minimally Invasive Endoscopy in Diffuse Lung Disease
We want to compare 2 new systems for obtaining very detailed images of the smallest airways, in the hope that they can be used to provide useful information about lung diseases without the need for invasive tests.
- Trial name
- NCT00934778
- Testing
- Confocal microscopy and endocytoscopy
- Volunteers
- 100 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Tibia Distal Fracture, Nonunion of Fracture of Tibia
Is Far Cortical Locking More Effective Than Bicortical Locking in Treating AO 43A1-3 Fractures?
Delayed union or nonunion, which is a common complication of periarticular fractures repaired with angled locking plate systems, may be due to the unintentionally rigid formation of this system.
- Trial name
- NCT06005090
- Testing
- Far Cortical Locking Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Saglik Bilimleri Universitesi
Pregnancy
Classic Cesarean Section Versus Minimally Invasive Cesarean Section: Pain Assessment
Cesarean section is the most performed abdominal surgery in women, worldwide. The World Health Organization (WHO) considers 15% of deliveries the ideal rate of this surgery.
- Trial name
- NCT02257255
- Testing
- Pfannenstiel cesarean section, Misgav-Ladach cesarean section
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade do Vale do Sapucai
Endometrial Cancer
Biomarkers for Diagnosis and Prognosis of Endometrial Carcinoma
Endometrial cancer (EC) is the most frequent gynecological malignancy but there is currently lack of both non-invasive diagnostic tools and novel markers to stratify patients based on their risk of future recurrence.
- Trial name
- BioEndoCar (NCT03553589)
- Testing
- Blood sampling
- Where
- 5 sites in Netherlands, Poland and 1 more
- Volunteers
- 400 people
- Sponsor
- Andrea Romano
Malocclusion, Angle Class II
Efficacy of Minimally Invasive Surgical Technique in Accelerating Orthodontic Treatment
Thirty six patients needs therapeutic extraction of the maxillary first premolars with subsequent retraction of the maxillary canines will be divided randomly into two groups : piezocision group and the ER:yttrium aluminum garnet…
- Trial name
- NCT02606331
- Testing
- Piezosurgery, ER:YAG laser
- Where
- Syria
- Volunteers
- 36 people
- Sponsor
- Damascus University
Coronary Artery Bypass Grafting, Off-pump Coronary Artery Bypass
Safety and Effectiveness of No-touch Technique for Ascending Aorta in MICS-CABG
The goal of this single-center prospective cohort study is to compare perioperative safety metrics and follow-up survival analyses in patients receiving Minimally Invasive Cardiac Surgery Coronary Artery Bypass…
- Conditions
- Coronary Artery Bypass Grafting, Off-pump Coronary Artery Bypass, Minimally Invasive Cardiac Surgery, Coronary Arterial Disease (CAD)
- Trial name
- NCT07172620
- Testing
- Non-extracorporeal multiple coronary artery bypass graft (CABG) performed under direct visualization through a small incision in the left side of the chest., Multi-branch coronary artery bypass grafting with conventional median open heart and off-pump circulation
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Peking University Third Hospital
Laparoscopic Hysterectomy, Enhanced Recovery After Surgery
Postoperative Bladder Testing After Total Laparoscopic Hysterectomy
The objective of this study is to determine if backfilling the bladder immediately post-operatively, prior to removal of the foley catheter, in patients undergoing same-day total laparoscopic hysterectomy will hasten time to…
- Trial name
- NCT03126162
- Testing
- InstilIing normal saline into bladder, Removal of foley catheter
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- University of Pittsburgh