Clinical trials: Minimum Effective Dose
Neuromuscular Blockade
Efficacy, Safety and Pharmacokinetics of Sugammadex (Org 25969; MK-8616) at 3 Different Time Points After 0.6 mg/kg Esmeron® in Male Participants (P05940; MK-8616-020).
This study investigates the efficacy, safety, and pharmacokinetics of sugammadex (Org 25969; MK-8616) when administered for the reversal of neuromuscular blockade in male participants receiving surgery, classified as American…
- Trial name
- NCT03519854
- Testing
- Sugammadex, Esmeron®
- Volunteers
- 99 people
- Sponsor
- Merck Sharp & Dohme LLC
Nerve Block, Efficiency
Femoral Nerve Blockade 7.5 ml of 1% Lidocaine: US Guidance Versus US Guidance With Electrical Stimulation of Peripheral Nerves (Influence of the Femoral Nerve Blockade on the Effectiveness of Small Doses of Local Anesthetic.). (EPBwEPN)
In modern anesthesiology, peripheral nerve blocks are performed using ultrasound control and electrical stimulation of peripheral nerves (PEN), or only ultrasound control or only EPN.
- Conditions
- Nerve Block, Efficiency, Femoral Nerve, Ultrasonography
- Trial name
- NCT05209711
- Testing
- Femoral nerve block under ultrasound control with a electrostimulator peripheral nerves 7.5 ml 1% lidocaine, Femoral nerve blockade under ultrasound control without a peripheral nerve stimulator 7.5 ml 1% lidocaine
- Where
- Belarus
- Volunteers
- 40 people
- Sponsor
- Mogilev Regional Clinical Hospital
Pulmonary Arterial Hypertension, Pulmonary Hypertension
Bardoxolone Methyl Evaluation in Patients With Pulmonary Hypertension (PH) - LARIAT
This study assesses the safety and efficacy of bardoxolone methyl relative to placebo in patients with pulmonary hypertension to determine the recommended dose range, evaluate the change from baseline in 6-minute walk distance…
- Conditions
- Pulmonary Arterial Hypertension, Pulmonary Hypertension, Interstitial Lung Disease, Idiopathic Interstitial Pneumonia
- Trial name
- NCT02036970
- Testing
- Bardoxolone methyl
- Where
- 32 sites in United States, Germany
- Volunteers
- 166 people
- Sponsor
- Biogen
Conscious Sedation
An Effectiveness and Safety Study of AQUAVAN® Injection (Fospropofol Disodium) for Sedation During Colonoscopy
Very often patients receive medication before a diagnostic procedure, like a colonoscopy, to help them relax and stay calm during the procedure. This is called procedural or minimal-to-moderate sedation.
- Trial name
- NCT00261599
- Testing
- AQUAVAN® (fospropofol disodium) Injection, Midazolam HCI
- Where
- 20 sites in United States
- Volunteers
- 300 people
- Sponsor
- Eisai Inc.
Idiopathic Pulmonary Fibrosis
A Clinical Study to Test How Effective and Safe GLPG1690 is for Subjects With Idiopathic Pulmonary Fibrosis (IPF) When Used Together With Standard of Care
The main purpose of this study was to see how GLPG1690 works together with your current standard treatment on your lung function and IPF disease in general.
- Trial name
- ISABELA1 (NCT03711162)
- Testing
- GLPG1690
- Where
- 132 sites in United States, Australia and 13 more
- Volunteers
- 525 people
- Sponsor
- Lakefront Biotherapeutics NV
Percutaneous Nephrolithotomy
The Minimal Effective Volume (MEV90) of Ropivacaine 0.75% for Ultrasound-guided Transmuscular Quadratus Lumborum Block
This double-blind dose-finding trial is based on a biased coin up-and-down sequential design, where the volume of local anesthetic administered to each patient depends on the response from the previous one.
- Trial name
- NCT04196270
- Testing
- Ropivacaine injection
- Volunteers
- 40 people
- Sponsor
- Zealand University Hospital
Primary Gonarthrosis
The Efficacy of Intra-articular Triamcinolone Acetonide 5mg vs. 10 mg vs. 40 mg in Patients With Knee Osteoarthritis
Osteoarthritis of the knee is a common problem that is increasing in prevalence as the population ages. In a knee with osteoarthritis, there is variable damage to the articular cartilage and underlying bone that can cause varying…
- Trial name
- NCT05806021
- Testing
- Triamcinolone Acetonide
- Where
- Canada
- Volunteers
- 327 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Hematologic Diseases, Neoplasms
A Dose Finding Study of Remifentanil and Propofol for Lumbar Punctures in Children
This study will examine whether the combination of two anaesthetic medications, propofol and remifentanil, is suitable for short duration surgical procedures, providing a shorter recovery time and fewer side effects than either…
- Trial name
- NCT00213239
- Testing
- Remifentanil
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- The Hospital for Sick Children
Solar Urticaria
Intravenous Immunoglobulins in Severe and Refractory Solar Urticaria
Solar urticaria is a rare but debilitating disease that can severely impact the quality of life, restricting outdoor activities.Treatment, based on sun protection and anti-histaminic drugs, is efficacious in 2 patients out of 3.
- Trial name
- IGUS (NCT01360658)
- Testing
- Intravenous immunoglobulins
- Where
- 12 sites in France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Menorrhagia
The Assessment of Tranexamic Acid in Women With Menorrhagia Who Have Bleeding Disorders
Many women have heavy periods and this can be associated with low blood, tiredness and inability to carry out normal activities. Approximately 10-30% of these women will have an underlying bleeding disorder.
- Trial name
- NCT00904709
- Testing
- tranexamic acid
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- K. Sue Robinson
Brachial Plexus Blocks, Lidocaine
Minimal Effective Volume 90% for Double-injection Costoclavicular Block
In 2020, a trial demonstrated that a 2-injection technique constitutes the optimal method for the costoclavicular block. This study aims to determine the minimum amount of medication required to achieve a successful…
- Conditions
- Brachial Plexus Blocks, Lidocaine, Nerve Block, Dose Finding Study
- Trial name
- NCT07374952
- Testing
- Ultrasound-guided double-injection costoclavicular nerve block with same previous volume, Ultrasound-guided double-injection costoclavicular nerve block with lower volume
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Femoral Neck Fracture
Ropivacaine Hypobaric Spinal Anaesthesia in Traumatic Hip Surgery
This is a prospective, monocentric, randomized study, comparing the effectiveness and tolerance of four different dosages of hypobaric ropivacaine for unilateral spinal anaesthesia during traumatic femoral neck surgery in the…
- Trial name
- NCT01005550
- Testing
- 6 mg of ropivacaine, 8 mg of ropivacaine, 10 mg of ropivacaine
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Hospices Civils de Lyon
Arthroscopic Shoulder Surgery
Effects of Technique on the Local Anesthetic Dose Required for Interscalene Brachial Plexus Block
Interscalene brachial plexus block (ISBPB) is a common nerve block given to patients who are undergoing shoulder surgery. This block has a low, but still significant, rate of complications.
- Trial name
- NCT00731146
- Testing
- Ultrasound Minimum Effective Anesthetic Volume, Nerve Stimulator Minimum Effective Anesthetic Volume
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Sunnybrook Health Sciences Centre
Type 2 Diabetes
Clinical Trail of Tang-min-Ling Pills in Type 2 Diabetes Mellitus
This is a randomized, doubled blind, dose-paralleled control, multi-centre clinical trail,to evaluate the efficacy of Tang-min-ling pills in the treatment of type 2 diabetes mellitus.
- Trial name
- NCT01087242
- Testing
- Tang-min Lin pill
- Where
- 4 sites in China
- Volunteers
- 480 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences