Clinical trials: Minocycline
Stroke, Ischemic
Neuroprotection in Acute Ischemic Stroke
This is a pilot randomized control trial (RCT) to explore the possible beneficial effect of a novel combination therapy consisting of molecular hydrogen H2 plus minocycline ("H2M"), on neurological recovery after acute ischemic…
- Trial name
- H2M (NCT03320018)
- Testing
- Hydrogen, Minocycline
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stony Brook University
Obsessive Compulsive Disorder
Pilot Study of Minocycline (NPL-2003) in Adults With Obsessive-Compulsive Disorder (OCD)
Obsessive-compulsive disorder (OCD) is a common psychiatric illness that affects up to 2-3% of the population. People with OCD experience anxiety-provoking, intrusive thoughts, known as obsessions, and feel compelled to perform…
- Trial name
- NCT00728923
- Testing
- NPL-2003
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- New York State Psychiatric Institute
Asthma
Open-Label Trial of the Use of Minocycline in the Treatment of Asthma
The tetracycline minocycline has, in addition to its anti-infective properties, anti-inflammatory properties which may be of use in the treatment of asthma.
- Trial name
- NCT00536042
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- State University of New York - Downstate Medical Center
Cystic Fibrosis
DPI-Tobra-Kind Cyclops® in Children With Cystic Fibrosis
The goal is to investigate the pharmacokinetic properties of dry powder tobramycin via the Cyclops® at different dosages in children with cystic fibrosis, together with the local tolerability.
- Trial name
- NCT03485456
- Testing
- Tobramycin
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- University Medical Center Groningen
Acne
Combination Treatment for Moderate to Severe Acne
To determine if a combination of three currently approved acne products are safe and effective for the treatment of moderate to severe acne
- Trial name
- NCT01206348
- Testing
- Minocycline, Clindamycin, Tretinoin, Benzoyl Peroxide
- Where
- 10 sites in United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Medicis Global Service Corporation
Colorectal Cancer
Phase II Study of Minocycline for Reducing Symptom Burden in Colorectal Patients
The goal of this clinical research study is to learn if minocycline can reduce numbness, pain, and/or loss of motor function in patients with colorectal cancer. In this study, minocycline will be compared to a placebo.
- Trial name
- NCT01906008
- Testing
- Minocycline, Questionnaires, Sensory Test
- Where
- 2 sites in United States
- Volunteers
- 122 people
- Sponsor
- M.D. Anderson Cancer Center
Peri-Implantitis
Arestin - Use in Subjects With Peri-Implantitis (With Subgingival Microbiological Evaluation)
The objective of the study is to evaluate the safety, effectiveness and anti-microbial effects of Arestin (minocycline HCl) 1 mg Microspheres in the treatment of subjects with peri-implantitis, when used in combination with…
- Trial name
- NCT01517334
- Testing
- Minocycline HCl Microspheres
- Where
- 10 sites in United States
- Volunteers
- 208 people
- Sponsor
- OraPharma
Spinal Cord Injuries
Minocycline in Acute Spinal Cord Injury (MASC)
The objective of this study is to assess the efficacy of IV minocycline in improving neurological and functional outcome after acute non-penetrating traumatic spinal cord injury (SCI).
- Trial name
- NCT01828203
- Testing
- Minocycline, Surgical spinal cord decompression, Maintenance of minimum mean arterial pressure (MAP)
- Where
- 7 sites in Australia, Canada
- Volunteers
- 248 people
- Sponsor
- Rick Hansen Institute
Skin Diseases
Minocycline Bioequivalence Study
This study compared the bioavailability of two formulations 100 mg (one capsule or other respectively) of each one of the products, of Minocycline, under fasting conditions, in healthy Mexican volunteers of both sexes.
- Trial name
- NCT01938508
- Testing
- Minocycline
- Where
- Mexico
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Epileptic Seizures Related to Drugs
The Efficacy and Safety of Minocycline in the Treatment of Drug-resistant Epilepsy in NORSE Patients
Exploring the efficacy and safety of oral minocycline combined with antiepileptic drugs in the treatment of drug-resistant epilepsy in NORSE patients, obtaining preliminary research data, and providing evidence and data support…
- Trial name
- NCT05958069
- Testing
- minocycline
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Xijing Hospital
Multiple Sclerosis, Relapsing-Remitting
Minocycline as add-on to Interferon Beta-1a [IFN Beta-1a] (Rebif®) in Relapsing-Remitting Multiple Sclerosis [RRMS]
This is a multicentric, double-blind, placebo-controlled, randomized, parallel group study to estimate the effect of minocycline as add-on to interferon beta-1a (IFN beta-1a) in subjects with relapsing-remitting multiple…
- Trial name
- RECYCLINE (NCT01134627)
- Testing
- Minocycline
- Where
- Denmark
- Volunteers
- 305 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Oral Lichen Planus
The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus
The aim of the present study is to assess the clinical efficacy of topical minocyclin in managing of symptoms associated with oral lichen planus (OLP).
- Trial name
- NCT01083420
- Testing
- Minocycline, Dexamethasone
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Schizophrenia
Minocycline add-on to Antipsychotics for the Treatment of Negative and Cognitive Symptoms in Schizophrenia
Current medications have only a limited effect on two core symptoms of schizophrenia, negative symptoms and cognitive deficits. Minocycline is a second-generation tetracycline which has a beneficial effect in various neurological…
- Trial name
- NCT02907437
- Testing
- Minocycline, Probiotics
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Beer Yaakov - Ness Ziona Mental Health Center
Lung Cancer
Minocycline Study in Non Small Cell Lung Cancer (NSCLC) Patients for Chemoradiation Therapy
The goal of this clinical research study is to learn if minocycline can reduce the side effects reported by patients with NSCLC who are receiving chemoradiation therapy. In this study, minocycline will be compared to a placebo.
- Trial name
- NCT01636934
- Testing
- Minocycline, Questionnaires
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- M.D. Anderson Cancer Center
Acute Ischemic Stroke, Vessel Occlusion
Minocycline After Successful Endovascular Thrombectomy Recanalization in Acute Anterior Circulation Large Vessel Occlusion (ATTRACTION-MINOA)
Endovascular thrombectomy (EVT) improves outcomes in patients with acute large vessel occlusion (LVO). However, despite successful recanalization rates exceeding 80%, fewer than 50% of patients achieve favorable functional…
- Conditions
- Acute Ischemic Stroke, Vessel Occlusion, Endovascular Thrombectomy, Anterior Circulation Brain Infarction
- Trial name
- NCT07594314
- Testing
- Minocycline hydrochloride capsule
- Where
- China
- Volunteers
- 860 people
- Sponsor
- Xiang Luo
Periodontitis, Adult
Locally Delivered Minocycline in Advanced Periodontitis
Local drug delivery provides higher concentrations in the availability of the drug at the specific infected sites with the advantage of sustained release.
- Trial name
- NCT04076098
- Testing
- Minocycline Hydrochloride
- Where
- Malaysia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mahsa University
Peri-Implantitis
Arestin - Use in Subjects With Peri-Implantitis
The objective of the study is to evaluate the safety and effectiveness of Arestin (minocycline HCl) 1 mg Microspheres in the treatment of subjects with peri-implantitis, when used in combination with mechanical debridement.
- Trial name
- NCT01539564
- Testing
- Minocycline HCl Microspheres
- Where
- 12 sites in United States, Germany and 2 more
- Volunteers
- 215 people
- Sponsor
- OraPharma
Helicobacter Pylori Infection
Minocycline for Helicobacter Pylori Rescue Treatment
Current guidelines have recommended classical bismuth-containing quadruple therapy including proton-pump inhibitor, bismuth, tetracycline, metronidazole as the empirical rescue therapy.
- Trial name
- NCT06332599
- Testing
- BQT, PBM4M4, PBM3M3
- Where
- China
- Volunteers
- 823 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Pneumothorax
Intrapleural Minocycline Following Simple Aspiration for Primary Spontaneous Pneumothorax
The optimal initial management of primary spontaneous pneumothorax (PSP) remains controversial. This study was conducted to evaluate the safety and efficacy of additional minocycline pleurodesis after successful aspiration of the…
- Trial name
- NCT00520221
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- National Taiwan University Hospital
Healthy
Bioequivalence Study of Minocycline HCl 135 mg ER Tablet Sunder Fed Conditions
The study was conducted as an open-label, balanced, randomized, two-treatment, two-period, two-sequence, single-dose, crossover, bioequivalence study comparing Minocycline hydrochloride extended release tablets 135 mg…
- Trial name
- NCT02312609
- Testing
- Minocycline hydrochloride
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited