Clinical trials: Minocycline
Chronic Pain, Post-operative Pain
Minocycline to Reduce Pain After Carpal Tunnel Release
The investigators are looking at whether peri-operative minocycline will reduce the duration of pain after minor hand surgery: carpal tunnel release and trigger finger release.
- Trial name
- NCT02051296
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- VA Palo Alto Health Care System
Ischemic Stroke, Acute
Efficacy and Safety of Minocycline in Patients With Moderate to Severe Acute Ischemic Stroke
The aim of this study was to evaluate the efficacy and safety of Minocycline versus placebo in the treatment of patients with moderate to severe acute ischemic stroke.
- Trial name
- EMPHASIS (NCT05836740)
- Testing
- Minocycline hydrochloride capsule
- Where
- 58 sites in China
- Volunteers
- 1,724 people
- Sponsor
- Beijing Tiantan Hospital
Healthy
Bioequivalecne Study of Minocycline 100mg Tablets Under Fed Conditions
The purpose of this study was to determine the bioequivalence of Minocycline formulations after administration of single doses to normal healthy subjects under fed conditions.
- Trial name
- NCT00777413
- Testing
- Minocycline 100mg Tablets
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Usability
Usability of Levodopa Cyclops™ vs INBRIJA® in Parkinson's Patients
Currently there is one Levodopa inhaler on the market, the INBRIJA® inhaler. When looking at the user instructions for the INBRIJA®, multiple steps are necessary including preparing and cleaning the inhaler.
- Trial name
- DPI-6 (NCT05499572)
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Martini Hospital Groningen
Acute Ischemic Stroke, Vessel Occlusion
Minocycline After Successful Endovascular Thrombectomy Recanalization in Acute Anterior Circulation Large Vessel Occlusion (ATTRACTION-MINOA)
Endovascular thrombectomy (EVT) improves outcomes in patients with acute large vessel occlusion (LVO). However, despite successful recanalization rates exceeding 80%, fewer than 50% of patients achieve favorable functional…
- Conditions
- Acute Ischemic Stroke, Vessel Occlusion, Endovascular Thrombectomy, Anterior Circulation Brain Infarction
- Trial name
- NCT07594314
- Testing
- Minocycline hydrochloride capsule
- Where
- China
- Volunteers
- 860 people
- Sponsor
- Xiang Luo
Peri-Implantitis
Arestin - Use in Subjects With Peri-Implantitis (With Subgingival Microbiological Evaluation)
The objective of the study is to evaluate the safety, effectiveness and anti-microbial effects of Arestin (minocycline HCl) 1 mg Microspheres in the treatment of subjects with peri-implantitis, when used in combination with…
- Trial name
- NCT01517334
- Testing
- Minocycline HCl Microspheres
- Where
- 10 sites in United States
- Volunteers
- 208 people
- Sponsor
- OraPharma
Allergic Rhinitis, Asthma
Assessment of Suppression of Cutaneous Allergic Responses and Pruritis by Topical Minocycline
Adults with known respiratory allergy/asthma with known skin test sensitization will undergo repeat skin prick testing at 4 areas of both arms (bilateral forearms, bilateral upper arms).
- Trial name
- GINA3 (NCT04202263)
- Testing
- Minocycline Topical
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- State University of New York - Downstate Medical Center
Alcohol Dependence
Minocycline's Effects on Alcohol Responses in Humans
This is a double-blind, placebo-controlled, outpatient study with a between-groups design. Sixty male and female heavy social drinkers will be randomly assigned to minocycline (200 or 400 mg/day) or placebo for 10 days.
- Trial name
- NCT02187211
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Yale University
Schizophrenia
Minocycline Augmentation in Schizophrenia
This study aims to examine the efficacy of minocycline augmentation in a sample of moderately ill outpatients with early-course schizophrenia on their chlorpromazine-equivalent doses of second-generation antipsychotic…
- Trial name
- NCT01561742
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- The University of Texas Health Science Center, Houston
Spinal Cord Injuries
Minocycline and Perfusion Pressure Augmentation in Acute Spinal Cord Injury
While research in animal models of spinal cord injury have provided many promising insights, human studies have failed to produce effective therapies.
- Trial name
- NCT00559494
- Testing
- Minocycline, SCPP augmentation, SCPP control
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- University of Calgary
Amyotrophic Lateral Sclerosis
Minocycline to Treat Amyotrophic Lateral Sclerosis
The purpose of this trial is to test the safety, tolerability, and effectiveness of minocycline compared to placebo in patients with amyotrophic lateral sclerosis (ALS).
- Trial name
- NCT00047723
- Testing
- minocycline
- Where
- 30 sites in United States
- Volunteers
- 400 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Diabetic Macular Edema
A Pilot Study for the Evaluation of Minocycline as a Microglia Inhibitor in the Treatment of Diabetic Macular Edema
The objective of this study is to investigate the safety and efficacy of minocycline as a microglia inhibitor in individuals with diabetic macular edema (DME).
- Trial name
- NCT01120899
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Eye Institute (NEI)
Stroke, Ischemic
Neuroprotection in Acute Ischemic Stroke
This is a pilot randomized control trial (RCT) to explore the possible beneficial effect of a novel combination therapy consisting of molecular hydrogen H2 plus minocycline ("H2M"), on neurological recovery after acute ischemic…
- Trial name
- H2M (NCT03320018)
- Testing
- Hydrogen, Minocycline
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stony Brook University
Acne
A Pharmacokinetic Study of Minocycline in Male and Female Volunteers
The purpose of this study is to assess the pharmakokinetic profile of Minocycline in FMX-101 4% foam product in male and female some of which are with acne
- Trial name
- NCT02250859
- Testing
- FMX101, Minocycline 4% foam
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Vyne Therapeutics Inc.
Diabetic Nephropathy
Minocycline and Proteinuria in Diabetic Nephropathy
Diabetic kidney disease increases the risk of illness and death from heart disease in patients with Type 2 diabetes. Some blood pressure medications called ACE inhibitors and ARBs slow progression of kidney disease, but the dose…
- Trial name
- NCT01779089
- Testing
- Minocycline 100 mg po bid for 6 months
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Pneumothorax
Additional Minocycline Pleurodesis After Thoracoscopic Procedures for Primary Spontaneous Pneumothorax
To test if additional minocycline pleurodesis after thoracoscopic procedures can reduce the rates of ipsilateral recurrence for patients with primary spontaneous pneumothorax.
- Trial name
- NCT00154895
- Testing
- intrapleural minocycline instillation
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Depressive Disorder, Mood Disorders
Minocycline as an Adjunct for the Treatment of Depressive Symptoms: Pilot Randomized Controlled Trial
In this double blind randomised controlled pilot trial the investigators aim to determine the efficacy of minocycline as an adjunct to treatment as usual in patients with major depressive disorder.
- Conditions
- Depressive Disorder, Mood Disorders, Depressive Disorder, Treatment Resistant, Antidepressive Agents
- Trial name
- NCT02263872
- Testing
- Minocycline
- Where
- 3 sites in Pakistan
- Volunteers
- 41 people
- Sponsor
- Pakistan Institute of Living and Learning
Fibromyalgia
The Effect of Minocycline and N-acetylcysteine for the Treatment of Fibromyalgia
Evaluation of the effect of combinatorial treatment of fibromyalgia patients (standard of care + minocycline + N-acetylcysteine (NAC) relative to standard of care on subjective pain measurement Revised Fibromyalgia Impact…
- Trial name
- NCT04594733
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Periodontitis
Effect of Adjunctive Treatment With Arestin on the Subgingival Microflora in Patients With Moderate to Advanced Periodontitis
The purpose of this study is to measure the antimicrobial effects of Arestin in subjects with moderate to advanced periodontal disease
- Trial name
- NCT00371332
- Testing
- Minocycline HCL Microspheres
- Where
- 5 sites in United States
- Volunteers
- 128 people
- Sponsor
- OraPharma
Renal Insufficiency, Acute, Renal Insufficiency, Chronic
Evaluate Safety and Pharmacokinetics of Minocin (Minocycline) for Injection in Subjects With Renal Insufficiency
This is a Phase 1, open-label, single-dose study of the safety, tolerability, and pharmacokinetics of Minocin® (minocycline) for injection in subjects with renal insufficiency.
- Conditions
- Renal Insufficiency, Acute, Renal Insufficiency, Chronic, Healthy Subjects
- Trial name
- NCT02808052
- Testing
- Minocin (minocycline) for Injection
- Where
- Germany
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Rempex (a wholly owned subsidiary of Melinta Therapeutics, Inc.)