Clinical trials: Miscarriage, Recurrent, open to volunteers
Cervical Insufficiency, Preterm Birth
Optimal Timing of Routine Cervical Length Measurements During Anatomy Survey
The goal of this clinical trial is to determine the optimal timing for measuring cervical length (CL) during fetal anatomy surveys in pregnant individuals.
- Conditions
- Cervical Insufficiency, Preterm Birth, Cervical Length Measurement
- Trial name
- NCT06822647
- Testing
- Cervical Length Measurement at the Beginning of the Anatomy Survey, Cervical Length Measurement at the End of the Anatomy Survey
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- Henry Ford Health System
Adverse Pregnancy Outcome
Using Placental Pathology to Prevent Recurrent Adverse Pregnancy Outcomes: A Pilot Project
The goal of this randomized clinical trial is to evaluate if we can use placental pathology in a prior pregnancy which had an adverse outcome, such as early delivery, stillbirth, a baby born smaller than expected, or severe forms…
- Trial name
- NCT06004674
- Testing
- Lovenox 40mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Endeavor Health
Infertility, Female, Recurrent Miscarriage
Immune Cell Populations in the Endometrium
Specialized immunological studies in the diagnostics of idiopathic infertility and recurrent miscarriages have limited applicability, as the role of the immune system in these conditions is not thoroughly understood.
- Conditions
- Infertility, Female, Recurrent Miscarriage, Gynecologic Disease
- Trial name
- NCT06826365
- Testing
- Percentage distribution of immune system cells in peripheral blood, Percentage distribution of immune system cells in endometrium
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Jagiellonian University
Mannose-Binding Lectin Deficiency, Recurrent Pregnancy Loss
Association Between Plasma Level of Mannose Binding Lectin and Human Reproduction
A low plasma level of mannose binding lectin (p-MBL) is associated with unexplained recurrent pregnancy loss (RPL), but it is not investigated if it is associated with unexplained reproductive failure in general, including…
- Conditions
- Mannose-Binding Lectin Deficiency, Recurrent Pregnancy Loss, Recurrent Implantation Failure, Infertility
- Trial name
- NCT05169541
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Aalborg University Hospital
Recurrent Miscarriage, Recurrent Pregnancy Loss
Prednisolone Administration in Patients With Unexplained REcurrent MIscarriages
Recurrent miscarriages (RM) affects 3% of all fertile couples, but remains unexplained in most cases, limiting therapeutic options. Possibly the maternal immune system plays a role in recurrent miscarriage.
- Conditions
- Recurrent Miscarriage, Recurrent Pregnancy Loss, Habitual Abortion, Miscarriage
- Trial name
- PREMI (NCT05725512)
- Testing
- Prednisolone
- Where
- Netherlands
- Volunteers
- 490 people
- Sponsor
- Leiden University Medical Center
Recurrent Miscarriage
Effect of Prednisolone Treatment on Uterine Natural Killer Cells
This study aims to investigate the role of uNK cells and the association with prednisolone.
- Trial name
- NCT03902912
- Testing
- Prednisolone
- Where
- Hong Kong
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Recurrent Miscarriage
Chronic Endometritis and Benefits of Antibiotics in Women With Recurrent Miscarriage
The aim of the study is to estimate the incidence of CE, evaluate the endometrial microorganism of CE, and investigate the therapeutic benefits of antibiotics for women with unexplained recurrent miscarriage and CE.
- Trial name
- NCT06163092
- Where
- Hong Kong
- Volunteers
- 175 people
- Sponsor
- Chinese University of Hong Kong
Preterm Birth, Cervical Length
Cervical Length Reference Range at 28-34 Weeks in Singleton Pregnancies
Cervical length, measured via transvaginal ultrasound, changes as pregnancy progresses. However, reference information for interpreting cervical length measurements during late pregnancy in Vietnam remains limited.
- Conditions
- Preterm Birth, Cervical Length, Cervical Incompetence
- Trial name
- CL-Trim3 (NCT07914595)
- Testing
- No Intervention: Observational Cohort
- Where
- Vietnam
- Volunteers
- 294 people
- Sponsor
- Mỹ Đức Hospital
Preterm Delivery, Cervical Cerclage
Use of Nitrous Oxide for Pain and Anxiety Management During Cervical Cerclage Removal
The goal of this clinical trial is to determine whether inhaled nitrous oxide can reduce pain and anxiety during cervical cerclage removal compared with standard care.
- Conditions
- Preterm Delivery, Cervical Cerclage, Cervical Insufficiency
- Trial name
- NCT07491874
- Testing
- Inhaled nitrous oxide
- Where
- 4 sites in Israel
- Volunteers
- 60 people
- Sponsor
- Kaplan Medical Center
Repeated Embryo Implantation Failure, Recurrent Miscarriage
Immune Profile Analysis and Biomarker Identification in Women With Repeated Implantation Failure or Unexplained Recurrent Spontaneous Miscarriage
Implantation is a determining step in human reproduction which requires the transition from a pro-inflammatory state to an anti-inflammatory state allowing the implantation of a competent embryo within a receptive endometrium…
- Conditions
- Repeated Embryo Implantation Failure, Recurrent Miscarriage, Immune System
- Trial name
- ERIM (NCT05648136)
- Testing
- blood sample
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Preterm Birth, Cervical Insufficiency
Bed Rest With a Short Cervix on Preterm Birth
Maternal AR has long been used to prevent PTB. However, definitions of AR vary widely, ranging from complete bed rest to partial limitation of physical activity for one or more hours daily.
- Conditions
- Preterm Birth, Cervical Insufficiency, Bed Rest, Pregnancy Complications
- Trial name
- BEWISE (NCT07577388)
- Testing
- Activity Restriction, No Activity Restriction
- Volunteers
- 6,000 people
- Sponsor
- Julie Glavind
Cervical Insufficiency
Azithromycin for Cerclage Prophylaxis
The primary goal is to assess the effectiveness in pregnancy prolongation utilizing azithromycin at the time of transvaginal cervical cerclage placement.
- Trial name
- NCT07608562
- Testing
- Azithromycin Prophylaxis, Cefazolin, Progesterone
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Wake Forest University Health Sciences
Miscarriage, Early Pregnancy Loss
Cohort of Patients Presenting Unexplained Recurrent Miscarriages and Identification of Early Miscarriage Recidivism Factors
About 1 to 3% of women of childbearing age suffer repeated early spontaneous miscarriages (RCF) defined by at least 3 fetal losses before 14 weeks of gestation.
- Trial name
- FALCO (NCT05557201)
- Where
- France
- Volunteers
- 700 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preterm Birth, Cervical Insufficiency
Nordic Randomized Trial on Laparoscopic Versus Vaginal Cerclage
Every year 15 million babies are born prematurely, which can lead to death or life-long disabilities. It is often caused by a dysfunction of the uterine cervix, which constitutes the narrow channel between the vagina and womb.
- Trial name
- NORACT (NCT06122506)
- Testing
- Laparoscopic cerclage, Vaginal cerclage
- Where
- 2 sites in Denmark
- Volunteers
- 188 people
- Sponsor
- University of Aarhus
Abortion, Habitual
LIGHT Trial: Levothyroxine for Gestational Hypothyroidism in Recurrent Pregnancy Loss
The goal of this randomized, double-blind, placebo-controlled clinical trial is to evaluate whether levothyroxine supplement improves pregnancy outcomes in women with recurrent pregnancy loss (RPL) and isolated maternal…
- Trial name
- LIGHT (NCT06999278)
- Testing
- Levothyroxin
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Recurrent Implantation Failure, Recurrent Pregnancy Loss
Study of Endometrial Immune and Microbiological Modifications in Cases of Recurrent Implantation Failure and/or Recurrent Pregnancy Loss
The IMERR study aims to improve understanding of certain causes of infertility related to recurrent implantation failure (RIF) and/or recurrent pregnancy loss (RPL), conditions that affect many women undergoing assisted…
- Conditions
- Recurrent Implantation Failure, Recurrent Pregnancy Loss, Infertility, Female, Endometrial Diseases
- Trial name
- IMERR (NCT07265505)
- Testing
- Endometrial Biopsy, Vaginal Swab, Blood sample
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infertility and Miscarriage
A Multicenter, Prospective, Randomized Controlled Clinical Study on the Effect of Hysteroscopic Uterine Septum Resection on IVF-ET Outcomes in Infertile Patients With Non-recurrent Miscarriage
This study aims to evaluate the impact of hysteroscopic transcervical resection of the septum (TCRS) on fertility in infertile women without recurrent miscarriage, primarily assessing its effect on subsequent IVF-ET outcomes.
- Trial name
- NCT07611656
- Testing
- Transcervical resection of septum
- Where
- China
- Volunteers
- 236 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Recurrent Pregnancy Loss
Prospective Recurrent Pregnancy Loss Registry
The purpose of this Registry is to prospectively collect data of Recurrent Pregnancy Loss (RPL) patients attending the specialized care centre at the BC Women's Hospital, in order to evaluate investigation practices, treatment…
- Trial name
- NCT05989178
- Testing
- Data Registry
- Where
- Canada
- Volunteers
- 3,000 people
- Sponsor
- University of British Columbia
Helicobacter Pylori Infection, Susceptibility to
Helicobacter Pylori Infection Among Women With Recurrent Abortion of Unknown Cause
Helicobacter pylori (H. pylori) infection affects approximately one half of the world population and it is more prevalent in developing countries. This microorganism colonizes the stomach.
- Trial name
- NCT07293169
- Testing
- H pylori eradication
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Infertility, Female, Miscarriage
Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages?
This study aims to explore the potential correlation between decreased ovarian reserve and previous history of early miscarriage.
- Conditions
- Infertility, Female, Miscarriage, Miscarriage, Recurrent, IVF
- Trial name
- NCT05969574
- Testing
- Transvaginal ultrasound, Blood test AMH
- Where
- 3 sites in United Arab Emirates
- Volunteers
- 2,059 people
- Sponsor
- ART Fertility Clinics LLC