Clinical trials: Miscarriage
Incomplete Abortion
Treatment of Incomplete Abortion With 600 Mcg Oral Misoprostol Compared to Standard Surgical Treatment
This study aims to compare the efficacy, side effects profile and acceptability of a single dose of 600mcg misoprostol taken orally compared to standard surgical treatment as per local protocols for the treatment of incomplete…
- Trial name
- NCT00674232
- Testing
- 600 mcg misoprostol, Surgical treatment
- Where
- 3 sites in Ecuador, Venezuela
- Volunteers
- 311 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Repeated Spontaneous Miscarriages, Fetal Deaths in Utero
Determinants of Repeated Spontaneous Miscarriages and Unexplained Fetal Deaths
The DEFI-1 study recruited 625 women witnesses and 299 of their spouses. With regard to case couples, 271 cases were recruited from the spontaneous repeated miscarriages (SRM) subgroup (≥3 spontaneous miscarriage (SM) from…
- Trial name
- DEFI-2 (NCT04207814)
- Testing
- biological sample
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Brest
IVF, Embryo Loss
The Use of High Concentration Hyaluronic Acid (HA) Transfer Medium in Repeated Implantation Failure (RIF) Patients
This is a pilot study with the aim to investigate the beneficial effect of bicarbonate buffered medium containing hyaluronan and recombinant human albumin (EmbryoGlue®, Vitrolife) in patients with documented repeated implantation…
- Conditions
- IVF, Embryo Loss, Miscarriage, Recurrent
- Trial name
- RIFLE (NCT04709796)
- Testing
- EmbryoGlue®, Vitrolife, Conventional Transfer
- Where
- Belgium
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Recurrent Miscarriages, Habitual Abortions
Description of the Uterine Cavity in Patients With Recurrent Miscarriages
To be diagnosed with recurrent miscarriages, a couple might have a child, however experiences three or more miscarriages, primarily this happens during the first trimester.
- Trial name
- NCT02746588
- Testing
- Office hysteroscopy
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Autoimmune Thyroiditis, Recurrent Miscarriage
Thyroid Hormone Values and Anti-thyroid Peroxidase Antibody Positivity in Recurrent Pregnancy Loss
The aim of this study is to compare the thyroid hormone values and anti-thyroid peroxidase (anti-TPO) levels of women with a diagnosis of recurrent pregnancy loss (RPL) and healthy pregnancies.
- Trial name
- NCT05680376
- Where
- Turkey (Türkiye)
- Volunteers
- 103 people
- Sponsor
- Zonguldak Bulent Ecevit University
Recurrent Early Pregnancy Loss
PGT-A in Screening of Embryos in the Treatment of Unexplained Recurrent Miscarriage
uRM patients selected PGT-A from 2012 to 2016 were included in this study. Their clinical outcomes were prospectively observed and analyzed to explore the factor influenced the outcomes.
- Trial name
- NCT04643938
- Where
- China
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
First Trimester Pregnancy, Fetal Heart Activity Absent
Markers of Oxidative Stress in a Early Week Miscarriage: Ischemia of Modified Albumin
The finding that ischemia-modified albumin (IMA) is increased in pre-eclamptic pregnancy suggests a role for IMA as a potential biomarker for abnormal placental development related to miscarriage.This study was undertaken to…
- Conditions
- First Trimester Pregnancy, Fetal Heart Activity Absent, Absence of Fetal Pole on Ultrasonographic Examination.
- Trial name
- IMA (NCT01988740)
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Infertility, Recurrent Pregnancy Loss
Preimplantation Genetic Diagnosis Using Blastocyst Biopsy and Array CGH
The investigators propose to perform a clinical randomized trial to evaluate the effect of single embryo (blastocyst) transfer (SET) with array CGH for the evaluation of the complete chromosome complement of the blastocyst in…
- Trial name
- NCT01546350
- Testing
- PGD
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Reprogenetics
Chronic Endometritis, in Vitro Fertilization
Chronic Endometritis and IVF
Background: Embryo quality is known to be a very important determinant to predict the implantation and pregnancy rate in IVF patients, however, the role of uterine integrity or endometrial receptivity cannot be overlooked.
- Trial name
- CEIVF (NCT02646930)
- Testing
- Endometrial biopsy
- Where
- 2 sites in United States
- Volunteers
- 57 people
- Sponsor
- Duke University
Subchorionic Hematoma in the First Trimester Pregnancy, Miscarriage
Vaginal Administration of ALA vs Progesterone for the Subchorionic Hematoma Treatment
The aim of this study was to compare the therapeutic efficacy of lipoic acid versus progesterone by vaginal administration on subchorionic hematoma resorption in women at the first trimester of pregnancy with threatened…
- Trial name
- NCT02601898
- Testing
- Lipoic acid, Progesterone
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Azienda USL Ferrara
Spontaneous Abortion
Post-traumatic Stress Disorder in Spontaneous Abortion
The objective of this questionnaire-based study is to prospectively assess the prevalence of post-traumatic stress disorder (PTSD) symptoms in a population of women who have experienced a spontaneous miscarriage during the first…
- Trial name
- NCT07306676
- Testing
- Impact of Event Scale - Revised (IES-R) questionnaire, Posttraumatic Stress Disorder Checklist - Specific (PCL-S) questionnaire, Trauma Recovery Measure (TRM) questionnaire
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Jagiellonian University
Birth Weight, Miscarriage
Micronutrient Supplementation Before and During 1st Pregnancy to Improve Birth Outcomes (JiVitA-5)
The purpose of this cluster-randomized trial is to evaluate the efficacy of daily, multiple micronutrient (MM) supplement versus identical placebo use among nulligravid, recently married women, starting preconceptionally through…
- Conditions
- Birth Weight, Miscarriage, Small-for-gestational Age, Preterm Birth
- Trial name
- JiVitA-5 (NCT03921177)
- Testing
- Multiple micronutrient supplement
- Where
- Bangladesh
- Volunteers
- 9,859 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Recurrent Pregnancy Loss(RPL)
Genomics and Microbiome Investigation in Cases of Recurrent Pregnancy Losses
Recurrent pregnancy losses (RPL) are characterized by the occurrence of more than one spontaneous pregnancy loss. It is caused by different known factors, but about half of the cases remain without an explanation.
- Trial name
- NCT06604338
- Testing
- Exome test, Microbiota analysis
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Fertility, Fecundability
Physical Activity, Fertility, and Spontaneous Abortion in Danish Couples Trying to Conceive
Physical activity in both the preconception period and during pregnancy may enhance the probability of getting pregnant and reduce the risks of complications during pregnancy.
- Conditions
- Fertility, Fecundability, Time-to-Pregnancy, Spontaneous Abortion
- Trial name
- SF/Activity (NCT06705712)
- Testing
- Use of activity trackers and motivational conversations to enhance focus on physical activity among women trying to conceive.
- Where
- Denmark
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Miscarriage in First Trimester, Prenatal Genetic Diagnosis
GRACE - Genetic Insights Into Early pRegnancy Loss Using Cell-free fEtal DNA
The aim of this study is to assess the impact of non-invasive prenatal testing right after an early isolated miscarriage on mental health and on the patient's subsequent care in the year following the miscarriage
- Trial name
- GRACE (NCT07639333)
- Testing
- Non invasive prenatal test
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Rennes University Hospital
Retained Products of Conception, Miscarriage
A Prospective Study Evaluating the Impact of Conservative Management on Retained Products of Conception and EMV
The goal of this observational study is to learn about the therapeutic effects of the conservative treatment approach on pepole with retained products of conception (RPOC) and Enhanced myometrial vascularity (EMV).
- Conditions
- Retained Products of Conception, Miscarriage, Conservative Management
- Trial name
- NCT06862089
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Polycystic Ovary Syndrome
Changes in Pregnancy in Egyptian Women With History of Recurrent Miscarriage
Introduction: Elevated levels of androgen and insulin-resistant have been implicated in recurrent miscarriage in women with PCOS.
- Trial name
- NCT04960982
- Testing
- blood test
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Miscarriage
Feasibility Study of a Coping Intervention for Recurrent Miscarriage
Some women experience the pain of miscarriage on numerous occasions. Studies show that these women experience feelings of anxiety and distress during the early stages of a new pregnancy as they worry another miscarriage will…
- Trial name
- NCT02989220
- Testing
- Positive Reappraisal Coping Intervention
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Erectile Dysfunction, Sexual Dysfunction
Erectile Dysfunction, Psychological Disorders, and Sexual Performance Among Men Seeking Medical Help for Fertility
According to the World Health Organization (WHO) and the World Association for Sexual Health (WAS), sexual health is directly related to everyone's mental health and quality of life.
- Conditions
- Erectile Dysfunction, Sexual Dysfunction, Premature Ejaculation, Infertile Men
- Trial name
- NCT04941690
- Testing
- A questionnaire method was used.
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- The First Hospital of Jilin University
Missed Abortion
Letrozole Pretreatment With Misoprostol Versus Misoprostol Alone in Missed Abortion
This study compares the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first-trimester pregnancy.
- Trial name
- NCT04217265
- Testing
- Letrozole then misoprostol
- Volunteers
- 200 people
- Sponsor
- Cairo University