Clinical trials: Miscarriage in First Trimester
First Trimester Pregnancy, Fetal Heart Activity Absent
Markers of Oxidative Stress in a Early Week Miscarriage: Ischemia of Modified Albumin
The finding that ischemia-modified albumin (IMA) is increased in pre-eclamptic pregnancy suggests a role for IMA as a potential biomarker for abnormal placental development related to miscarriage.This study was undertaken to…
- Conditions
- First Trimester Pregnancy, Fetal Heart Activity Absent, Absence of Fetal Pole on Ultrasonographic Examination.
- Trial name
- IMA (NCT01988740)
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Effect of Drug
Analgesia From Conscious Sedation Versus Paracervical Block for Manual Vacuum Aspiration
Miscarriage is one of the major causes of early pregnancy losses. Incomplete miscarriage is a major cause of maternal morbidity and mortality.
- Trial name
- NCT06539143
- Testing
- Lidocaine
- Where
- Nigeria
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Darlington-Peter Chibuzor Ugoji
Pregnancy
Randomized Double-blind Controlled Trial of Use of Dydrogesterone in Threatened Miscarriage
The aim of this study is to determine whether the dydrogesterone therapy is associated with reduction in miscarriage in women with first trimester threatened miscarriage.
- Trial name
- NCT02128685
- Testing
- Dydrogesterone
- Where
- 3 sites in Hong Kong
- Volunteers
- 406 people
- Sponsor
- The University of Hong Kong
Spontaneous Abortion in First Trimester
Comparing Buccal and Vaginal Misoprostol in Management of Early Pregnancy Loss
First trimester miscarriages are common. When the failed pregnancy does not pass spontaneously on its own, it is called a missed abortion.
- Trial name
- NCT02141555
- Testing
- Vaginal Misoprostol, Buccal Misoprostol
- Where
- 2 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Abortion, Missed
Isonicotinic Acid Hydrazide Pretreatment With Misoprostol Induction of Abortion in First-trimester Missed Miscarriage
This study compares the success rate of Adjuvant isonicotinic acid hydrazide and misoprostol versus misoprostol alone for medical termination of first-trimester pregnancy among women with one or more previous cesarean deliveries.
- Trial name
- NCT04499976
- Testing
- Isonicotinic Acid, Misoprostol
- Where
- Egypt
- Volunteers
- 240 people
- Sponsor
- Aswan University Hospital
Threatened Miscarriage, Early Pregnancy Bleeding
Comparison of Dydrogesterone Alone Versus Dydrogesterone Plus HCG in Threatened Miscarriage
This randomized controlled trial aims to compare the efficacy of Dydrogesterone alone versus Dydrogesterone combined with human chorionic gonadotrophin (HCG) in the treatment of threatened miscarriage in first trimester…
- Trial name
- DYD-HCG (NCT07608133)
- Testing
- Dydrogesterone, Human chorionic gonadotrophin (hCG)
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Pakistan Air Force (PAF) Hospital Islamabad
Miscarriage in First Trimester
Angular Pregnancy - Ultrasound Definition and Correlation With Clinical Outcomes
The aim of this study is to establish clinically meaningful ultrasound-based diagnostic criteria for AP. To this end, the investigators will prospectively collect clinical and ultrasound data from early intrauterine pregnancies…
- Trial name
- NCT06262373
- Testing
- Ultrasound
- Where
- United Kingdom
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Miscarriage, Missed Abortion
Letrozole Pretreatment With Misoprostol fInduction of Abortion In First-Trimester Missed Miscarriage
This study compares the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first trimester pregnancy.
- Trial name
- NCT03628625
- Testing
- Letrozole 2.5mg, Misoprostol
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Miscarriage
Comparison Between Letrozole and Mifepristone in Medical Termination of First Trimester Miscarriages
Prospective interventional study where participants with non-viable pregnancy at 1st trimester will be randomized into two arms, one group will receive conventional treatment with oral mifepristone followed by misoprostol…
- Trial name
- NCT05304273
- Testing
- Mifepristone, Letrozole
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Calcutta National Medical College and Hospital
Infertility, Female, First Trimester Spontaneous Abortion
Determination of Circulating Placental Biomarkers Levels to Predict the Pregnancy Outcome of First Trimester After IVF.
This study will assess the predictive potential of circulating placental biomarkers for spontaneous miscarriage within the following month in an IVF setting.
- Trial name
- NCT04387994
- Testing
- Blood samples collection
- Where
- Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidade de Lisboa
Recurrent Miscarriage
Habitual Abortion Study: Oral Dydrogesterone Treatment During Pregnancy in Women With Recurrent Miscarriage
The purpose of this clinical study is to demonstrate the shift from inflammatory cytokines to non-inflammatory cytokines in women suffering from habitual abortion treated with dydrogesterone (Duphaston).
- Trial name
- NCT00193674
- Testing
- Dydrogesterone
- Where
- 3 sites in Austria, Poland
- Volunteers
- 71 people
- Sponsor
- Abbott Products
Missed Abortion
Letrozole Pretreatment With Misoprostol Induction of Abortion In First-Trimester Missed Miscarriage
This study compares the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first-trimester pregnancy among women with one or more previous cesarean deliveries.
- Trial name
- NCT04215835
- Testing
- letrozole then misoprostol
- Volunteers
- 200 people
- Sponsor
- Cairo University
Luteal Phase, Biomarkers
Early Pregnancy Cohort and Preimplantation Factor
Miscarriage is a common event associated with severe psychological and social morbidity, further tormenting in women suffering recurrent pregnancy loss (RPL) by at least three consecutive losses.
- Conditions
- Luteal Phase, Biomarkers, Abortion, Spontaneous, Abortion, Habitual
- Trial name
- PEP-cohort (NCT02761772)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Nordsjaellands Hospital
Subchorionic Hematoma in the First Trimester Pregnancy, Miscarriage
Vaginal Administration of ALA vs Progesterone for the Subchorionic Hematoma Treatment
The aim of this study was to compare the therapeutic efficacy of lipoic acid versus progesterone by vaginal administration on subchorionic hematoma resorption in women at the first trimester of pregnancy with threatened…
- Trial name
- NCT02601898
- Testing
- Lipoic acid, Progesterone
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Azienda USL Ferrara
Miscarriage, Misoprostol
Comparison of Vaginal Versus Sublingual Misoprostol in the Treatment of First Trimester Missed Miscarriage
The miscarriage is one of the adverse outcomes of pregnancy and is responsible for stress and anxiety of the couple. there are different types of miscarriages.missed miscarriage also known as early fetal demise is one of the type…
- Trial name
- NCT04604366
- Testing
- misoprostol
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Islamabad Medical and Dental College
Recurrent Spontaneous Abortion
Difference Between Mean Gestational Sac Diameter and Crown-rump Length as a Marker of First-trimester Pregnancy Outcome in Patients With Recurrent Spontaneous Abortion
Objective: To determine the effect and predictive value of the difference between the mean gestational diameter (mGSD) sac and crown-rump length (CRL) of the first trimester on the pregnancy outcomes of patients with recurrent…
- Trial name
- mGSD-CRL& RSA (NCT06081556)
- Testing
- ultrasonic testing
- Where
- China
- Volunteers
- 256 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
IUCD Complication
Isonicotinic Acid Hydrazide (INH) Pretreatment With Misoprostol Versus Misoprostol Alone in Missed Abortion
The primary endpoint was the success rate of adjuvant isonicotinic acid hydrazide (INH) and misoprostol versus misoprostol alone for medical termination of first-trimester pregnancy.
- Trial name
- NCT04500002
- Testing
- Isonicotinic Acid Hydrazide, Misoprostol
- Where
- Egypt
- Volunteers
- 240 people
- Sponsor
- Aswan University Hospital
Miscarriage
Vaginal Misoprostol In Medical Treatment of First Trimester Missed Miscarriage
Efficacy of vaginal misoprostol 600 Mg versus 800 Mg in termination of the first trimester missed abortion were assist
- Trial name
- NCT05094375
- Testing
- Vaginal Misoprostol 600 mcg, Vaginal Misoprostol 800 mcg
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- hany farouk
Cesarean Scar Pregnancy
Surgery Alone Versus Methotrexate Before Surgery in Cesarean Scar Pregnancy
There are no universal treatment guidelines available. The ultimate purpose of the management of CSP is to simultaneously remove the pregnancy and successfully preserve the woman's fertility (Gonzalez \& Tulandi, 2017).
- Trial name
- NCT04379219
- Testing
- Methotrexate
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Mansoura University
Miscarriage in First Trimester
Non-invasive Monitoring of Miscarriage
cfDNA is extremely useful to ascertain chromosomal causes of miscarriages at the point of miscarriage diagnosis by a simple blood test.
- Trial name
- NCT06581692
- Testing
- This is a routine procedure, no intervention will be provided.
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong