Clinical trials: Mitochondria Health
Mitochondrial Function, Glucose Intolerance
Dose-response Relationship Between Exercise and Health Outcomes
In this study 11 healthy volunteers will perform high intensity exercise training during 4 weeks. The exercise frequency will increase progressively during the first three weeks, followed by a fourth week with lower exercise…
- Trial name
- NCT04753021
- Testing
- Exercise
- Where
- Sweden
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- The Swedish School of Sport and Health Sciences
Cognition, Multiomics
Probiotic Research: Open-label Functional Intervention and Longitudinal Evaluation in Healthy Adults
This study is a pre-post, open-label cohort study designed to investigate how a food-grade probiotic supplement affects biological measurements and wellbeing in healthy adults.
- Conditions
- Cognition, Multiomics, Microbiome Analysis, Metabolome
- Trial name
- PROFILE (NCT07457242)
- Testing
- Probiotic Supplementation (Lactobacillus plantarum)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- OneCarbon
Beneficial Health Effects of Living in Filtered Air
Air Pollution Reduction in the Elderly and Cardiovascular and Cognitive Outcomes
Short-term and chronic exposure to ambient levels of particulate matter (PM) is associated with increased morbidity and mortality related to respiratory and cardiovascular disease.
- Trial name
- ELIFA (NCT02411240)
- Testing
- Air filtering
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Skin Aging
Evaluation of the Anti-aging Efficacy of a Novel Skin Health Product
The aim of this study is to investigate the effect of cosmetic products with two different concentrations of the active on skin aging and in acting on the mitochondrial health of skin in comparison to a placebo product.
- Trial name
- NCT05300984
- Testing
- Topical Cream with 0.5% Active, Topical Cream with 1% Active
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Lipid Metabolism, Omega-3 Polyunsaturated Fatty Acids
Novel Approach to Increase EPA and DHA Levels
The goal of this intervention trial is to evaluate whether combining meldonium therapy with PUFAs (polyunsaturated fatty acids) supplements containing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) changes the plasma…
- Conditions
- Lipid Metabolism, Omega-3 Polyunsaturated Fatty Acids, Supplementation
- Trial name
- NCT07304921
- Testing
- Meldonium + PUFA, PUFA + meldonium, PUFA supplementation only
- Where
- Latvia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Riga Stradins University
Obesity Adult Onset
Gut Microbiota, Mitochondrial Function and Metabolic Health in Obesity
It has been suggested that individuals with the condition known as metabolically healthy obesity (MHO) may not have the same increased risk of developing metabolic abnormalities as their non-metabolically healthy counterparts.
- Trial name
- NCT06279780
- Testing
- very low-calorie diet
- Where
- Spain
- Volunteers
- 109 people
- Sponsor
- Celia Bañuls
Chronic Kidney Disease
Mitochondrial Oxidative Stress and Vascular Health in Chronic Kidney Disease
The purpose of this study is to examine the effect of mitochondria derived oxidative stress on vascular function in patients with moderate to severe Chronic Kidney Disease.
- Trial name
- NCT02364648
- Testing
- MitoQ
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Delaware
Frailty, Aging
MItochondrial Intervention for Resilience in Older Adults With Coenzyme Q10
This randomized, double-blind, placebo-controlled clinical trial will investigate whether 10 weeks of CoQ10 supplementation can improve biological resilience and functional health in community-dwelling adults aged 65 years or…
- Conditions
- Frailty, Aging, Mitochondria Health, Skin Aging
- Trial name
- MIRO-Q (NCT07772336)
- Testing
- Q10Vital® (CoQ10, ubiquinone)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Aging, Insulin Sensitivity
Antecedent Metabolic Health and Metformin Aging Study
Aging is the number one risk factor for the majority of chronic diseases. There are no pharmaceutical treatments to slow aging and prolong healthspan.
- Conditions
- Aging, Insulin Sensitivity, Chronic Disease, Mitochondria
- Trial name
- ANTHEM (NCT04264897)
- Testing
- Metformin
- Where
- 2 sites in United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Oklahoma Medical Research Foundation
Perimenopausal Biomarkers, Mitochondrial Biomarkers
Development of Biomarkers for Monitoring Menopause in Women
This cross-sectional study aims to develop and validate mitochondrial biomarkers for monitoring menopause in women. The study will involve 100 participants divided into three groups: reproductive period, perimenopausal transition…
- Trial name
- NCT06852755
- Testing
- Blood Sample Collection
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fu Jen Catholic University Hospital
Covid19
Correlation Between Cycle Threshold (Ct) Values in COVID-19, Health Status and Laboratory Biomarkers in the Population of Medellin- Colombia Evaluated in a Specialized Laboratory.
This study will evaluate the correlation between the symptomaticity, Ct value, laboratory biomarkers associated to COVID-19 and the disease progression in hospitalized patients and outpatients with SARS-CoV2 infection diagnosed…
- Trial name
- NCT05067920
- Testing
- Levels of SARS-COV-2 antibodies, rRT-PCR SARS-Cov-2, Hematological and immunological biomarkers
- Where
- Colombia
- Volunteers
- 120 people
- Sponsor
- Universidad de Antioquia
Dyslipidemias
Combined Effects of Statins and Exercise on Training Sensitive Health Markers
Around the world, about 4 in 10 adults have abnormal blood fat levels-known as dyslipidaemia-which raises their chances of getting heart disease.
- Trial name
- NCT06841536
- Testing
- Atorvastatin 80mg, Exercise
- Where
- Faroe Islands
- Volunteers
- 120 people
- Sponsor
- University of the Faroe Islands
Assessment of Vascular Health Risk Factors
Innsbruck Health Promotion Program
The primary goal of this single-centre. single-arm, unblinded, pre-post interventional study is to evaluate whether a one-time health assessment and intervention affects the overall vascular health evaluated through the Life's…
- Trial name
- INNHEALTH (NCT06813677)
- Testing
- In-person health promotion
- Where
- Austria
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- VASCage GmbH
Obesity, Insulin Resistance
Nicotinamide Riboside and Metabolic Health
This study will investigate the effects of 6 week Nicotinamide Riboside supplementation (1000 mg/day) on metabolic health in healthy (pre)obese humans. The primary objective will be hepatic and whole body insulin sensitivity.
- Trial name
- NCT02835664
- Testing
- Nicotinamide Riboside (Niagen)
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Aging, Postmenopause
Oral Antioxidant Therapy Targeted to the Mitochondria for Improving Brain Artery Health in Postmenopausal Women
The goal of this clinical trial is to learn if 3 months of taking the dietary supplement MitoQ [a mitochondria-targeted antioxidant that targets to reduce mitochondrial reactive oxygen species (mitoROS)] works to treat age- and…
- Trial name
- NCT07406243
- Testing
- Mitoquinone (MitoQ)
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Colorado State University
Mitochondrial Diseases
Digital Health Technology for People With Mitochondrial Disease
Abstract: A lack of exercise combined with low levels of activity is prominent in people with Mitochondrial Disease (MD). Unfortunately, access to health professionals such as physiotherapists with experience in MD is difficult…
- Trial name
- NCT06535646
- Testing
- Home exercise program using Physitrack exercise program and a smart watch
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Neuroscience Research Australia
Muscle Protein Synthesis, Muscle Atrophy
Exogenous Ketosis During Bed Rest in Older Adults
The goal of this randomized, double-blind, parallel group interventional study is to evaluate the effect of ketone bodies on healthy older adults (65-85 y) during 5 days of bed rest.
- Conditions
- Muscle Protein Synthesis, Muscle Atrophy, Insulin Sensitivity, Mitochondrial Function
- Trial name
- KBR (NCT05679596)
- Testing
- ketone monoester (R)-3-hydroxybutyl (R)-3- hydroxybutyrate
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McGill University
Cardiovascular Diseases, Hypertension
Mitochondria Oxidative Stress and Vascular Health Study
Cardiovascular diseases (CVDs) are the number one cause of death in America and most of the post-industrial world. Hypertension is a leading risk factor for CVDs including stroke, myocardial infarction, and heart failure.
- Conditions
- Cardiovascular Diseases, Hypertension, Racism, Vascular Diseases
- Trial name
- MOVHS (NCT05561556)
- Testing
- MitoQ
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Auburn University
Malnutrition Pregnancy, Malnutrition in Children
Early Life Malnutrition, Environmental Enteric Dysfunction and Microbiome Trajectories
Malnutrition in women of reproductive age remains a public health concern in Sub-Saharan Africa (SSA). Malnutrition during pregnancy affects foetal growth with a tendency of the exposed infants to also develop it.
- Conditions
- Malnutrition Pregnancy, Malnutrition in Children, Malnutrition (Calorie), Environmental Enteric Dysfunction
- Trial name
- UZBCS-2 (NCT07195006)
- Testing
- Malnutrition in pregnancy as exposure, Poor WASH living conditions as exposure
- Where
- Zimbabwe
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Oxygen Consumption, Mitochondria
Boosting Performance: The Power of Cranberry Supplementation
Cranberry is a fruit native to North America that is widely grown in Quebec and has been shown to have the highest antioxidant capacity among the most commonly eaten fruits.
- Conditions
- Oxygen Consumption, Mitochondria, Blood Flow, Aerobic Capacity
- Trial name
- NCT06186297
- Testing
- Cranberry extract
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Concordia University, Montreal