Clinical trials: Mitochondrial Disorder
Fatty Liver
The Effects of Low Carbohydrate Diet on Liver Fat Content and Mitochondrial Fluxes
The purpose of this study is to examine whether a low carbohydrate diet as compared to simple calorie restriction decreases hepatic lipid content and changes hepatic mitochondrial flux in humans.
- Trial name
- NCT03737071
- Testing
- Low Carbohydrate Diet, Simple Calorie Restriction Diet
- Where
- Finland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Pearson Syndrome
Natural History of Pearson Syndrome
The purpose of this 3-year, multi-site, non-randomized, prospective, observational study is to characterize the natural history of Pearson Syndrome.
- Trial name
- NCT02327364
- Volunteers
- 11 people
- Sponsor
- Sumit Parikh
Aging, Frailty
Metabolic Dysregulation as Biomarker of Frailty: Role of the Mitochondrial Dysfunction
The goal of this observational study is to evaluate the presence of mitochondrial dysfunction related to oxidative stress and its possible role in frailty, with and without multimorbidity, and to identify possible frailty…
- Conditions
- Aging, Frailty, Mitochondrial Dysfunction, Chronic Disease
- Trial name
- FRAMITO (NCT06433427)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital of Ferrara
Propionic Acidemia, Type I and/or Type II, Methylmalonic Acidemia
Short-Term Outcome of N-Carbamylglutamate in the Treatment of Acute Hyperammonemia
The overall objective of this drug trial is to determine whether the treatment of acute hyperammonemia with N-carbamyl-L-glutamate (NCG, Carglumic acid) in propionic acidemia (PA), methylmalonic acidemia (MMA), late-onset CPS1…
- Conditions
- Propionic Acidemia, Type I and/or Type II, Methylmalonic Acidemia, Carbamoyl-Phosphate Synthase I Deficiency Disease, Ornithine Carbamoyltransferase Deficiency
- Trial name
- STO (NCT01599286)
- Testing
- Carbaglu
- Where
- 9 sites in United States
- Volunteers
- 35 people
- Sponsor
- Mendel Tuchman
Gingivitis, Periodontitis
TBC1D15 / Rab7 / Fis1 Pathway in Periodontal Disease
This study will look at certain proteins in the fluid found around the gums (called gingival crevicular fluid, or GCF) of people with healthy gums, gingivitis (mild gum inflammation), or periodontitis (more severe gum disease).
- Trial name
- NCT07835477
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Inonu University
Migraine Disorders, Headache Disorders
Idebenone for the Preventive Treatment of Migraine
Idebenone improves energy metabolism similarly to Coenzyme Q10, which is effective in migraine prophylaxis. The investigators compare idebenone (90 mg/day, 270 mg/day) and placebo in 180 migraine patients in a double-blind…
- Trial name
- NCT04151472
- Testing
- 90mg Idebenone, 270mg Idebenone
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Atherosclerosis, Peripheral Arterial Disease
The Effects of Allicor on Patients After Revascularization Treatment During a Year
A significant challenge in medical care is atherosclerotic occlusion of peripheral arteries, such as lower extremities and brachiocephalic arteries, which can eventually lead to loss of limbs or fatal ischemic strokes.
- Trial name
- TEA-PARTY (NCT05813171)
- Testing
- Allicor
- Where
- Russia
- Volunteers
- 300 people
- Sponsor
- Institute for Atherosclerosis Research, Russia
Amyotrophic Lateral Sclerosis
Mitochondrial Functions and Oxidative Stress in ALS Patients
In Amyotrophic Lateral Sclerosis (ALS), malnutrition is frequent (16 to 50 % of the patients) and is an independent prognostic factor.
- Trial name
- NCT00331812
- Testing
- Mitochondrial functions and oxidative stress
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Pyruvate Dehydrogenase Complex Deficiency
Use of Phenylbutyrate Therapy for Patients With Pyruvate Dehydrogenase Complex Deficiency.
In this study phenylbutyrate is used for patients with pyruvate dehydrogenase complex deficiency. The aim of the study is to investigate the safety and efficacy of therapy.
- Trial name
- TIGEM2-PDH (NCT03734263)
- Testing
- sodium phenylbutyrate
- Where
- Italy
- Volunteers
- 1 people
- Sponsor
- Fondazione Telethon
Type 2 Diabetes
Influence of Physical Training on Mitochondrial Function in Type 2 Diabetic Patients
Physical activity as treatment for patients with type 2 diabetes (T2D). Treatment of T2D is often done by medication, changing the diet and increased physical activity.
- Trial name
- NCT00365495
- Testing
- Physical training (aerobic training)
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Cytomegalovirus Retinitis, HIV Infections
A Study of Ganciclovir in the Treatment of Cytomegalovirus of the Eyes
To determine whether alternating oral ganciclovir with intravenous ( IV ) ganciclovir can prevent relapse of Cytomegalovirus ( CMV ) retinitis and improve quality of life in AIDS patients.
- Trial name
- NCT00001062
- Testing
- Ganciclovir
- Where
- 6 sites in United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Mitochondrial Diseases, Mitochondrial Respiratory Chain Deficiencies
A Phase Ia/Ib, SAD and MAD Study of of KL1333 in Healthy Subjects and Patients With Primary Mitochondrial Disease
This will be a double blind, randomised, placebo controlled, single and multiple oral dose study conducted in 3 parts: Part A, Part B and Part C.
- Conditions
- Mitochondrial Diseases, Mitochondrial Respiratory Chain Deficiencies, MELAS Syndrome, Mitochondrial Myopathies
- Trial name
- NCT03888716
- Testing
- KL1333
- Where
- 2 sites in United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Abliva AB
Sarcopenia, Mitochondrial DNA
Association of Uremic Sarcopenia and Mitochondrial Copy Number and Its Clinical Correlates
Sarcopenia is the decline of muscle mass and strength with age. Evidence suggests that oxidative stress and molecular inflammation play important roles in age-related muscle atrophy.
- Trial name
- NCT03929458
- Where
- Taiwan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Tungs' Taichung Metroharbour Hospital
Acute Lymphoblastic Leukemia, Hyperbilirubinemia
Levocarnitine and Vitamin B Complex in Treating PEG-Asparaginase or Inotuzumab Ozogamicin-Induced Hyperbilirubinemia in Patients With Acute Lymphoblastic Leukemia
This phase II trial studies how well levocarnitine and vitamin B complex works in treating abnormal high liver enzyme levels (hyperbilirubinemia) caused by treatment with PEG-asparaginase or inotuzumab ozogamicin in patients with…
- Trial name
- NCT03564678
- Testing
- Levocarnitine, Vitamin B Complex
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- M.D. Anderson Cancer Center
Mitochondrial Myopathies
Home Based Personalized Training and Video Consultation in Mitochondrial Myopathies: Study of Efficacy and Tolerance.
Positive effect of physical activity on health arouses a strong interest at international level and is developped within the scope of national programs.
- Trial name
- TELE-MIT (NCT05346627)
- Testing
- Personalized and mixed training program
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Sepsis, Acute Kidney Injury
miRNA in Septic Acute Kidney Injury
Acute kidney injury is a common and serious complication of sepsis and septic shock, which may be associated with a worse outcome of the patient's condition.
- Conditions
- Sepsis, Acute Kidney Injury, Acute Kidney Injury Due to Sepsis
- Trial name
- NCT06498336
- Testing
- Laboratory examination to determine the presence of sepsis, Laboratory examination to determine the presence of sepsis and acute kidney injury, Laboratory examination to determine miRNA and biochemical parameters
- Where
- 2 sites in Czechia
- Volunteers
- 211 people
- Sponsor
- University Hospital Ostrava
Friedreich Ataxia
A Double-Blind, Placebo-Controlled, Dose Exploration Study of CTI-1601 in Adult Subjects With Friedreich's Ataxia
To evaluate the safety and tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of subcutaneous (SC) administration of CTI-1601 over 28 days in subjects with Friedreich's ataxia (FRDA).
- Trial name
- NCT05579691
- Testing
- CTI-1601
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Larimar Therapeutics, Inc.
Sarcopenia
Impact of Orally Administered BPM31510 on Mitochondrial Energetics in Older Adults With Sarcopenia
This study is being done to gather data on whether oral supplementation of CoQ10 is enriched in the blood and muscles in older adults with sarcopenia.
- Trial name
- COQ10 (NCT04999488)
- Testing
- BPM31510
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Friedreich's Ataxia
Safety, Tolerability and Efficacy of ACTIMMUNE® Dose Escalation in Friedreich's Ataxia
The purpose of this phase 3 randomized, multi-center, double-blind, placebo-controlled study is to evaluate the efficacy and safety of ACTIMMUNE® (interferon-γ 1b) in the treatment of Friedreich's Ataxia (FA) and to evaluate the…
- Trial name
- STEADFAST (NCT02415127)
- Testing
- Interferon γ-1b
- Where
- 4 sites in United States
- Volunteers
- 92 people
- Sponsor
- Amgen
Moderate-severe Chronic Kidney Disease Not Treated With Dialysis, Diabetic Kidney Disease, HgbA1c Less Than 8.5
Exercise Study Testing Enhanced Energetics of Mitochondria Video Integrated Delivery of Activity Training in CKD
Skeletal muscle dysfunction (sarcopenia) is an under-recognized target organ complication of CKD with substantial adverse clinical consequences of disability, hospitalization, and death.
- Trial name
- ESTEEM-VIDA (NCT02923063)
- Testing
- Combined Aerobic and Resistance Exercise via videoconferencing
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, Davis