Clinical trials: Mitochondrial Disorder
Malnutrition Pregnancy, Malnutrition in Children
Early Life Malnutrition, Environmental Enteric Dysfunction and Microbiome Trajectories
Malnutrition in women of reproductive age remains a public health concern in Sub-Saharan Africa (SSA). Malnutrition during pregnancy affects foetal growth with a tendency of the exposed infants to also develop it.
- Conditions
- Malnutrition Pregnancy, Malnutrition in Children, Malnutrition (Calorie), Environmental Enteric Dysfunction
- Trial name
- UZBCS-2 (NCT07195006)
- Testing
- Malnutrition in pregnancy as exposure, Poor WASH living conditions as exposure
- Where
- Zimbabwe
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Irritable Bowel Syndrome, Digestive System Diseases
Abnormal Expression Proteins, Mitochondrial DNA and miRNA of Irritable Bowel Syndrome
In the investigators study, the investigators will focus on the screening of the related proteins and miRNA to IBS in order to reveal the possible clues or molecular mechanism for this disorder.
- Conditions
- Irritable Bowel Syndrome, Digestive System Diseases, Gastrointestinal Diseases, Intestinal Diseases
- Trial name
- IBS (NCT01028898)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Metabolism Disorder, Mitochondrial Alteration
Mitochondrial Energy Metabolism in Obese Women
Considering that the failure of the treatment of obesity is justified by the multifactorial pathophysiology of this morbidity, the present project has the following hypotheses: 1.
- Conditions
- Metabolism Disorder, Mitochondrial Alteration, Physical Activity, Obesity
- Trial name
- NCT03119350
- Testing
- Physical Training
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- University of Sao Paulo
Mitochondrial Disease
Defining 31Phosphorous Magnetic Resonance Spectroscopy Characteristics in Patients With Mitochondrial Myopathy
This is a developmental protocol to determine the MRI based 31P-MRS changes seen in subjects with mitochondrial myopathy using our dynamic exercise protocol and to identify the ideal variable(s) to represent mitochondrial…
- Trial name
- NCT01301235
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Massachusetts General Hospital
Obesity, Endocarditis
Human Cardiac Mitochondria in Acute Endocarditis and Obesity
Data about human cardiac mitochondria are cruelly lacking in the literature. However, damages of the activity of these organelles are often the source of abnormal cardiac function in several pathologies.
- Trial name
- MITHOM (NCT03690076)
- Testing
- Endocarditis, Obese vs. control
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Clermont-Ferrand
Polycystic Ovary Syndrome
Metformin Treatment in Polycystic Ovary Syndrome (PCOS)
PCOS occurs when a woman does not release an egg regularly each month, causing her periods to be irregular. Women with PCOS can also have increased hair growth on the face and body, acne, head balding, infertility, pre-diabetes…
- Trial name
- NCT02198417
- Testing
- Metformin ER
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Eye Diseases Hereditary, Retinal Disease
Inherited Retinal Degenerative Disease Registry
The My Retina Tracker® Registry is sponsored by the Foundation Fighting Blindness and is for people affected by one of the rare inherited retinal degenerative diseases studied by the Foundation.
- Conditions
- Eye Diseases Hereditary, Retinal Disease, Achromatopsia, Bardet-Biedl Syndrome
- Trial name
- MRTR (NCT02435940)
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Foundation Fighting Blindness
Diabetes Mellitus, Type 2, Metformin Adverse Reaction
Metformin Gastrointestinal Intolerance: Measurement of Mitochondrial Complex I
Metformin is associated with a high degree of gastrointestinal intolerance, which limits the effective use of the medication. It is proposed to be an inhibitor of liver mitochondrial glycerophosphate dehydrogenase which results…
- Trial name
- NCT03445702
- Testing
- Metformin
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Prediabetes, Insulin Resistance
MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity
This Phase 2a study evaluates whether 12 weeks of treatment with investigational MOTS-c improves insulin sensitivity compared with placebo in adults with prediabetes and overweight/obesity.
- Conditions
- Prediabetes, Insulin Resistance, Overweight/Obesity
- Trial name
- MOTS-MET (NCT07505745)
- Testing
- MOTS-c (MDP), Route Subcutaneous injection, Regimen
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Hudson Biotech
HIV Infections, Lipodystrophy
Effectiveness of Nucleoside Supplementation or Switch to Tenofovir in Reversing Fat Loss in HIV Infected Adults
HIV lipoatrophy is a condition marked by fat loss; it occurs in many patients taking antiretroviral (ARV) therapy that includes nucleoside reverse transcriptase inhibitors (NRTIs).
- Conditions
- HIV Infections, Lipodystrophy, Metabolic Diseases, Nutrition Disorders
- Trial name
- NCT00119379
- Testing
- NucleomaxX, Tenofovir Disoproxil Fumarate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Mitochondrial, Leukoencephalopathies
Natural History and Genotype-Phenotype Correlations in Mitochondrial Leukoencephalopathies
Mitochondrial disorders (MDs) are among the most common inherited metabolic diseases, caused by genetic defects in mitochondrial or nuclear DNA that impair cellular energy production.
- Conditions
- Mitochondrial, Leukoencephalopathies, Leukoencephalopathy
- Trial name
- Leuko Mito (NCT07868796)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Hiv, Frailty Syndrome
Altering Mechanisms of Frailty in Persons Living With HIV Aged 50 to 65
People living with HIV are living longer as their disease is controlled with antiretroviral medications. Yet they are experiencing frailty more often and more than ten years earlier than those without HIV.
- Trial name
- ALTER (NCT04321603)
- Testing
- Walking
- Sponsor
- University of Maryland, Baltimore
Atrial Fibrillation
Ultrastructure of Atrial Myocytes in Patients in Sinus Rhythm and With Atrial Fibrillation
The aim of this work is to study the prevalence of T-tubular system in left and right myocytes from patients in sinus rhythm and whether this is altered in paroxysmal and permanent atrial fibrillation.
- Trial name
- NCT01493128
- Volunteers
- 45 people
- Sponsor
- Norwegian University of Science and Technology
Friedreich Ataxia
Efficacy of Omaveloxolone Treatment for Dysphagia in French Patients With Friedreich's Ataxia
Friedreich's ataxia (FA) is a rare, inherited neurodegenerative disease that typically begins in children and young people. It primarily affects the spinal cord, peripheral nerves and cerebellum of the brain.
- Trial name
- NCT07013292
- Testing
- SKYCLARYS (omaveloxolone)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Mitochondrial Diseases, Mitochondrial Myopathies
The KHENERGYZE Study
Mitochondrial diseases, estimated prevalence 1 in 4,300 adults, is caused by pathogenic mutations in genes finally encoding for mitochondrial proteins of the various enzyme complexes of the OXPHOS.
- Conditions
- Mitochondrial Diseases, Mitochondrial Myopathies, Mitochondrial Encephalomyopathies, MELAS Syndrome
- Trial name
- NCT04165239
- Testing
- KH176
- Where
- 4 sites in Denmark, Germany and 2 more
- Volunteers
- 27 people
- Sponsor
- Khondrion BV
Cachexia, Neoplasms
Cancer-associated Muscle Mass - Molecular Factors and Exercise Mechanisms
Muscle mass loss is a common adverse effect of cancer. Muscle mass loss occurs with or without reduction in body weight. Cancer cachexia (CC) is the involuntary loss of body weight of >5% within 6 months and it occurs in 50-80%…
- Conditions
- Cachexia, Neoplasms, Exercise, Metabolism
- Trial name
- PANACEA (NCT05307367)
- Testing
- Exercise training
- Where
- Denmark
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Preterm Birth
Mitochondrial DNA Signatures of Poor Aerobic Exercise Trainability in Young Adults Born Preterm
Young adults born very preterm (32 weeks gestation or earlier) do not respond well to aerobic exercise training, meeting the recommendations set by the Physical Activity Guidelines for Americans, where they do not increase their…
- Trial name
- NCT06334107
- Testing
- Exercise
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Stomach Neoplasms
Association Between Mitochondrial DNA Content and Risk of Gastric Cancer
Compelling epidemiological evidence indicates that alterations of mitochondrial DNA, including mutations and abnormal content of mitochondrial DNA (mtDNA), are associated with the initiation and development of gastric cancer.The…
- Trial name
- NCT02944539
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Mitochondrial Disease, Neurology
EPI-743 for Metabolism or Mitochondrial Disorders
Background: Mitochondria are the parts of cells that help produce energy. Metabolism is the process by which the body uses energy to help cells grow and reproduce.
- Conditions
- Mitochondrial Disease, Neurology, Myopathy
- Trial name
- NCT01642056
- Testing
- EPI-743
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Coronary Heart Disease
Association Between Mitochondrial DNA Content and Risk of Coronary Heart Disease
Compelling epidemiological evidence indicates that alterations of mitochondrial DNA, including mutations and abnormal content of mitochondrial DNA (mtDNA), are associated with the initiation and development of cardiovascular…
- Trial name
- NCT02500823
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China