Clinical trials: Mitochondrial Disorder
Obesity
Mitochondrial Metabolism and Hepatic Complications of Obesity
The study aims to characterize mitochondrial metabolism in the liver of obesity surgery patients and to study its relationships with hepatic steatosis, inflammation, and fibrosis.
- Trial name
- DMSO (NCT03302481)
- Testing
- liver biopsy
- Sponsor
- Nantes University Hospital
Asthma
Role of Mitochondria in Non Severe Asthma
Asthma is a frequent disease characterized by bronchial hyperresponsiveness, inflammation and remodelling. Bronchial remodelling is an abnormal repair process that contributes to the development of poorly reversible airway…
- Trial name
- MITASTHME (NCT00808730)
- Testing
- fiberoptic fibroscopy
- Where
- France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Bordeaux
Mitochondrial Diseases
A Study of Bezafibrate in Mitochondrial Myopathy
The purpose of this study is to gather preliminary data on whether bezafibrate can improve cellular energy production in mitochondrial disease.
- Trial name
- NCT02398201
- Testing
- Bezafibrate
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Hypoxia, Altitude
The Impact of Physical Training Under Normobaric Hypoxia on Oxidative Stress Level, Inflammatory State, Intestinal Damage, and Mitochondrial Metabolism in Young Males
Cognitive assessment of the influence of a 4-week proprietary training program under normobaric hypoxia conditions on the levels of inflammatory markers, disturbances in prooxidant-antioxidant balance, degree of intestinal…
- Trial name
- NCT06204731
- Testing
- Exercise and environmental conditions
- Where
- Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University School of Physical Education, Krakow, Poland
Coronary Artery Disease, Diabetes Mellitus
Mitochondrial Bioenergetics and Role in Cellular Damage in Ischemic Myocardium
Cardiac ischemia is a common pathological condition, known to elicit multiple pathological processes at the cellular level. One of the most affected is thought to be cellular metabolism, key for the adequate cardiac function.
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Mitochondrial Metabolism Disorders
- Trial name
- NCT03179137
- Testing
- Standard therapy
- Where
- Croatia
- Volunteers
- 80 people
- Sponsor
- University of Split, School of Medicine
Diabetes Mellitus, Type 2
"TAKE TIME" Pioglitazone Reverses Defects in Mitochondrial Biogenesis in Patients With T2DM
This study is designed to look at the effect of Pioglitazone treatment on the body's ability to burn food in order to produce energy.
- Trial name
- NCT00402012
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Pennington Biomedical Research Center
Schizophrenia and Related Disorders, Mitochondrial Alteration
MitoQ for Early-phase Schizophrenia-spectrum Disorder and Mitochondrial Dysfunction
The goal of this double-blind, placebo-controlled randomized clinical trial is to test the effect of 12 weeks of orally administered MitoQ (mitoquinol mesylate) supplementation on cognition in 50 people with early phase…
- Conditions
- Schizophrenia and Related Disorders, Mitochondrial Alteration, Cognitive Impairment
- Trial name
- NCT06191965
- Testing
- MitoQ
- Where
- 3 sites in United States, Switzerland
- Volunteers
- 100 people
- Sponsor
- Mclean Hospital
Mitochondrial Disorders
DINAMITE Study Nutritional State and Effect Diet in Mitochondrial Disease
The m.3243A>G mutation is the most frequent cause of mitochondrial disease in adults, for which currently no therapy is available and treatment is solely supportive.
- Trial name
- DINAMITE (NCT02286856)
- Testing
- diet intervention
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Myotonic Dystrophy 1
Home-based Training and Supplementation in DM1 Patients
Myotonic dystrophy type 1 (DM1) is a rare genetic disease that affects about 1 in 2100 people. Patients diagnosed with DM1 present with many symptoms, however, their muscles are mainly affected.
- Trial name
- DM1HBET (NCT05848830)
- Testing
- Mult-ingredient supplement, Concurrent exercise training
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McMaster University
Aortic Aneurysm and Dissection
MITAORTA - Role of Mitochondrial Dynamic in Aneurysm and Dissection of Ascending Thoracic Aorta
The main objective is to compare the mitochondrial dynamic between patients operated for aneurysm of ascending aorta or type A aortic dissection (AAD) or control group
- Trial name
- MITAORTA (NCT05434481)
- Testing
- Mitochondrial dynamic analysis in the aorta samples and metabolomic profiling in the aortic diseases
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Periodontal Disease, Periodontal Bone Loss
Osteoclast Impairment in Chronic Periodontitis by Regenerative Materials.
The present study is an effort to investigate the hypothesis that Platelet Rich Fibrin/Biphasic Calcium Phosphate may play a role in inhibiting osteoclasts differentiation and in bone loss.
- Conditions
- Periodontal Disease, Periodontal Bone Loss, Osteoclastic Bone Loss
- Trial name
- NCT03227367
- Testing
- other : PRF
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Cachexia, Neoplasms
Cancer-associated Muscle Mass - Molecular Factors and Exercise Mechanisms
Muscle mass loss is a common adverse effect of cancer. Muscle mass loss occurs with or without reduction in body weight. Cancer cachexia (CC) is the involuntary loss of body weight of >5% within 6 months and it occurs in 50-80%…
- Conditions
- Cachexia, Neoplasms, Exercise, Metabolism
- Trial name
- PANACEA (NCT05307367)
- Testing
- Exercise training
- Where
- Denmark
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Leukemia
Biomarkers in Patients With Acute Myeloid Leukemia
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01138319
- Testing
- DNA analysis, mutation analysis, polymerase chain reaction
- Volunteers
- 18 people
- Sponsor
- Children's Oncology Group
Friedreich's Ataxia
Safety and Efficacy Study of A0001 in Subjects With Friedreich's Ataxia
This is a Phase 2a double-blind, placebo-controlled study with two dose levels of A0001 given twice daily for 28 days. Potential subjects will be screened first to determine eligibility, after which they will be randomized to…
- Trial name
- NCT01035671
- Testing
- alpha-tocopherolquinone (A0001)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Penwest Pharmaceuticals Co.
Muscle Function, Mitochondrial Function, Overweight
AMAZ-02 Effect on Exercise ToLerance in Healthy, Overweight Middle Aged Subjects (ATLAS Trial)
This is a Phase 2 randomized, double-blind, placebo-controlled study enrolling 90 healthy, overweight, middle aged subjects (30 placebo, 30 low dose and 30 high dose AMAZ-02 intervention), 40-65 years of age, who are otherwise…
- Conditions
- Muscle Function, Mitochondrial Function, Overweight, Healthy Aging
- Trial name
- ATLAS (NCT03464500)
- Testing
- Mitopure 500mg, Mitopure 1000mg
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)
This is a parallel arm non-randomized dose-escalation, open-label basket exploratory phase 1 clinical trial where Mitochondrial encephalopathy, lactic acidosis, stroke-like episodes (MELAS) and Leber's hereditary optic…
- Trial name
- NCT06792500
- Testing
- Glycerol Tributyrate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- George Washington University
Atherosclerosis, Peripheral Arterial Disease
The Effects of Allicor on Patients After Revascularization Treatment During a Year
A significant challenge in medical care is atherosclerotic occlusion of peripheral arteries, such as lower extremities and brachiocephalic arteries, which can eventually lead to loss of limbs or fatal ischemic strokes.
- Trial name
- TEA-PARTY (NCT05813171)
- Testing
- Allicor
- Where
- Russia
- Volunteers
- 300 people
- Sponsor
- Institute for Atherosclerosis Research, Russia
Sepsis, Acute Kidney Injury
miRNA in Septic Acute Kidney Injury
Acute kidney injury is a common and serious complication of sepsis and septic shock, which may be associated with a worse outcome of the patient's condition.
- Conditions
- Sepsis, Acute Kidney Injury, Acute Kidney Injury Due to Sepsis
- Trial name
- NCT06498336
- Testing
- Laboratory examination to determine the presence of sepsis, Laboratory examination to determine the presence of sepsis and acute kidney injury, Laboratory examination to determine miRNA and biochemical parameters
- Where
- 2 sites in Czechia
- Volunteers
- 211 people
- Sponsor
- University Hospital Ostrava
Chronic Myeloid Leukemia
Vitro Study of Tigecycline to Treat Chronic Myeloid Leukemia
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm companies with the BCR-ABL fusion gene encoded by the Philadelphia (Ph) chromosome.
- Trial name
- NCT02883036
- Testing
- blood sampling
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Leigh Syndrome
Sirolimus for Leigh Syndrome
The purpose of this study is to evaluate the safety and efficacy of the drug Sirolimus in participants with Leigh syndrome.
- Trial name
- NCT06843811
- Testing
- Sirolimus
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Matthew Demczko