Clinical trials: Mitochondrial Dysfunction
Aging, Endothelial Dysfunction
Role of Mitochondrial-derived Oxidative Stress to Promote Vascular Endothelial Dysfunction in Non-exercisers With Aging
The primary goal of this intervention is to determine the efficacy of acute mitochondrial-specific antioxidants to improve vascular endothelial function in middle-aged and older (≥45 y) adults who do no perform regular aerobic…
- Conditions
- Aging, Endothelial Dysfunction, Cardiovascular Function, Arterial Stiffness
- Trial name
- NCT05872139
- Testing
- Mitoquinone Mesylate
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Ball State University
Clinically Isolated Syndrome, Relapsing-Remitting Multiple Sclerosis
Mitochondrial Dysfunction and Disease Progression
While the last several years have seen great strides in the treatment of relapsing forms of MS, progressive MS, responsible for the majority of MS-related disability, lags far behind.
- Conditions
- Clinically Isolated Syndrome, Relapsing-Remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Primary Progressive Multiple Sclerosis
- Trial name
- NCT02549703
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Depression, Bipolar Disorder
Mitochondrial Dysfunction, Inflammation, and White Matter Integrity in Youth With Mood Disorders
This study consists of three separate appointments including a clinical assessment (interview and questionnaires), a blood draw, a social stress test, and a brain MRI.
- Conditions
- Depression, Bipolar Disorder, Bipolar Disorder Not Otherwise Specified, Unspecified Mood Disorder
- Trial name
- NCT02596698
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Phelan-McDermid Syndrome
Mitochondrial Dysfunction in Phelan-McDermid Syndrome
The purpose of this study is to determine whether a relationship exists between gene deletion(s) specific to the mitochondrial electron transport chain and presentation of clinical characteristics in patients with Phelan-McDermid…
- Trial name
- NCT02000167
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Arkansas
Lung Diseases, Mechanical Ventilation
Mitochondrial Dysfunction of Alveolar and Circulating Immune Cells During Acute Respiratory Distress Syndrome: Impact of Infectious Aggression and Alveolar Stretching as a Result of Mechanical Ventilation.
Sepsis leads to a deregulated host response that can lead to organ failure. During sepsis, experimental and clinical data suggest the occurrence of mitochondrial dysfunctions, particularly in circulating muscle and monocytes…
- Conditions
- Lung Diseases, Mechanical Ventilation, Bronchoalveolar Lavage
- Trial name
- PNEUMOCHONDRIE (NCT03955887)
- Testing
- bronchoalveolar lavage fluid (BAL), Venous blood
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Diabetes, Obese
Mitochondrial Dysfunction in Diabetes
The purpose of this study is to determine whether insulin resistance is accompanied by "exercise resistance". Investigators will use mass spectrometry and proteomics analysis to test the hypothesis is that a bout of exercise that…
- Trial name
- PGC-1 (NCT01724502)
- Testing
- Exercise and muscle biopsies
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
COVID, Corona Virus Infection
Intensive Care Associated Complications and Outcome of Acute Respiratory Distress Syndrome Due to COVID-19
COVID-19 patients with a severely symptomatic progression with development of an Acute respiratory distress syndrome (ARDS) due to SARS-CoV-2 need prolonged intensive care treatment involving pharmacological immobilization…
- Conditions
- COVID, Corona Virus Infection, Sars-CoV2
- Trial name
- NCT04397172
- Testing
- Study Arm
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Ovarian Function at Advanced Reproductive Age
Co Enzyme Q10 Improves IVF Outcome in With Advanced Reproductive Age
The goal of the investigators research is to explore energy production of the ovarian follicle in older reproductive age women at the time of oocyte retrieval.
- Trial name
- NCT01659788
- Testing
- Coenzyme Q10 concomitant treatment
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Neurofibromatosis 1
Evaluating Mitochondrial Dysfunction in Patients With Neurofibromatosis Type 1
Neurofibromatosis type 1 is a common genetic disease with a broad spectrum of clinical manifestations in multiple organs of the body.
- Trial name
- NCT05912400
- Testing
- Blood draw, FACIT-F and Pain Scales
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Aging, Inflammation
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence
The MIRACLE study aims to investigate age-related mitochondrial dysfunction, mitochondrial RNA (mtRNA) release, inflammation, and cellular senescence in adult participants across three age groups.
- Conditions
- Aging, Inflammation, Healthy Ageing
- Trial name
- MIRACLE (NCT07596615)
- Testing
- Skin biopsy and venous blood sampling
- Where
- 2 sites in Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
Non-proliferative Diabetic Retinopathy, Diabetes Mellitus Type 2
Efficacy of Ubiquinone and Combined Antioxidant Therapy in Non-proliferative Diabetic Retinopathy
The purpose of this study is to evaluate the efficacy of ubiquinone and combined antioxidant therapy on progression, clinical regression, oxidative stress markers and mitochondrial dysfunction in non-proliferative diabetic…
- Trial name
- NCT02062034
- Testing
- Ubiquinone, Combined antioxidant therapy
- Where
- Mexico
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Diabetes Mellitus
Study of Cellular Impairments Involved in Diabetic Complications
The purpose of this study is to examine if an early detectable dysfunction in a cellular component (mitochondria) may predict complications in diabetes mellitus.
- Trial name
- diabmito I (NCT00985101)
- Volunteers
- 80 people
- Sponsor
- Naestved Hospital
Long COVID, Post-COVID-19 Condition
Mitochondrial Function in Peripheral Blood Mononuclear Cells, Muscle, and Skin of Long COVID Patients
Mitochondria are structures inside cells that are responsible for producing energy from nutrients through a series of steps, using oxygen.
- Trial name
- MitoLoCo (NCT07134673)
- Where
- Belgium
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Non-alcoholic Fatty Liver Disease (NAFLD)
Elucidating Hepatic Metabolism in Non-alcoholic Fatty Liver Disease
The goal of this observational, cross-sectional, case-control clinical study is to investigate the metabolic adaptations underlying the progression of nonalcoholic fatty liver disease (NAFLD), and to test the hypothesis that…
- Trial name
- ECHO (NCT06942312)
- Testing
- Ketoisocaproic acid breath test, Ammonium Chloride, Bicarbonate de sodium
- Where
- Finland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Parkinson Disease, Mitochondrial
Measures of Mitochondria Dysfunction in PD
This study evaluates metabolic and functional parameters in the skeletal muscle of Parkinson's disease patients for comparison to a set of healthy age-matched controls.
- Trial name
- NCT04300608
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Washington
Diabetes, Obesity
PGC-1 & Muscle Mitochondrial Dysfunction in Diabetes
The goal of this study is to understand how and why insulin resistant individuals respond differently to exercise as compared with insulin sensitive individuals at the skeletal muscle and gene expression level.
- Trial name
- PGC-1 (NCT02282423)
- Testing
- Pre-study dietary and exercise instruction., Screening examination and oral glucose tolerance test, Euglycemic clamp
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Primary Open-Angle Glaucoma (POAG)
MEXIDOL® Sequential Therapy of Patients With Primary Open-angle Glaucoma (POAG)
Hypothesis: The use of neurocytoprotectors helps restore the functional activity of mitochondria, improve the nervous activity of the retina and optic nerve, and stabilize the glaucomatous process.
- Trial name
- NCT06437639
- Testing
- Mexidol
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Pharmasoft
Post-Acute Sequelae of SARS-CoV-2 (PASC) Infection
Efficacy, Safety, Tolerability of AXA1125 in Fatigue After COVID-19 Infection
This study will compare the effects of AXA1125, an orally active mixture of amino acids, compared to placebo, on improving muscle function (metabolism) following moderate exercise in subjects with fatigue-Predominant Post-Acute…
- Trial name
- NCT05152849
- Testing
- AXA1125
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Axcella Health, Inc
Ataxia Telangiectasia
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside
Study design: Single arm open-label clinical trial in ataxia-telangiectasia to test the effects of nicotinamide riboside on ataxia scales, immune function, and neurofilament light chain.
- Trial name
- ATNAD (NCT06324877)
- Testing
- Nicotinamide riboside
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- The University of Queensland
Postural Tachycardia Syndrome
Phenotyping Mitochondrial and Immune Dysfunction in POTS With Targeted Clinical Intervention.
The mechanisms underlying POTS are not well understood. Though heterogeneous in nature, patients often present with symptoms that include fatigue, orthostatic lightheadedness and tachycardia, "brain fog", shortness of breath, and…
- Trial name
- NCT05409651
- Testing
- Time restricted eating
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of California, San Diego