Clinical trials: Mitral Regurgitation
Heart Failure, Mitral Regurgitation
Mitral Regurgitation Treatment in Advanced Heart Failure
MITRADVANCE-HF is a prospective, randomized, parallel-controlled, open-label, multicentre study trial enrolling patients with SMR and advanced HF on maximally tolerated standard of care therapies for HF according to the most…
- Trial name
- MITRADVANCE (NCT05292716)
- Testing
- MitraClip
- Where
- Italy
- Volunteers
- 172 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Mitral Valve Insufficiency, Dilated Cardiomyopathy
Prospective Study Looking at Quality of Life Measures in Non-ischaemic Cardiomyopathy After Mitral Valve Repair
Chronic severe mitral regurgitation can lead to symptoms and left ventricular dysfunction. The purpose of this study is to prospectively follow patients with non-ischaemic cardiomyopathy who are eligible for mitral valve repair…
- Conditions
- Mitral Valve Insufficiency, Dilated Cardiomyopathy, Congestive Heart Failure
- Trial name
- NCT00483236
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Mitral Valve Prolapse, Left Ventricular Fibrosis
PRIMARY Ancillary Substudy
The PRIMARY trial (NCT05051033), which compares mitral valve repair (MVr) to transcatheter-edge-to-edge-repair (TEER), offers a platform for conducting mechanistic studies to develop early insights into the pathophysiological…
- Conditions
- Mitral Valve Prolapse, Left Ventricular Fibrosis, Ventricular Arrhythmias
- Trial name
- NCT07103733
- Testing
- Cardiac Magnetic Resonance Imaging, ZioPatch Monitoring, Myocardial Tissue Biopsy
- Where
- 25 sites in United States, Germany and 1 more
- Volunteers
- 250 people
- Sponsor
- Annetine Gelijns
Aortic Valve Insufficiency, Mitral Valve Insufficiency
Investigation of Heart Function in Patients With Heart Valve Defects
In this study researchers plan to perform a diagnostic test called transesophageal echocardiography in order to see and record the movement and function of the heart.
- Trial name
- NCT00001314
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Fasting
Long-term Fasting: Multi-system Adaptations in Humans
The aim of this trial is to investigate the effects of long-term fasting on size, mass, composition and function of metabolic active tissues in several organs that reexpand possibly rejuvenated after 1-4 months.
- Trial name
- NCT05031598
- Testing
- Long-term fasting according to the Buchinger Wilhelmi fasting program
- Where
- Germany
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Buchinger Wilhelmi Development & Holding GmbH
Low Back Pain, Foot Posture
Biomechanical Taping on Low Back Pain With Increased Foot Pronation
It is stated that abnormal lower extremity posture and biomechanics are effective in the development and progression of Low Back Pain (LBP).
- Conditions
- Low Back Pain, Foot Posture, Taping, Functional Mitral Regurgitation
- Trial name
- NCT04776798
- Testing
- Taping
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University - Cerrahpasa
Functional Tricuspid Regurgitation
Outcome of MC3 Ring Annuloplasty for Functional Tricuspid Regurgitation
This study includes 105 patients who underwent repair for ≥ moderate tricuspid regurgitation (TR) during mitral valve replacement for rheumatic valve disease.
- Trial name
- NCT04078867
- Testing
- tricuspid valve repair
- Volunteers
- 105 people
- Sponsor
- Minia University
Bipolar I Disorder, Psychosis
Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder
This is a randomized, controlled clinical trial to assess the effects of the ketogenic diet in combination with treatment as usual on brain energy metabolism and psychiatric symptoms in individuals with first episode bipolar…
- Conditions
- Bipolar I Disorder, Psychosis, Schizoaffective Disorder
- Trial name
- NCT06221852
- Testing
- Ketogenic diet, Dietary Guidelines for Americans
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mclean Hospital
Mitral Valve Regurgitation
GISE Registry of Transcatheter Treatment of Mitral Valve Regurgitation With the MitraClip G4
The aim of the GISE study is to confirm the MitraClip safety and improve the device effectiveness in a selected all comers ("more-comers") population with symptomatic severe mitral regurgitation undergoing/undergone Transcatheter…
- Trial name
- NCT05455489
- Where
- Italy
- Volunteers
- 264 people
- Sponsor
- Fondazione GISE Onlus
Mitral Valve Regurgitation
Coronary and Structural Interventions Ulm - Transcatheter Mitral Valve Repair (CSI-Ulm-TMVR)
To evaluate the long-term results after transcatheter mitral valve repair
- Trial name
- NCT03104660
- Testing
- CE certified mitral valve repair systems
- Where
- Germany
- Volunteers
- 355 people
- Sponsor
- University of Ulm
Mitral Regurgitation
TEER for Severe DMR of Low to Intermediate Surgery Risk
To investigate the efficacy and safety of transcatheter mitral valve edge-to-edge repair (TEER) for severe degenerative mitral regurgitation (DMR) patients of low to intermediate surgery risk.
- Trial name
- NCT06162780
- Testing
- ultrasonic cardiography (UCG), TEER
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Polycystic Ovary Syndrome, Non-Alcoholic Fatty Liver Disease
NAFLD in Adolescents and Young Adults With PCOS
This project focuses on an at-risk adolescent and young adult population who may gain long-term health benefits from detection of risk factors at a young age.
- Conditions
- Polycystic Ovary Syndrome, Non-Alcoholic Fatty Liver Disease, Metabolic Syndrome
- Trial name
- NCT02506946
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Columbia University
Alzheimer Disease (AD)
Brain NAD in Alzheimer's Disease
The goal of this observational study is to learn about the levels of nicotinamide adenine dinucleotide (NAD) in the brains of people with Alzheimer's disease.
- Trial name
- ALZNAD (NCT07127510)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Florida Atlantic University
Mitral Regurgitation, Mitral Valve Insufficiency
Erector Spinae Plane Block for Minimally Invasive Mitral Valve Surgery
The goal of this project is to study whether local anesthetic via the erector spinae plane (ESP) block may be beneficial in minimally invasive mitral valve surgery (MIMVS).
- Conditions
- Mitral Regurgitation, Mitral Valve Insufficiency, Mitral Valve Prolapse
- Trial name
- NCT04770961
- Testing
- Erector spinae plane catheter with 0.5% Ropivacaine, Erector spinae plane catheter with saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Healthy Infants
Measurement of in Vivo Mitochondrial Capacity in Infants
The overarching aim of this project is to determine the test re-test reliability of 31P-magnetic resonance spectroscopy measurements in infants.
- Trial name
- NCT03976596
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Mitral Valve Regurgitation (Degenerative or Functional)
TVMR With the Innovalve System Trial - Pilot in Georgia
Study to evaluate the safety and performance of the Innovalve mitral valve replacement system
- Trial name
- TWIST-PILOT-GE (NCT05682066)
- Testing
- Innovalve MR system
- Where
- Georgia
- Volunteers
- 11 people
- Sponsor
- Edwards Lifesciences
Schizo Affective Disorder, Schizophrenia
L-arginine Study for Persistent Symptoms of Schizophrenia
The purpose of this research is to see if daily combination treatment of L-arginine and Kuvan changes brain chemistry in people experiencing schizophrenia as measured by MRS brain scans.
- Trial name
- NCT04054973
- Testing
- L-arginine, Sapropterin Dihydrochloride
- Where
- United States
- Sponsor
- University of Massachusetts, Worcester
Atrial Fibrillation (AF), Mitral Valve (MV) Regurgitation
EPX-HTG for Structural Heart Procedures
To investigate and evaluate the benefits of adding EchoPixel Holographic Therapy Guidance to the current standard of care in Structural Heart (SH) procedures.
- Trial name
- EPX-HTG-2026 (NCT07705425)
- Testing
- Left Atrial Appendage Occlusion, Mitral Valve Transcatheter Edge to Edge Repair
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- EchoPixel, Inc.