Clinical trials: Mitral Regurgitation Functional
Mitral Valve Insufficiency
To Evaluate the Efficacy and Safety of the Transfemoral Mitral Valve Repair System in the Treatment of Patients With Moderately Severe and Severe Functional Mitral Regurgitation(FMR) Who Remained Clinically Symptomatic After Guideline-directed Medical Treatment
To confirm the effectiveness and safety of the transcatheter mitral valve repair system for the treatment of chronic moderate to severe (3+) or severe (4+) functional mitral regurgitation (FMR) who remained clinically symptomatic…
- Trial name
- NCT05508438
- Testing
- Transfemoral mitral-valve repair
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Pan Xiangbin
Functional Mitral Regurgitation
Plasty or Prosthesis to Treat Functional Mitral Regurgitation
Functional Mitral regurgitation is a now well known entity due to tethering of the valve either mono-lateral, as happens in lateral myocardial infarction, or bilateral as happens in dilated cardiomyopathy.
- Trial name
- POP (NCT00947921)
- Testing
- Plasty, Prosthesis
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Cardiochirurgia E.H.
Heart Failure With Preserved Ejection Fraction, Functional Mitral Regurgitation
Sacubitril-Valsartan in Heart Failure With Preserved Ejection Fraction and Secondary Mitral Valve Regurgitation
The main objective of this study is to assess the hemodynamic effects of sacubitril-valsartan in patients with heart failure with preserved ejection fraction and at least moderate atrial functional mitral regurgitation (AFMR)…
- Trial name
- PRAISE-MR (NCT05991284)
- Testing
- Sacubitril-valsartan, Standard of care
- Where
- Belgium
- Volunteers
- 84 people
- Sponsor
- Ziekenhuis Oost-Limburg
Non-invasive Neuromodulation in Healthy Subjects
Mechanisms of Non-Invasive Neuromodulation Interventions: Influence on Human Neurochemistry and Functional Connectivity
The aim of this project is to increase our understanding of how two different protocols of repetitive transcranial magnetic stimulation (rTMS), inhibitory (1 Hz) and excitatory (5 Hz), applied over the primary motor cortex of the…
- Trial name
- NCT02677740
- Testing
- Inhibitory rTMS (1 Hz), Excitatory rTMS (5 Hz)
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Mitral Regurgitation
Is Mitral Annuloplasty an Effective Treatment for Severe Atrial Functional MR?
Atrial functional mitral regurgitation (MR) is caused by annular dilatation and flattering associated with altered atria/annulus dynamics in patients with severely dilated left atrium and normal leaflets anatomy.
- Trial name
- NCT05836376
- Testing
- Mitral valve annuloplasty
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- Michele De Bonis
Functional Mitral Regurgitation
Evaluation of Safety and Efficacy of the BACE™ Device in the Treatment of Functional Mitral Valve Regurgitation [FMR
The preclinical and clinical evidence of safety and efficacy with the BACE device (concept and feasibility) paved the way for the evaluation of the BACE device in this prospective, multi-center, single-arm, self-controlled study…
- Trial name
- BACE (NCT02701972)
- Testing
- BACE Device
- Volunteers
- 35 people
- Sponsor
- Phoenix Cardiac Devices, Inc.
Heart Failure and Reduced Ejection Fraction, Functional Mitral Regurgitation
Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance
This is a multi-center, prospective, observational study designed to evaluate the impact of LV myocardial fibrosis extent assessed by CMR on LV reverse remodeling and clinical outcomes post TEER.
- Trial name
- SMARTER-CMR (NCT07131631)
- Testing
- Cardiac MRI
- Where
- 6 sites in United States, Italy
- Volunteers
- 125 people
- Sponsor
- Minneapolis Heart Institute Foundation
Mitral Valve (MV) Regurgitation
A Prospective, Multicenter, Single-Arm Study to Support the Clinical Evidence Base for MRace as a Treatment Option for FMR Patients With Complex M-TEER Anatomies (FR)
A pilot study to evaluate the safety and performance of the MRace System to treat severe mitral regurgitation and to gather data on its performance thereby providing guidance for future clinical development.
- Trial name
- ACCESS-MR (FR) (NCT07757607)
- Testing
- Transcatheter mitral valve repair (MRace Implant and Delivery System)
- Volunteers
- 20 people
- Sponsor
- Polares Medical SA
Dilated Cardiomyopathy
Effect of Dapagliflozin on Cardiac Structure, Function and Secondary Mitral Regurgitation in Patients with Left Ventricle Dysfunction
A significant reduction in the incidence of CV death or hospitalization for HF has been observed in randomized trials investigating the CV benefit of Dapagliflozin.
- Trial name
- NCT05849766
- Testing
- Dapagliflozin Farxiga®, Ramipril Tritace®, Carvedilol Carvid®,and Spironolactone Aldactone®
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- October 6 University
Major Depressive Disorder
5-HTP and Creatine for Depression
This is a three-armed clinical trial examining the effect of 5-hydroxytryptophan and creatine monohydrate as augmenting agents for the treatment of depression.
- Trial name
- NCT04395183
- Testing
- 5-Hydroxytryptophan 100 MG, Creatine monohydrate
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Utah
Mitral Valve Regurgitation (Degenerative or Functional)
TVMR With the INNOVALVE System Trial - Early Feasibility Study
Study to evaluate the safety and performance of the INNOVALVE system
- Trial name
- TWIST-EFS (NCT04919980)
- Testing
- INNOVALVE system
- Where
- 21 sites in United States
- Volunteers
- 85 people
- Sponsor
- Edwards Lifesciences
Cardiovascular Diseases, Heart Diseases
Impact of Medical and Surgical Therapy on Functional Mitral Regurgitation
The Transesophageal Echocardiography (TEE) Surgical Treatment of Ischemic Heart Failure (STICH) ancillary study will define the mechanism(s) of functional mitral regurgitation (MR) by TEE in patients with ischemic cardiomyopathy…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease
- Trial name
- NCT00224809
- Testing
- Angiotensin-Converting Enzyme Inhibitors, Coronary Artery Bypass Graft, Angiotensin Receptor Blockers
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Baylor Research Institute
Stroke, Acute
Health Disparities in Stroke Patients and Their Families: a Longitudinal Multicenter Study (HDSS)
The meeting point of the patient and his/her immediate family with the health care system is complicated and traumatic. While having to deal with medicalization geared towards providing evidence-based and cost-effective medical…
- Trial name
- HDSS (NCT03330652)
- Where
- 4 sites in Israel
- Volunteers
- 600 people
- Sponsor
- Sheba Medical Center
Functional Mitral Regurgitation
The JensClip Transcatheter Valve Repair System for Treating Functional Mitral Regurgitation
To evaluate the efficacy and safety of the JensClip transcatheter valve repair system for patients with moderate-severe or greater (MR ≥ 3+) functional mitral regurgitation (FMR) who have received adequate treatment but are still…
- Trial name
- NCT05931900
- Testing
- moderate-severe or greater (MR ≥ 3+) functional mitral regurgitation (FMR) patients
- Where
- China
- Volunteers
- 129 people
- Sponsor
- Jenscare Scientific
Atrial Fibrillation (AF), Catheter Ablation
Efficacy and Safety of Catheter abLation in patiEnts With seVere mitrAl regurgiTation and pErsistent Atrial Fibrillation: a Randomized Controlled Trial
Atrial fibrillation (AF) leads to atrial functional mitral regurgitation (MR) through mechanisms including mitral annular dilatation, systolic leaflet motion distance alteration, and contractility decrease.
- Conditions
- Atrial Fibrillation (AF), Catheter Ablation, Atrial Functional Mitral Regurgitation
- Trial name
- ELEVATE-AF (NCT06883864)
- Testing
- Catheter ablation plus medication, Medication, (ELEVATE-AF X) experimental group
- Where
- 17 sites in China
- Volunteers
- 146 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation, Mitral Regurgitation Functional
Treatment of Functional Mitral Regurgitation in Patients With Atrial Fibrillation
The objective of the CAMERA-Pilot trial is to generate a hypothesis for a proper randomized controlled clinical endpoint trial to show the noninferiority of restoration and maintenance of sinus rhythm (via catheter ablation [CA]…
- Trial name
- CAMERA-Pilot (NCT05846412)
- Testing
- Catheter Ablation and M-TEER
- Volunteers
- 66 people
- Sponsor
- University of Luebeck
Mitral Valve Regurgitation, Left Ventricular Dysfunction
RESTOR-MV: Randomized Evaluation of a Surgical Treatment for Off-Pump Repair of the Mitral Valve
The purpose of this prospective, randomized, multi-center, pivotal trial is to compare the safety and effectiveness of the off-pump, closed heart Coapsys System (Myocor, Inc.) to open surgical repair of the mitral valve using an…
- Conditions
- Mitral Valve Regurgitation, Left Ventricular Dysfunction, Heart Failure
- Trial name
- NCT00120276
- Testing
- Less invasive mitral valve repair
- Where
- 10 sites in United States
- Volunteers
- 250 people
- Sponsor
- Myocor
Major Depressive Disorder
5-HTP and Creatine for Depression R33 Phase
This is a three-armed clinical trial examining the effect of 5-hydroxytryptophan and creatine monohydrate as augmenting agents for the treatment of depression.
- Trial name
- NCT05895747
- Testing
- Low Dose 5-hydroxytryptophan, High Dose 5-hydroxytryptophan, Low Dose Creatine Monohydrate
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- University of Utah
Cardiomyopathy, Cardiovascular Diseases
Improving Mitral Repair for Functional Mitral Regurgitation
The investigators are interested in determining the best surgical technique to correct functional mitral regurgitation, as there is currently not one technique that is established to work better than the other.
- Conditions
- Cardiomyopathy, Cardiovascular Diseases, Congestive Heart Failure, Coronary Artery Disease
- Trial name
- IMPROVE-FMR (NCT03366649)
- Testing
- Undersizing Mitral Annuloplasty, Papillary Muscle Approximation
- Where
- 3 sites in United States
- Volunteers
- 34 people
- Sponsor
- Emory University
Mitral Valve Insufficiency, Heart Failure
Carillon Mitral Contour System® for Reducing Functional Mitral Regurgitation
The objective of this prospective, multi-center, randomized, double-blind trial is to assess the safety and efficacy of the Carillon Mitral Contour System in treating functional mitral regurgitation (FMR) associated with heart…
- Trial name
- REDUCE FMR (NCT02325830)
- Testing
- Carillon Mitral Contour System
- Where
- 31 sites in Australia, Czechia and 6 more
- Volunteers
- 163 people
- Sponsor
- Cardiac Dimensions Pty Ltd