Clinical trials: Mitral Valve Disease
Mitral Valve Regurgitation, Pulmonary Hypertension
Cardiopulmonary Exercise Testing in Severe Mitral Regurgitation
The purpose of this study is the evaluation of cardiac and pulmonary response to cardiopulmonary exercise in severe mitral regurgitation and its variation under treatment (surgical mitral valve repair, percutaneous mitral valve…
- Trial name
- NCT03154034
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- University Hospital Regensburg
Mitral Valve Prolapse
Exercise Capacity Evaluation in Patients With Non-rheumatic Mitral Valve Prolapse (MVP)
Mitral valve prolapse (MVP) is a relatively common cardial problem in which one or more of the leaflets of the mitral valve prolapse during systole into the left atrium.
- Trial name
- NCT02499419
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Mitral Valve Insufficiency
The Effect of Posterior Annulus Elevation Technique in Reducing Residual Regurgitation During Mitral Valve Repair in Children
The main problem in mitral valve repair surgery in children is the high number of postoperative residual lesions (49% of the total cases).
- Trial name
- NCT04518709
- Testing
- Posterior Mitral Annulus Elevation Technique, Conventional Mitral Valve Repair
- Volunteers
- 58 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Mitral Regurgitation
Treatment of Mitral Regurgitation Using a Minimally Invasive Approach With the HARPOON Device.
To evaluate the long-term safety and performance of the HARPOON™ MVRS for use in patients presenting with severe degenerative mitral regurgitation due to posterior leaflet prolapse in the post-market phase.
- Trial name
- ASCEND (NCT04382612)
- Testing
- HARPOON Beating Heart Mitral Valve Repair System (MVRS)
- Where
- 10 sites in Austria, Germany and 2 more
- Volunteers
- 42 people
- Sponsor
- Edwards Lifesciences
Ischemic Mitral Regurgitation
Serotonin Receptor Blockers in Ischemic Mitral Regurgitation
This study is intended to investigate the effect of cyproheptadine (a 5HT2B receptor blocker) on mitral regurgitation severity.
- Trial name
- CYPRO-MR (NCT05469165)
- Testing
- Cyproheptadine 4 Mg Oral Tablet
- Where
- Canada
- Volunteers
- 214 people
- Sponsor
- Laval University
Mitral Valve Disease, Damaged Mitral Valve
HALO: A Single Arm Prospective Investigation of the SJM™ Masters HP™ 15mm Rotatable Mechanical Heart Valve
The purpose of the study is to provide evidence of safety and effectiveness of the study valve. The rationale is to offer a replacement mitral valve for patients with anatomy that is too small for the currently commercially…
- Conditions
- Mitral Valve Disease, Damaged Mitral Valve, Malfunctioning Mitral Heart Valve, Mitral Valve Replacement
- Trial name
- NCT02097420
- Testing
- Mitral valve replacement SJM™ Masters HP™ 15mm Rotatable Mechanical Heart Valve
- Where
- 24 sites in United States
- Volunteers
- 23 people
- Sponsor
- Abbott Medical Devices
Coronary Artery Disease, Aortic Valve Disease
Robustness Check of Placement and Measurement Algorithms for Blood Flow Measurement on Common Carotid Artery
This study is set up to test the robustness of algorithms and models and to optimize them. Furthermore, data are used to investigate the influence of probe orientation on parameters of the common carotid artery.
- Conditions
- Coronary Artery Disease, Aortic Valve Disease, Mitral Valve Disease
- Trial name
- RAdiUS (NCT05193760)
- Where
- Netherlands
- Volunteers
- 67 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Systolic Heart Failure Stage D (Disorder), Mitral Regurgitation
The Prognostic Impact of Using High-dose Hydralazine in Severe Systolic Heart Failure With Hemodynamically Significant Mitral Regurgitation
Background: Severe systolic heart failure would be complicated with low cardiac output and high left ventricular filling pressure and the clinical presentations would be low blood pressure, poor peripheral perfusion, and…
- Trial name
- NCT04217135
- Testing
- evidence-based medications vs. high-dose hydralazine + evidence-based medications
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Mitral Valve Insufficiency, Mitral Valve Prolapse
Primary Mitral Regurgitation Repair
This longitudinal cohort study evaluates the relationship of myocardial tissue markers characteristics assessed by cardiac MRI, with clinical measures of symptoms and functions in adults with primary mitral regurgitation.
- Conditions
- Mitral Valve Insufficiency, Mitral Valve Prolapse, Chronic Mitral Disease, Mitral Regurgitation
- Trial name
- NCT04067635
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Eric Y. Yang, MD PhD
Longstanding Persistent Atrial Fibrillation
Evaluation of the Cardioblate CryoFlex Surgical Ablation System in Longstanding Persistent Atrial Fibrillation
Studies have shown that taking drugs to stay out of AF has limited success. This research is designed to study heart rhythm after surgical therapy, namely by measuring if there are benefits to having surgery to treat Atrial…
- Trial name
- CRYO-AF (NCT01558635)
- Testing
- Cardioblate CryoFlex Surgical Ablation, Mitral Valve surgery, Medtronic Reveal XT Insertable Cardiac Monitor
- Where
- 4 sites in Germany, Israel and 2 more
- Volunteers
- 17 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Mitral Valve Replacement, Transfusion Reaction
Blood Transfusion Management in Patients With Mitral Valve Replacement in China
The evaluation uses ΔHb as an independent factor combined with artificial intelligence (AI) to predict its impact on the prognosis and blood transfusion of patients undergoing cardiac surgery, thereby guiding perioperative…
- Conditions
- Mitral Valve Replacement, Transfusion Reaction, Blood Transfusion Complication
- Trial name
- NCT03885570
- Testing
- Mitral valve replacement
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Coronary Artery Disease, Aortic Valve Disease
Cardiac Index, SVR/SVRI During Weaning From ECC- Data Obtained From Femoral and Radial Artery Transducer
Swan Ganz catheter-Edwards Lifesciences obtains values of cardiac output/index and systemic vascular resistance/index using the mean artery pressure of either radial or femoral artery.
- Conditions
- Coronary Artery Disease, Aortic Valve Disease, Mitral Valve Disease
- Trial name
- RaFe (NCT06112561)
- Testing
- CO/CI/SVR
- Volunteers
- 50 people
- Sponsor
- George Papanicolaou Hospital
AORTIC VALVE DISEASES, Mitral Valve Failure
Advanced Robotic Beds for the Early Rehabilitation of Cardiac Surgery Patients
The goal of this clinical trial is to evaluate whether LOLE.K, a new and specialized robotic bed, is effective in the rehabilitation of patients who have undergone surgery.
- Trial name
- CARE (NCT07273669)
- Testing
- use of the robotic bed
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Salerno
Mitral Valve Stenosis
Three Dimensional Versus Two Dimensional Echocardiography in Assessment of Severity and Scoring of Rheumatic Mitral Stenosis.
Although the prevalence of rheumatic fever is decreasing in developed countries, it still affects numerous areas in the non- industrialized world.
- Trial name
- NCT04968431
- Testing
- 2D Echocardiography, 3D Echocardiography
- Volunteers
- 60 people
- Sponsor
- Assiut University
Valve Disease, Heart, Valve Replacement
Mosaic Mitral Valve: Long-Term Outcomes in Patients Under 65
The safety and efficacy of the Mosaic bioprosthetic heart valves for cardiac valve replacement in the aortic position has been well documented throughout the literature.
- Conditions
- Valve Disease, Heart, Valve Replacement, Valve Regurgitation, Mitral, Valve Heart Stenosis
- Trial name
- MMV (NCT06917586)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Michael Moront
Mitral Regurgitation
Artificial Intelligence Assisting Transcatheter Mitral Edge-to-Edge Repair
This multicenter, retrospective study develops and validates artificial intelligence (AI)-based semantic segmentation algorithms for intraprocedural transesophageal echocardiography (TEE) during Transcatheter Mitral Edge-to-Edge…
- Trial name
- AutoClip (NCT07632794)
- Where
- 3 sites in China, Italy
- Volunteers
- 1,500 people
- Sponsor
- Mi Chen
Mitral Stenosis
Prospective Multicenter Registry of Patients With Mitral Stenosis Undergoing Percutaneous Mitral Balloon Commissurotomy
The goal of this observational study is to learn about the clinical outcomes after percutaneous mitral balloon commissurotomy (PMBC) for patients with mitral stenosis (MS) using nation-wide multicenter prospective registry…
- Trial name
- NCT07175532
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Asan Medical Center
Mitral Regurgitation, Mitral Valve Disease
Evaluation of Mitral Valve Insufficiency Under General Anesthesia
Observational study in adult humans undergoing surgical or cardiological intervention for mitral valve insufficiency. Investigators aim to evaluate hemodynamic changes on an arterial pressure waveform level in patients before and…
- Conditions
- Mitral Regurgitation, Mitral Valve Disease, Mitral Valve Insufficiency
- Trial name
- MITIGATE (NCT05736289)
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Mitral Regurgitation
Multimodality Imaging Assessment of the Severity of Mitral Regurgitation
To investigate to assess the severity of mitral regurgitation by multimodality imaging.
- Trial name
- NCT06266858
- Testing
- rehydration, UCG, CMR
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Hypertrophic Obstructive Cardiomyopathy
Hyp Obst Cardiomyopathy
Hypertrophic Obstructive cardiomyopathy (HOCM) is the most common genetic cardiomyopathy, heterogeneous in phenotype and clinical course.
- Trial name
- NCT04329689
- Testing
- The Septal myectom
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Assiut University