Clinical trials: Mitral Valve Regurgitation
Depression
Functional Neuroanatomy and Regional Metabolism Before and After Treatment With Duloxetine
The findings may guide future investigations on novel therapeutic targets in depressive subjects. Based on the depicted link between personality traits and altered brain metabolism and function, the latter might be used as…
- Trial name
- NCT02658617
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Heinz Boeker
Heart Failure
ARNI Combined With SGLT2 Inhibitors on Functional Mitral Regurgitation Remodeling
This study aimed to compare the effects of ARNI monotherapy versus combined ARNI and SGLT2 inhibitor therapy on Mitral Remodeling Index (MRIx) and Functional mitral regurgitation (FMR) remodeling in patients with heart failure…
- Trial name
- NCT07379788
- Testing
- Sacubitril/Valsartan 49 MG-51 MG Oral Tablet [ENTRESTO], Empagliflozin10Mg Tab
- Where
- Saudi Arabia
- Volunteers
- 180 people
- Sponsor
- Rehab Werida
Fibromyalgia
The Effect of Autoreactive Autoantibodies on Peripheral and Central Disease Mechanisms in Fibromyalgia.
This observational study aims to compare disease burden and pain characteristics between fibromyalgia patients with high levels of autoreactive autoantibodies, fibromyalgia patients with low levels of autoreactive autoantibodies…
- Trial name
- FINE (NCT07346950)
- Where
- Sweden
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Low Back Pain
Examination of Nociscan Impact on Low Back Pain Surgical Outcomes
This study is looking into how useful NOCISCAN is. NOCISCAN is a software as a Service (SaaS) tool that uses Magnetic Resonance (MR) spectroscopy.
- Trial name
- CLARITY (NCT06661850)
- Testing
- Fusion or TDR determined by investigator.
- Where
- 10 sites in United States
- Volunteers
- 300 people
- Sponsor
- Aclarion
Mitral Regurgitation
Is Mitral Annuloplasty an Effective Treatment for Severe Atrial Functional MR?
Atrial functional mitral regurgitation (MR) is caused by annular dilatation and flattering associated with altered atria/annulus dynamics in patients with severely dilated left atrium and normal leaflets anatomy.
- Trial name
- NCT05836376
- Testing
- Mitral valve annuloplasty
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- Michele De Bonis
Mitral Valve Disease
Assessment of Sustained Systolic-to-diastolic Flexibility of the Mitral Valve Annulus With the Sorin MEMO 3D Mitral Anuloplasty Ring
Mitral valve reconstruction commonly requires the use of an anuloplasty device to assure long-term durability of the repair. Among mitral anuloplasty devices, varying from rigid to complete flexible ring substitutes, the most…
- Trial name
- MEMO 3D (NCT01987635)
- Testing
- MEMO 3D ring, Standard use of rigid ring., 3D Echocardiography
- Where
- Belgium
- Volunteers
- 33 people
- Sponsor
- University Hospital, Ghent
Non-invasive Neuromodulation in Healthy Subjects
Mechanisms of Non-Invasive Neuromodulation Interventions: Influence on Human Neurochemistry and Functional Connectivity
The aim of this project is to increase our understanding of how two different protocols of repetitive transcranial magnetic stimulation (rTMS), inhibitory (1 Hz) and excitatory (5 Hz), applied over the primary motor cortex of the…
- Trial name
- NCT02677740
- Testing
- Inhibitory rTMS (1 Hz), Excitatory rTMS (5 Hz)
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Polycystic Ovary Syndrome, Non-Alcoholic Fatty Liver Disease
Metformin for Ectopic Fat Deposition and Metabolic Markers in Polycystic Ovary Syndrome (PCOS)
This project, "A double-blind placebo-controlled randomized clinical trial assessing the efficacy of metformin for hepatic fat in adolescents and young adults with polycystic ovary syndrome", proposes exploring the use of novel…
- Conditions
- Polycystic Ovary Syndrome, Non-Alcoholic Fatty Liver Disease, Metabolic Syndrome
- Trial name
- NCT02500147
- Testing
- Metformin
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Columbia University
Bipolar Disorder
The Treatment of Children and Adolescents With Treatment-Resistant Depression
This study seeks to learn about brain function in adolescents with depression and to determine whether adding lithium carbonate to antidepressant medication can reduce depression in children and adolescents.
- Trial name
- NCT00029640
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Mental Health (NIMH)
Mitral Valve Regurgitation
STS/ACC TVT Registry Mitral Module
The TVT Registry™ is a benchmarking tool developed to track patient safety and real-world outcomes related to the transcatheter mitral valve repair (TMVR) procedure.
- Trial name
- TMVR (NCT02245763)
- Testing
- Leaflet Clip
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- American College of Cardiology
Mild Tricuspid Regurgitation, Moderate Tricuspid Regurgitation
Evaluating the Benefit of Concurrent Tricuspid Valve Repair During Mitral Surgery
The purpose of the research is to determine whether repairing a tricuspid valve (TV) in patients with mild to moderate tricuspid regurgitation (TR), at the time of planned mitral valve surgery (MVS), would improve the heart…
- Conditions
- Mild Tricuspid Regurgitation, Moderate Tricuspid Regurgitation, Tricuspid Regurgitation
- Trial name
- NCT02675244
- Testing
- TV Annuloplasty, MVS
- Where
- 41 sites in United States, Canada and 1 more
- Volunteers
- 401 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Mitral Regurgitation
Left Chamber Function in Mitral Regurgitation and Predicting Outcome After Replacement and Targeting for Early Surgery
The study aims to analyze the role of left ventricular and left atrial functional parameters by speckle tracking echocardiography in predicting outcome after mitral valve replacement and targeting for early intervention compared…
- Trial name
- NCT03870516
- Testing
- Mitral valve replacement, Speckle tracking echocardiography
- Volunteers
- 100 people
- Sponsor
- Assiut University
Mitral Regurgitation
Epicardial Mitral Repair Trial - ENRAPT-MR
Mitral Touch System This device is designed to epicardially reshape the mitral valve annulus without the need for cardiopulmonary bypass (CPB) and open heart access (atriotomy), in patients with left ventricular dilation and…
- Trial name
- ENRAPT-MR (NCT03864848)
- Testing
- Mitral Touch Implant
- Where
- Lithuania
- Volunteers
- 50 people
- Sponsor
- Mitre Medical Corp.
Diurnal Variations of Cerebral Metabolite
Diurnal Variations of Brain Metabolite Concentrations in 1H-MRS
Proton Magnetic Resonance Spectroscopy (1H-MRS) is a magnetic resonance imaging (MRI) technique. It allows the quantification of cerebral metabolite concentrations.
- Trial name
- Dyn24 (NCT03497832)
- Testing
- magnetic resonance spectroscopy (MRI)
- Where
- France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Central Retinal Artery Occlusion
A Phase III Randomized, Blind, Double Dummy, Multicenter Study Assessing the Efficacy and Safety of IV THrombolysis (Alteplase) in Patients With acutE Central retInal Artery Occlusion
The aim of the THEIA study is to determine if Alteplase administrated within 4.5 hours improve visual deficit due to acute CRAO with a good safety profile.
- Trial name
- THEIA (NCT03197194)
- Testing
- Alteplase, acetylsalicylic acid
- Where
- 17 sites in France
- Volunteers
- 70 people
- Sponsor
- Nantes University Hospital
Mitral Regurgitation, Atrial Fibrillation
Optimal PeriproCeduraL AnticOagulation in Structural Transseptal Interventions
The transcatheter edge to edge mitral valve repair (TEER) and left atrial appendage closure (LAAC) are the interventional cardiology procedures that require periprocedural anticoagulation with unfractionated heparin (UFH).
- Conditions
- Mitral Regurgitation, Atrial Fibrillation, Anticoagulation
- Trial name
- STOP CLOT (NCT05305612)
- Testing
- early anticoagulation, late anticoagulation
- Where
- 5 sites in Poland
- Volunteers
- 410 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Mitral Regurgitation
Abrogation of Mitral Regurgitation Using the MitraClip System in High-Risk Patients Unsuitable for Surgery
The primary objective in this randomized trial is to evaluate the safety and efficacy of a MitraClip treatment in symptomatic patients with severe mitral regurgitation in comparison to the previous default medical treatment - in…
- Trial name
- ISAR-CLIP (NCT01431222)
- Testing
- percutaneous treatment by implanting a Mitra Clip device
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Low Back Pain, Foot Posture
Biomechanical Taping on Low Back Pain With Increased Foot Pronation
It is stated that abnormal lower extremity posture and biomechanics are effective in the development and progression of Low Back Pain (LBP).
- Conditions
- Low Back Pain, Foot Posture, Taping, Functional Mitral Regurgitation
- Trial name
- NCT04776798
- Testing
- Taping
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University - Cerrahpasa
Functional Mitral Regurgitation
Evaluation of Safety and Efficacy of the BACE™ Device in the Treatment of Functional Mitral Valve Regurgitation [FMR
The preclinical and clinical evidence of safety and efficacy with the BACE device (concept and feasibility) paved the way for the evaluation of the BACE device in this prospective, multi-center, single-arm, self-controlled study…
- Trial name
- BACE (NCT02701972)
- Testing
- BACE Device
- Volunteers
- 35 people
- Sponsor
- Phoenix Cardiac Devices, Inc.
Symptomatic Functional MR 3 or Greater
AMEND TS Early Feasibility Study
Valcare Medical AMEND Trans-Septal System is a mitral valve repair annuloplasty ring implanted in a trans-catheter method intended for correction of mitral regurgitation.
- Trial name
- NCT06951672
- Testing
- This study will evaluate the safety and functionality of the AMEND™ Trans-Septal System for annuloplasty as a therapy for mitral regurgitation.
- Where
- 11 sites in United States
- Volunteers
- 15 people
- Sponsor
- Valcare Medical Ltd.