Clinical trials: Mitral Valve Regurgitation
Mitral Regurgitation, Coronary Artery Disease
Randomised Ischaemic Mitral Evaluation (RIME) Trial
The study is a randomised controlled trial comparing two treatment strategies for patients with moderate functional ischaemic mitral regurgitation undergoing coronary artery bypass grafting (CABG).
- Trial name
- RIME (NCT00413998)
- Testing
- CABG + Mitral valve annuloplasty, CABG
- Where
- 9 sites in Poland, United Kingdom
- Volunteers
- 73 people
- Sponsor
- Imperial College London
Mitral Regurgitation
Repair of Ischemic Mitral Regurgitation: Comparison Between Flexible and Rigid Annuloplasty Rings
Mitral valve repair for ischemic mitral regurgitation is performed primarily by annuloplasty. There is some degree of late failure, which may be due in part to the type of ring employed.
- Trial name
- IMR2 (NCT00491452)
- Where
- Israel
- Sponsor
- Shaare Zedek Medical Center
Mitral Valve Stenosis With Incompetence or Regurgitation
The Effects of Levosimendan During Mitral Valve Surgery
The effects of levosimendan on renal function in patients with low ejection fraction undergoing mitral valve surgery will be investigated in a prospective, double-blinded, randomized clinical trial using serum creatinine…
- Trial name
- NCT01969071
- Testing
- Levosimendan, Dobutamine
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Heavy Dose Drinkers
MRS Probe Study of Alcohol
This protocol will investigate the neurobiological underpinnings of alcohol craving in recently detoxified alcoholic drinkers utilizing novel functional brain imaging.
- Trial name
- NCT01679444
- Testing
- Magnetic Resonance Spectroscopy
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Chronic Pancreatitis, Pain Management
Neural Sensitisation and Neuropsychological Alterations in Painful Chronic Pancreatitis
Chronic pancreatitis (CP) is a progressive inflammatory disease in which chronic abdominal pain affects up to 80% of patients and remains difficult to manage despite treatment of pancreatic pathology.
- Trial name
- NEURO-CP (NCT07707609)
- Testing
- Comprehensive Neuropsychological Assessment, Resting-State Functional MRI (fMRI), Magnetic Resonance Spectroscopy (MRS)
- Where
- India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Mitral Valve Regurgitation, Mitral Regurgitation
The MitraClip® EXPAND Study of the Next Generation of MitraClip® Devices
The MitraClip EXPAND Study (A Contemporary, Prospective Study Evaluating Real-world Experience of Performance and Safety for the Next Generation of MitraClip Devices) is designed to confirm the safety and performance of the…
- Trial name
- NCT03502811
- Testing
- MitraClip NTR/XTR System
- Where
- 57 sites in United States, Germany and 6 more
- Volunteers
- 1,041 people
- Sponsor
- Abbott Medical Devices
Atrial Functional, Mitral Regurgitation (MR)
PRECISE-AFMR I: Transcatheter Mitral Valve Edge-to-Edge Repair for Atrial Functional Mitral Regurgitation in Patients at High Surgical Risk
Atrial functional mitral regurgitation (AFMR) develops when enlargement and remodeling of the left atrium and mitral annulus prevent the mitral valve leaflets from closing completely, allowing blood to leak backward through the…
- Trial name
- PRECISE-AFMR I (NCT07741253)
- Testing
- Transcatheter Edge-to-Edge Repair
- Where
- China
- Volunteers
- 182 people
- Sponsor
- China National Center for Cardiovascular Diseases
Mitral Regurgitation
3D Echocardiography and Cardiovascular Prognosis in Mitral Regurgitation
The 3D-PRIME study will analyse whether use of 3D echocardiography can improve risk stratification and cardiovascular outcome in patients with mitral regurgitation of different etiologies.
- Trial name
- 3D-PRIME (NCT04442828)
- Testing
- Use of 3D echocardiography in patient follow-up
- Where
- Norway
- Volunteers
- 300 people
- Sponsor
- Haukeland University Hospital
Moderate Mitral Regurgitation
Moderate Mitral Regurgitation in CABG Patients
Background: The presence of a mild to moderate ischemic mitral regurgitation (IMR) results in a significantly reduced long-term survival and increased hospitalizations for heart-failure.
- Trial name
- MoMIC (NCT00613548)
- Testing
- CABG alone, CABG + Mitral repair
- Where
- Denmark
- Volunteers
- 550 people
- Sponsor
- University of Aarhus
Ischemic Mitral Regurgitation, Coronary Heart Disease (CHD)
Coronary Heart Disease Complicated With Ischemic Mitral Regurgitation in China
This project will rely on the established multi-center cooperation platform for total valve disease and based on the Carpentier classification, which is newly proposed and widely recognized by the academic community, and will…
- Trial name
- China-IMR (NCT07230756)
- Volunteers
- 6,000 people
- Sponsor
- China National Center for Cardiovascular Diseases
Functional Mitral Regurgitation
Evaluation of Safety and Efficacy of the BACE™ Device in the Treatment of Functional Mitral Valve Regurgitation [FMR
The preclinical and clinical evidence of safety and efficacy with the BACE device (concept and feasibility) paved the way for the evaluation of the BACE device in this prospective, multi-center, single-arm, self-controlled study…
- Trial name
- BACE (NCT02701972)
- Testing
- BACE Device
- Volunteers
- 35 people
- Sponsor
- Phoenix Cardiac Devices, Inc.
Acute Mitral Regurgitation
Early Transcatheter Mitral Valve Repair After Myocardial Infarction
To explore the impact of early transcatheter edge-to-edge repair of acute functional mitral regurgitation after myocardial infarction on the combined incidence of death and heart-failure associated hospitalisations at one-year…
- Trial name
- EMCAMI (NCT06282042)
- Testing
- Early transcatheter edge-to-edge mitral valve repair (TEER)., MitraClip, Optimal medical treatment
- Where
- 32 sites in Israel, Italy and 2 more
- Volunteers
- 250 people
- Sponsor
- Fundación para la Investigación Biosanitaria del Principado de Asturias
Alzheimer's Disease
Effects of Memantine on Magnetic Resonance (MR) Spectroscopy in Subjects at Risk for Alzheimer's Disease
Recent data show that marked cell damage precedes the clinical manifestation of Alzheimer's disease (AD). Hence, targeting populations at risk with pharmacological interventions is a possible strategy to lessen the burden of the…
- Trial name
- NCT00933608
- Testing
- memantine
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Mitral Regurgitation
The Papillary Muscle Approximation Provide Stability of Mitral Valve Repair for Ischemic Mitral Regurgitation
Recent publications show that an adjunctive subvalvular repair during mitral annuloplasty for secondary mitral regurgitation effective in preventing recurrent regurgitation.
- Trial name
- PMA (NCT03038204)
- Testing
- The papillary muscle approximation
- Volunteers
- 100 people
- Sponsor
- The Federal Centre of Cardiovascular Surgery, Russia
Mitral Valve Insufficiency
High and Intermediate Risk Degenerative Mitral Regurgitation Treatment: A Trial Comparing MitraClip® to Surgical Therapy
The study is comparing MitraClip® to Surgical therapy in high and intermediate risk patients, who should be older than 18 years, and shall evaluate safety and efficacy of MitraClip® vs.
- Trial name
- HiRiDe (NCT02534155)
- Testing
- MitraClip®, Mitral valve Surgery
- Where
- 12 sites in Germany, Italy and 1 more
- Volunteers
- 294 people
- Sponsor
- University of Zurich
Atherosclerosis
Technical Innovation Protocol for MR & US Plaque Imaging: Reproducibility.
The aim of this study is to develop non-invasive MRI, and MRS approaches that will quantify the plaque composition and lipid content of plaques and will have the potential for repeated in vivo measurements.
- Trial name
- NCT01196221
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Atrial Fibrillation (AF), Mitral Regurgitation
The Multi-center Study of Comprehensive Atrial Fibrillation Regurgitation and Recurrent Events Evaluation
Atrial fibrillation (AF) is the most common cardiac arrhythmia in the clinic and can lead to valve regurgitation and a poor prognosis.
- Conditions
- Atrial Fibrillation (AF), Mitral Regurgitation, Tricuspid Regurgitation
- Trial name
- NCT07085650
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- First Hospital of China Medical University
Mitral Regurgitation
MITRAClip GENeration 5 Mitral Valve Transcatheter Edge-to-Edge Repair Registry
The MITRAGEN5 Registry is an international, multicenter, observational registry that collects data on patients with mitral regurgitation who are treated with the fifth-generation MitraClip (G5) device.
- Trial name
- MITRAGEN5 (NCT07543874)
- Testing
- MitraClip G5
- Volunteers
- 1,000 people
- Sponsor
- University Hospital of Cologne
Cardiac Disease
Exercise-induced in Secondary Mitral Regurgitation: Analysis of Echocardiographic Parameters at Rest Predicting the Onset of Significant Exercise-induced Mitral Regurgitation
Secondary mitral insufficiency is a common complication of heart failure, aggravating symptoms and prognosis, and may be responsible for worsening dyspnea, pulmonary edema, and excess mortality.
- Trial name
- IM EFFORT (NCT03978676)
- Where
- France
- Volunteers
- 87 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Multiple Sclerosis
Correlation of Serum Lactate and Activity of Multiple Sclerosis
Correlation of serum lactate and activity of multiple sclerosis and its correlation to different type of MS
- Trial name
- NCT04210960
- Testing
- Magentic resonanace imaging, Magentic resonanace spectroscopy
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mansoura University Hospital