Clinical trials: Mixed Dementias
Dementia, Cognitive Impairment
Caring for Persons With Dementia and Their Caregivers in the Community
The study consists of two phases - i) a comprehensive assessment of biopsychosocial needs among cognitively impaired persons and their family caregivers residing in the Whampoa residential estate in Singapore ; ii) a…
- Trial name
- NCT04479033
- Testing
- Multidisciplinary collaborative model of community care management
- Where
- Singapore
- Volunteers
- 300 people
- Sponsor
- Duke-NUS Graduate Medical School
Cerebral Small Vessel Diseases, Dementia, Mixed
WHIte MAtter Hyperintensity Shape and Glymphatics
In a society with increased life expectancy, the economic, social and personal burden of dementia increases. Dementia is often caused by a combination of neurovascular and neurodegenerative diseases.
- Conditions
- Cerebral Small Vessel Diseases, Dementia, Mixed, Dementia, Vascular, Mild Cognitive Impairment
- Trial name
- WHIMAS (NCT06010511)
- Testing
- 3T MRI scan, 7T MRI scan, Neuropsychological assessment
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Leiden University Medical Center
Dementia, Caregiver Burden
Trialling an Online UK Dementia Awareness for Caregivers Course
The purpose of this study is to investigate whether an online Dementia Awareness Course is feasible for delivery and acceptable to informal caregivers of people living with dementia in the UK.
- Trial name
- DAC-UK (NCT05887063)
- Testing
- Dementia Awareness Course UK
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University College, London
Dementia, Alzheimer Disease
A Multidomain Intervention Program for Older People With Dementia
This is a pilot study to assess the feasibility of a multidomain intervention for older people with dementia in nursing homes. Participants will be randomized into two equal groups, to receive either an intensive multidomain…
- Conditions
- Dementia, Alzheimer Disease, Dementia, Mixed
- Trial name
- NCT04948450
- Testing
- Physical activity intervention, Cognitive stimulation intervention, Social intervention
- Where
- 4 sites in Vietnam
- Volunteers
- 60 people
- Sponsor
- National Geriatric Hospital
Dementia; Alzheimer, Mixed Type (Etiology)
Probiotics in Dementia
Dementia is associated with changes in gut microbiome composition, gut barrier dysfunction, intestinal inflammation and systemic inflammation. Probiotics are a possibility to modulate the gut-brain axis.
- Trial name
- PIDE (NCT03847714)
- Testing
- Omni-Biotic Stress Repair
- Where
- Austria
- Volunteers
- 17 people
- Sponsor
- Medical University of Graz
Alzheimer Disease
Conservation of Praxis in the Food and Alzheimer Disease
The insanities, priority of public health in 2008, have significant prevalency in Limousin, region in the ageing demography (1/3 of the population is more than 60 years old against 1/5th of average in France).
- Trial name
- PRAXALIM (NCT01743534)
- Where
- France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Limoges
Dementia, Vascular, Dementia, Mixed
Cannabidiol's Role in Dementia Management
This trial investigates the therapeutic benefits of cannabidiol (CBD) for Dementia patients in Malaysia. As dementia becomes increasingly prevalent worldwide, there's a pressing demand for impactful remedies.
- Trial name
- MyC4D (NCT06514066)
- Testing
- Cannabidiol Oil
- Where
- Malaysia
- Volunteers
- 486 people
- Sponsor
- Hospital Pengajar Universiti Putra Malaysia
Dementia
The Sunnybrook Dementia Study
The prospect of disease-modifying therapies in the pipeline for Alzheimer's Disease (AD) has intensified efforts to use brain imaging more effectively for diagnosis and monitoring of dementing illnesses.
- Trial name
- SDS (NCT01800214)
- Where
- Canada
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Alzheimer Disease, Dementia
SAFE at Home: A Service to Provide Social Engagement to Community-Dwelling Persons With Dementia
The proposed Phase 1 study will involve initial development and evaluation of a new service called Social Activities For Engagement at Home or SAFE at Home (SaH).
- Conditions
- Alzheimer Disease, Dementia, Dementia, Vascular, Dementia, Mixed
- Trial name
- NCT05516147
- Testing
- SAFE at Home
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Hopeful Aging
Alzheimer Disease, Late Onset
The Predictive Factors of Good Clinical Response to Cholinesterase Inhibitors in Alzheimer Disease and Mixed Dementia
Background and objectives: The aims of this naturalistic study were: to analyze factors which could be predictive of good response to cholinesterase inhibitors (ChEI), such as: age, sex, schooling, mild (CDR 1) or moderate…
- Trial name
- NCT02187276
- Testing
- cholinesterase inhibitors
- Volunteers
- 129 people
- Sponsor
- Federal University of Minas Gerais
Dementia
The Use of Galantamine (Reminyl ER) in Patients With MIXed Dementia: Effects on Cognition and Quality of Life
The purpose of this study is to evaluate the combination of galantamine with nimodipine in patients with mixed dementia on cognition and quality of life.
- Trial name
- NCT00814658
- Testing
- Galantamine, Nimodipine
- Volunteers
- 22 people
- Sponsor
- Janssen-Cilag Farmaceutica Ltda.
Obstructive Sleep Apnea, Alzheimer Disease
ENhancing Outcomes in Cognitive Impairment Through Use of Home Sleep ApNea Testing
Obstructive sleep apnea (OSA), which causes abnormal pauses in breathing during sleep, is common in patients with vascular cognitive impairment (VCI) and Alzheimer's disease (AD), and exacerbates the cognitive deficits seen in…
- Conditions
- Obstructive Sleep Apnea, Alzheimer Disease, Vascular Dementia, Mild Cognitive Impairment
- Trial name
- ENCHANT (NCT04335994)
- Testing
- In-laboratory polysomnography, Home Sleep Apnea Test
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Sunnybrook Health Sciences Centre
Psychological Distress
Guided Eight-week Online Acceptance and Commitment Therapy for Distressed Family Caregivers of People With Dementia
The pilot randomized controlled trial aims to assess effects of a guided online acceptance and commitment therapy (ACT) intervention on distressed family caregivers of people with dementia (PwD) compared to the control group.
- Trial name
- NCT04847986
- Testing
- acceptance and commitment therapy (ACT), Control group
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Alabama at Birmingham
Dementia, Cognitive Impairment, Mild
Cognitive Stimulation Therapy for Dementia: A Two-Armed Pragmatic Trial
Cognitive Stimulation Therapy (CST) is an evidence-based non-pharmacological group therapy shown to benefit people with mild to moderate dementia.
- Conditions
- Dementia, Cognitive Impairment, Mild, Dementia, Vascular, Dementia, Mixed
- Trial name
- NCT05860127
- Testing
- Referral for Cognitive Stimulation Therapy, No change to Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 133 people
- Sponsor
- University of Massachusetts, Amherst
Dementia, Dementia, Vascular
Exploring Biomarkers in Age Stratified PUMCH Dementia Cohort
Biomarkers are important for early and precise diagnosis of dementia. However, the causes of dementia in different age are different.
- Conditions
- Dementia, Dementia, Vascular, Dementia Frontal, Dementia, Mixed
- Trial name
- NCT04924361
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Dementia
Preparing Surrogates of Dementia Patients Through an Advance Care Planning Intervention
The goal of this clinical trial is to evaluate the effects of a nurse-facilitated post-discharge advance care planning intervention with family surrogates of dementia patients on outcomes that reflect the preparedness of…
- Trial name
- NCT06152120
- Testing
- Nurse-facilitated advance care planning intervention
- Where
- Hong Kong
- Volunteers
- 58 people
- Sponsor
- The University of Hong Kong
Adolescence Idiopathic Scoliosis, AIS
Smartphone App for Adolescents With Idiopathic Scoliosis
This study aims to evaluate a smartphone application (DinSkoliose) designed to support adolescents with idiopathic scoliosis (AIS) in managing their condition and following their treatment.
- Trial name
- NCT07686848
- Testing
- DinSkoliose smartphone application
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Oslo Metropolitan University
Dementia, Alzheimer Disease
A Study of the Effectiveness and Safety of Risperidone Versus Placebo in the Treatment of Behavioral Disturbances in Patients With Dementia
The purpose of the study is to evaluate the safety and efficacy of risperidone (an antipsychotic medication) versus placebo in the treatment of behavioral disturbances associated with dementia.
- Conditions
- Dementia, Alzheimer Disease, Dementia, Vascular
- Trial name
- NCT00253123
- Testing
- risperidone
- Volunteers
- 626 people
- Sponsor
- Janssen, LP
Dementia, Dementia, Mixed
Uppsala-Dalarna Dementia and Gait Project
UDDGait™ is a multidisciplinary research project with the overreaching goal of providing an aid for early identification of cognitive impairment and risk of dementia development, thereby providing a basis for adequate symptom…
- Conditions
- Dementia, Dementia, Mixed, Dementia Senile, Dementia of Alzheimer Type
- Trial name
- UDDGait™ (NCT05893524)
- Testing
- Timed Up-and-Go (TUG single-task), Timed Up-and-Go dual-task (TUGdt), Clinical functional assessment
- Where
- 2 sites in Sweden
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Dalarna University
Dementia, Alzheimer Disease
Feasibility of Passive Data Collection in Dementia Subjects With Agitation
This is a multi-center, observational, feasibility study, to evaluate long term passive data collection, data quality, and user experience of HealthMode Agitation (Apps) to collect motion, location, physiological, and audio data…
- Conditions
- Dementia, Alzheimer Disease, Vascular Dementia, Frontotemporal Dementia
- Trial name
- NCT04413851
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- HealthMode Inc.