Clinical trials: Modafinil
Schizophrenia
Modafinil Effects on Cognition in Schizophrenia Patients
Patients with schizophrenia have problems in thinking, known as cognitive dysfunction. This includes many types of cognitive dysfunction, such as in attention, memory and language.
- Trial name
- InO (NCT00711464)
- Testing
- modafinil (M1, M2, M4)
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Brain and Central Nervous System Tumors, Cognitive/Functional Effects
Modafinil in Treating Children With Memory and Attention Problems Caused by Cancer Treatment for a Brain Tumor
RATIONALE: Modafinil may help improve memory, attention, and fatigue caused by cancer treatment. PURPOSE: This phase II randomized trial studies how well modafinil works in treating children with memory and attention problems…
- Conditions
- Brain and Central Nervous System Tumors, Cognitive/Functional Effects, Fatigue, Neurotoxicity
- Trial name
- NCT01381718
- Testing
- modafinil
- Where
- 60 sites in United States
- Volunteers
- 112 people
- Sponsor
- University of South Florida
Schizophrenia, Schizoaffective Disorder
Effects of Armodafinil on Cognition for Patients With Schizophrenia or Schizoaffective Disorder
This is a six week, double blind,placebo controlled study for patients with schizophrenia or schizoaffective disorder treated with an atypical antipsychotic for at least two months.
- Trial name
- NCT00373672
- Testing
- armodafinil (Nuvigil)
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Northwestern University
Schizophrenia
Modafinil Augmentation in Chronic Schizophrenia and Schizoaffective Disorder
This is an open label 8-week trial of modafinil up to 400 mg daily added to a stable antipsychotic regimen to evaluate the effect modafinil on cognition, sedation, and weight in patients with chronic schizophrenia.
- Trial name
- NCT00838227
- Testing
- modafinil
- Sponsor
- Manhattan Psychiatric Center
Fatigue
Study of Modafinil to Treat Fatigue in Persons With Traumatic Brain Injury
The purpose of this study is to determine whether Modafinil is effective in: (1) reducing fatigue and excessive daytime sleepiness (EDS) in individuals with Traumatic Brain Injury (TBI); and (2) improving cognitive function and…
- Trial name
- NCT00702637
- Testing
- Modafinil
- Volunteers
- 60 people
- Sponsor
- Craig Hospital
Atypical Depression
Modafinil for Atypical Depression
The purposes of the study are to: 1) evaluate the short-term efficacy and safety of modafinil in atypical depression; and 2) to evaluate the efficacy of modafinil in preventing relapse of atypical depression.
- Trial name
- NCT00215176
- Testing
- modafinil
- Volunteers
- 65 people
- Sponsor
- Duke University
Sleep Restriction, Impaired Glucose Metabolism
The Effects of Modafinil to Counteract the Adverse Metabolic Consequences of Sleep Restriction
The purpose of the study is to examine the effects of sleep and modafinil on how the body processes glucose.
- Trial name
- NCT00895570
- Testing
- modafinil
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Methamphetamine Dependence
Modafinil for Methamphetamine Dependence
Fifty methamphetamine dependent treatment-seeking volunteers will be enrolled in this 10 week, double bind, placebo controlled, randomized clinical trial to receive either modafinil or placebo.
- Trial name
- NCT00859573
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Arkansas
Postoperative Cognitive Dysfunction
Modafinil to Prevent Postoperative Cognitive Decline
Postoperative cognitive dysfunction is a well-recognized complication of surgery. The aim of the study is to investigate whether cognitive dysfunction is reduced by the use of modafinil as shown by neurocognitive testing.The…
- Trial name
- NCT03914118
- Testing
- Preoperative modafinil + postoperative modafinil
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- The Cooper Health System
Narcolepsy, Cataplexy
Provigil (Modafinil) Study by Taiwan Biotech Co.
The primary objective is to evaluate the therapeutic effect of excessive daytime sleepiness associated with narcolepsy. Both of the subjective and objective sleepiness of the patients were assessed in the experiment by repeat…
- Conditions
- Narcolepsy, Cataplexy, Sleep Disorders, Hypersomnolence
- Trial name
- NCT00174174
- Testing
- Modafinil
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Attention Deficit Hyperactivity Disorder, ADHD
Dose-Finding Study to Evaluate the Efficacy and Safety of Modafinil as Treatment for Adults With ADHD
The purpose of the study is to evaluate the efficacy and safety of modafinil administered once daily for 9 weeks at doses of 255, 340, 425, and 510 mg as treatment for adults with ADHD.
- Trial name
- NCT00315276
- Testing
- Modafinil
- Where
- 18 sites in United States
- Volunteers
- 370 people
- Sponsor
- Cephalon
Primary Insomnia
The Effects of Modafinil on Waking Function and on Sleep in Individuals With Primary Insomnia
This study examines how treatment with the drug modafinil, by itself or in combination with cognitive behavioral treatment for insomnia (CBT-I), may improve daytime functioning and/or diminish the severity of insomnia.
- Trial name
- NCT00124384
- Testing
- CBT-I, modafinil
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Healthy, Narcolepsy
A Clinical Study of MK-6552 and Modafinil in Healthy Men (MK-6552-005)
The goal of this study is to learn what happens to MK-6552 in a person's body over time. Researchers will compare what happens to levels of MK-6552 in people's blood when it is taken with and without modafinil.
- Trial name
- NCT06665230
- Testing
- MK-6552, Modafinil
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Healthy Volunteers
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of TAK-925 Study in Sleep-Deprived Healthy Adults
The purpose of this study is to determine the effect of TAK-925 after a single intravenous dose (compared to placebo) on promoting wakefulness as measured by sleep latency on the maintenance of wakefulness (MWT) in sleep-deprived…
- Trial name
- NCT03522506
- Testing
- TAK-925, Modafinil
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Takeda
Relapsing-Remitting Multiple Sclerosis
Combination Therapy (Provigil + Avonex) to Treat Cognitive Problems in MS
MS has been associated with fatigue, attention problems, and a number of cognitive difficulties. There is no treatment approved yet to treat these problems.
- Trial name
- NCT00210301
- Testing
- Provigil (modafinil)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Institute for Clinical Research
Cocaine Dependence, Cocaine Abuse
Modafinil - Escitalopram Study for Cocaine Dependence
The purpose of this study is to improve the efficacy of modafinil as a potential treatment for cocaine dependence.
- Conditions
- Cocaine Dependence, Cocaine Abuse, Cocaine Addiction, Substance Abuse
- Trial name
- NCT01601730
- Testing
- Modafinil and Escitalopram, Modafinil, Escitalopram
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Baylor College of Medicine
Apathy, Alzheimer's Disease
Treatment of Apathy in Alzheimer's Disease With Modafinil
This study examined the effects of modafinil on apathetic symptomatology, performance of activities of daily living (ADLs) and caregiver burden in individuals with Alzheimer's disease (AD).
- Trial name
- NCT01172145
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Brown University
Methamphetamine Dependence
Phase 2, Multi-Center Trial of Modafinil for Methamphetamine Dependence
The purpose of this study will be to examine the safety and efficacy of modafinil in increasing number of methamphetamine non-use weeks in subjects with methamphetamine dependence.
- Trial name
- NCT00520286
- Testing
- Modafinil
- Where
- 8 sites in United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Methamphetamine Dependence
Safety and Tolerability of Modafinil for Methamphetamine Dependence
This 7 week, open-label pilot clinical trial will examine the safety and tolerability of modafinil up to 400mg/day as a potential treatment to reduce methamphetamine use in methamphetamine-dependent volunteers.
- Trial name
- NCT00569374
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Alcohol
Modafinil-Alcohol Interactions in Healthy Volunteers
The UCSF Pain Clinical Research Center (PCRC) is conducting a study of the effects of modafinil (Provigil®; Vigiver, Alertec), alcohol and the combination on alertness, mood, visual motor and cognitive performance, and pain…
- Trial name
- NCT00305292
- Testing
- Modafinil-Alcohol Interactions
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco