Clinical trials: Mode of Therapy
HER2-negative Breast Cancer
Study of Multi-mode Thermal Therapy Combined With Immunotherapy In Patients With HER2-negative Breast Cancer With Liver Metastases
This is a prospective, open-label, phase II platform trial. The purpose of this study is to test the safety and effectiveness of multi-mode thermal therapy combined with immunotherapy in patients with HER2-negative breast cancer…
- Trial name
- NCT07466927
- Testing
- SHR-A1811, SKB264, Pembrolizumab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fudan University
Pelvic Floor Disorders
M-mode Ultrasonography in the Assessment and Treatment of Pelviperineal Dysfunctions (PerineUM)
Objectives: To analyze the Mode M ultrasound use in the assessment of pelvic floor musculature (PFM) and in the rehabilitation of motor control in pelviperineal dysfunctions that affect the support of pelvic organs, urinary and…
- Trial name
- PerineUM (NCT05399901)
- Testing
- Electromyographic biofeedback, M-mode US biofeedback
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Major Depressive Disorder, Mood Disorders
Mechanisms of Rumination Change in Adolescent Depression
This study will evaluate whether a newer treatment, rumination-focused cognitive behavioral treatment, which includes mindfulness and can be used to reduce ruminative habits, change ways in which key brain regions interact with…
- Trial name
- RuMeChange (NCT03859297)
- Testing
- Rumination-Focused CBT, Relaxation-based Therapy
- Where
- 3 sites in United States
- Volunteers
- 183 people
- Sponsor
- Ohio State University
Diabetes, Diabetes Mellitus, Type 2
Examination of the Effects of Liraglutide on the Mode of Action of Insulin Detemir
This trial is conducted in the United States. The aim of this clinical trial is to investigate whether chronic liraglutide administration affects the mode of action (pharmacokinetics) of insulin detemir
- Trial name
- NCT00873223
- Testing
- liraglutide, insulin detemir
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Novo Nordisk A/S
Healthy Volunteers, HIV Infection
Safety Study Comparing a Vaccine Transcutaneous Administration to the Intramuscular Route
The rationale for transcutaneous vaccination is based on the unique ability of cutaneous immune cells, especially Langerhans cells (LCs), to present antigens to the immune system.
- Trial name
- MANON-05 (NCT00261001)
- Testing
- Transcutaneous mode of administration, Intramuscular mode of administration
- Where
- 2 sites in Germany
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Objectif Recherche Vaccins SIDA
Methamphetamine-dependence, Transcranial Direct Current Stimulation
Transcranial Direct Current Stimulation (tDCS) Combined With Computerized Cognitive Addiction Therapy(CCAT) and, Electronic Follow-up for Methamphetamine(MA) Dependent Patients
Transcranial direct current stimulation (tDCS) combined with computerized cognitive addiction therapy(CCAT) for methamphetamine(MA) dependent patients in voluntary drug rehabilitation center.
- Conditions
- Methamphetamine-dependence, Transcranial Direct Current Stimulation, Computerized Cognitive AddictionTherapy, Electronic Health Records
- Trial name
- NCT04139148
- Testing
- Ture Transcranial Direct Current Stimulation (tDCS)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Mental Health Center
Colorectal Cancer Liver Metastasis
A Study on the Efficacy and Safety of Multi-mode Ablation Combined With Systemic Therapy in the Treatment of CRCLM
The goal of this study is to evaluate the efficacy and safety of multi-mode ablation combined with systemic therapy including PD-1(programmed death receptor 1) inhibitor for colorectal cancer liver metastasis and furthermore to…
- Trial name
- NCT06590259
- Testing
- Multi-mode tumor treatment system, Sintilimab+mFOLFOX6 or FOLFIRI+bevacizumab or cetuximab
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai 6th People's Hospital
Albumin, Dialysis
Functionality of Albumin in the Context of Hemodialysis
Hemodialysis treatment enables patients with end-stage chronic kidney disease to survive. At the same time, however, this treatment also increases cardiovascular mortality, in particular due to a chronically increased level of…
- Conditions
- Albumin, Dialysis, Redox State, Uremic; Toxemia
- Trial name
- FACED (NCT06561191)
- Testing
- Hemodialysis mode, dialyzer type
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Universität Duisburg-Essen
Seasonal Allergic Rhinitis, Hay Fever
PK/PD and Steady State Efficacy Study of Bilastine Compared With Placebo Given Orally in the Treatment of the Symptoms of SAR in an EEC Model (5-arm)
The purpose of this study is to evaluate the relative efficacy of four dosing regimens of bilastine tablets versus placebo in subjects with SAR exposed in controlled ragweed pollen using the EEC model based on the mean change…
- Conditions
- Seasonal Allergic Rhinitis, Hay Fever, Rhinoconjunctivitis
- Trial name
- NCT00574210
- Testing
- Bilastine
- Where
- Canada
- Volunteers
- 502 people
- Sponsor
- Faes Farma, S.A.
Sarcoma
Study on Clinical Features, Treatment Mode and Survival of Sarcoma
The clinical data of all eligible patients who received chemotherapy, radiotherapy, targeted therapy, immunotherapy, interventional therapy and surgery in Henan Tumor Hospital from June 1, 2012 to May 30, 2022 were…
- Trial name
- NCT05453409
- Testing
- No intervention
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Henan Cancer Hospital
End Stage Renal Disease, Inflammation
Evaluation of Biocompatibility and Performances of 4 Dialyzers in Different Mode Treatments
Prospective multicenter randomized cross-over study Number of patients : 32 (8 patients per group) Obtain objectives data to advise each hemodialyzer according to dialysis treatment and patient profile.
- Trial name
- BIOMODAL (NCT03262272)
- Testing
- VIE A Hemodialyzer, Rexsys 27H hemodialyzer, Leoceed 21HX hemodialyzer
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Hemotech
Transcranial Magnetic Stimulation, Alzheimer Disease
Cerebellar ITBS Mode Transcranial Magnetic Stimulation for the Treatment of Alzheimer's Disease
Study the therapeutic effect and potential neural mechanisms of cerebellar iTBS mode transcranial magnetic stimulation on Alzheimer's disease patients through MRI and EEG.
- Conditions
- Transcranial Magnetic Stimulation, Alzheimer Disease, Magnetic Resonance Imaging, Electroencephalogram
- Trial name
- NCT06379100
- Testing
- transcranial magnetic stimulation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xijing Hospital
Advanced Solid Tumor, Refractory Tumor
Thymalfasin-based PRaG Mode for Advanced Refractory Solid Tumors
This is an open-label, single-arm, Phase II investigator-initiated trial of precise thymalfasin-regulated therapy combined with hypofractionated radiotherapy, PD-1/PD-L1 inhibitor sequential GM-CSF for treatment of advanced…
- Trial name
- NCT05790447
- Testing
- Thymalfasin, Radiotherapy, PD-1/PD-L1 inhibitor
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Knee, Osteoarthritis (OA), Biomarkers for Prediction of OA Treatment Efficacy
Biomarkers for Prediction of Analgesic Efficacy in Knee OA.
With high NNTs for indiscriminative use in chronic pain, treatment unavoidably entails frustrating long trial and errors. It is timely to identify biomarkers that can predict analgesic efficacy for the individual patient.
- Trial name
- NCT05256342
- Testing
- Duloxetine 60mg, Etoricoxib 60 mg, omeprazol
- Where
- 2 sites in Israel
- Volunteers
- 17 people
- Sponsor
- Rambam Health Care Campus
Posttraumatic Stress Disorder
Exploring Efficacy of Multi-Mode Cognitive Processing Therapy (CPT) for PTSD
This study is a longitudinal, multicenter, single-blind, two-arm randomized controlled trial designed to evaluate the effectiveness of Multi-Modal Cognitive Processing Therapy (MMCPT) for individuals with posttraumatic stress…
- Trial name
- PTSD (NCT07105345)
- Testing
- Cognitive Processing Therapy (CPT), Treatment as Usual (TAU)
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Far Eastern Memorial Hospital
Trauma, Psychological, Personality Disorders
Strengthening the Healthy Adult Mode: a Case Experimental Study Exploring the Effects of a New Schema Therapy Protocol in an Adult Outpatient Population.
Background: Strengthening the Healthy Adult schema mode is the ultimate goal in Schema Therapy, working as an assumed mechanism of long-term change through improved positive mental health.
- Conditions
- Trauma, Psychological, Personality Disorders, Chronic Psychiatric Disorder
- Trial name
- ST-HA (NCT04466163)
- Testing
- Schema Therapy and the Healthy Adult
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Zuyderland Medisch Centrum
Chronic Idiopathic Urticaria
Mode of Action Study of Omalizumab in Patients With Chronic Idiopathic Urticaria (CIU) Who Fail to Respond to Antihistamine Treatment
The study is designed to explore the mode of action for omalizumab therapy in patients with chronic idiopathic urticaria.
- Trial name
- NCT01599637
- Testing
- IGE025
- Where
- 4 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Novartis Pharmaceuticals
Non Small Cell Lung Cancer
Immune Treatment of Brain Metastasis of Lung Cancer Combined With Large-segmentation Precision Radiotherapy
This is a prospective multicenter clinical study. This study aims to construct an auxiliary decision-making system for lung cancer immunotherapy combined with radiotherapy by fusing three modes of imagomics, clinicopathological…
- Trial name
- NCT05584267
- Testing
- radiotherapy, Chemotherapy + immunotherapy
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Hunan Province Tumor Hospital
Bone and Soft Tissue Tumors, Clinical Features
Study on Clinical Features, Treatment Mode and Survival of Bone and Soft Tissue Tumors
It is planned to prospectively collect, collate and report real-world clinical data of BSTS patients treated in our hospital in the next ten years to evaluate the changes in clinical characteristics, treatment patterns and…
- Trial name
- NCT05468970
- Testing
- NO Intervention
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Henan Cancer Hospital
Subacromial Impingement Syndrome
The Effect of Phonophoresis in Subacromial Impingement Syndrome.
Subacromial impingement syndrome (SIS) is a dysfunction caused by an impingement of the rotator cuff tendon between the head of the humerus and the acromion as a result of changes in the subacromial space.
- Trial name
- NCT04676919
- Testing
- phonophoresis therapy with pulsed mode ultrasound, phonophoresis therapy with continuous mode ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Cukurova University