Clinical trials: Moderate Asthma
Moderate Asthma
Study Comparing At-Home Mobile Spirometry to In-Clinic in Moderate Asthma Participants Taking Long-Acting Beta Agonist
The goal of this interventional study is to compare at-home mobile spirometry to in-clinic spirometry in participants with moderate asthma while taking a long-acting beta agonist (LABA).
- Trial name
- LEARN (NCT05757908)
- Testing
- Long-Acting Beta Agonist
- Where
- 9 sites in United States
- Volunteers
- 29 people
- Sponsor
- Koneksa Health
Moderate to Severe Allergic Asthma
A Clinical Study of Omalizumab in the Treatment of Allergic Asthma(ESSENCE)
Allergic asthma being the most widespread and easily identifiable phenotype, accounting for 60-80% of cases.Previous studies have reported that nearly 90% of patients with severe asthma were cases of allergic asthma, in which…
- Trial name
- ESSENCE (NCT06348407)
- Testing
- IgE monoclonal antibody
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Moderate to Severe Persistent Asthma
Efficacy and Safety of CBP-201 in Patients With Moderate to Severe Persistent Asthma With Type 2 Inflammation
This study will evaluate the efficacy, safety of two dose levels of CBP-201 in patients with moderate to severe persistent asthma with Type 2 inflammation.
- Trial name
- NCT04773678
- Testing
- CBP-201
- Where
- 76 sites in United States, China and 3 more
- Volunteers
- 322 people
- Sponsor
- Connect Biopharm LLC
Moderate to Severe Asthma
A Study of CM310 in Subjects With Moderate to Severe Asthma
This study is a multi-center, randomized, double-blind, placebo-controlled Phase Ⅱ/Ⅲ clinical study to evaluate the efficacy, safety, PK characteristics, PD effects and immunogenicity of CM310 in subjects with moderate to severe…
- Trial name
- NCT05761028
- Testing
- CM310
- Where
- China
- Volunteers
- 600 people
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Moderate to Severe Asthma
A Study of CM326 in Subjects With Moderate to Severe Asthma
This study is a multi-center, randomized, double-blind, placebo-controlled Phase Ⅱ clinical study to evaluate the efficacy, safety, PK characteristics, PD effects and immunogenicity of CM326 in subjects with moderate to severe…
- Trial name
- NCT05774340
- Testing
- CM326
- Where
- China
- Volunteers
- 207 people
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Asthma, Mild Asthma
MANI Real-life Perspective Observatory
The purpose of this registry aims is to collect a large number of patients with mild and moderate asthma in a real-word conditions for a perspective observation of epidemiological evolution of the disease in relation to the…
- Conditions
- Asthma, Mild Asthma, Moderate Asthma
- Trial name
- MANI (NCT04796844)
- Where
- Italy
- Volunteers
- 20,000 people
- Sponsor
- Societa Italiana di Pneumologia
Moderate to Severe Asthma
Study to Assess the Effect of Tezepelumab on the Immune Response to Influenza Vaccination in Participants With Asthma
This is a Phase 3b, multicenter, randomized, double-blind, parallel group, placebo-controlled study designed to investigate the potential effect of tezepelumab (210 mg subcutaneous [SC] every 4 weeks [Q4W]) on antibody responses…
- Trial name
- VECTOR (NCT05062759)
- Testing
- Tezepelumab
- Where
- 15 sites in United States
- Volunteers
- 70 people
- Sponsor
- AstraZeneca
Allergic Asthma, Uncontrolled Moderate to Severe
Efficacy and Safety of Zerafil® (Omalizumab) in Participants With Uncontrolled Moderate to Severe Allergic Asthma
The purpose of this study is to evaluate the efficacy and safety of Omalizumab produced by CinnaGen compared with Xolair® (Genentech, Inc., USA And Novartis Pharmaceuticals Corp, Switzerland) in subjects with uncontrolled…
- Trial name
- NCT05813470
- Testing
- Omalizumab (CinnaGen), Omalizumab (Genentech, Inc., USA and Novartis Pharmaceuticals Corp, Switzerland)
- Where
- 22 sites in Iran
- Volunteers
- 256 people
- Sponsor
- Cinnagen
Ulna Length in Otherwise Healthy Children (With the Exception of Mild to Moderate Asthma)
Ulna Length in Black Children
Height measurement is unreliable when neuromuscular weakness or spinal deformity is present. The aim of this study was to accurately predict pulmonary function from a limb segment (ulna) measurement that is precise and…
- Trial name
- ULNOIR (NCT04062422)
- Where
- France
- Volunteers
- 350 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Moderate Persistent Asthma
The Possible Efficacy and Safety of L-carnitine and Biotin as Adjunctive Therapies in Children With Moderate Persistent Asthma
The Possible Efficacy and Safety of L-carnitine and Biotin as Adjunctive Therapies in Children with Moderate Persistent Asthma
- Trial name
- NCT05632549
- Testing
- L-Carnitine 500Mg Oral Tablet, Biotin Capsules
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Tanta University
Moderate-to-severe Allergic Asthma
A Study to Assess the Impact of Omalizumab on Exercise Capacity, Physical Activity, and Sleep Quality in Participants With Moderate to Severe Allergic Asthma
This study will assess the effect of omalizumab on exercise capacity, physical activity, and sleep quality after 24 weeks of treatment in participants with moderate to severe allergic asthma.
- Trial name
- EDURO (NCT04195958)
- Testing
- Omalizumab
- Where
- 12 sites in United States
- Volunteers
- 3 people
- Sponsor
- Genentech, Inc.
Moderate Persistent Asthma, Severe Persistent Asthma
Expressions of TRPV1 in Airway of Asthmatics
The purpose of this study is to measure the density of a temperature-sensitive protein, named TRPV1, in the airway mucosa tissue of both non-asthmatic and moderate to severe persistent asthmatic patients.
- Conditions
- Moderate Persistent Asthma, Severe Persistent Asthma, Nodule Solitary Pulmonary, Pulmonary Atelectasis
- Trial name
- TRPV1 (NCT02952066)
- Testing
- Bronchial biopsy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Lu Yuan Lee
Moderate to Severe Asthma
Study of Multiple Ascending Dose of KBL693 in Healthy Participants
The study is designed to investigate the safety and tolerability of KBL693 in healthy volunteers. KBL693 has been developed as a potential new treatment for moderate to severe asthma..
- Trial name
- NCT04307173
- Testing
- KBL693
- Where
- Australia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- KoBioLabs
Asthma, Moderate Asthma
Study of Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of REGN3500 in Adults With Moderate Asthma
Purpose of this study is to assess the safety and tolerability of multiple ascending subcutaneous doses of REGN3500 to moderate asthmatics.
- Trial name
- NCT02999711
- Testing
- REGN3500
- Where
- 3 sites in United Kingdom
- Volunteers
- 23 people
- Sponsor
- Regeneron Pharmaceuticals
Moderate Asthma
A Study to Assess Pharmacokinetics, Safety and Tolerability of Multiple Doses of CAT-354 in Subjects With Moderate Asthma
The study includes participants with moderate asthma who were randomly assigned to receive the study medication (CAT-354) or placebo.
- Trial name
- NCT00974675
- Testing
- CAT-354 1mg/kg, CAT-354 5 mg/kg, CAT-354 10mg/kg
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- MedImmune LLC
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
Evaluate Safety of Technosphere® Insulin (TI) in Diabetic Subjects With Moderate Obstructive Pulmonary Disease
Examine the effects of TI in combination with an anti-diabetic regimen including inhaled insulin versus anti-diabetic treatment without inhaled insulin on lung function \& pulmonary safety
- Conditions
- Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Moderate Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT00642616
- Testing
- Technosphere® Insulin, Usual Care
- Where
- 21 sites in United States, Russia and 1 more
- Volunteers
- 34 people
- Sponsor
- Mannkind Corporation
Moderate Asthma
Effect of Bronchial Thermoplasty on Moderate Bronchial Asthma in China
This study aims to investigate the efficacy and safety of Bronchial Thermoplasty on moderate bronchial asthma in China, by observing the improvement of quality of life, the decrease of acute attack and emergence, as well as the…
- Trial name
- NCT02965807
- Testing
- Bronchial Thermoplasty
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Mild to Moderate Asthma
A Study to Compare the Bioavailability Intranasal Administration of 200 and 400 µg or 400 µg Alone of OPTINOSE™ FLUTICASONE With 440 µg of Flovent® HFA (Fluticasone Propionate) Inhalation Aerosol (Part 2)
To compare the systemic exposure of a single dose of 400 µg of OPTINOSE FLUTICASONE with 440 µg of Flovent® HFA (fluticasone propionate) Inhalation Aerosol in asthmatic subjects.
- Trial name
- NCT02266927
- Testing
- Flovent HFA, OPTINOSE™ FLUTICASONE
- Where
- Ireland
- Volunteers
- 28 people
- Sponsor
- Optinose US Inc.
Mild to Moderate Bronchial Asthma
Safety and Efficacy of SA09012 in Asthma
Clinical Study to Evaluate the Efficacy, Dose-response and Safety of SA09012 in Bronchial Asthma Patients
- Trial name
- NCT01740986
- Testing
- SA09012 Low dose, SA09012 High dose
- Where
- 14 sites in South Korea
- Volunteers
- 225 people
- Sponsor
- SamA Pharmaceutical Co., Ltd
Moderate-to-Severe Asthma
Effect of KB003 in Subjects With Asthma Inadequately Controlled by Corticosteroids
This study will evaluate the safety, tolerability and efficacy of a single dose level of KB003 in subjects with inadequately controlled asthma.
- Trial name
- KB003-04 (NCT01603277)
- Testing
- Anti-GM-CSF Monoclonal Antibody 400mg
- Where
- 70 sites in United States, Australia and 4 more
- Volunteers
- 160 people
- Sponsor
- Humanigen, Inc.