Clinical trials: Moderate Asthma, open to volunteers
Asthma
Intervention Effects of High-intensity Tai Chi in Mild or Moderate Asthma
1、 Research objective The main objective of this study is to investigate the therapeutic effect of a comprehensive lifestyle adjustment and stress management plan based on high-intensity Tai Chi on asthma patients.
- Trial name
- NCT06728904
- Testing
- Tai Chi intervention
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Yufen Wu, MD
Rhinitis, Rhinoconjunctivitis
Efficacy and Safety of SLIT in Patients With Rhinitis/RC With/Without Mild-moderate Asthma, Due to Dpt and/or Df
The goal of this clinical trial is to learn if MM09 works to treat patients allergic to house mites, displaying rhinitis/rhinoconjunctivitis with or without mild to moderate asthma. It will also learn about the safety of MM09.
- Trial name
- Oraltek-58 (NCT07348302)
- Testing
- Allergen Immunotherapy Extract
- Where
- 19 sites in Argentina, China and 2 more
- Volunteers
- 736 people
- Sponsor
- Inmunotek S.L.
Asthma, Asthma Chronic
Improving the Quality of Care for Asthma Patients at Risk of Exacerbations
The goal of this trial test two known effective asthma strategies. Treatment guidelines recommend combination therapy of inhaled corticosteroids (ICS) with a long-acting beta-agonist (LABA) inhaled medications.
- Conditions
- Asthma, Asthma Chronic, Asthma Severe Persistent With Exacerbation, Asthma Moderate Persistent With Exacerbation
- Trial name
- iCARE (NCT06596512)
- Testing
- PARTICS using a single ICS add on, MART
- Where
- 6 sites in United States
- Volunteers
- 4,100 people
- Sponsor
- Brigham and Women's Hospital
Asthma
Mechanism(s)of Airflow Limitation in Moderate-severe Persistent Asthma
The purpose of this study is to evaluate the site and mechanisms responsible for expiratory airflow limitation in chronic, treated, non-smoking, stable asthmatics with moderate to severe persistent expiratory airflow obstruction.
- Trial name
- NCT00576069
- Testing
- budesonide/formoterol, fluticasone/salmeterol, mometasone/formoterol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Gelb, Arthur F., M.D.
Asthma
A Randomized, Double-Blind, Placebo-Controlled Phase Ib Study of Multiple Ascending Doses of EB070 Injection in Adults With Moderate-to-Severe Asthma
This is a multicenter, randomized, double-blind, placebo-controlled, multiple-dose, dose-escalation Phase Ib clinical study designed to evaluate the safety, tolerability, pharmacokinetic (PK) and pharmacodynamic (PD)…
- Trial name
- NCT07886710
- Testing
- EB070
- Volunteers
- 20 people
- Sponsor
- Biotech Pharmaceutical Co., Ltd.
Allergic Asthma
Evaluate the Efficacy and Safety of FB825 in Adult With Allergic Asthma
This is a randomized, placebo-controlled and double-blind study to evaluate the efficacy and safety of FB825 in adult patients with moderate-to-severe allergic asthma.
- Trial name
- NCT05008965
- Testing
- FB825
- Where
- 13 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- Oneness Biotech Co., Ltd.
Asthma (Diagnosis), Persistent Asthma
Anakinra Rescue Treatment for Moderate Asthma Attacks (ARTMA)
In this single center, interventional pilot study, 40 participants at high risk for future exacerbation will be randomized to anakinra (v.
- Conditions
- Asthma (Diagnosis), Persistent Asthma, Moderate Asthma Exacerbation
- Trial name
- ARTMA (NCT07600190)
- Testing
- Anakinra 100 Mg/0.67 Ml Inj Syringe
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of North Carolina, Chapel Hill
Asthma Control
A Study Assessing the Effect of Dupilumab on Inducing Clinical Remission in Asthma
This study tests whether an asthma medication called dupilumab can help people achieve complete asthma control (called "remission") when given earlier in their disease, before asthma becomes severe.
- Trial name
- HOTHOT (NCT07309614)
- Testing
- Dupilumab Prefilled Syringe
- Where
- 5 sites in Australia, Canada and 1 more
- Volunteers
- 150 people
- Sponsor
- Université de Sherbrooke
Eosinophilic Asthma
A Multi-dose Study on the Safety and Efficacy of Self-administered Intranasal AD17002 Treatment for Eosinophilic Asthma
1. Eosinophilic asthma, a type 2 immune disorder, often involves the excessive production of type 2 cytokines. 2. Excessive Type 2 cytokines lead to chronic inflammation, airway hyperresponsiveness, and airflow obstruction. 3.
- Trial name
- NCT07250594
- Testing
- AD17002, Formulation buffer
- Where
- Taiwan
- Volunteers
- 126 people
- Sponsor
- Advagene Biopharma Co. Ltd.
Moderate to Severe Asthma
A Phase III Study of CM326 in Subjects With Moderate to Severe Asthma
This study is a multi-center, randomized, double-blind, placebo-controlled Phase Ⅲ clinical study to evaluate the efficacy, safety, PK characteristics, PD effects and immunogenicity of CM326 in subjects with moderate to severe…
- Trial name
- NCT07372287
- Testing
- CM326
- Where
- China
- Volunteers
- 230 people
- Sponsor
- CSPC Baike (Shandong) Biopharmaceutical Co., Ltd.
Asthma, Mild Asthma
MANI Real-life Perspective Observatory
The purpose of this registry aims is to collect a large number of patients with mild and moderate asthma in a real-word conditions for a perspective observation of epidemiological evolution of the disease in relation to the…
- Conditions
- Asthma, Mild Asthma, Moderate Asthma
- Trial name
- MANI (NCT04796844)
- Where
- Italy
- Volunteers
- 20,000 people
- Sponsor
- Societa Italiana di Pneumologia
Rhinitis, Allergic, Rhinoconjunctivitis
Efficacy and Safety Evaluation for the Treatment of Allergy Against Mites
A double-blinded, placebo-controlled, prospective, multicenter randomized of 2 active treatment groups, compared to 1 placebo group, for the determination of the efficacy and safety of subcutaneous immunotherapy in patients with…
- Conditions
- Rhinitis, Allergic, Rhinoconjunctivitis, Asthma, Allergic
- Trial name
- MM09-SIT-023 (NCT04435990)
- Testing
- 10,000 MM09, 30,000 MM09
- Where
- 32 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Inmunotek S.L.
Moderate to Severe Asthma
PULmonary Stimulation for Asthma Relief
This study aims to assess the safety and efficacy of Pulmonary Neuromodulation in patients suffering from moderate to severe asthma
- Trial name
- PULSAR (NCT07709754)
- Testing
- Spinal Cord Stimulation
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Spiro Medical, Inc.
Allergic Asthma
Efficacy, Safety, and Pharmacokinetics of LP-003 Injection in Allergic Asthma Patients
This is a multicenter, randomized, masked, active and placebo controlled, Phase II clinical study to evaluate the efficacy, safety, and pharmacokinetics of LP-003 injection in adult patients with moderate to severe persistent…
- Trial name
- NCT07342803
- Testing
- LP-003 Injection, Omalizumab
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Longbio Pharma
Asthma Acute, Asthma Attack
Nebulized Ketamine Plus Standard Care vs. Standard Care Alone in Moderate to Severe Asthma Exacerbations
The goal of this clinical trial is to learn if nebulized ketamine helps treat moderate to severe asthma attacks in adults in the emergency department.
- Conditions
- Asthma Acute, Asthma Attack, Asthma Exacerbations
- Trial name
- KET-AIR (NCT07112456)
- Testing
- Nebulized ketamine (0.5 mg/kg in normal saline to a total volume of 5ml) plus standard asthma excaerbationcare
- Where
- Oman
- Volunteers
- 100 people
- Sponsor
- Oman Medical Speciality Board
Asthma
Clinical Trial of MG-K10 in Stage III of Moderate to Severe Asthma
A randomized, double-blind, placebo-controlled Phase III clinical trial on the efficacy and safety of MG-K10 humanized monoclonal antibody injection in adolescent and adult patients with moderate to severe asthma.
- Trial name
- NCT06837922
- Where
- China
- Volunteers
- 504 people
- Sponsor
- Shanghai Mabgeek Biotech.Co.Ltd
Asthma
Measuring the Effect of Dupilumab Treatment on Mucociliary Clearance (MCC) in Subjects With Moderate to Severe Asthma
Single center, randomized, placebo- controlled study to assess change in mucociliary clearance of moderate to severe asthma patients after treatment with dupilumab or placebo.
- Trial name
- NCT04743791
- Testing
- Dupilumab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Sally E. Wenzel MD
Asthma Exacerbations, Biomarkers / Blood
Blood Eosinophil Guided Versus Usual Care In The Management Of Mild To Moderate Asthma at Primary Care (BEAM)
The aim of this study is to evaluate usual care versus biomarker-directed care (using blood eosinophil counts) for the management of asthma patients in primary care setting.
- Conditions
- Asthma Exacerbations, Biomarkers / Blood, Eosinophil Blood Count
- Trial name
- BEAM (NCT07486401)
- Testing
- Biomarker-directed treatment for asthma management, Usual Care
- Where
- Singapore
- Volunteers
- 240 people
- Sponsor
- National Healthcare Group Polyclinics
Asthma
ENV-294 for Moderate-to-Severe Asthma: A 12-Week Study in Adults
This study will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and potential efficacy of ENV-294 in adults with moderate to severe asthma who are receiving background treatment with inhaled…
- Trial name
- NCT07301255
- Testing
- ENV-294
- Where
- 20 sites in United States
- Volunteers
- 50 people
- Sponsor
- Enveda Therapeutics
Asthma
Study to Evaluate the Safety, Pharmacology and Efficacy of WIN378 in Adults With Moderate or Severe Asthma
This is a global Phase 2 study divided in two parts. Part A is a double-blind, randomized dose-range finding study in adults with moderate to severe asthma to confirm the dosing regimen of WIN378 that can be tested in future…
- Trial name
- Polaris (NCT07120503)
- Testing
- WIN378
- Where
- 73 sites in United States, Argentina and 6 more
- Volunteers
- 600 people
- Sponsor
- Windward Bio