Clinical trials: Moderate Depression
Cancer
Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain
RATIONALE: Ketamine hydrochloride may lessen neuropathic pain in patients with cancer. It is not yet known whether ketamine hydrochloride given together with the best pain management is more effective than a placebo given…
- Trial name
- NCT01316744
- Testing
- ketamine hydrochloride, pharmacogenomic studies, questionnaire administration
- Where
- 3 sites in United Kingdom
- Volunteers
- 214 people
- Sponsor
- University of Glasgow
Hepatic Impairment
Pharmacokinetics of AGO178 in Participants With Liver Impairment
AGO178 was developed for the treatment of depression. A new formulation is being tested in the present study: a tablet to be placed and dissolved under the tongue (sublingual tablet).
- Trial name
- NCT01531309
- Testing
- AGO178
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Perimenopause, Depression
Effectiveness and Safety of Electro-acupuncture for Mild-to-moderate Perimenopausal Depression
Main objective: to compare the effects of electro-acupuncture and escitalopram oxalate tablets on mild-to-moderate perimenopausal depression, and to evaluate the safety of electroacupuncture stimulation.
- Trial name
- NCT02423694
- Testing
- electro-acupuncture, escitalopram oxalate tablets
- Where
- China
- Volunteers
- 252 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Major Depression
A Study to Evaluate SAGE-217 in Participants With Moderate to Severe Major Depressive Disorder
This is a two-part (open-label followed by double-blind) study evaluating the safety, tolerability, pharmacokinetics, and efficacy of SAGE-217 in 102 participants diagnosed with moderate to severe Major Depressive Disorder.
- Trial name
- NCT03000530
- Testing
- SAGE-217
- Where
- 8 sites in United States
- Volunteers
- 102 people
- Sponsor
- Biogen
Depressive Disorder, Major, Anhedonia
A Study of Aticaprant as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy
The purpose of this study is to evaluate the efficacy of aticaprant compared with placebo as adjunctive therapy to an antidepressant in improving depressive symptoms in adult participants with major depressive disorder (MDD) with…
- Trial name
- VENTURA-1 (NCT05455684)
- Testing
- Aticaprant
- Where
- 120 sites in United States, Argentina and 11 more
- Volunteers
- 513 people
- Sponsor
- Janssen Research & Development, LLC
Mild to Moderate Depressive Symptoms
Effectiveness of Internet-based Depression Treatment
Care for people suffering from depressive symptoms should be given in a step-wise approach. One first step can be the provision of self-help material. Online self-help is an innovative way of providing self-help.
- Trial name
- EVIDENT (NCT01636752)
- Testing
- Deprexis
- Where
- 4 sites in Germany
- Volunteers
- 1,013 people
- Sponsor
- University of Luebeck
Depressive Disorder, Major
A Study of Participants With Moderate or Severe Major Depressive Disorder (MDD) Requiring Urgent Symptom Control in a Psychiatric Emergency
The purpose of the study is to describe the clinical outcomes (severity of depression, severity of suicidality \& frequency of suicidal thinking, suicide events) and quality of life (QoL) of participants with symptoms of major…
- Trial name
- POWER (NCT04829669)
- Sponsor
- Janssen-Cilag Ltd.
Depression
Clinical Study of Cang Ai Volatile Oil (CAVO) on Mild to Moderate Depression in Children and Adolescents
A randomized controlled trial was conducted to observe the improvement of mild to moderate depressive symptoms in children and adolescents with the aromatic herbal compound Cang Ai Volatile Oil (CAVO) and to evaluate the…
- Trial name
- NCT05789186
- Testing
- CAVO aromatherapy patch at 3% concentration+Fluoxetine hydrochloride mimetic, Fluoxetine hydrochloride tablet+CAVO aromatherapy patch at 0.1% concentration, Fluoxetine hydrochloride mimetic+CAVO aromatherapy patch at 0.1% concentration
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Chen Qian
Depression, Post-COVID-19 Syndrome
Evaluation of DEPREXIL in Patients With Clinical Depression Through Psychological and Neuroendocrine Assessment
Clinical depression is a mood disorder that affects people of all ages with symptoms such as sadness, anger or frustration, appetite changes, difficulty concentrating and suicidal thoughts.
- Conditions
- Depression, Post-COVID-19 Syndrome, Depression Mild, Depression Moderate
- Trial name
- NCT06496087
- Testing
- DEPREXIL
- Where
- Colombia
- Volunteers
- 100 people
- Sponsor
- Catalysis SL
Major Depressive Disorder (MDD)
Group Acceptance and Commitment Therapy (ACT) Among Depressive Patients in Kelantan, Malaysia
The goal of this clinical trial is to learn if group acceptance and commitment therapy works to improve depressive symptoms, psychological flexibility and quality of life in adults. The main questions it aims to answer are: 1.
- Trial name
- Group ACT (NCT06710912)
- Testing
- Group acceptance and commitment therapy (ACT), Treatment as usual
- Where
- Malaysia
- Volunteers
- 44 people
- Sponsor
- Universiti Sains Malaysia
Depression, Mild or Moderate
Green VR for Depression
Depression is a common mental health condition that can cause low mood, lack of energy, sleep problems, and difficulties in daily functioning.
- Trial name
- VR&depression (NCT07530952)
- Testing
- Studio-based VR experiences, Self-managed VR experiences, Standard Treatment
- Where
- Norway
- Volunteers
- 45 people
- Sponsor
- Sykehuset Innlandet HF
Healthy, Depression Symptoms
Effects of a Single-bout of Moderate-intensity Aerobic Exercise on Mood and Mental Health Biomarkers in Adults with Depressive And/or Anxiety Symptoms
This study investigates whether a single session of aerobic exercise (like running) can improve the participants' mood and whether such benefits can be explained by changes in the blood factors (like hormones) and brain activity.
- Conditions
- Healthy, Depression Symptoms, Anxiety Symptoms
- Trial name
- NCT06736067
- Testing
- Exercise
- Where
- Hong Kong
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- YAU Suk Yu Sonata
Depression Mild, Depression Moderate
Factorial Trial Investigating Outcome and Adherence Relevant Factors in an Online Self-help Intervention for Depression
A vast amount of studies show that online interventions are suitable to reduce symptoms of mental illness as for instance depression or anxiety.
- Trial name
- HERMES (NCT04318236)
- Testing
- HERMES (Online Self-Help Intervention based on problem-solving therapy)
- Where
- Switzerland
- Volunteers
- 316 people
- Sponsor
- University of Bern
Depression, Unspecified Adult Solid Tumor, Protocol Specific
Sertraline Compared With Hypericum Perforatum (St.John's Wort) in Treating Depression
RATIONALE: Antidepressants such as sertraline and the herb hypericum perforatum (St. John's wort) may be effective in treating mild to moderate depression.
- Trial name
- NCT00066859
- Testing
- Zoloft 50 mg, St. John's Wort 600 mg
- Where
- 6 sites in United States
- Volunteers
- 2 people
- Sponsor
- Wake Forest University Health Sciences
Treatment Resistant Depression
KET-RO Plus RO DBT for Treatment Resistant Depression
This pilot study will assess the safety and feasibility of intravenous (IV) ketamine combined with RO DBT in young adults with Treatment-Resistant Depression (TRD).
- Trial name
- KET-RO (NCT06138691)
- Testing
- Ketamine Infusion plus RO DBT
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Washington University School of Medicine
Depressive Symptoms
Physical Exercise and Depressive Symptoms in Moderately or Severely Depressed Adults
This study is a comparative trial comparing the time course of depressive symptoms between moderately and severely depressed participants over a 10-week long exercise program
- Trial name
- EXIMOS (NCT05703776)
- Testing
- Nordic Walking
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Je Bouge Pour Mon Moral
Depression
Efficacy of an Online Program for the Treatment of Mild and Moderate Depression
iFighDepression is an online self-help programme based on cognitive-behavioral therapy that could be useful for the treatment of mild to moderate depression
- Trial name
- NCT02312583
- Testing
- Psychoeducational online information, iFightDepression online programme
- Where
- 5 sites in Spain
- Volunteers
- 310 people
- Sponsor
- Parc de Salut Mar
Depression
Efficacy of Rice Bran Extract in Mildly to Moderately Depressed Adults
The investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects and tolerability of rice bran extract on depressive symptoms and related biomarkers in mildly to moderately depressed…
- Trial name
- NCT05180136
- Testing
- Rice bran extract group, Control group
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Depression
Lifestyle Modification Program in the Prevention and Treatment of Depression
Introduction: Major depression is a highly prevalent pathology that is currently the second most common cause of disease-induced disability in our society.
- Trial name
- NCT03951350
- Testing
- Lifestyle Modification Program (LMP), Lifestyle Modification Program (LMP) + Information Communication Technologies (ICTs)
- Where
- Spain
- Volunteers
- 159 people
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Depression, Anxiety
Mitigating Mental Health Issues Among Women's Sport Student-Athletes Through a Moderate-Intensity Exercise Intervention
The goal of this clinical trial is to learn about moderate-intensity indoor cycling interventions in women's sport student-athletes transitioning into college and collegiate sport.
- Conditions
- Depression, Anxiety, Stress, Psychological
- Trial name
- NCT06182150
- Testing
- Moderate-Intensity Indoor Cycling Exercise
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill