Clinical trials: Moderate Depression, active
Depressive Disorder
Comparison of Esketamine Nasal Spray vs.Aripiprazole in Treat.Resistant Major Depressive Disorder in Elderly Patients
Phase III, open label, randomised, multicentre, blind for evaluators clinical trial to evaluate the efficacy of esketamine nasal spray at flexible dosis compared to aripiprazole in elderly participants (>60 years) who suffer from…
- Trial name
- CESAR (NCT07153406)
- Testing
- Experimental regimen, Control regimen
- Where
- 9 sites in Spain
- Volunteers
- 220 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Breast Cancer, Breast Cancer Female
Abbreviated MBCT for Depression in Older Black or African American Breast Cancer Survivors
The purpose of this research study is to develop and test an intervention designed to improve mood and reduce symptoms of depression.
- Conditions
- Breast Cancer, Breast Cancer Female, Breast Cancer Stage I, Breast Cancer Stage II
- Trial name
- NCT06336538
- Testing
- MBCT
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Case Comprehensive Cancer Center
Major Depression Moderate, Major Depression Severe
Virtual Reality-Augmented At-Home tDCS for Major Depression
The goal of this clinical trial is to investigate the efficacy of combining Virtual Reality (VR)-based relaxation and Transcranial Direct Current Stimulation (tDCS) for treating Major Depression.
- Trial name
- VR-TMD (NCT07146269)
- Testing
- tDCS, VR-based relaxation therapy
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Technical University of Munich
Postoperative Complications, Respiratory Depression
Comparison of Remimazolam and Propofol in Endoscopic Examinations and Treatments
This study aims to evaluate the efficacy and safety of Remimazolam, either used alone or in combination with Propofol, for moderate sedation anesthesia during endoscopic therapies or examinations.
- Conditions
- Postoperative Complications, Respiratory Depression, Postoperative Nausea, Vomiting
- Trial name
- Remimazolam (NCT06777758)
- Testing
- Remimazolam, Propofol
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Anxiety, Mild to Moderate Depression
Guided Internet-based Interventions in Primary Care Effectiveness-implementation Randomized Controlled Trial
Internet-based cognitive behavioral therapy for anxiety and depression have far-reaching potential to overcome common barriers to accessing evidence-based treatment, such as waiting lists, travel distance and costs.
- Trial name
- INTERMENTAL (NCT05118828)
- Testing
- Guided internet-based cognitive behavioural therapy, Treatment as usual in Prompt Mental Health Care (TAU-PMHC)
- Where
- 6 sites in Norway
- Volunteers
- 1,000 people
- Sponsor
- Norwegian Institute of Public Health
Mild-to-moderate Depression, Neural Activity
Probiotics for Depressive Symptomatology and Neural Activity.
This study aims to investigate the acute and chronic effects of 16-week probiotic supplementation (Ecologic® Barrier) on depressive symptoms and neural activity in those with mild-to-moderate depression.
- Conditions
- Mild-to-moderate Depression, Neural Activity, Executive Function (Cognition)
- Trial name
- PRODAN (NCT07667530)
- Testing
- Ecologic® Barrier
- Where
- United Kingdom
- Volunteers
- 76 people
- Sponsor
- University of Reading
Depression and/or Anxiety in the Mild-to-moderate Range, Stress (Psychology)
SanaMente: A Peer-Led Program to Reduce Health Disparities in Rural Latino/a Communities
The goal of this clinical trial is to evaluate the feasibility, acceptability, and preliminary effectiveness of the SanaMente peer-led mental health and lifestyle program for rural Latino/a adults with chronic medical conditions…
- Conditions
- Depression and/or Anxiety in the Mild-to-moderate Range, Stress (Psychology), Chronic Medical Illness
- Trial name
- SanaMente (NCT07705776)
- Testing
- SanaMente
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Major Depressive Disorder
A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder
X-NOVA2 is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the clinical efficacy, safety, and tolerability of azetukalner as a monotherapy in adult participants diagnosed with Major…
- Trial name
- X-NOVA2 (NCT06775379)
- Testing
- Azetukalner
- Where
- 45 sites in United States
- Volunteers
- 450 people
- Sponsor
- Xenon Pharmaceuticals Inc.
PTSD, Post Traumatic Stress Disorder, Major Depressive Disorder
Ketamine Treatment for PTSD and MDD in TBI
The goal of this clinical trial is to examine the use of sedative ketamine to treat depression and post-traumatic stress disorder (PTSD) in Veterans with mild to moderate traumatic brain injury (TBI).
- Conditions
- PTSD, Post Traumatic Stress Disorder, Major Depressive Disorder, Traumatic Brain Injury
- Trial name
- NCT06228391
- Testing
- IV ketamine, Midazolam
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Major Depressive Disorder
Home-Based Wearable rTMS Therapy for Moderate to Severe Depression
Background and Rationale With rapid economic development and increasing societal pressures, the incidence of neuropsychiatric disorders has risen annually, ranking as the leading cause of disability worldwide and imposing a…
- Trial name
- NCT07775586
- Testing
- rTMS-Tiny Treatment
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Shanghai Mental Health Center
Rheumatoid Arthritis, Sjogren's Syndrome
Creating Health Course Study for People With Rheumatological Conditions and Mood Disorders
The goal of this project is to critically evaluate the effectiveness of an online health program designed to improve diet and self-care in patients with rheumatological conditions, including rheumatoid arthritis (RA), Sjogren's…
- Conditions
- Rheumatoid Arthritis, Sjogren's Syndrome, Systemic Lupus Erythematosus, Mixed Connective Tissue Disease
- Trial name
- NCT07180537
- Testing
- Creating Health Online Course, Delayed access to Creating Health Online Course
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Terry L. Wahls
Fibromyalgia Syndrome
Effects of Basic Body Awareness Therapy Added to Aerobic Exercise in Women With Fibromyalgia
This study aims to investigate the effects of Basic Body Awareness Therapy combined with aerobic exercise on inflammatory biomarkers (interleukin-6 and cortisol), cognitive functions, and depression levels in women diagnosed with…
- Trial name
- BBAT-FMS (NCT07851896)
- Testing
- Basic Body Awareness Therapy, Moderate-Intensity Aerobic Exercise
- Volunteers
- 40 people
- Sponsor
- Hacer Önen Tekin
Mental Health, Depression and/or Anxiety in the Mild-to-moderate Range
Effect of a Programme Including an AI-enhanced Mobile Application on the Mental Well- Being of Young Adolescents in Hong Kong
Study Aim and Methods (≈250 words) It aims to evaluate the effectiveness, user perceptions, and applicability of the e-CAMP intervention in improving mental well-being and reducing depressive symptoms among adolescents aged 11-15…
- Trial name
- AI-eCAMP_RCT (NCT07704996)
- Testing
- Control Group :health talk and usual care by school, mobile app group
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Tung Wah College
Major Depressive Disorder, Recurrent, in Remission, Major Depressive Disorder, Recurrent, Mild
Mindfulness-Based Cognitive Therapy (MBCT) for the Prevention of Depression Relapse or Recurrence Using Videoconference
Objectives: To evaluate the clinical- and cost-effectiveness of two delivery formats of mindfulness-based cognitive therapy (MBCT) - (i) MBCT delivered through eight videoconference group sessions (group MBCT), and (ii) MBCT…
- Conditions
- Major Depressive Disorder, Recurrent, in Remission, Major Depressive Disorder, Recurrent, Mild, Major Depressive Disorder, Recurrent, Moderate
- Trial name
- BECOME (NCT06832605)
- Testing
- Group Mindfulness-Based Cognitive Therapy, Mindfulness-Based Cognitive Therapy Self-Help, Treatment as Usual (TAU)
- Where
- 5 sites in Spain
- Volunteers
- 342 people
- Sponsor
- Fundació Sant Joan de Déu
Depression Mild, Depression
fMRI Neurofeedback With Matter Neuroscience App
Study will utilize an app, Matter Neuroscience, designed to help users with depression understand positive emotions and the neurotransmitters that create them.
- Conditions
- Depression Mild, Depression, Depression Moderate
- Trial name
- NCT06735885
- Testing
- Matter Neuroscience App, Stock Photos, No Home Training
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Stanford University
Depression and/or Anxiety in the Mild-to-moderate Range, Cognitive Behavioral Therapy
Internet-Based Cognitive Behavioural Therapy (iCBT) for Anxiety and Depression in Singapore
Cognitive-behavioural therapy (CBT) has a robust evidence base for treating anxiety disorders and depression, including transdiagnostic CBT. Internet-based CBT (iCBT) offers a new approach to delivering these therapies.
- Trial name
- NCT07532551
- Testing
- Internet-delivered cognitive behavioural therapy (iCBT)
- Where
- 3 sites in Singapore
- Volunteers
- 390 people
- Sponsor
- National University of Singapore
Working Memory, Mild to Moderate Depression
Cross-over Study on the Influence of Fampridine on Working Memory in Mild to Moderate Depression
Cognitive deficits, including working memory deficits, are often present in depression and there are currently no effective pharmacological treatments targeting working memory deficits. Papassotiropoulos et al.
- Trial name
- FamD_2025 (NCT06751784)
- Testing
- Fampridine SR
- Where
- Switzerland
- Volunteers
- 38 people
- Sponsor
- University of Basel
Depressive Symptoms Mild to Moderate in Severity
A Pilot Study of Synbiotics in Adults With Depressive Symptoms
This study aims to explore the efficacy and safety of a synbiotic formula (MQU10) in improving mood and well-being in adults with mild to moderate depressive symptoms.
- Trial name
- NCT06905223
- Testing
- MQU10
- Where
- 2 sites in Hong Kong
- Volunteers
- 30 people
- Sponsor
- GenieBiome Limited
Mild to Moderate Depressive Symptoms
Online Self-healing Program
Background. Almost two thirds of adolescents experience a mental disorder before the age of 25. Among mental disorders, depression is one of the most common among young people aged between 15 to 24, with a prevalence of 13.5% to…
- Trial name
- iCBT-A (NCT07374653)
- Testing
- Online Cognitive Behaviural Therapy, Online Relaxation
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- City University of Hong Kong
Depression
Improvement of Depression With Use of ATP
This clinical study is a randomized, double-blind, placebo-controlled trial with an intervention period of 4 weeks. Participants will be patients with moderate to severe depression who meet the inclusion criteria during the…
- Trial name
- NCT06266715
- Testing
- ATP Group
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Nanfang Hospital, Southern Medical University