Clinical trials: Moderate Pain in Knee Osteoarthritis, active
Knee Osteoarthritis (Mild to Moderate, Medial Compartment)
Enhancing Medial Knee Pain Rehabilitation : A Clinical Trial On The Effectiveness Of Blood Flow Restriction In Combination With Targeted Exercises For Adult With Varus Deformity
Medial knee pain is common in active adults with varus knee alignment and can limit daily and sports activities. Standard physiotherapy can reduce pain and improve function, but strength gains may be suboptimal when patients…
- Trial name
- NCT07283237
- Testing
- Targeted Exercise Program, Blood Flow Restriction (BFR) Training with Targeted Exercise Program
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Osteoarthritis (OA) of the Knee, Neuromodulation
Percutaneous Neurostimulation in Knee Osteoarthritis
Peripheral nerve stimulation (PNS) is a drug-free pain management procedure that uses electrical impulses to target specific nerves and block pain signals.
- Trial name
- NCT07637682
- Testing
- nerve stimulation using a nerve stimulator to the genicular nerve, nerve stimulation using a nerve stimulator to the saphenous nerve
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Tanta University
Osteo Arthritis Knee
Safety and Tolerability of StroMel™ in Subjects with Moderate to Severe Osteoarthritis of the Knee Joint
The aim of this trial is to evaluate the safety and tolerability of autologous StroMel™ for the treatment of moderate to severe OA of the knee joint.
- Trial name
- NCT04750252
- Testing
- StroMel
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Akan Biosciences, LLC
Knee Osteoarthritis
Ultrasound Guided Intra Articular Injection of Platelet Rich Fibrin Versus Hyaluronic Acid As Means of Pain Relief in Patients with Moderate Degree Knee Osteoarthritis
Randomised controlled trial
- Trial name
- NCT06797960
- Testing
- Ultra sound guided Injection of PRF intra articularly, Intra articular injection of HA
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Mild Knee Osteoarthritis, Moderate Knee Osteoarthritis
The Efficacy and Safety Study of 2107 Injection in Subjects With Mild to Moderate Knee Osteoarthritis
This will be a 26-week, prospective, international, multi-center, randomized, active-controlled, double-blinded (to subject and Investigator) study in subjects with mild to moderate OA in the knees to assess safety and efficacy…
- Trial name
- NCT07746843
- Testing
- 2107 Injection, DUROLANE®
- Where
- 3 sites in Poland, Spain and 1 more
- Volunteers
- 286 people
- Sponsor
- BioRegen Biomedical (Changzhou) Co., Ltd
Osteoarthritis, Osteo Arthritis Knee
An Study to Evaluate Safety and Tolerability of OA-SYS in Subjects With Moderate to Severe Osteoarthritis of the Knee Joint
This study is being conducted to evaluate the safety and tolerability of OA-SYS in patients with moderate to severe OA of the knee joint.
- Trial name
- OA-SYS-01 (NCT06485843)
- Testing
- OA-SYS
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Ageless Biotech, Inc.
Gonarthrosis; Primary
Intra-articular Infiltration of Platelet-Rich Fibrin vs Corticosteroid in Mild to Moderate Knee Osteoarthritis
Methodology: Randomized double-blind clinical trial comparing intra-articular injection of Platelet-Rich Fibrin (PRF) versus intra-articular injection of corticosteroids in mild to moderate arthrosis of the knee.
- Trial name
- iPRF (NCT06905860)
- Testing
- Platelet-rich fibrin (PRF), Corticosteroid
- Where
- Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Osteoarthritis, Osteoarthritis (OA) of the Knee
Effect of Autologous Ear Cartilage Micrografting in Knee Osteoarthritis
The goal of this clinical trial is to learn if a single injection of autologous cartilage micrografts suspension, obtained through processing with a specialized technology patient's own small piece of ear cartilage, can improve…
- Conditions
- Osteoarthritis, Osteoarthritis (OA) of the Knee, Moderate Osteoarthritis
- Trial name
- EAR2KNEE (NCT07755579)
- Testing
- Mytocel MSK - Autologous Ear Cartilage Micrografting
- Where
- Hungary
- Volunteers
- 33 people
- Sponsor
- Regenera Activa Worldwide S.L.
Osteoarthritis, Knee
Performance of CCoat Intra-Articular Injections in Mild to Moderate Knee Osteoarthritis: A Prospective, Randomized, Double-Blind, Multi-center Trial
Performance of CCoat Intra-Articular Injections in Mild to Moderate Knee Osteoarthritis: A Prospective, Randomized, Double-Blind, Multi-center Trial
- Trial name
- NCT07052851
- Testing
- CCoat, Liposphere Ltd, Synvisc-One® (hylan G-F 20)
- Volunteers
- 200 people
- Sponsor
- Lipo-Sphere
Knee Osteoarthritis, Blood Flow Restriction Therapy
Different Levels of Blood Flow Restriction Versus Moderate Intensity Exercises in Patients With Knee Osteoarthritis
This clinical trail will be conducted to investigate the effect of blood flow restriction (BFR) with different load levels between low blood occlusion percentage (50%) group and high blood occlusion percentage (70%) compared to…
- Trial name
- NCT06637124
- Testing
- Blood Flow Restriction Therapy Device, 45° leg-press machine, 90°-0° of knee flexion knee extension machine, leg curl machine and calf raise machine.
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Cairo University
Osteoarthitis, Osteoarthritic Knee Pain
Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection
The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee.
- Conditions
- Osteoarthitis, Osteoarthritic Knee Pain, Osteoarthritis (OA), Osteoarthritis (OA) of the Knee
- Trial name
- Medial OA CSI (NCT07804446)
- Testing
- Anteromedial Injection, Anterolateral Injection
- Where
- 5 sites in United States
- Volunteers
- 140 people
- Sponsor
- University of Chicago
Knee Osteoarthritis (Knee OA)
Phase II/III Randomized Trial of UC-MSC Secretome vs Sodium Hyaluronate in Knee Osteoarthritis
This study is a randomized, double-blind, multicenter Phase II/III clinical trial designed to evaluate the effectiveness and safety of umbilical cord-derived mesenchymal stem cell (UC-MSC) secretome compared with sodium…
- Trial name
- SECRET-OA (NCT07337863)
- Testing
- UC-MSC-Derived Secretome, Sodium Hyaluronate (Hyalein)
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Universitas Sriwijaya
Knee Osteoarthritis
HILT Dose Optimization for Knee Osteoarthritis Pain
This study aims to find the best settings (dose) for High-Intensity Laser Therapy (HILT) to reduce pain and improve function in people with moderate knee osteoarthritis.
- Trial name
- NCT06916676
- Testing
- Low-Dose High-Intensity Laser Therapy (10 J/cm²), Medium-Dose High-Intensity Laser Therapy (15 J/cm²), High-Dose High-Intensity Laser Therapy (20 J/cm²)
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Al Hayah University In Cairo
Knee Osteoarthritis
"Effectiveness of Mulligan Mobilization Technique and Proprioceptive Exercises Among Patients With Knee Osteoarthritis"
This research analyzes the effectiveness of Mulligan mobilization in comparison to proprioceptive exercises for treating patients with mild to moderate Knee osteoarthritis whose condition falls under Kellgren and Lawrence grading…
- Trial name
- MWMPETKOA (NCT06971016)
- Testing
- Mulligan Mobilization technique, Proprioceptive Exercises, Traditional Physical therapy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- National Healthcare Center
Knee Osteoarthritis
Cartilage Biomarker Response to Acute Mechanical Loading in Women With Knee Osteoarthritis: Comparison by Antiresorptive Treatment Status
This study evaluates how acute mechanical loading affects cartilage degradation biomarkers in postmenopausal women with mild-to-moderate knee osteoarthritis.
- Trial name
- NCT07881861
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Knee Pain Chronic, Osteoarthritis
Persona Total Knee Arthroplasty Outcomes Study
The primary objective of this study is to obtain implant survivorship and clinical outcomes data for commercially available Persona fixed bearing knee implants used in total knee arthroplasty.
- Conditions
- Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
- Trial name
- NCT02255383
- Testing
- Zimmer Persona Total Knee System
- Where
- 14 sites in United States
- Volunteers
- 737 people
- Sponsor
- Zimmer Biomet