Clinical trials: Moderate Traumatic Brain Injury (TBI)
Cerebral Palsy, Traumatic Brain Injury
Targeted Training for Trunk Control_case Series Cerebral Palsy
If a child with cerebral palsy does not develop independent sitting balance by 4 years of age, their prognosis for walking is very poor.
- Trial name
- CP_TT (NCT02097836)
- Testing
- Targeted Training
- Volunteers
- 11 people
- Sponsor
- University of Oregon
Pituitary Disorders, Traumatic Brain Injury
The PIT-TBI Pilot Study
Damage to the pituitary gland is a frequently overlooked but potentially important complication of traumatic brain injury (TBI). Disorders of the pituitary gland can cause dysfunction of the thyroid, adrenals, ovaries and testes.
- Trial name
- NCT02480985
- Testing
- Pituitary function evaluation
- Where
- 5 sites in Canada
- Volunteers
- 70 people
- Sponsor
- CHU de Quebec-Universite Laval
Moderate Traumatic Brain Injury
MLC901 in Moderate Traumatic Brain Injury
This study wants to evaluate whether MLC901 will help improve the condition of adult patients with moderate traumatic brain injury.
- Trial name
- ANDROMEDA (NCT04766281)
- Testing
- MLC901
- Where
- 3 sites in Philippines
- Volunteers
- 120 people
- Sponsor
- University of the Philippines
Traumatic Brain Injuries
Anti-inflammatory Effect of MgSO₄ in Patients With Moderate Traumatic Brain Injury by Measurming Nucleotide-binding Oligomerization Domain-Like Receptor Pyrin Domain-containing 3 (NLRP3) Inflammasome-a Multiprotein Complex
The primary objective of this study is to evaluate the biochemical efficacy of Magnesium Sulfate (MgSO₄) as an anti-inflammatory therapeutic agent in patients suffering from moderate traumatic brain injury (TBI) at Assiut…
- Trial name
- NCT07763665
- Testing
- Magnesium sulfate (MgSO4), Normal Saline
- Volunteers
- 64 people
- Sponsor
- Assiut University
Traumatic Brain Injury
Effects of Moderate/Severe Traumatic Brain Injury in the Subacute or Chronic Phase on Locomotor Strategies Involved in Navigation in Complex Virtual Environments
While clinical assessment of locomotor function in this population is carried out using tasks involving walking in a straight line without any obstacles, it does not take into account ecological situations (i.e., situations…
- Trial name
- NAVIGO (NCT07230002)
- Testing
- Locomotion in a virtual reality setting
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pôle Saint Hélier
Traumatic Brain Injury
Growth Hormone and Insulin Growth Factor 1 Deficiencies in Children/Adolescents Following Traumatic Brain Injury: The Impact on Growth and Neuropsychological Development
The purpose of this study is to look at the relationship between growth hormones, and recovery from a TBI - traumatic brain injury. It is believed that a TBI may interfere with the body's ability to produce growth hormones.
- Trial name
- NCT00929045
- Testing
- Growth Hormone Replacement
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Mild to Moderate Traumatic Brain Injury
PoNS Clinical Experience Program (TBI)
Brief Summary: Prospective, cohort, open-label study. The cohort consists of people who have a chronic balance dysfunction due to a mild to moderate traumatic brain injury (TBI).
- Trial name
- NCT03882554
- Testing
- PoNS Treatment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Helius Medical Inc
Chronic Traumatic Brain Injury, TBI (Traumatic Brain Injury)
Cognitive Network Restoration Therapy for Moderate to Severe Traumatic Brain Injury: A Feasibility Study
The purpose of this feasibility clinical investigation is to evaluate the safety and usability of central thalamic deep brain stimulation (CT-DBS) for use in patients with chronic moderate to severe traumatic brain injury (TBI)…
- Trial name
- NCT07730099
- Testing
- Deep brain stimulation
- Volunteers
- 40 people
- Sponsor
- ReEmerge, Inc.
Traumatic Brain Injury
Virtual Reality in Rehabilitation of Executive Functions in Children With Mild or Moderate Traumatic Brain Injury
Traumatic brain injury (TBI) causes lifelong disability. Children with TBI often have difficulties in attention regulation and executive functions affecting their daily living.
- Trial name
- VREALFUN-TBI (NCT06127459)
- Testing
- Parental Guidance, Virtual Reality Game
- Where
- Finland
- Volunteers
- 44 people
- Sponsor
- Merja Nikula
Traumatic Brain Injury
Prediction of Secondary Neurological Deterioration in Patients With Moderate Traumatic Brain Injury
Patients with moderate traumatic brain injury (mTBI) are 1,5 times more frequent than those with severe TBI and some of them will develop secondary neurologic deterioration (SND) within the first 7 days.
- Trial name
- PREDICT-TCM (NCT04854954)
- Where
- France
- Volunteers
- 142 people
- Sponsor
- University Hospital, Brest
Multiple Sclerosis, Spinal Cord Injury
PURO - PUlmonary Rehabilitation With O-RAGT Platform
The goal of this interventional study is to assess differences in the metabolic consumption, the cardiorespiratory effort, the cardiac autonomic adaptation, and fatigability during ADL, such as standing from a chair and walking…
- Conditions
- Multiple Sclerosis, Spinal Cord Injury, Stroke, Traumatic Brain Damage
- Trial name
- PURO (NCT05757830)
- Testing
- UANGO suite exoskeleton
- Where
- 4 sites in Italy, Lithuania and 2 more
- Volunteers
- 20 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Traumatic Brain Injury
Co-ultra PEALut Enhances Neuronal Recovery Following Moderate Traumatic Brain Injury
Traumatic brain injury (TBI) typically provokes secondary injury mechanisms, including the dynamic interplay between the ischemic, inflammatory, and cytotoxic processes.
- Trial name
- GLIA13 (NCT03818451)
- Testing
- Co-ultraPEALut (Glialia)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Messina
Traumatic Brain Injury
Propranolol Versus Propranolol and Clonidine in Sympathetic Hyperactivity After Moderate Traumatic Brain Injury
evaluation of the effect of Propranolol versus propranolol and clonidine on decreasing sympathetic hyperactivity after moderate traumatic brain injury
- Trial name
- NCT04833218
- Testing
- Propranolol
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Minia University
Traumatic Brain Injury
Effects of Huperzine A in Treatment of Moderate to Severe TBI
We will explore the use of Huperzine A in patients who have sustained a moderate to severe Traumatic Brain Injury. We aim to determine whether Huperzine A, as compared with placebo, would have an effect on memory function after…
- Trial name
- NCT01676311
- Testing
- Huperzine A
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Spaulding Rehabilitation Hospital
Trauma, Brain
Transcranial Doppler in Mild and Moderate Traumatic Brain Injury (TBI)
Utility of transcranial Doppler as an Early Predictor of Neurological deterioration in Mild and Moderate Traumatic Brain Injury
- Trial name
- NCT05151978
- Testing
- Transcranial Doppler
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Tanta University
Moderate Traumatic Brain Injury (TBI)
Light Therapy for Moderate Traumatic Brain Injury
The purpose of this research study is to find out if a specialized helmet that provides low levels of near infrared light, also known as low-level light therapy (LLLT) has any effect on the recovery of people who have recently…
- Trial name
- LLLT for TBI (NCT02233413)
- Testing
- Active LLLT helmet application, Non-active LLLT helmet application
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Massachusetts General Hospital
Mild to Moderate Traumatic Brain Injury, Cognitive Rehabilitation
Goal-oriented Telehealth Rehabilitation of Executive Functioning for Veterans With Chronic TBI
Provision of interventions that address cognitive and emotional problems faced by Veterans with history of TBI pursuing community reintegration is an important concern for VA.
- Conditions
- Mild to Moderate Traumatic Brain Injury, Cognitive Rehabilitation, Veteran
- Trial name
- GOALS TH (NCT07190365)
- Testing
- GOALS TH, EDU TH
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Head Injury Trauma, Hyperventilation
Hyperventilation in Patients With Traumatic Brain Injury
Elevated intracranial pressure is a dangerous and potentially fatal complication after traumatic brain injury. Hyperventilation is a medical intervention to reduce elevated intracranial pressure by inducing cerebral…
- Trial name
- NCT03822026
- Testing
- Hyperventilation test
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- University of Zurich
Mild to Moderate Traumatic Brain Injury
PoNS Clinical Experience Program in Traumatic Brain Injury Patients (TBI)
Brief Summary: Prospective, cohort, open-label study. The cohort consists of people who have a chronic balance dysfunction due to a mild to moderate traumatic brain injury (TBI).
- Trial name
- NCT03881176
- Testing
- PoNS Treatment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Helius Medical Inc
Trauma, Brain
Caregiver Wellness After Traumatic Brain Injury (CG-WELL): An Intervention Designed to Promote Well-being in Caregivers of Acute Moderate to Severe Traumatic Brain Injuries
After injury, survivors of msTBI depend on informal family caregivers. Upwards of 77% of family caregivers experience poor outcomes, such as adverse life changes, poor health related quality of life, and increased depressive…
- Trial name
- CG-Well (NCT05307640)
- Testing
- CG-Well, Information Support & Referral (ISR)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Natalie Kreitzer