Clinical trials: Moderate to Severe Traumatic Brain Injury
Chronic Traumatic Brain Injury, TBI (Traumatic Brain Injury)
Cognitive Network Restoration Therapy for Moderate to Severe Traumatic Brain Injury: A Feasibility Study
The purpose of this feasibility clinical investigation is to evaluate the safety and usability of central thalamic deep brain stimulation (CT-DBS) for use in patients with chronic moderate to severe traumatic brain injury (TBI)…
- Trial name
- NCT07730099
- Testing
- Deep brain stimulation
- Volunteers
- 40 people
- Sponsor
- ReEmerge, Inc.
Multiple Sclerosis, Spinal Cord Injury
PURO - PUlmonary Rehabilitation With O-RAGT Platform
The goal of this interventional study is to assess differences in the metabolic consumption, the cardiorespiratory effort, the cardiac autonomic adaptation, and fatigability during ADL, such as standing from a chair and walking…
- Conditions
- Multiple Sclerosis, Spinal Cord Injury, Stroke, Traumatic Brain Damage
- Trial name
- PURO (NCT05757830)
- Testing
- UANGO suite exoskeleton
- Where
- 4 sites in Italy, Lithuania and 2 more
- Volunteers
- 20 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Traumatic Brain Injury
Effects of Huperzine A in Treatment of Moderate to Severe TBI
We will explore the use of Huperzine A in patients who have sustained a moderate to severe Traumatic Brain Injury. We aim to determine whether Huperzine A, as compared with placebo, would have an effect on memory function after…
- Trial name
- NCT01676311
- Testing
- Huperzine A
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Spaulding Rehabilitation Hospital
Trauma, Brain
Caregiver Wellness After Traumatic Brain Injury (CG-WELL): An Intervention Designed to Promote Well-being in Caregivers of Acute Moderate to Severe Traumatic Brain Injuries
After injury, survivors of msTBI depend on informal family caregivers. Upwards of 77% of family caregivers experience poor outcomes, such as adverse life changes, poor health related quality of life, and increased depressive…
- Trial name
- CG-Well (NCT05307640)
- Testing
- CG-Well, Information Support & Referral (ISR)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Natalie Kreitzer
Craniocerebral Trauma, Hypothalamic-pituitary Disorders
Long-term Follow-up of Pituitary and Hypothalamic Dysfunction in Children Who Have Suffered Moderate to Severe Head Trauma Included in the ENDOC TC Cohort
The annual incidence of traumatic brain injury (TBI), all causes combined, varies between 180 and 300 per 100,000. TBI increases the risk of death or serious sequelae by a factor of 8.
- Conditions
- Craniocerebral Trauma, Hypothalamic-pituitary Disorders, Pediatric, Endocrinology
- Trial name
- ENDOC TC 2 (NCT07533435)
- Testing
- Telephone questionnaire
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Hospices Civils de Lyon
Traumatic Brain Injury, Cognitive Impairment
Strategy Based Technique to Enhance Memory (STEM) for Improving New Learning and Memory (NLM) in Moderate to Severe TBI
The purpose of this research study is to investigate the effectiveness of a memory enhancement technique in persons with a Traumatic Brian Injury (TBI).
- Trial name
- STEM (NCT04054596)
- Testing
- SME
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Kessler Foundation
Traumatic Brain Injury
Emotional Awareness Therapy Study
The purpose of this study is to learn about the potential benefits of two different training programs in helping improve emotional health and well-being in people who have had a traumatic brain injury.
- Trial name
- TREAT (NCT07624825)
- Testing
- TREAT-A, TREAT-B
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Hackensack Meridian Health
Self-management, Feasibility Studies
Self-management Program for Patients in the Sub-acute Phase After Traumatic Injury - a Feasibility Study
The goal of this descriptive non-randomized feasibility study is to assess aspects of feasibility of the intervention arm in a planned full-scale randomized controlled trial testing the effectiveness of a self-management program…
- Conditions
- Self-management, Feasibility Studies, Spinal Cord Injuries, Brain Injuries
- Trial name
- SMS_trauma (NCT06093074)
- Testing
- self-management program after traumatic injuries
- Where
- Norway
- Volunteers
- 11 people
- Sponsor
- Oslo University Hospital
Traumatic Brain Injury (TBI)
Prognostic Model for Predicting Outcome After Moderate to Severe Paediatric Traumatic Brain Injury
Due to ethical and logistical challenges related to paediatric research, there is limited age-appropriate evidence for managing paediatric traumatic brain injury (pTBI).
- Trial name
- PROMPT (NCT07538440)
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Traumatic Brain Injury
Ketogenic Diet Following Moderate to Severe Pediatric Traumatic Brain Injury
The primary objective of this study is to evaluate the feasibility and safety of using the ketogenic diet (KD) in children who sustained moderate to severe traumatic brain injury (TBI).
- Trial name
- NCT04933448
- Testing
- Ketogenic Diet
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- Gillette Children's Specialty Healthcare
Traumatic Brain Injury
MLC901 for Moderate to Severe Traumatic Brain Injury (Specified Drug Code)
Patients with a diagnosis of moderate to severe traumatic brain injury (TBI) will be enrolled. Subjects will be randomly assigned to receive either MLC901 (Specified Drug Code) or placebo capsules three times per day over 6…
- Trial name
- MLC901 (NCT04487275)
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Ali Amini Harandi
Traumatic Brain Injury
A Phase 2a Dose Escalation Study With SLV334 in Patients With Traumatic Brain Injury.
A Randomized, Double Blind, Placebo Controlled, Phase 2 Dose Escalation Study to Investigate the Safety and Pharmacokinetics after Single and Multiple I.V.
- Trial name
- NCT00735085
- Testing
- SLV334
- Where
- 14 sites in United States, Israel and 2 more
- Volunteers
- 57 people
- Sponsor
- Abbott Products
Traumatic Brain Injury, Degeneration
Offsetting Hippocampal Degeneration in m-sTBI
The goal of this study is to establish the feasibility of an intervention designed to improve memory in patients who have experienced a moderate or severe traumatic brain injury (m-sTBI) and to examine its effect on brain…
- Conditions
- Traumatic Brain Injury, Degeneration, Memory; Loss, Mild, Following Organic Brain Damage
- Trial name
- m-sTBI (NCT03727334)
- Testing
- Online Spatial Navigation Training
- Where
- 2 sites in Canada
- Volunteers
- 25 people
- Sponsor
- University of British Columbia
Traumatic Brain Injury
Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury
The goal of this clinical trial is to test the safety of the drug Angiotensin (1-7) and learn whether it works well as a treatment in people who have suffered a moderate to severe traumatic brain injury (TBI).
- Trial name
- ANGel T (NCT06282965)
- Testing
- Angiotensin (1-7), Sterile saline
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Arizona
Traumatic Brain Injury
Methylprednisolone for Moderate to Severe Traumatic Brain Injury
The goal of this clinical trial is to learn if standard-dose methylprednisolone sodium succinate can improve neurological recovery and safety in adults with moderate to severe traumatic brain injury (TBI).
- Trial name
- ESM-TBI (NCT07180277)
- Testing
- Methylprednisolone (MP)
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Zhangjiagang First People's Hospital
Traumatic Brain Injury (TBI)
Noninvasive Monitoring of Cerebral Blood Flow Autoregulation in Patients With Traumatic Brain Injury (TBI)
BACKGROUND: The brain is very sensitive to both excessive and insufficient flow of blood. Cerebral blood flow (CBF) is normally auto-regulated by the blood vessels in the brain, but this protective mechanism is often disturbed…
- Trial name
- REG01 (NCT01605838)
- Where
- United States
- Sponsor
- Advanced Brain Monitoring, Inc.
Traumatic Brain Injury
Effect of Early Memantine Administration on Outcome of Patients With Moderate to Severe Traumatic Brain Injury
Effect of Early Memantine Administration on Outcome of Participents with Moderate to Severe Traumatic Brain Injury
- Trial name
- NCT05531383
- Testing
- Memantine Hydrochloride
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Minia University
Traumatic Brain Injury
GetUp&Go: A Randomized Controlled Trial of an Intervention to Enhance Physical Activity After TBI
The goal of this clinical trial is to evaluate GetUp\&Go, a program for promoting increased physical activity in individuals at least 6 months post moderate-to-severe traumatic brain injury.
- Trial name
- NCT06028334
- Testing
- GetUp&Go, GetUp&Go with 10-Week Delay
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Albert Einstein Healthcare Network
Traumatic Brain Injury
Ketogenic Diet & Functional Recovery in Moderate to Severe Traumatic Brain Injury
Traumatic Brain Injury (TBI) represents a significant public health risk in the United States leaving many survivors with significant long term cognitive deficits and at risk for neurodegenerative diseases.
- Trial name
- NCT04530032
- Testing
- ketogenic/modified Atkins diet, Standard diet
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Loma Linda University
Brain-damaged Patients
IRM Cognition in Patients With Head Trauma
Longitudinal descriptive study of a cohort of twenty brain-damaged patients for a two years period.
- Trial name
- NCT03181373
- Testing
- Cognitive rehabilitation program
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Clermont-Ferrand