Clinical trials: Moderately Obese
Overweight and Obesity
Effect of Exercise Programme on Gut Microbiota, CVD Risk Factors and Appetite Regulation in Overweight Women
Evidence suggests that gut microbiota contributes to the development of atherosclerosis and therefore CVDs. Exercise has been extensively reported to be protective against CVDs due to modification of body fatness, metabolic risk…
- Trial name
- NCT03344133
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Bariatric Surgery Candidate
Influence of a Moderate Physical Exercise Program in Health of Patients Underwent Bariatric Surgery in Talca City, Chile
Obesity is a multifactorial disorder resulting from multivariate etiopathogenic factors. The current lifestyle, causes a gradual increase in weight both in the adult population and in the child population.
- Trial name
- NCT03159312
- Testing
- Physical activity based on a moderate exercise program
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Asthma, Obesity
Pilot Study of Pioglitazone for the Treatment of Moderate to Severe Asthma in Obese Asthmatics (Glitz Asthma)
Asthmatics who are significantly overweight tend to have more severe symptoms, more flare ups, and are more likely to have poorly-controlled asthma when compared to other asthmatics.
- Trial name
- GLITZ (NCT00787644)
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Vermont
Knee Osteoarthriis and Oxidative Stress
Do Obese Patients With Primary Knee Osteoarthritis Benefit From a Single Bout of Moderate Intensity Aerobic Exercise?
Background: Obesity and degenerative joint disease are typically concomitant . Each are in the course of aerobic focus and excited inflammatory response.
- Trial name
- NCT03927339
- Testing
- pre and post excercise group
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Obstructive Sleep Apnea
Effect of a Very Low Calorie and Low Calorie Diet on Moderate to Severe Obstructive Sleep Apnea in Obese Adults
The purpose of this study is to test the effectiveness of two different weight loss diets on obstructive sleep apnea (OSA) severity.
- Trial name
- NCT02251574
- Testing
- Low Calorie Diet, Very Low Calorie Diet, Standard Care
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Hematologic Tests
Interval Training and Plasma Volume Variation
The goal of this clinical trial is to to compare the effects of high (HIIWT) versus moderate-intensity interval walking training (MIIWT) on body composition, plasma volume variations (PVV), hematological parameters, muscle damage…
- Trial name
- NCT07019285
- Testing
- High intensity interval walking training, Moderate-intensity interval walking training
- Where
- Tunisia
- Volunteers
- 32 people
- Sponsor
- Wissal Abassi
Obesity, Abdominal, Physical Activity
Efficacy of ECE PEDO (Equipment for Clever Exercise) on Abdominal Obesity
Objective: To show the effectiveness of walking with ECE PEDO (Equipment for Clever Exercise) comparing supervised treadmill walking corresponding moderate aerobic exercise intensity on abdominal obesity and cardiorespiratory…
- Trial name
- NCT03109340
- Testing
- Supervised treadmill group (Group I), ECE PEDO pedometer (Group II)
- Volunteers
- 65 people
- Sponsor
- Pamukkale University
Subjects With Moderate-to-severe OSA and Obesity Who Are on PAP Therapy
A Multicenter, Randomized, Double-blind, Placebo-controlled Phase III Clinical Study to Evaluate the Efficacy and Safety of HRS9531 Injection in Subjects With Obstructive Sleep Apnea (OSA) and Obesity Who Are on Positive Airway Pressure Ventilation (PAP) Therapy
This study is a phase 3 clinical trial, aiming to evaluate the efficacy and safety of HRS-9531 injection in obese subjects with obstructive sleep apnea (OSA) who are on positive airway pressure ventilation (PAP) therapy.
- Trial name
- NCT06994650
- Testing
- HRS9531
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Overweight, Obesity
Efficacy and Safety of IBI362 in Hypertensive Patients With Overweight/Obesity
A multicenter, randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy and safety of IBI362 in participants with mild to moderate hypertension complicated by overweight/obesity who have not received…
- Conditions
- Overweight, Obesity, Hypertensive
- Trial name
- NCT07469800
- Testing
- IBI362
- Where
- China
- Volunteers
- 336 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Obesity, Body Composition
Individualized Cadence Thresholds for Moderate-to-Vigorous Intensity in Obese Taiwanese Young Adults
This study aims to determine the step cadence thresholds for moderate-to-vigorous physical activity (MVPA) in obese young adults.
- Conditions
- Obesity, Body Composition, Cadence, Physical Activity Intensity
- Trial name
- NCT06883253
- Testing
- treadmill walking
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- Chinese Culture University
Pulmonary Disease, Chronic Obstructive
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Doses of GSK2256294 in Healthy Volunteers, and Single and Repeat Doses of GSK2256294 in Adult Male Moderately Obese Smokers
This study is the First Time in Human Study for GSK2256294 and will evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single and repeat oral doses of GSK2256294 administered to healthy male…
- Trial name
- NCT01762774
- Testing
- GSK2256294
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Obstructive Sleep Apnea (OSA)
Evaluate the Efficacy and Safety of GZR18 Injection in Obese Subjects With Obstructive Sleep Apnea Not Treated With Positive Airway Pressure (PAP) Therapy
This study is a multicenter, randomized, double-blind, parallel, placebo-controlled Phase III clinical trial evaluating the efficacy and safety of GZR18 injection in obese subjects with moderate to severe obstructive sleep apnea…
- Trial name
- NCT07493057
- Testing
- GZR18 injection
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Gan & Lee Pharmaceuticals.
Obstructive Sleep Apnea, Obesity
UBT251 Injection Phase Ⅲ Study (OSA-NPAP)
The objective of this clinical trial is to evaluate the efficacy of investigational drug UBT251 in the treatment of moderate-to-severe obstructive sleep apnea (OSA) with obesity, as well as to assess its safety.
- Trial name
- UNISHAPE-OSA-1 (NCT07767942)
- Testing
- UBT251
- Volunteers
- 150 people
- Sponsor
- The United Bio-Technology (Hengqin) Co., Ltd.
Type 2 Diabetes, Obesity, Abdominal
Long-term Effect of Moderate and Vigorous Exercise on Incident Diabetes in Obese Subjects
Our previous randomized controlled trial has recruited 220 subjects with central obesity and allocated the subjects to the non-exercise control, moderate exercise and vigorous exercise groups.
- Trial name
- NCT05346250
- Testing
- Non-exercise control, Moderate intensity exercise, Vigorous intensity exercise
- Volunteers
- 220 people
- Sponsor
- Shanghai Zhongshan Hospital
Covid19, Diabetes
Camostat and Artemisia Annua vs Placebo in COVID-19 Outpatients
This is a randomized, double-blind, placebo-controlled, multi-arm, multicenter, phase II trial design to allow a rapid efficacy and toxicity assessment of potential therapies (camostat mesilate and artemisia annua) immediately…
- Conditions
- Covid19, Diabetes, Hypertension, Obesity
- Trial name
- NCT04530617
- Testing
- Camostat Mesilate, Artemisia Annua Leaf
- Where
- Mexico
- Volunteers
- 246 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Sedation Complication, Obesity
Effect of HFNO on Spontaneous Ventilation in Obese Patients During Analgo-sedation for Vitrectomy
Patients suffering from pathology of posterior eye chamber such as diabetic retinopathy, retinal detachment, traumatic eye injury, retained lens fragments, macular hole, pucker, dislocated intraocular lens after cataract surgery…
- Conditions
- Sedation Complication, Obesity, Hypoxic Respiratory Failure, Airway Obstruction, Nasal
- Trial name
- NCT04049240
- Testing
- Device: low-flow nasal oxygenation (LFNO) 18<BMI<30 kg/m2, Device: low-flow nasal oxygenation (LFNO) 30≤BMI<35 kg/m2, Device: low-flow nasal oxygenation (LFNO) BMI≥35 kg/m2
- Where
- Croatia
- Volunteers
- 126 people
- Sponsor
- University of Split, School of Medicine
Sleep Apnea, Obstructive, Obesity
A Study of Eloralintide (LY3841136) in Participants With Obstructive Sleep Apnea and Obesity or Overweight
The purpose of the studies is to evaluate the efficacy and safety of eloralintide in participants with moderate-to-severe obstructive sleep apnea and obesity or overweight.
- Conditions
- Sleep Apnea, Obstructive, Obesity, Overweight
- Trial name
- ENLIGHTEN-3 (NCT07369011)
- Testing
- Eloralintide
- Where
- 115 sites in United States, Australia and 9 more
- Volunteers
- 800 people
- Sponsor
- Eli Lilly and Company
Asthma
Pilot Study of Pioglitazone for the Treatment of Moderate to Severe Asthma in Obese Asthmatics
Asthmatics who are significantly overweight tend to have more severe symptoms, more flare ups, and are more likely to have poorly-controlled asthma when compared to other asthmatics.
- Trial name
- GLITZ Asthma (NCT00634036)
- Testing
- pioglitazone
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Fernando Holguin
Diabete Mellitus, Obesity & Overweight
Comparing Two Low-Carbohydrate Diets With a Standard Diet in Type 2 Diabetes
Type 2 diabetes is often accompanied by high blood triglycerides and excess weight, and diet plays a central role in managing these conditions together.
- Conditions
- Diabete Mellitus, Obesity & Overweight, Hypertriglyceridaemia
- Trial name
- NCT07801378
- Testing
- High-Protein Low-Carbohydrate Diet, High-Fat Low-Carbohydrate Diet, Standard diet
- Volunteers
- 168 people
- Sponsor
- National Nutrition and Food Technology Institute
Hidradenitis Suppurativa
Efficacy and Safety of Olatorepatide Versus Placebo in Adults With Moderate to Severe Hidradenitis Suppurativa Living With Overweight or Obesity
This study will test an experimental Regeneron drug called olatorepatide ("study drug") to see if it can help treat Hidradenitis Suppurativa (HS).
- Trial name
- NCT07830329
- Testing
- Olatorepatide
- Volunteers
- 300 people
- Sponsor
- Regeneron Pharmaceuticals