Clinical trials: Moderately Obese
Ulcerative Colitis, Obesity or Overweight
Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
The main purpose of this study is to show whether in these individuals, treatment with both mirikizumab and tirzepatide, compared with treatment with mirikizumab and placebo, leads to decrease or disappearance of UC symptoms, and…
- Trial name
- COMMIT-UC (NCT06937086)
- Testing
- Mirikizumab, Tirzepatide
- Where
- 187 sites in United States, Austria and 21 more
- Volunteers
- 350 people
- Sponsor
- Eli Lilly and Company
Weight Loss
PENS T6 With Ambulatory Self-applied Patch vs Conventional Procedure
A prospective randomized study, including moderately obese patients will be included. Patients will be randomized in 3 groups: PENS of dermatome T6 with an ambulatory self-applied patch + 1200Kcal/day diet PENS of dermatome T6…
- Trial name
- NCT02564627
- Testing
- Self-applied patch, Conventional procedure, 1200 Kcal/day diet
- Volunteers
- 90 people
- Sponsor
- Abdel Kadar Clinic
Obstructive Sleep Apnea, Obesity
UBT251 Injection Phase Ⅲ Study (OSA-PAP)
UBT251 will be compared with placebo (an inactive substance identical in appearance) to evaluate its therapeutic effect in participants with moderate-to-severe obstructive sleep apnea maintained on positive airway pressure…
- Trial name
- UNISHAPE-OSA-2 (NCT07806851)
- Testing
- UBT251
- Volunteers
- 150 people
- Sponsor
- The United Bio-Technology (Hengqin) Co., Ltd.
Psoriasis
Open Label Study Etanercept's Maintenance Dose in Obese Patients With Moderate to Severe Plaque Type Psoriasis
This is a single-center, open-label, pilot study. A total of 30 subjects (15 in each study arm) will be enrolled in this 6 month study to evaluate whether the addition of narrow band UVB (NB-UVB) phototherapy can enhance the…
- Trial name
- NCT00800982
- Testing
- Narrow band (310-312 nm) ultraviolet light B phototherapy, etanercept
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Overweight, Obesity
Mono Unsaturated Fatty Acids in Obesity - Weight Maintenance and Prevention of Lifestyle Diseases in Obese Subjects.
The purpose of this study is to investigate the effect of three diets different in type and amount of fat in weight maintenance and prevention of life-style diseases in obese subjects.
- Trial name
- NCT00274729
- Testing
- Mono Unsaturated Fatty Acids in Obesity
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Obesity, Diabetes Mellitus
Comparison of the Effect of Intense-Exercise/Moderate-Calorie, Topiramate-Phentermine and Cognitive Behavioral Therapy on Obesity
Obesity is a prevalent disorder and linked with inflammation, insulin resistance, dyslipidemia, obstructive sleep apnea, atherosclerosis, and associated with significant morbidity and mortality.
- Trial name
- NCT01970566
- Testing
- Behavioral and Drug, Behavioral
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Binge Eating Disorder
An Open-Label Trial of Memantine in the Treatment of Binge Eating Disorder
We hypothesize that memantine may be a safe and effective treatment for moderate to severe binge eating disorder associated with obesity.
- Trial name
- NCT00330655
- Testing
- memantine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mclean Hospital
Obesity, NAFLD
Vigorous- Versus Moderate-intensity Exercise to Reduce Liver Fat in Adults With Obesity and NAFLD
Non-alcoholic fatty liver disease (NAFLD) arising from obesity has become a global health concern. Although exercise is a cornerstone approach for managing NAFLD, detailed exercise prescription guidelines are unavailable.
- Trial name
- NCT06124456
- Testing
- Usual Care Control Group, Moderate-intensity Exercise Intervention, Vigorous-intensity Exercise Intervention
- Where
- Hong Kong
- Volunteers
- 330 people
- Sponsor
- The University of Hong Kong
Cardiovascular Diseases, Cognition
Acute Impact of Whey Protein-enriched Milk Fat Globule Membrane Supplementation on Postprandial Markers of Heart and Brain Health
In a single-blind, randomised, placebo-controlled crossover manner, this study aims to assess the impact of a high-fat mixed meal containing a whey protein (WP)-enriched milk fat globule membrane (MFGM) powdered ingredient on…
- Conditions
- Cardiovascular Diseases, Cognition, Overweight or Obesity, Postmenopausal Women
- Trial name
- NCT06953232
- Testing
- Whey protein-enriched milk fat globule membrane supplement, Whey protein-based supplement
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Obesity, Body Weight
The Effect of Alcohol on Food Reward
Rationale It has been shown in several studies that alcohol increases subsequent food intake. However, moderate alcohol consumption has no clear effects on hunger and satiety hormones.
- Trial name
- NCT01738906
- Testing
- Orange juice, maltodextrin, Vodka
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Henk FJ Hendriks
High Intensity Interval Training, Child Obesity
The Effect of HIIT in Handling Obesity in Children
In this study the investigators wish to investigate whether a short duration High-intensity Interval Training(HIT) is superior to a moderate activity training modus with regards to improving weight-loss, Blood pressure and sleep…
- Trial name
- NCT03433690
- Testing
- HIIT, Moderate training
- Volunteers
- 30 people
- Sponsor
- Regionshospital Nordjylland
Obesity, Hypertension
Exercise Effects on Cardiometabolic Health and Sestrin-2 in Hypertensive Obese Women
Obesity is a chronic and complex disease characterized by excessive fat accumulation that adversely affects health and quality of life.
- Trial name
- SES-EX (NCT07370363)
- Testing
- Moderate-Intensity Continuous Exercise, Brisk Interval Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Havva Talay Çalış
Obesity
Nutrigenomics And Children Obesity: A Moderate Weight Loss Intervention Study
The consumption of diets enriched in proteins (legumes and fish) or antioxidant (fruits and vegetables) could have beneficial effects beyond those of the caloric restriction on biomarkers of the inflammatory and oxidative status.
- Trial name
- NUGENOI (NCT01329367)
- Testing
- Control group, Protein group, Antioxidant group
- Where
- 2 sites in Spain
- Volunteers
- 42 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Appetite Suppression, Weight Loss
Effects of a Dietary Fibre Supplementation of a Low Calorie Diet on Appetite and Body Weight
This 18 week, randomized, double blind, placebo controlled trial will examine the effects of thick dietary fibre (PGX) supplementation of a low calorie diet (LCD) on appetite, weight loss, body composition, and compliance in…
- Trial name
- NCT01109199
- Testing
- PolyGlycopleX (PGX), Rice flour
- Where
- 2 sites in Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Canadian Center for Functional Medicine
Irritable Bowel Syndrome, Obesity
Moderate Continuous Versus High Interval Intensity Training on Gut Dysbiosis and GLP1 Hormone in IBS
investigating the response of gut bacteria via measuring short chain fatty acids and Glucagon like peptide hormone to two different modes of exercises in pre-diabetic, obese patients with irritable bowel syndrome.
- Conditions
- Irritable Bowel Syndrome, Obesity, Dysbiosis
- Trial name
- NCT06408610
- Testing
- moderate intensity continuous training
- Where
- 2 sites in Egypt
- Volunteers
- 66 people
- Sponsor
- Cairo University
Central Obesity
Effectiveness of High-intensity Interval Training (HIIT) Versus Moderate-intensity Continuous Training (MICT) in Reducing Visceral Fat in Adults With Central Obesity
Obesity is a major risk factor for cardiovascular disease and diabetes as well as all-cause mortality. The prevalence of obesity has continuously increased in most countries and has doubled in over 70 countries since 1980.
- Trial name
- NCT04545320
- Testing
- Usual care control group, HIIT group, MICT group
- Where
- Hong Kong
- Sponsor
- The University of Hong Kong