Clinical trials: Molar, Third
Oral Complication
Effect of CGF on Postoperative Edema in Third Molar Surgery
The purpose of this study is to evaluate the effects of concentrated growth factor (CGF) on edema after bilateral impacted third molar surgery and to determine its contribution to the healing process.
- Trial name
- NCT06893523
- Testing
- Concentrated Growth Factor, Non-CGF
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Ege University
Trismus
Effectiveness of Serratiopeptidase After Mandibular Third Molar Surgery
This randomized controlled trial was conducted to compare the effect of serratiopeptidase versus no intervention on postoperative mouth opening, swelling, and trismus following surgical removal of mesioangular mandibular third…
- Trial name
- NCT07543146
- Testing
- Serratiopeptidase, Standard Postoperative Care
- Where
- Pakistan
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Sharif Medical Research Center
Mandible Fracture
Forensic Dental Age Estimation : Validation of Computed Tomography for Third Molar Demirjian's Staging
Age can be estimated in different ways by using skeletal age and dental age. Currently, bone age is determine thanks to the wrist x-rayed, and the dental age using variation in mineralization (Demirjian's score) on the dental…
- Trial name
- SCAO (NCT04907552)
- Where
- France
- Volunteers
- 557 people
- Sponsor
- University Hospital, Montpellier
Trismus, Edema
Etodalac, Etoricoxib and Dexamethasone for Prevention of Pain ,Swelling and Trismus Following Third Molar Surgery
The purpose of this study is to determine whether Etodalac, Etoricoxib and Dexamethasone are effective for Prevention of Pain ,Swelling and Trismus Following Third Molar Surgery
- Conditions
- Trismus, Edema, Pain
- Trial name
- NCT00793052
- Testing
- Etodalac, Etoricoxib and Dexamethasone
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Swelling, Trismus
Comparing Different Suturing Techniques on the Post-operative Morbidity After Removal of Impacted Mandibular Third Molar
This study compares the effect of two types of suturing techniques in the postoperative swelling and mouth opening after surgical removal of impacted mandibular third molar.
- Trial name
- NCT03492814
- Testing
- partial wound closure, total wound closure
- Where
- Malaysia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Melaka Manipal Medical College
Impacted Mandibular Third Molar, Pain
Ultrasonic vs Rotary Instruments in Impacted Mandibular Third Molar Surgery: Clinical and Salivary CRP Outcomes
In the surgical removal of impacted mandibular third molars, ultrasonic surgical devices (piezosurgery) have been introduced with the expectation of reducing postoperative complications such as swelling, pain, and trismus…
- Conditions
- Impacted Mandibular Third Molar, Pain, Swelling, Trismus
- Trial name
- PiezoCRP (NCT07196904)
- Testing
- Ultrasonic Device (Piezosurgery), Conventional rotary instruments
- Where
- Vietnam
- Volunteers
- 22 people
- Sponsor
- Le Huynh Thien An
Dental Anxiety
Evaluation on the Anxiety of Third Molar Extraction
This study was performed on 66 patients who were admitted for third molar extraction under local anesthesia. The patients were divided into three groups: group 1 with verbal information, group 2 with written information, and…
- Trial name
- NCT03838081
- Testing
- Spielberger State Anxiety Inventory (STAI-S),, Dental Fear Scale (DFS), Modified Dental Anxiety Scale (MDAS)
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ankara University
Surgical Wound, Post Operative Pain
Effect of Preemptive Etoricoxib and Dexamethasone on Wound Healing and Clinical Parameters After Third Molar Surgery
The goal of this clinical trial is to compare preemptive single-dose selective cyclooxygenase 2 (COX-2) inhibitor - etoricoxib and dexamethasone use in systemically healthy patients during the surgical extraction of impacted…
- Trial name
- NCT05791721
- Testing
- Etoricoxib 90 Mg Oral Tablet, Dexamethasone 4mg
- Where
- Serbia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Impacted Third Molar, Postoperative Pain
Kynurenic Acid and Serotonin as Perioperative Neuroinflammatory Biomarkers in Sequential Third Molar Surgery
A prospective cohort of 40 consecutive patients with bilateral impacted mandibular third molars underwent two sequential surgical extractions separated by a two-week interval.
- Conditions
- Impacted Third Molar, Postoperative Pain, Neuroinflammation, Anxiety
- Trial name
- KYNA-3M (NCT07644065)
- Testing
- Ibuprofen, Ibuprofen + Gabapentin
- Where
- Bulgaria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University
Healthy, Inflammation
Etanercept (Enbrel) to Treat Pain and Swelling After Third Molar Extraction
This study will evaluate the effects of the anti-inflammatory drug etanercept (Enbrel) on relieving pain and swelling after oral surgery.
- Trial name
- NCT00006070
- Testing
- etanercept (Enbrel)
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Impacted Third Molar Tooth, Postoperative Pain
Effects of Platelet-Rich Fibrin and Kinesio Taping on Postoperative Recovery in Oral Surgery
This study investigates the effectiveness of Platelet-Rich Fibrin (PRF) and Kinesio Taping in reducing postoperative pain, edema, and improving recovery following impacted third molar surgery.
- Conditions
- Impacted Third Molar Tooth, Postoperative Pain, Postoperative Edema
- Trial name
- PRFKTOralSur (NCT06900894)
- Testing
- Platelet-Rich Fibrin (PRF), Kinesio Taping, Standard Postoperative Care
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Mustafa Kemal University
Healthy Subjects, Hyperalgesia
Effect of High-dose Naloxone Following Third Molar Extraction
Recent studies have focused on the role of endogenous opioids on central sensitization. Central sensitization is known to be impaired or altered in chronic pain conditions, as fibromyalgia or chronic tension headache.
- Conditions
- Healthy Subjects, Hyperalgesia, Inflammations, Endodontic, Pain, Acute
- Trial name
- TME (NCT02976337)
- Testing
- Naloxone, Normal Saline
- Where
- Denmark
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- mads u werner
Tooth, Impacted, Molar, Third
The Role of Matrix Metalloproteinases (MMPs) in Orthodontic Tooth Movement
The purpose of this study is to test whether the two MMPs can be up-regulated during orthodontic treatment. Alveolar bone samples will be collected from partially impacted third molars after orthodontic uprighting for different…
- Trial name
- NCT00154518
- Testing
- Orthodontic treatment
- Where
- Taiwan
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Impacted Wisdom Tooth
Comparison The Postoperative Effects of Local and Systemic Antibiotics Applied With Platelets Rich Fibrin
The aim of this study was investigate the comparison of postoperative effects of local antibiotics mixed with platelet-rich fibrin and postoperative systemic antibiotic applications prescribed for mandibular impacted third molar…
- Trial name
- NCT04989127
- Testing
- Diagnosis, traditional osteotomies, Platelet Rich Fibrin
- Where
- Cyprus
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ceren Melahat Donmezer
Impacted Third Molar Tooth
Post-Surgical Morbidity and Bone Healing of Impacted Lower Third Molars: Piezosurgery vs. Conventional Instruments
The aim of this study is to compare piezosurgery and conventional surgery in impacted third molar surgery and to determine its effect on postoperative outcomes and quality of life.
- Trial name
- NCT06262841
- Testing
- Piezosurgery, Conventional burs
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Ankara University
Post-Operative Wound Infection
A Tetracycline Drain Reduces Alveolar Osteitis in Third Molar Surgery
The aim of this study was to investigate the effect of an oxytetracycline impregnated gauze drain on the incidence of alveolar osteitis (AO) and postoperative pain during the first week after mandibular third molar surgery.
- Trial name
- Wisdomsteeth (NCT03494972)
- Testing
- Tetracyclin ointment
- Where
- Norway
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Oral Surgery
The Effect of Platelet-rich Fibrin on Clinical and Patient-centered Outcomes of Third Molar Extractions
The fear of oral surgeries is mostly dedicated to pain and swelling in the following days. It is not surprising, that it is of high interest to do anything to reduce these consequences.
- Trial name
- PRF (NCT05089812)
- Testing
- Third-molar extraction using platelet-rich fibrin as a filling of the alveolus
- Where
- Austria
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Platelet-Rich Fibrin (PRF), Impacted Mandibular Third Molar
Salivary α-Amylase as a Non-Invasive Biomarker of PRF-Enhanced Wound Healing After Third Molar Surgery
This randomized clinical study evaluated salivary α-amylase as a non-invasive biomarker of early wound healing after mandibular third molar surgery.
- Conditions
- Platelet-Rich Fibrin (PRF), Impacted Mandibular Third Molar, Postoperative Wound Healing, Salivary Alpha Amylase
- Trial name
- NCT07600619
- Testing
- PRF group
- Where
- Indonesia
- Volunteers
- 28 people
- Sponsor
- Hasanuddin University
Dental Anxiety, Impacted Mandibular Third Molar
Audiovisual vs Verbal Information in Third Molar Surgery
This study evaluates whether audiovisual (video-based) or verbal preoperative information is more effective in reducing dental anxiety and stabilizing physiological responses in patients undergoing impacted mandibular third molar…
- Trial name
- AVID (NCT07528755)
- Testing
- Audiovisual Information, Verbal Information
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Gazi University
Pain, Postoperative
Extraction of Distoangular and Vertically Positioned Mandibular 3rd Molars
Mandibular 3rd molars are the most commonly impacted teeth in oral cavity followed by maxillary 3rd molars and maxillary canines respectively.
- Trial name
- NCT05032989
- Testing
- Extraction of mandibular 3rd molar via Cowhorn forcep technique, Extraction of mandibular 3rd molar via conventional technique
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences