Clinical trials: Molecular Diagnosis
Diffuse Large B-cell-lymphoma
CD30 Imaging in Diffuse Large B-cell Lymphoma
The antibody drug conjugate (ADC) brentuximab vedotin (BV), targeting CD30, is currently registered for the treatment of previously untreated stage III-IV Hodgkin lymphoma (HL), relapsed Hodgkin lymphoma, relapsed systemic…
- Trial name
- NCT06186986
- Testing
- Brentuximab vedotin
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Insulin Sensitivity/Resistance, Breast Cancer
Insulin Sensitivity After Breast Cancer
Epidemiological studies have revealed that 60-80% of women with breast cancer (BC) develop metabolic disorders that are similar to those observed in conditions like type 2 diabetes.
- Conditions
- Insulin Sensitivity/Resistance, Breast Cancer, Survivorship, Metabolic Disturbance
- Trial name
- NCT05010356
- Testing
- Insulin
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Lung Neoplasms, Esophageal Neoplasms
The Impact of Different Anticoagulant Therapy on Hemorrhage and Coagulation After Thoracic Surgery
The purpose of this study is to determine whether the use of different dose of LMWH compared with fondaparinux for thromboprophylaxis is efficacious and safety after thoracic surgery.
- Conditions
- Lung Neoplasms, Esophageal Neoplasms, Venous Thromboembolism
- Trial name
- NCT01267305
- Testing
- Fondaparinux, Nadroparin Calcium
- Where
- China
- Volunteers
- 362 people
- Sponsor
- Shanghai Zhongshan Hospital
Breast Cancer
Short-term Presurgical Study to Assess Molecular Predictors of Lapatinib's Effects in Primary Breast Cancer
To provide an in vivo measure of the activity of lapatinib. To assess the antiproliferative effects of lapatinib in breast cancer, ie how much lapatinib slows down the growth of cancer cells by measuring K167 (a marker of…
- Trial name
- MAPLE (NCT00299286)
- Testing
- Lapatinib
- Where
- United Kingdom
- Volunteers
- 121 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Schizophrenia, Neuronal Plasticity
Insight Into Hippocampal Neuroplasticity in Schizophrenia by Investigating Molecular Pathways During Physical Training
Aerobic endurance training has shown positive effects on symptoms, cognition, daily functioning, and the structure of the hippocampus in patients with schizophrenia.
- Conditions
- Schizophrenia, Neuronal Plasticity, Exercise
- Trial name
- BrainTrain (NCT05956327)
- Testing
- Aerobic Endurance Training, Flexibility, strengthening and balance training
- Where
- Germany
- Volunteers
- 156 people
- Sponsor
- LMU Klinikum
Colorectal Cancer
Molecular Stool Testing for Colorectal Cancer Surveillance
Rationale: Since January 2014 the Dutch screening programme for bowel cancer has been implemented. Screening will increase the demand for surveillance.
- Trial name
- MOCCAS (NCT02715141)
- Testing
- Collection of stool sample
- Where
- Netherlands
- Volunteers
- 3,966 people
- Sponsor
- The Netherlands Cancer Institute
ABO Blood Type Incompatible Kidney Transplantation, Antibody-mediated Rejection
Diagnostic Efficacy of Molecular Diagnostic Method for AMR in ABOiKT
The purpose of this study is to determine whether the peripheral blood marker-based molecular diagnostic method developed in the previous study can differentiate and predict accommodation and antibody-mediated rejection (AMR) in…
- Trial name
- NCT04541914
- Testing
- 5-gene classification model
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Diffuse Large B Cell Lymphoma (DLBCL)
Molecular Characterization and Outcomes of Aggressive B-Cell Lymphomas.
This is a retrospective analysis of the presence of chromosomal rearrangements involving MYC, BCL2 and BCL6 genes by FISH in a retrospective, single-center series of large B-cell lymphomas, in order to allow a better…
- Trial name
- CHARTHER (NCT07181785)
- Testing
- Treatments: anthracycline-based combinations followed or not by involved-field radiotherapy
- Where
- Italy
- Volunteers
- 555 people
- Sponsor
- Andrés José Maria Ferreri
Healthy Subjects
Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases: Case-control
Connective tissue diseases (CTD) or systemic autoimmune diseases (SADs) as they are known today are a group of chronic inflammatory conditions with autoimmune aetiology with few treatment options and difficult diagnosis.Brest…
- Trial name
- PRECISESADST (NCT02890147)
- Where
- 17 sites in Austria, Belgium and 7 more
- Volunteers
- 649 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza Progreso y Salud
Diabetes
Diabetic Cardiovascular Complications: Multi-Omics Analysis
The goal of this observational study is to learn about the molecular mechanisms underlying cardiovascular complications in individuals with type 2 diabetes (T2DM) and how they differ from healthy individuals.
- Trial name
- D-CCMOA (NCT06824233)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Second Xiangya Hospital of Central South University
Cardiovascular Disease, Atherosclerosis
Cardiovascular Molecular Calcification Assessed by 18F-NaF PET CT
The purpose of the CAMONA study is to demonstrate the feasibility of cardiovascular molecular calcification (CMC) assessment by means of 18F-sodium-fluoride (18F-NaF) positron emission tomography (PET) computed tomography (CT) in…
- Conditions
- Cardiovascular Disease, Atherosclerosis, Angina Pectoris
- Trial name
- CAMONA (NCT01724749)
- Where
- 2 sites in Denmark
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Breast Cancer
Pilot Study: Combined Molecular Breast Imaging/Ultrasound System for Diagnostic Evaluation of MBI-detected Lesions
A combined molecular breast imaging / ultrasound system will enable coregistration of a functional abnormality seen on Molecular Breast Imaging (MBI) with the corresponding anatomical abnormality seen on ultrasound.
- Trial name
- MBI/US (NCT01806558)
- Testing
- Molecular Breast Imaging
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Autoimmune Bullous Dermatosis
Coagulopathy of Immunodermatologic Diseases
This study will examine the coagulation and fibrinolysis profiles of those with autoimmune skin diseases. Blood samples will be collected from participants with active/poorly controlled immune-mediated skin diseases and…
- Trial name
- NCT06037187
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Type 2 Diabetes Mellitus
Insulin Receptor Substrate 1 (IRS-1) Regulation in Insulin Resistance
The study is being conducted to find out why too much fat in your blood stream may cause insulin resistance in your muscles. Insulin is the hormone, produced normally by your body, which causes your blood sugar to return to…
- Trial name
- NCT01240252
- Testing
- Human insulin
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
ctDNA Monitoring, Breast Cancer
Abemaciclib for Molecular Residual Disease Detected by Circulating Tumor DNA in HR+/HER2- Early Breast Cancer
The goal of this clinical study is to determine whether monitoring ctDNA and treating patients who become ctDNA-positive with abemaciclib can help prevent the recurrence of hormone receptor-positive, HER2-negative breast cancer…
- Trial name
- ARCHE (NCT07292207)
- Testing
- Abemaciclib 150 MG Oral Tablet
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Nagoya City University
Treatment-naive Prostate Cancer, Suspected Prostate Cancer
Delayed PSMA PET/CT Imaging for Diagnosing Clinically Significant Prostate Cancer in Biopsy-Naïve Men With Suspected Prostate Cancer
Brief Summary This prospective, multicenter study evaluates whether delayed PSMA PET imaging improves diagnostic efficacy for detecting clinically significant prostate cancer (Gleason score ≥7) compared with standard imaging in…
- Conditions
- Treatment-naive Prostate Cancer, Suspected Prostate Cancer, Molecular Imaging
- Trial name
- DEPICT (NCT07531329)
- Testing
- [⁶⁸Ga]Ga-PSMA PET/CT with Delayed Pelvic PET-Only Acquisition
- Where
- 9 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Xijing Hospital
Lung Cancer
Identifying Biomarkers for Lung Cancer Using Tissue Samples From Patients With Lung Cancer and From Healthy Participants
RATIONALE: Studying samples of tissue, blood, sputum, and urine from patients with lung cancer and from healthy participants in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers…
- Trial name
- NCT00899028
- Testing
- comparative genomic hybridization, fluorescence in situ hybridization, gene expression analysis
- Where
- 4 sites in United States
- Volunteers
- 689 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Carcinoma, Non-Small-Cell Lung
Lung Cancer Early Molecular Assessment Trial
The investigators hypothesize that an early molecular profiling, that includes both tissue and blood-bases analysis, for all NSCLC patients, including stage I-III, will increase diagnostic efficiency.
- Trial name
- LEMA (NCT02894853)
- Testing
- Liquid (blood) biopsies and tumor biopsy (optional)
- Where
- Netherlands
- Volunteers
- 1,297 people
- Sponsor
- The Netherlands Cancer Institute
Diffuse Large B Cell Lymphoma
Mixed Molecular Clinical Index (MMCI) in Diffuse Large B-cell Lymphoma (DLBCL)
This is a prospective and retrospective observational study. The primary objective is to identify new prognostic biomarkers for DLBCL patients in terms of progression-free survival (PFS) and able to add predictive capacity to…
- Trial name
- MMCI (NCT04300101)
- Testing
- Prospective cohort, Retrospective cohort
- Where
- 4 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Amyloidosis, Primary, Cardiomyopathy
Molecular Imaging of Primary Amyloid Cardiomyopathy
Cardiac amyloidosis is a major cause of early treatment-related death and poor overall survival in individuals with systemic light chain amyloidosis.
- Trial name
- MICA (NCT02641145)
- Testing
- F-18 florbetapir/C-11 acetate PET, MRI, N-13 ammonia PET
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- Brigham and Women's Hospital
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