Clinical trials: Monocytes
Regulation of Inflammatory Response
Attenuated Inflammatory Response in Laparoscopic Colon Surgery
Pro-inflammatory responses following laparoscopic surgery.
- Trial name
- NCT01419431
- Testing
- Laparoscopic resection
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Amyotrophic Lateral Sclerosis &Amp; Other Neuromuscular Disorders
Interest of Measuring P2X4 Receptors on Blood Monocytes as a Diagnostic Marker in Amyotrophic Lateral Sclerosis: P2X4 as a Diagnostic Biomarker for ALS
Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease and is characterized by the degeneration of motor neurons leading to progressive paralysis and death within 3 to 5 years after diagnosis.
- Trial name
- PALS (NCT07091799)
- Testing
- P2X4 receptors in blood samples
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Lymphoma, T-Cell, Peripheral, Lymphoma, T-Cell, Cutaneous
A Study of MT-101 in Subjects With CD5+ Relapsed/Refractory TCL
This is a Phase 1/2 study to test the safety, tolerability, and efficacy of the investigational agent MT-101 in patients with T cell Lymphoma. MT-101 is made with myeloid cells collected from the patient's blood.
- Conditions
- Lymphoma, T-Cell, Peripheral, Lymphoma, T-Cell, Cutaneous, Mycosis Fungoides, Adoptive Cellular Immunotherapy
- Trial name
- IMAGINE (NCT05138458)
- Testing
- MT-101, MT-101 + Conditioning (Lymphodepleting) Chemotherapy
- Where
- 6 sites in United States
- Volunteers
- 40 people
- Sponsor
- Myeloid Therapeutics
HIV Infections
The Effectiveness of Indinavir Plus Zidovudine Plus Lamivudine in HIV-Infected Patients With No Symptoms of Infection
To evaluate the ability of the combination of indinavir, zidovudine, and lamivudine to suppress HIV-1 infection as measured by: (1) the maintenance of HIV-1 serum viral RNA below the limit of detection of the most sensitive…
- Trial name
- NCT00002179
- Testing
- Indinavir sulfate, Lamivudine, Zidovudine
- Where
- 17 sites in United States, Canada
- Volunteers
- 200 people
- Sponsor
- Merck Sharp & Dohme LLC
Cognitive Impairment
Changes in Cognition During a 24-h Simulated Military Operation
Sustained military operations (SUSOPs) result in psychological stress and cognitive dysfunction, which may be related to the recruitment of classical monocytes into the brain.
- Trial name
- NCT04250480
- Testing
- beta-alanine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Leukemia, Lymphoma
Donor Umbilical Cord Blood Transplant in Treating Patients With Advanced Hematologic Cancer
RATIONALE: Giving chemotherapy, such as fludarabine, busulfan, and etoposide, before a donor umbilical cord blood stem cell transplant helps stop the growth of cancer cells.
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
- Trial name
- NCT00304018
- Testing
- anti-thymocyte globulin, sargramostim, busulfan
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of California, San Francisco
Atherosclerosis
Effects of PA-1 Transcriptional Regulation on Monocyte Function
Researching genetic differences in people with no prior medical conditions for better understanding of cardiac diseases through genetic research.
- Trial name
- NCT00512369
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Sepsis
Adult MDW Dual Cut-Off Accuracy Study
This study will establish the clinical performance of the Monocyte Distribution Width (MDW) parameter on the DxH 900/ DxH 690T hematology analyzers to aid in the detection and risk assessment of patients in the Emergency…
- Trial name
- MDW (NCT06885528)
- Testing
- Complete Blood Count with differential
- Where
- 5 sites in United States
- Volunteers
- 524 people
- Sponsor
- Beckman Coulter, Inc.
Stroke, Post-Stroke Cognitive Impairment
Immune-Inflammatory Biomarkers in Predicting Early Cognitive Impairment in Adults With Acute Basal Ganglionic Stroke
Post-stroke cognitive impairment (PSCI) is a common and disabling complication that affects memory, thinking, and daily functioning after a stroke.
- Conditions
- Stroke, Post-Stroke Cognitive Impairment, Ischemic Stroke, Intracerebral Hemorrhage
- Trial name
- NCT07837466
- Volunteers
- 100 people
- Sponsor
- Assiut University
Ulcerative Colitis
Granulocyte-monocyte Apheresis in Ulcerative Colitis
BACKGROUND: Granulocyte-monocyte apheresis has been proposed for the treatment of ulcerative colitis, although is limited by costs and variability of results.
- Trial name
- NCT03189888
- Testing
- apheresis
- Volunteers
- 33 people
- Sponsor
- Valduce Hospital
Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
Ixazomib (MLN9708) in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
This phase 2 trial studies how well ixazomib(MLN9708) works in treating study participants with relapsed or refractory acute myeloid leukemia.
- Conditions
- Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0), Adult Acute Monoblastic Leukemia (M5a), Adult Acute Monocytic Leukemia (M5b)
- Trial name
- NCT02030405
- Testing
- Ixazomib
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Steven E. Coutre
Myocardial Infarction
Innate Immune Cell Phenotypes and Early Fibrotic Repair in Acute Myocardial Infarction
To determine the relationship of the phenotypes of neutrophils and monocytes with early fibrotic repair after acute myocardial infarction.
- Trial name
- ICE-AMI (NCT07764588)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai 10th People's Hospital
Myeloproliferative Neoplasm, Polycythemia Vera
Functional and Phenotypic Characterization of Monocytes in Myeloproliferative Syndromes
Prospective study for functional and phenotypic characterization of monocytes in philadelphia-negative myeloproliferative neoplasms
- Conditions
- Myeloproliferative Neoplasm, Polycythemia Vera, Essential Thrombocythemia, Primary Myelofibrosis
- Trial name
- PHEMOP (NCT06361641)
- Testing
- Monocytes signatures in myeloproliferative neoplasms at diagnosis
- Where
- 3 sites in France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Angers
Sepsis, Septic Shock
Immune Failure in Critical Therapy (INFECT) Study
Patients admitted to intensive care units (ICU) are at high risk of developing secondary infections, and this is in part due to dysfunction or failure of their 'germ killing' functions (the immune system).
- Trial name
- INFECT (NCT02186522)
- Where
- 4 sites in United Kingdom
- Volunteers
- 168 people
- Sponsor
- University of Edinburgh
Diabetic Retinopathy
Monocyte Chemoattractant Protein-1 2518A/G Polymorphism
The pathogenesis of proliferative diabetic retinopathy (PDR) remains poorly understood. Recent studies have implicated that monocyte chemoattractant protein-1 (MCP-1) is associated with diabetic microvascular or macrovascular…
- Trial name
- MCP-1 (NCT02077127)
- Where
- China
- Volunteers
- 1,043 people
- Sponsor
- Harbin Medical University
Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Erythroid Leukemia (M6)
Tipifarnib in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Tipifarnib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. This phase I trial is studying the side effects and best dose of tipifarnib in treating patients with relapsed or refractory…
- Conditions
- Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Erythroid Leukemia (M6), Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
- Trial name
- NCT00101296
- Testing
- tipifarnib, pharmacological study, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Multiple Myeloma, Monocytes
Quantitative and Qualitative Monocytes Analysis and Their Impact on CART Cells Reponse in Multiple Myeloma
Tumoral micro-environment in malignant haematological diseases, notably in multiple myeloma, is active on plasma cells survival and proliferation.
- Conditions
- Multiple Myeloma, Monocytes, CART Cells
- Trial name
- MONOMM (NCT07180992)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Sepsis
Efficacy of Thymosin Alpha 1 on Improving Monocyte Function for Sepsis
The purpose of this study is to determine whether thymosin alpha 1 is effective on improving monocyte function and has the desired pharmacologic activity for sepsis
- Trial name
- NCT02883595
- Testing
- thymosin alpha 1
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sun Yat-sen University
Tumor, Cancer
Transcriptomal and Molecular Characterization of Tumor Associated Monocytes/Macrophages in Human Cancers
Recent studies from both human and mice cancer models have demonstrated a crucial role for monocytes/macrophages in contributing to cancer progression and disease prognosis.
- Trial name
- NCT00979277
- Where
- Singapore
- Sponsor
- National University Hospital, Singapore
Immune System, Nutrition
Postprandial Monocyte Study
The purpose of this research is to determine the role of a type of immune cell in blood, called a non-classical monocytes (NCMs), following consumption of a high-fat meal.
- Conditions
- Immune System, Nutrition, Inflammation
- Trial name
- PPMS (NCT05792137)
- Testing
- High saturated fat challenge meal, High mono unsaturated fat challenge meal
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center