Clinical trials: Monocytes
Arteriosclerosis, Acute Myocardial Infarction
Menopause Related Influences on Leukocyte Distribution, Monocyte Function and Platelet Reactivity
Women and men show marked differences in cardiovascular risk profile and outcome. Women experience fewer cardiovascular events than men before menopause, but this relationship seems to reverse at menopause.
- Conditions
- Arteriosclerosis, Acute Myocardial Infarction, Cardiovascular Events, Menopause
- Trial name
- NCT05985447
- Where
- Germany
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Megakaryoblastic Leukemia (M7)
7-Hydroxystaurosporine and Perifosine in Treating Patients With Relapsed or Refractory Acute Leukemia, Chronic Myelogenous Leukemia or High Risk Myelodysplastic Syndromes
This phase I trial is studying the side effects and best dose of 7-hydroxystaurosporine when given together with perifosine in treating patients with relapsed or refractory acute leukemia, chronic myelogenous leukemia, or…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0), Adult Acute Monoblastic Leukemia (M5a)
- Trial name
- NCT00301938
- Testing
- 7-hydroxystaurosporine, perifosine, pharmacological study
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Inflammation, Periodontal Disease
Advanced Oxidation Protein Product and Monocyte Chemoattractant Protein-1 in Periodontal Disease
This study investigates the levels of advanced oxidation protein product and monocyte chemoattractant protein-1 in gingival crevicular fluid in periodontal disease and health.
- Trial name
- NCT02848378
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Leukemia
Genetics Study of Tissue Collected From Patients With Acute Myeloid Leukemia
RATIONALE: Collecting and storing samples of tissue and blood from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00898092
- Testing
- microarray analysis, molecular genetic technique, mutation analysis
- Where
- United States
- Volunteers
- 735 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Peanut Hypersensitivity
Development of an Algorithm to Better Predict Clinical Responsiveness to Peanut
The purpose of this study is to develop a tool to better predict clinical allergy to peanut, so that those who are skin test positive but non allergic will not have to unnecessarily avoid peanut, and those with true allergy can…
- Trial name
- NCT00243555
- Testing
- allergy skin testing, venepuncture
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Leukemia, Leukemia, Myeloid
Enasidenib in MDS &Non-proliferative Chronic Myelomonocytic Leukemia w/o IDH2 Mutation
This is a phase 1b/2, open-label, single arm study to evaluate if enasidenib is safe and effective in improving anemia and decreasing transfusion needs in subjects diagnosed with lower risk myelodysplastic syndrome (MDS) or…
- Conditions
- Leukemia, Leukemia, Myeloid, Monocytic Leukemia
- Trial name
- NCT05282459
- Testing
- Enasidenib mesylat dose escalation
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Tian Yi Zhang
Renal Failure, Renal Insufficiency, Acute
The Effect of Vitamin E-coated Polysulfone Membrane on Oxidative Stress, Inflammation and Monocytes in Critically Ill Patients in CRRT
The study evaluate the effect of a membrane in polysulfone covered with vitamin E (ViE15-A, ASAHI Kasey, Tokyo, Japan) versus non-vitamin E polysulfone membrane (REXEED-15A, ASAHI Kasey, Tokyo, Japan) in critically ill patients…
- Trial name
- Vitabrane E (NCT03489759)
- Testing
- ViE15-A, REXEED-15A
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- St. Bortolo Hospital
Leukemia, Myelodysplastic Syndromes
Intensive Compared With Nonintensive Chemotherapy in Treating Older Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. It is not yet known if stronger doses of chemotherapy given over a longer period of time are as well…
- Conditions
- Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms
- Trial name
- NCT00005823
- Testing
- cytarabine, daunorubicin hydrochloride, etoposide
- Where
- 3 sites in United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Leukemia Research Fund
Myelodysplastic Syndrome, Acute Myeloid Leukemia
Idarubicin + Cytarabine and Lenalidomide in Patients With Myelodysplastic Syndrome (MDS), Acute Myeloid Leukemia (AML)
The purpose of this study is to: Test the safety of the research study drug, lenalidomide, when given with Idarubicin and Cytarabine See how many respond to combination treatment with lenalidomide, Idarubicin and Cytarabine See…
- Trial name
- NCT00831766
- Testing
- Idarubicin, Cytarabine, Lenalidomide (Revlimid®)
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Chronic Obstructive Pulmonary Disease, Type 2 Diabetes Mellitus
The Early Predictors for Developing Type 2 Diabetes Mellitus in Patients With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease(COPD), characterized by persistent airflow limitation, associated with an progressive chronic inflammatory response of the lung to noxious particles or gases, can lead to dyspnea and limited…
- Trial name
- NCT03152994
- Testing
- Checking fasting blood glucose(FBG)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Zhujiang Hospital
End Stage Renal Disease on Dialysis
The Immune System in End Stage CKD Patients - Comparison Among Different Modalities of RRT
The evaluation and assessment of the influence of the different modalities of renal replacement therapy (RRT), including peritoneal dialysis (PD), conventional hemodialysis with high flux dialyzers, hemodiafiltration (HDF) and…
- Trial name
- NCT04286477
- Where
- Greece
- Volunteers
- 45 people
- Sponsor
- University of Ioannina
Acute Myeloid Leukemia, Myeloid Leukemia
FT538 in Combination With Daratumumab in AML Acute Myeloid Leukemia
This Phase I open-label dose escalation study is conducted in two stages with a primary endpoint to identify the maximum tolerated dose (MTD) of FT538 when administered with daratumumab in patients 12 years and older with…
- Conditions
- Acute Myeloid Leukemia, Myeloid Leukemia, Monocytic Leukemia
- Trial name
- NCT04714372
- Testing
- Daratumumab/rHuPH20, FT538, Fludarabine
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Multiple Sclerosis
Anti-Inflammatory Type II Monocyte Induction by Glatiramer Acetate (Copaxone) Treatment of Multiple Sclerosis
The purpose of this study is to determine whether glatiramer acetate (Copaxone) will induce anti-inflammatory type II monocyte development during treatment of MS, and if these antigen presenting cells (APC) will promote Th2 and…
- Trial name
- NCT00819195
- Testing
- Glatiramer acetate
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cervical Cancer
CERvical Cancer The InFlammatory Index (CERTIFIKO)
Although significant advances in screening and treatment , cervical cancer is the fifth most common female cancer in Europe. Major prognostic factors for oncological outcome are used to categorise patients at high, intermediate…
- Trial name
- CERTIFIKO (NCT05673252)
- Testing
- Venous blood sample, biopsy
- Where
- Italy
- Volunteers
- 128 people
- Sponsor
- University of Campania Luigi Vanvitelli
Leukemia
S0106 Cytarabine and Daunorubicin w/ or w/o Gemtuzumab Followed By HD Cytarabine and Either Gemtuzumab or Nothing in de Novo AML
RATIONALE: Drugs used in chemotherapy, such as cytarabine and daunorubicin, work in different ways to stop cancer cells from dividing so they stop growing and die.
- Trial name
- NCT00085709
- Testing
- gemtuzumab ozogamicin, observation, Cytosine arabinoside
- Where
- 279 sites in United States, Canada and 1 more
- Volunteers
- 637 people
- Sponsor
- SWOG Cancer Research Network
Coronary Heart Disease
CD16+ Monocytes in Coronary Heart Disease (CHD)
Monocytes may be separated into phenotypically and functionally distinct cell types by the presence or absence of the lipopolysaccharide receptor CD14 and the Fcγ-receptor CD16.
- Trial name
- PHAMOS (NCT01442948)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Atherosclerosis, Inflammation
Specifying the Anti-inflammatory Effects of Ziltivekimab
The goal of this randomized, double blind, placebo controlled trial is to study whether ziltivekimab therapy reduces arterial wall inflammation as assessed by imaging, and reduces the systemic inflammatory tone as assessed by…
- Trial name
- SPIDER (NCT06263244)
- Testing
- Ziltivekimab
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Respiratory Distress Syndrome, Mechanical Ventilation
A Role for RAGE/TXNIP/Inflammasome Axis in Alveolar Macrophage Activation During ARDS (RIAMA): a Proof-of-concept Clinical Study
RAGE (the receptor for advanced glycation end-products) is a marker of alveolar type I cell injury and a pivotal mediator of acute inflammation and innate immunity.
- Trial name
- NCT02545621
- Testing
- RAGE TXNIP Inflammasome axis
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Clermont-Ferrand
Periodontal Disease
Effects of Periodontal Pathogens, Porphyromonas Gingivalis and Tannerella Forsythensis, on Cytokine Production From Human Monocyte-Derived Dendritic Cells
Periodontitis develops due to subgingival infection with specific microbial pathogen from dental plaque. The bacteria can activate immunoinflammatory mechanisms within the local periodontal tissues that lead to destruction of…
- Trial name
- NCT00162838
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Heart Valve Diseases, Systemic Inflammatory Response Syndrome
Corticosteroid Prophylaxis on the Cardiopulmonary Bypass-Induced Systemic Inflammatory Response
To observe the effect of glucocorticoid on the dynamic changes of monocyte subsets in the peripheral blood of valve disease patients undergoing cardiopulmonary bypass perioperatively.
- Trial name
- NCT01296074
- Testing
- Corticosteroid
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Anzhen Hospital