Clinical trials: Monocytes
Leukemia, Myeloid Leukemia
Mitoxantrone for Venetoclax Resistant Acute Myeloid Leukemia
This is an open label, phase 1 study for AML subjects with relapsed or refractory disease or subjects in morphologic remission with MRD+ after first line therapy with venetoclax+HMA.
- Conditions
- Leukemia, Myeloid Leukemia, Monocytic Leukemia
- Trial name
- NCT06429449
- Testing
- Venetoclax, Azacitidine, Mitoxantrone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Colorado, Denver
Lung Diseases
Phenotypic Characterization of Alveolar Macrophages 2016 (Caract-Aires-2016)
The aim of the study is to investigate by flow cytometry the phenotype of alveolar macrophages (AMs) isolated from patients with non-infectious lung diseases.
- Trial name
- Caract-Aires (NCT03250897)
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Rennes University Hospital
Obstructive Sleep Apnea, Cardiovascular Disease
Metabolic Profiling in Patients With Obstructive Sleep Apnea: From Plasma to Hypoxic Cell Model of Peripheral Monocyte
This three-year project aims to 1. Profile the differentially expressed metabolites in healthy patients with severe Obstructive sleep apnea (OSA) before and after six-month continuous positive airway pressure (CPAP) treatment 2.
- Trial name
- NCT02130050
- Where
- Taiwan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Bacteremia, Bacteremia Sepsis
Monocyte Distribution Width (MDW) in the General Population of Emergency Department Patients With and Without Bacteremia
This project will evaluate the usefulness of Monocyte Distribution Width (MDW) for the diagnosis of blood culture positivity (BSI) in patients in the Emergency Department (ED) and reevaluate the usefulness of MDW in patients with…
- Conditions
- Bacteremia, Bacteremia Sepsis, Sepsis, Septic Shock
- Trial name
- NCT05296590
- Testing
- Monocyte Distribution Width (MDW) , observation
- Where
- United States
- Volunteers
- 50,000 people
- Sponsor
- Henry Ford Health System
Leukemia
VNP40101M Followed by Cytarabine in Treating Older Patients With Acute Myeloid Leukemia
RATIONALE: Drugs used in chemotherapy, such as VNP40101M and cytarabine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00354276
- Testing
- cytarabine, laromustine
- Where
- 3 sites in United States, France and 1 more
- Volunteers
- 85 people
- Sponsor
- Vion Pharmaceuticals
Hematologic Malignancies
Safety of Romiplostim (Nplate®) Following UCBT
This is a single institution, phase I dose escalation study of weekly romiplostim post umbilical cord blood transplantation in patients who fail to achieve platelet engraftment by day +30.
- Trial name
- NCT02046291
- Testing
- Romiplostim
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Thyroid Neoplasms Benign, Thyroid Nodule
Red Blood Cell Distributions (RDW, RDW-CW) and Lymphocyte Monocyte Ratios (LMR) for the Malignant Thyroid Nodules
Thyroid surgery is the most common type of surgery among endocrine surgeries. This surgery is performed for patients with suspected malignancy, patients diagnosed with malignancy, and toxic nodular goiter.
- Conditions
- Thyroid Neoplasms Benign, Thyroid Nodule, Thyroid Cancer, Thyroid Diseases
- Trial name
- NCT06283368
- Testing
- Thyroidectomy, Bilaterally Total, Thyroidectomy, Unilaterally Total, Thyroidectomy, Complementary
- Volunteers
- 172 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Acute Myeloid Leukemia
Fractionated Gemtuzumab Ozogamicin in Treating Measurable Residual Disease in Patients With Acute Myeloid Leukemia
This phase II trial studies the how well fractionated gemtuzumab ozogamicin works in treating measurable residual disease in patients with acute myeloid leukemia.
- Trial name
- NCT03737955
- Testing
- Gemtuzumab Ozogamicin, Quality-of-Life Assessment, Bone Marrow Aspiration
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Washington
Leukemia
S0106B Studying Bone Marrow Samples From Women With Acute Myeloid Leukemia
RATIONALE: Studying samples of bone marrow from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
- Trial name
- NCT01575535
- Testing
- gene expression analysis, flow cytometry, fluorescence activated cell sorting
- Volunteers
- 100 people
- Sponsor
- SWOG Cancer Research Network
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
High-Dose Busulfan and High-Dose Cyclophosphamide Followed By Donor Bone Marrow Transplant in Treating Patients With Leukemia, Myelodysplastic Syndrome, Multiple Myeloma, or Recurrent Hodgkin or Non-Hodgkin Lymphoma
RATIONALE: Giving high doses of chemotherapy drugs, such as busulfan and cyclophosphamide, before a donor bone marrow transplant helps stop the growth of cancer cells.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Monoblastic Leukemia (M5a)
- Trial name
- NCT01177371
- Testing
- busulfan, cyclophosphamide, allogeneic bone marrow transplantation
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Case Comprehensive Cancer Center
Leukemia, Myelodysplastic Syndromes
Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Conditions
- Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms
- Trial name
- NCT00003593
- Testing
- asparaginase, cytarabine, daunorubicin hydrochloride
- Where
- 237 sites in United States, Australia and 5 more
- Volunteers
- 254 people
- Sponsor
- Children's Oncology Group
Venous Thromboembolism, Pulmonary Embolism
IgG Dependent Monocyte Activation in Proximal Venous Thromboembolism
The primary objective of this study is to search for, in vitro, elements associated with IgG-dependent monocyte activation (signaling pathway activation, expression of pro-coagulant and pro-inflammatory factors) and to describe…
- Trial name
- ActiMon (NCT02713581)
- Testing
- Blood sampling
- Where
- 2 sites in France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
Idarubicin, Cytarabine, and Pravastatin Sodium in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes
This clinical trial studies idarubicin, cytarabine, and pravastatin sodium in treating patients with newly diagnosed acute myeloid leukemia or myelodysplastic syndromes.
- Conditions
- Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0), Adult Acute Monoblastic Leukemia (M5a), Adult Acute Monocytic Leukemia (M5b)
- Trial name
- NCT01831232
- Testing
- pravastatin sodium, idarubicin, cytarabine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Fred Hutchinson Cancer Center
Cirrhosis
Microvesicles and Monocytes to Predict Mortality of Patients with Cirrhosis
Chronic liver diseases related to viral hepatitis, metabolic syndrome or excessive alcohol consumption can evolve towards cirrhosis. Cirrhosis is responsible for 170 000 deaths per year in Europe.
- Trial name
- PROMICE (NCT03837444)
- Where
- 5 sites in France
- Volunteers
- 335 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Human Immunodeficiency Virus
Inflammasome Activation Via Circulating Metabolites
The clinical challenges confronting patients with HIV has shifted over the past 10 years from acquired immunodeficiency syndrome to chronic diseases including atherosclerosis, neurocognitive disorders, and osteoporosis.
- Trial name
- InflammoVIH (NCT03191175)
- Testing
- blood sample
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Breast Cancer, Hodgkin Lymphoma
Integrated Actionable Aging Assessment for Cancer Patients Pilot
Aging is the greatest risk factor for cancer incidence and mortality. Geriatric screening is recommended to help with treatment discussions, inform intensity of treatment, and identify supportive care needs.
- Conditions
- Breast Cancer, Hodgkin Lymphoma, Kidney Cancer, Leukemia
- Trial name
- NCT05871008
- Testing
- Assessment tool IA3-CP with SDoH, Assessment tool IA3-CP without SDoH
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Colorado, Denver
Leukemia
Combination Chemotherapy Plus PSC 833 Followed by Interleukin-2 in Treating Patients With Acute Myelogenous Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Some cancers may become resistant to chemotherapy drugs.
- Trial name
- NCT00002925
- Testing
- ara-C, Daunorubicin, Etoposide
- Where
- 33 sites in United States
- Volunteers
- 410 people
- Sponsor
- National Cancer Institute (NCI)
Obesity, Cardiovascular Diseases
Inflammatory Status of Monocytes in Obesity
The study of the pro-inflammatory activation of circulating monocytes/macrophages in obesity is the main problem of this project.
- Trial name
- NCT05490862
- Testing
- Lifestyle Modification, Traditional Recommendations
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Federal State Budgetary Scientific Institution
Acute Myeloid Leukemia
Cladribine Venetoclax in Monocytic AML
Investigation of Relapsed or refractory AML with a monocytic phenotype after failure of hypomethylating agent+venetoclax
- Trial name
- NCT06232655
- Testing
- Cladribine, Venetoclax, Azacitidine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus
Association Between Uric Acid / High Density Lipoprotein Ratio and Monocyte / High Density Lipoprotein Ratio With Diabetic Complications
Type 2 diabetes mellitus (T2DM) poses a formidable global health challenge, with complications arising in both the microvascular and macrovascular domains as glycemic control worsens.the aim of the study to evaluate uric acid /…
- Trial name
- NCT06754813
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University