Clinical trials: Monocytes
Sepsis Syndrome
Metabolism of Branched-chain Amino Acids in Monocyte/Macrophage During Sepsis
The current project was designed to examine the metabolic level of branched-chain amino acids in plasm and monocyte/macrophage, and its role in immune dysfunction during sepsis.
- Trial name
- NCT03842371
- Testing
- Metabolic level of BCAAs in monocytes and macrophages
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Sepsis
Clinical Trial to Evaluate MDW for Early Detection of Sepsis
This study is intended to clinically verify Monocyte Distribution Width (MDW) parameter of DxH 900 Hematology Analyzer for use in early detection and risk assessment of sepsis, severe sepsis, and septic shock in critically ill…
- Trial name
- NCT06267742
- Testing
- Complete Blood Count (CBC) with Differential
- Where
- 3 sites in China
- Volunteers
- 2,200 people
- Sponsor
- Beckman Coulter, Inc.
Coronary Artery Disease
Study of ADAMTS-13 Activity, Von Willebrand Factor and Platelet-Monocyte Aggregation in Coronary Artery Disease
The purpose of this research is to determine the relationship between proteins and enzymes in the blood and how they work with platelets to form blood clots in patients with coronary artery disease.
- Trial name
- ADVANCE-PCI (NCT00905294)
- Testing
- Blood draws
- Where
- 2 sites in Ireland
- Volunteers
- 11 people
- Sponsor
- University College Cork
Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia
Idarubicin, Cytarabine, and Tipifarnib in Treating Patients With Newly Diagnosed Myelodysplastic Syndromes or Acute Myeloid Leukemia
This phase I/II trial is studying the side effects and best dose of tipifarnib when given with idarubicin and cytarabine and to see how well it works in treating patients with newly diagnosed myelodysplastic syndromes or acute…
- Conditions
- Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia, Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
- Trial name
- NCT00096122
- Testing
- cytarabine, idarubicin, tipifarnib
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- National Cancer Institute (NCI)
Diabetes Mellitus, Type 2, Atherosclerosis
The Gene Expression Patterns in the Peripheral White Blood Cells of Type 2 Diabetic Patients
The investigators hypothesize that macrophages play a crucial role in the pathogenesis of atherosclerosis in patients with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT00155922
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Ovarian Cancer
Systemic Inflammatory Biomarkers in Ovarian Cancer
In cancer patients, prognostic markers are needed to improve the management and clinical course of both the cancer itself and surgery therefor.
- Trial name
- NCT06629831
- Testing
- group with complications, group without complications
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Childhood Solid Tumor
Cancer Immune Therapy for the Treatment of Refractory Solid Tumours of Childhood
This is an un-blinded Phase 1 study in which 21 patients suffering from solid advanced paediatric malignancies (14 sarcoma and 7 non-sarcoma patients) are treated with AV0113, an anti-tumour immune therapy with autologous…
- Trial name
- NCT02533895
- Testing
- AV0113 DC-CIT, Data evaluation
- Where
- 2 sites in Austria
- Volunteers
- 67 people
- Sponsor
- Activartis Biotech
Inflammation
Suppression of Postprandial Monocyte Activation by Blueberries or Docosahexaenoic Acid in Humans
The overall goal of the research study is to determine whether a high-fat meal causes postprandial (after meal) inflammation, and whether eating n-3 polyunsaturated fatty acids (PUFAs) or blueberries that are rich in…
- Trial name
- NCT02472171
- Testing
- High saturated fat meal, blueberry powder and sunflower oil
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Left Ventricular Hypertrophy
Protective Monocytes and Macrophages to Limit Decompensation and Heart Damaging
The working hypothesis is that cardiac macrophages specific for the compensated cardiac hypertrophic phase limit the progression toward the decompensated state of heart failure by promoting an inflammatory environment favouring…
- Trial name
- PROMOMA (NCT04022330)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia
XK469R in Treating Patients With Refractory Hematologic Cancer
Phase I trial to study the effectiveness of XK469R in treating patients who have refractory hematologic cancer. Drugs used in chemotherapy, such XK469R, work in different ways to stop cancer cells from dividing so they stop…
- Conditions
- Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia, Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
- Trial name
- NCT00095797
- Testing
- R(+)XK469, pharmacological study, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute (NCI)
Sepsis and Septic Shock
MIRNA QUANTIFICATION IN PATIENTS WITH SEPTIC SHOCK
Sepsis-induced immunosuppression (SIS) is a common complication in patients with septic shock. Reduced expression of Human leukocyte antigen isotype DR (HLA-DR) on circulating monocytes is a marker for SIS and correlates with…
- Trial name
- MIRSEP (NCT07597122)
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
Early Discharge and Outpatients Care in Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia Previously Treated With Intensive Chemotherapy
This phase II trial studies how well early discharge and outpatient care works in patients with myelodysplastic syndrome or acute myeloid leukemia previously treated with intensive chemotherapy.
- Conditions
- Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0), Adult Acute Monoblastic Leukemia (M5a), Adult Acute Monocytic Leukemia (M5b)
- Trial name
- NCT01235572
- Testing
- standard follow-up care, medical chart review, quality-of-life assessment
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Fred Hutchinson Cancer Center
Diabetic Nephropathy
Telmisartan Promotes the Differentiation of Monocytes Into Macrophages M2 in Diabetic Nephropathy?
The severity of the diabetic nephropathy is proportional to proteinuria rate and degree of renal interstitial fibrosis. Despite many treatments available today, diabetic nephropathy is responsible for a quarter of cases of…
- Trial name
- NCT02768948
- Testing
- telmisartan during 6 months, Losartan during 6 months, blood sample
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Leukemia
Clofarabine and Cytarabine in Treating Young Patients With Refractory or Relapsed Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia
RATIONALE: Drugs used in chemotherapy, such as clofarabine and cytarabine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00372619
- Testing
- clofarabine, cytarabine, methotrexate
- Where
- 79 sites in United States, Canada
- Volunteers
- 74 people
- Sponsor
- Children's Oncology Group
Metabolic Syndrome
Effects of Pitavastatin on Monocyte, Endothelial Dysfunction and HDL-C in Subjects With Metabolic Syndrome
The purpose of this study is to examine in detail the acute and chronic effects of pitavastatin on plasma lipid transport and atheroma biomarkers in patients at elevated risk for the premature development of atherosclerosis…
- Trial name
- CAPITAIN (NCT01595828)
- Testing
- Pitavastatin
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Kowa Research Europe
Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
AML Therapy With Irradiated Allogeneic Cells
This pilot clinical trial studies if cells donated by a close genetic relative can help maintain acute myeloid leukemia (AML) complete remission (CR). Eligible patients will receive a standard induction chemotherapy.
- Conditions
- Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0), Adult Acute Monoblastic Leukemia (M5a), Adult Acute Monocytic Leukemia (M5b)
- Trial name
- NCT02105116
- Testing
- fludarabine phosphate, cytarabine, donor lymphocytes
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Rutgers, The State University of New Jersey
Thyroid Carcinoma, Nonmedullary
Effects of Radioactive Iodine on the Immune System in Thyroid Cancer
Blood will be drawn 1 month before and 2 month after regular radioactive iodine treatment. Monocytes will be isolated. The three main outcomes are whole blood counts, cytokine production upon in vitro stimulation of monocytes and…
- Trial name
- SCIMITAR (NCT05989555)
- Testing
- Blood drawing
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Hodgkin Lymphoma
Prognostic Value Of Lymphocyte Count and Lymphocyte/ Monocyte Ratio in Patients With Hodgkin's Lymphoma
This study is to assess the utility of using Absolute Lymphocyte count, Lymphocyte/Monocyte Ratio and International Prognostic Scote at diagnosis in Hodgkin's Lymphoma as a prognostic predictor of therapeutic response, overall…
- Trial name
- NCT04893538
- Testing
- First analysis: Lymphocyte count > or = 1500 cells per microlitre, second analysis: IPS < 3 and third analysis: Lymphocyte/Monocyte ratio > or = 2.9, First analysis: Lymphocyte count < 1500 cells per microlitre, second analysis: IPS > or = 3 and third analysis: Lymphocyte/Monocyte ratio < 2.9
- Where
- Syria
- Volunteers
- 100 people
- Sponsor
- Latakia University
Yellow Fever
Turnover of Antigen Specific Lymphocytes and Monocytes After Immunization With the 17D Yellow Fever Vaccine
The yellow fever vaccine is a live, attenuated virus that results in a robust immune response, especially in the T cell compartment.
- Trial name
- NCT01290055
- Testing
- Yellow fever vaccine, Deuterium (70% enriched 2H2O) labeled water
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Sri Edupuganti
Leukemia, Myeloid
Physical Activity as Self-Management Approach to Improve Health Outcomes in AML
Physical Activity as a Self-Management Approach to Improve Health Outcomes in Acute Myeloid Leukemia
- Conditions
- Leukemia, Myeloid, Monocytic
- Trial name
- NCT02584296
- Testing
- BSMA
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Virginia Commonwealth University