Clinical trials: Monocytes
Healthy, HIV Infection
Immune Responses to HIV in Blood Cells in HIV-Infected and HIV-Uninfected Volunteers
This study will explore the responses of the immune system to infection with HIV and other pathogens and the changes in these responses over time.
- Trial name
- NCT00027482
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 2 Diabetes, Chronic Renal Failure
Rapid Effects Linagliptin on Monocyte Polarization and Endothelial Progenitor Cells in Type 2 Diabetes
Diabetes mellitus is characterized by chronic low grade inflammation, which is worsened by the co-existence of renal failure. One key aspect of chronic inflammatory diseases is the alteration in the polarization profile of…
- Trial name
- NCT01617824
- Testing
- Linagliptin
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- University of Padova
Myeloproliferative Neoplasm
Exploring the Impact of Monocytes in Myeloproliferative Neoplasia (EMYNEM)
Impact of monocytes on Myeloproliferative Neoplasm hematopoietic stem cell growth and differentiation in vitro
- Trial name
- EMYNEM (NCT06462664)
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Brest
Leukemia
Biomarkers in Bone Marrow and Blood Samples From Older Patients With Acute Myeloid Leukemia Treated With Cytarabine-Based Therapy
RATIONALE: Studying samples of bone marrow and blood from patients with cancer in the laboratory may help doctors predict how well patients will respond to treatment.
- Trial name
- NCT01169363
- Testing
- proteomic profiling, flow cytometry, laboratory biomarker analysis
- Volunteers
- 200 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Diabetic Nephropathies, Proteinuria
N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy
The study is designed to test if the combination of two potent antioxidant nutritional supplements, N-acetylcysteine and the milk thistle extract silibin, is capable of correcting the shedding of urine protein, the oxidative…
- Conditions
- Diabetic Nephropathies, Proteinuria, Oxidative Stress
- Trial name
- NCT00915200
- Testing
- N-acetylcysteine, silibin, high-dose silibin
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Chronic Obstructive Pulmonary Disease
Apoptotic Cell (AC) Uptake by Human Alveolar Macrophages (AM)
The purpose of this study is to compare the ability of two types of white blood cells to eat dead host cells, and how this process affects their ability to protect the body from infection.
- Trial name
- NCT01099410
- Testing
- Fiberoptic bronchoscopy, blood draw, intravenous catheter
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Leukemia
S9333A Study of Blood and Bone Marrow Samples From Patients With Previously Untreated Primary Acute Myeloid Leukemia
RATIONALE: Studying samples of blood and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00899743
- Testing
- polyacrylamide gel electrophoresis, western blotting, immunologic technique
- Volunteers
- 132 people
- Sponsor
- SWOG Cancer Research Network
Hepatocellular Carcinoma, Secondary Malignant Neoplasm of Liver
Radioembolization of Primary and Secondary Liver Malignancies and The Effect On The Immune System
The goal of this study is to understand the immunologic effects radioembolization has on the immune system. This will be done by evaluating the changes on biopsy, peripheral blood monocytes, and cytokines.
- Trial name
- NCT03889093
- Testing
- Yttrium-90
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Minnesota
Sepsis
Reconstruction of Monocytic Immunocompetence by Granulocyte-macrophage-colony Stimulating Factor (GM-CSF) in Patients With Severe Sepsis and Septic Shock
There is basic science evidence that GM-CSF reconstructs cellular immunity in septic patients. In this prospective, randomised double-blind, placebo-controlled trial, we investigate whether this can be achieved in patients with…
- Trial name
- NCT00252915
- Testing
- GM-CSF (verum)
- Volunteers
- 38 people
- Sponsor
- Charite University, Berlin, Germany
Atrial Fibrillation, Arrhythmia
Epigenetic Analysis of Regulation of the Inflammasome-activating NLRP3 Gene in Monocytes From Atrial Fibrillation Patients and Controls
The study will analyze blood from volunteers to determine whether there is an underlying epigenetic cause of the inflammation of the heart associated with atrial fibrillation (AF) and its progression with age.
- Trial name
- NCT04766814
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Tulane University
Cardiovascular Disease
Genetic Predictors of Cardiovascular Disease
This study, conducted in collaboration with the Johns Hopkins University School of Medicine, will explore the genetic influences on susceptibility to atherosclerotic cardiovascular disease (ASCVD).
- Trial name
- NCT00339599
- Where
- United States
- Volunteers
- 2,306 people
- Sponsor
- National Cancer Institute (NCI)
Adult Acute Megakaryoblastic Leukemia, Adult Acute Monoblastic Leukemia
Cytarabine With or Without SCH 900776 in Treating Adult Patients With Relapsed Acute Myeloid Leukemia
This randomized phase II trial studies how well cytarabine with or without SCH 900776 works in treating adult patients with relapsed acute myeloid leukemia.
- Conditions
- Adult Acute Megakaryoblastic Leukemia, Adult Acute Monoblastic Leukemia, Adult Acute Monocytic Leukemia, Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11
- Trial name
- NCT01870596
- Testing
- Cytarabine, CHK1 Inhibitor SCH 900776, Laboratory Biomarker Analysis
- Where
- 5 sites in United States
- Volunteers
- 32 people
- Sponsor
- National Cancer Institute (NCI)
Diabetes Mellitus Type II
The Effect of n-3 Fatty Acid Supplementation on Serum Levels, and Gene Expression of type2 Diabetes Patient
The aim of this study is to determine the effects of supplementation with n-3 fatty acid or placebo for 10 weeks on the expression of Sirt-1, AdipoR1 \& AdipoR2 genes in the peripheral blood mononuclear cell (PBMC) and…
- Trial name
- NCT02261545
- Testing
- n-3 Fatty Acid
- Volunteers
- 88 people
- Sponsor
- Tehran University of Medical Sciences
Melanoma (Skin)
Vaccine Therapy in Treating Patients With Stage IV Cutaneous Melanoma
RATIONALE: Vaccines made from a person's dendritic cells and antigens may make the body build an immune response to kill tumor cells.
- Trial name
- NCT00074230
- Testing
- Autologous Dendritic Cells loaded with MAGE-A3, MelanA and Survivin
- Where
- Germany
- Volunteers
- 82 people
- Sponsor
- University Hospital Erlangen
Leukemia
Multidrug Resistance Genes in Patients With Acute Myeloid Leukemia
This research trial studies multidrug resistance genes in patients with acute myeloid leukemia. Studying samples of bone marrow or blood from patients with cancer in the laboratory may help doctors learn more about changes that…
- Trial name
- NCT00898456
- Testing
- gene expression analysis, molecular genetic technique, polymorphism analysis
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Leukemia, Lung Cancer
Phenylbutyrate Plus Azacitidine in Treating Patients With Acute Myeloid Leukemia, Myelodysplasia, Non-Hodgkin's Lymphoma, Multiple Myeloma, Non-small Cell Lung Cancer, or Prostate Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one chemotherapy drug may kill more cancer cells.
- Conditions
- Leukemia, Lung Cancer, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00006019
- Testing
- azacitidine, sodium phenylbutyrate
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Coronary Heart Disease, Unstable Angina
Fecal Microbiota and Monocyte Trained Immunity in CHD Patients With Different hsCRP
This single-center study enrolled patients aged 35-75 years who were diagnosed with unstable angina (UA), and had at least one of the three major coronary arteries with a ≥ 50% reduction in lumen diameter by angiographic visual…
- Trial name
- NCT06562309
- Testing
- take feces and blood samples from patients
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Acute Myeloid Leukemia, Myeloid Neoplasm
CPX-351 or CLAG-M Regimen for the Treatment of Acute Myeloid Leukemia or Other High-Grade Myeloid Neoplasms in Medically Less-Fit Patients
This phase II trial studies how well CPX-351 or the CLAG-M regimen (consisting of the drugs cladribine, cytarabine, G-CSF, and mitoxantrone) works in treating medically less-fit patients with acute myeloid leukemia or other…
- Trial name
- NCT04195945
- Testing
- Liposome-encapsulated Daunorubicin-Cytarabine, Cladribine, Cytarabine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Fred Hutchinson Cancer Center
Leukemia, Lymphoma
Arsenic Trioxide in Treating Patients With Advanced Hematologic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of arsenic trioxide in treating patients who have advanced…
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00003395
- Testing
- arsenic trioxide
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Sepsis, Severe Infection
Evaluation of Monocyte Volume Distribution Width (MDW) for Early Detection of Sepsis
The measurement of monocyte volume width distribution (MDW) is intended for use with adult patients presenting to the emergency department (ED), where a CBC with Differential has been ordered, as an aid in the early detection of…
- Trial name
- MDW (NCT03145428)
- Testing
- CBC-Diff Monocyte volume width distribution (MDW)
- Where
- 3 sites in United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Beckman Coulter, Inc.