Clinical trials: Monosomy X
Congenital Adrenal Hyperplasia, Hypogonadotropic Hypogonadism
Growing up With the Young Endocrine Support System (YESS!)
Transition from paediatric to adult endocrinology is a challenge for adolescents, families and doctors. Up to 25% of young adults with chronic endocrine disorders are lost to follow-up ('drop-out') once the young adult moves out…
- Conditions
- Congenital Adrenal Hyperplasia, Hypogonadotropic Hypogonadism, Growth Hormone Deficiency, Combined Pituitary Hormone Deficiency
- Trial name
- YESS (NCT04252001)
- Testing
- YESS! game, Snake '97, Transition-toolkit
- Where
- 7 sites in Belgium, Netherlands and 2 more
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- dr. Laura C. G. de Graaff-Herder
Turner's Syndrome
A Clinical Study to Assess the Efficacy and Safety of DA-3002
A study demonstrates the non-inferiority of DA-3002 when compared with Genotropin®.
- Trial name
- NCT01813630
- Testing
- DA-3002, Genotropin®
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Dong-A ST Co., Ltd.
Turner Syndrome
Long Term Follow-up of Bone Mineral Density in Hormone Treated Turner Syndrome
Turner Syndrome (TS) is associated with osteopenia and osteoporosis. Reduced bone mineral density (BMD) and increased risk of fractures are present in many younger and middle-aged women with TS.
- Trial name
- NCT00625001
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Sensorineural Hearing Loss, Turner Syndrome
Genetic and Epigenetic Background of Inner Ear Dysfunction in Turner Syndrome
The goal of this case-control study is to pave the way for new revolutionary treatment measures within hearing loss that could either replace or delay the need for hearing aids.
- Conditions
- Sensorineural Hearing Loss, Turner Syndrome, Inner Ear Disease
- Trial name
- EPIHEAR (NCT06507007)
- Where
- Denmark
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Gødstrup Hospital
Turner Syndrome
Turner Syndrome Prenatal Diagnosis Study
The goal of this study is to compare the features of Turner syndrome in girls who are diagnosed before birth because of fetal concerns versus those who are diagnosed when their mother has an amniocentesis for another reason.
- Trial name
- NCT01668251
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Seattle Children's Hospital
Gonadal Dysgenesis, Turner's Syndrome
The Effects of Estrogen on Cognition in Girls With Turner Syndrome
The development of the brain in females is a result of a combination of factors. During puberty estrogen plays a role in influencing brain development.
- Trial name
- NCT00001253
- Testing
- cognitive tests and scales
- Where
- United States
- Volunteers
- 950 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Dwarfism, Pituitary, Turner Syndrome
Bone Mineral Density (BMD) in Adolescents With Growth Hormone Deficiency (GHD)
This study is a multicenter, open-label, postmarketing surveillance study. The substudy will collect information on BMD in adolescents and young adults with GHD or Turner syndrome who are completing GH treatment for statural…
- Trial name
- NCT00097526
- Volunteers
- 125 people
- Sponsor
- Genentech, Inc.
Hypothalamic Obesity, Hypothalamic Tumor
Efficacy and Safety of Phentermine/Topiramate in Youth With Hypothalamic Obesity
Hypothalamic obesity (HO) refers to the substantial weight gain that often complicates hypothalamic brain tumors. Children with this treatment-recalcitrant form of obesity have excess rates of metabolic sequelae compared to…
- Conditions
- Hypothalamic Obesity, Hypothalamic Tumor, Craniopharyngioma
- Trial name
- NCT06299891
- Testing
- Phentermine / Topiramate Extended Release Oral Capsule [Qsymia]
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Seattle Children's Hospital
Growth Hormon Deficiency, Turner Syndrome in Pre-pubertal Children
Long Term Follow up Study of Predictive Markers in GHD and TS Children
Primary objective is to assess the relationship between changes from serum biomarkers observed after 1 month of Saizen® therapy and change in height, weight after up to 5 years of treatment with Growth Hormone in children with…
- Trial name
- PREDICT LT FUP (NCT00699855)
- Volunteers
- 182 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Growth Hormone Deficiency
Use of miRNAs in Growth Hormone Deficiency (GHD)
This study aims at improving knowledge about the diagnosis of growth hormone deficiency (GHD) and treatment with growth hormone (GH), with the goal of providing information on the presence of new biomarkers, such as miRNAs, for…
- Trial name
- GH-miRNA2 (NCT06455956)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- University of Parma
Hypothalamic Obesity, Diabetes Mellitus
Effects of Exenatide on Obesity and/or Diabetes Mellitus Due to Hypothalamic Damage
The purpose of this study is to examine the effect of exenatide on body weight and glycemic control in subjects with obesity and/or diabetes mellitus due to hypothalamic damage.
- Trial name
- NCT01783717
- Testing
- Exenatide
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Huashan Hospital
Turner Syndrome
Quantitative Liver Functions in Turner Syndrome With and Without Hormone Replacement Therapy
Several studies have demonstrated that Turner Syndrome patients have elevated liver enzymes readily suppressible by a short course of HRT.
- Trial name
- NCT00825617
- Testing
- Hormone replacement therapy
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Turner Syndrome
Characterization of Hepatopathy in Turner Syndrome: Analysis of Determinants
The present study is therefore aimed at investigating the prevalence of hepatic alterations (laboratory and imaging) in adult patients with TS and generating hypothesissto the possible etiopathogenetic factors most involved, as…
- Trial name
- NCT06794190
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Oxytocin Deficiency, Hypopituitarism
Identification and Clinical Relevance of an Oxytocin Deficient State (Melatonin Study)
Oxytocin (OT) is a hypothalamic peptide that enters the peripheral circulation via the posterior pituitary gland. OT plays a key role in regulating appetite, psychopathology, prosocial behavior and sexual function.
- Conditions
- Oxytocin Deficiency, Hypopituitarism, Hypothalamic Obesity, Pituitary Dysfunction
- Trial name
- NCT05319301
- Testing
- Melatonin
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Turner Syndrome
A Trial to Investigate Different Doses of Lonapegsomatropin Compared to Somatropin in Individuals With Turner Syndrome
A 104 week dose finding open label trial followed by an optional 78 week open label extension of lonapegsomatropin, a long-acting growth hormone product, administered once-a-week versus daily somatropin product in prepubertal…
- Trial name
- NCT05690386
- Testing
- Lonapegsomatropin, Somatropin
- Where
- 19 sites in United States
- Volunteers
- 48 people
- Sponsor
- Ascendis Pharma Endocrinology Division A/S
Obesity Associated With Defects in Leptin-melanocortin Pathway
Open-Label Extension Study of Setmelanotide
This is an open-label extension study designed to evaluate the long-term safety and tolerability of continued setmelanotide treatment in male and female patients ≥2 years of age who have completed or transitioned from a previous…
- Trial name
- NCT06596135
- Testing
- Setmelanotide
- Where
- 13 sites in United States
- Volunteers
- 28 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Turner Syndrome, Hypogonadism
Estrogen Treatment (Oral vs. Patches) in Turner Syndrome
The study attempts to evaluate if the way of administering estrogen, the principal female hormone, via patches or orally, affects the way estrogen works in girls with Turner Syndrome.
- Conditions
- Turner Syndrome, Hypogonadism, Premature Ovarian Failure
- Trial name
- NCT00140998
- Testing
- 17 beta estradiol
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Nemours Children's Clinic
Turner Syndrome, Pterygium Colli
Mehri Turki Webbed Neck Classification
This study aims to identify all types of congenital neck deformities called " webbed neck ". Through a literature survey, the researcher selected 27 articles describing the surgical treatment of the webbed neck, but without…
- Conditions
- Turner Syndrome, Pterygium Colli, Web Neck, Klippel-Feil Syndrome
- Trial name
- NCT06489392
- Where
- Tunisia
- Volunteers
- 78 people
- Sponsor
- Mohamed Tahar Maamouri University Hospital