Clinical trials: Mood
Major Depressive Disorder, Chronic Major Depression, Recurrent
Establishing Multimodal Brain Biomarkers for Treatment Selection in Depression
The purpose of the study is to identify brain biomarkers and characteristics that predict individual responses to treatment of major depression with the antidepressant drug sertraline (tradename Zoloft), a common selective…
- Trial name
- Re-EMBARC (NCT05892744)
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Texas at Austin
Major Depressive Disorder
Tracking Response to Antidepressants in Advance of Investigational Trials, Relapse Study
TRAIT-RS is an observational study to evaluate ongoing treatment response stability to standard of care antidepressant treatments (ADTs) among individuals who met criteria for Major Depressive Disorder (MDD) and completed the…
- Trial name
- TRAIT-RS (NCT04933630)
- Testing
- FDA-approved selective-serotonin reuptake inhibitors (SSRIs) and selective-norepinephrine reuptake inhibitors (SNRIs)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Adams Clinical
Child Development Disorder, Post Partum Depression
Optimization of Mother-child Dyad Follow-up by a Multidomain Application: Real-world Cross Sectional Study
After birth, the mother-child dyad can be impacted by issues which are usually under-detected or detected at early stage. Among these issues, neurodevelopmental disorders (NDD) such as autism spectrum disorder are common and…
- Trial name
- MALO_2 (NCT05215028)
- Testing
- web-application
- Where
- France
- Volunteers
- 4,346 people
- Sponsor
- Weprom
Schizophrenia, Bipolar Disorder
Impact of Cognitive & Metacognitive Performance on Knowledge Learning When Conducting Therapeutic Education Programs
People with schizophrenia and bipolar disorder display alterations in cognition and metacognition. These alterations may have an impact on learning during therapeutic education programs.
- Trial name
- MetaCOGNITION (NCT04590300)
- Testing
- QUESTIONNAIRES
- Where
- France
- Volunteers
- 108 people
- Sponsor
- Centre Hospitalier Charles Perrens, Bordeaux
Major Depressive Disorder
Open-label, Flexible-dose Study of Vortioxetine in Patients With Depression in India
The purpose of this study is to evaluate the safety and tolerability of flexible doses of vortioxetine (5 - 20 mg/day) over a period of 12 weeks in patients with depression in India
- Trial name
- NCT04288895
- Testing
- Vortioxetine
- Where
- 24 sites in India
- Volunteers
- 400 people
- Sponsor
- H. Lundbeck A/S
Major Depression
Duke Conte Center for the Neuroscience of Depression in Late Life
The proposed Silvio O. Conte Center for Neuroscience of Depression will focus on understanding the neurobiological mechanism of depression. A total of 5 projects are proposed. The center is focused on a single hypothesis.
- Trial name
- NCT00576875
- Where
- United States
- Volunteers
- 795 people, healthy volunteers welcome
- Sponsor
- Duke University
Bipolar Disorder, Bipolar Depression
Vitamin D Supplementation for Bipolar Depression
The purpose of this study is to whether vitamin d supplementation in those with low levels may reduce depression symptoms in people experiencing bipolar depression.
- Trial name
- NCT01884844
- Testing
- Vitamin D3, Cholecalciferol
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- University of Massachusetts, Worcester
Bipolar Disorder, Bipolar Depression
Empagliflozin Adjunctive Therapy in Bipolar Depression
Bipolar disorder is a long-term mental health condition that causes mood changes, with depressive episodes being the most frequent and disabling.
- Conditions
- Bipolar Disorder, Bipolar Depression, Insulin Resistance
- Trial name
- EMPA-BD (NCT07472920)
- Testing
- Empagliflozin (EMPA)
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Major Depressive Disorder
An International Study of the Safety and Tolerability of Corlux for Psychotic Symptoms in Psychotic Major Depression
Corlux (mifepristone) is a new medication that modulates the body's use of a hormone called cortisol. Under normal conditions, cortisol and other hormones are created by the body in response to physical and emotional stress…
- Trial name
- NCT00146523
- Testing
- Mifepristone
- Where
- 19 sites in Bulgaria, Croatia and 2 more
- Volunteers
- 247 people
- Sponsor
- Corcept Therapeutics
Bipolar Disorder Depression
Candesartan as an Adjunctive Treatment for Bipolar Depression
This study will assess the safety and tolerability of Candesartan when used in patients with Bipolar Disorder, in addition to their medication treatment.
- Trial name
- NCT04430959
- Testing
- Candesartan
- Where
- United States
- Sponsor
- The University of Texas Health Science Center, Houston
Schizophrenia, Schizoaffective Disorder
Context-Aware Mobile Intervention for Social Recovery in Serious Mental Illness
This open trial will test a new technology-supported blended intervention, mobile Social Interaction Therapy by Exposure (mSITE), that targets social engagement in consumers with serious mental illness.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Mood Disorder, Psychotic
- Trial name
- mSITE (NCT05660070)
- Testing
- mobile Social Interaction Therapy by Exposure (mSITE)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of California, San Diego
Bipolar Disorder
Lithium Therapy: Understanding Mothers, Metabolism and Mood
Lithium, the gold standard for treatment of Bipolar Disorder (BD) and a common augmentation to medication therapy for Major Depression, is commonly continued in pregnancy due to its therapeutic benefit and more recent data that…
- Trial name
- LiThiUM (NCT02490241)
- Testing
- Lithium
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Weight Loss, Gut Microbiome
Low Sugar Protein Pacing, Intermittent Fasting Diet in Men and Women
This study will systematically quantify the effects of protein pacing and intermittent fasting (P-IF) on total and regional (abdominal) body composition (lean mass and fat mass), blood glucose and lipids, and anti-aging…
- Conditions
- Weight Loss, Gut Microbiome, Anti-Aging
- Trial name
- NCT04327141
- Testing
- P-IF, HH
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Skidmore College
Schizophrenia, Bipolar Disorder
Olanzapine Treated Adolescents With Schizophrenia or Bipolar I Disorder
The purpose of this study is to characterize olanzapine pharmacokinetics: the inter- and intra- subject variabilities of olanzapine pharmacokinetics; and the potential influence of patient factors such as age, weight, gender…
- Trial name
- NCT00113594
- Testing
- Olanzapine
- Where
- 17 sites in United States, Puerto Rico and 1 more
- Volunteers
- 100 people
- Sponsor
- Eli Lilly and Company
Cognition, Mood
Investigation of the Acute Effects of Nepalese Pepper Extract (Zanthoxylum Armatum DC) on Cognitive Function, Mood and Gaming Performance in Young, Healthy, Competitive Gamers
The goal of this clinical trial is to learn if a Nepalese Pepper Extract (Zanthoxlum Armatum, ZA) supplement can improve cognitive performance and mental abilities in competitive gamers aged 16 to 34.
- Conditions
- Cognition, Mood, Gaming Performance, Fatigue
- Trial name
- NCT07047105
- Testing
- Nepalese Pepper (Zanthoxylum Armatum) extract 150mg, Nepalese Pepper (Zanthoxylum Armatum) extract 300mg, Caffeine 75mg
- Where
- United Kingdom
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Fibromyalgia Syndrome
Effect of Soundscapes on Emotional Distress in Fibromyalgia: a 4×4 Crossover Trial
This study tests whether different types of sounds can help reduce emotional distress in people with fibromyalgia. Fibromyalgia is a condition that causes widespread muscle and joint pain and makes people extra sensitive to…
- Trial name
- FMSounDistress (NCT07231289)
- Testing
- Natural soundscape exposure, Urban soundscape exposure, Broadband sound active control
- Where
- Spain
- Volunteers
- 72 people
- Sponsor
- Universidad de Granada
Major Depressive Disorder
A Long-Term Study of Brexpiprazole in Patients With Major Depressive Disorder
This trial is a 52-week study to assess the safety of long-term use of brexpiprazole as adjunctive therapy in combination with an antidepressant.
- Trial name
- NCT03737474
- Testing
- Brexpiprazole
- Where
- Japan
- Volunteers
- 248 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Major Depression
Study of Brain Response to Emotional Pictures Using a fMRI While on Duloxetine
The purpose of this study is to find out what parts of the brain have increased or decreased activity when people are depressed and how antidepressant medicine changes this activity in depressed patients.
- Trial name
- NCT00532480
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Indiana University
Major Depressive Disorder
Incorporating Patient Treatment Choice to Improve Treatment Retention in Depressed Hispanics
This study will determine whether combination treatment driven by patient choice is better than standardized medication treatment at retaining and improving Hispanic patients with major depressive disorder.
- Trial name
- NCT00742573
- Testing
- Antidepressants through Texas Medication Algorithm (TMA), Brief Interpersonal Psychotherapy (IPT-B)
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- New York State Psychiatric Institute
Bipolar Disorder
Controlled Study of the Use of Quetiapine Fumarate in the Treatment of Patients With Bipolar Depression
The purpose of this study is to determine the efficacy of quetiapine compared to placebo in the treatment for a major depressive episode in patients with bipolar disorder after receiving treatment for up to 8 weeks.
- Trial name
- NCT00083954
- Testing
- Quetiapine Fumarate
- Where
- 36 sites in United States
- Volunteers
- 530 people
- Sponsor
- AstraZeneca