Clinical trials: Mood Disorders
Major Depressive Disorder (MDD)
Assessment of Whether Telehealth Family Psychoeducation for Major Depressive Disorder is Doable
The goal of this single-arm interventional study is to assess the feasibility and acceptability of co-designed telehealth family psychoeducation (FPE) among individuals with major depressive disorder (MDD) and families.
- Trial name
- SPARKED (NCT07014241)
- Testing
- Family psychoeducation
- Where
- 2 sites in Australia
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Southern Queensland
Major Depressive Disorder (MDD), Physical Activity
Lifestyle Interventions to Prevent Cognitive Deficits in Subjects With Depressive Symptoms: From Mechanisms to Clinical Practice
The goal of this clinical study is to investigate if lifestyle changes can help prevent cognitive decline and reduce depressive symptoms in people between the ages of 50 and 80 with depressive symptoms or a diagnosis of major…
- Conditions
- Major Depressive Disorder (MDD), Physical Activity, Inflammation, Metabolome
- Trial name
- POWER (NCT07009223)
- Testing
- Mediterranean Diet, Physical Activity, Cognitive Training
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
MDD, Citalopram
Glutamatergic and GABAergic Mediators of Antidepressant Response in Major Depression
Primarily, this study seeks to evaluate whether citalopram treatment is associated with an increase in the Glutamine (Gln)/Glutamate (Glu) ratio in the anterior cingulate cortex (ACC) from baseline to day 3 of treatment.
- Conditions
- MDD, Citalopram, Major Depressive Disorder
- Trial name
- NCT01557946
- Testing
- citalopram
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Mclean Hospital
Bipolar I Disorder, Borderline Personality Disorder
Effects of Comorbid Personality Disorder on the Treatment of Bipolar I Disorder
This study will examine the impact of comorbid personality disorder on the outcome of treatment among patients with bipolar I disorder.
- Trial name
- NCT00178061
- Testing
- Interpersonal Social Rhythm Therapy (IPSRT)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Pittsburgh
Treatment Resistant Depression
Tianeptine for Treatment Resistant Depression
The studies will be conducted in parallel at two sites: the the Mood and Anxiety Disorders Program at the Icahn School of Medicine at Mount Sinai (MSSM), and Stanford Depression Research Clinic at Stanford University School of…
- Trial name
- NCT04249596
- Testing
- Tianeptine Sodium
- Where
- 3 sites in United States
- Volunteers
- 38 people
- Sponsor
- Jonathan A. Javitch, MD, PhD
Postpartum Depression
Mother-Infant Intervention for Postpartum Depression and Associated Mother-Infant Relationship Dysfunction
Maternal depression and mother-infant relationship dysfunction have reciprocal effects on each other. An integrated approach addressing both problems simultaneously may improve outcomes.
- Trial name
- NCT02057627
- Testing
- Perinatal Dyadic Psychotherapy
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Spaulding Rehabilitation Hospital
Major Depressive Disorder, Bipolar Depression
The Study of Effectiveness of rTMS on Rumination and Anhedonia in Patients With Major Depressive Disorder
Rumination is significantly frequent in major depressive disorder. However, not a lot of studies have investigated the effects of repetitive transcranial magnetic stimulation on rumination and its electrophysiological correlates.
- Trial name
- NCT03468686
- Testing
- Bilateral rTMS, Unilateral rTMS (High frequency)
- Where
- Iran
- Volunteers
- 61 people
- Sponsor
- University of Tehran
Healthy
Study Evaluating the Pharmacokinetics of Venlafaxine ER and Desvenlafaxine SR in Healthy Subjects
The purpose of this study is to determine if the relative difference in PK between extensive metabolizers (EMs) and poor metabolizers (PMs) is the same with desvenlafaxine SR and venlafaxine ER when a single dose is administered.
- Trial name
- NCT00329186
- Testing
- desvenlafaxine SR, venlafaxine ER
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Depression, Postpartum
Cerebral Synchronization Between Mothers and Their Newborns During Breastfeeding
Different reciprocal positions of mother and newborn during breastfeeding may be adopted. Other than the one derived from UNICEF guidelines, or standard position, an approach called biological nurturing has been recently…
- Trial name
- NCT05821569
- Testing
- Standard approach, Biological nurturing
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Burlo Garofolo
Schizophrenia, Drug Abuse
A Pilot, Proof-of-concept Cohort Study of the Prevalence of Comorbid Mental Illness and Substance Abuse
The prevalence estimates for specific mental disorders and illicit drugs have been separately reported in U.S. government surveys.
- Conditions
- Schizophrenia, Drug Abuse, Anxiety Disorder, Bipolar Disorder
- Trial name
- NCT02476877
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Advanced Clinical Laboratory Solutions, Inc.
Mood Disorder, Substance-Related Disorders
Pharmacological Interaction Between Doxazosin and Methylenedioxymethamphetamine (MDMA)
The purpose of this study is to determinate the effect of a pre-treatment with doxazosin, a alpha1-adrenergic receptor blocker, on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy").
- Conditions
- Mood Disorder, Substance-Related Disorders, Amphetamine-Related Disorders
- Trial name
- NCT01386177
- Testing
- 3,4-Methylenedioxymethamphetamine, Doxazosin
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Depression, Major Depressive Disorder
pBFS-guided High-dose TMS Over DMPFC for Treatment-resistant Major Depressive Disorder
The investigators aim to evaluate the safety and efficacy of pBFS-guided DMPFC target and high-dose rTMS therapy for the treatment of patients with treatment-resistant depression
- Conditions
- Depression, Major Depressive Disorder, Severe Depression
- Trial name
- NCT05964036
- Testing
- active TMS
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Changping Laboratory
Major Depressive Disorder
Mini Theta Burst TMS in MDD Patients
This is not a treatment study. In this study, the researchers are primarily interested in examining whether functional MRI (fMRI)-guided transcranial magnetic stimulation (TMS) may be more effective than traditional TMS methods…
- Trial name
- NARSAD (NCT04014959)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Pennsylvania
Major Depressive Disorder
Efficacy and Safety Study of SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder
This study will examine SPD489 in subjects aged 18-65 with major depressive disorder (MDD) who are taking certain types of antidepressants but continue to have residual depression symptoms.
- Trial name
- NCT01436162
- Testing
- Antidepressant + SPD489 (Lisdexamfetamine dimesylate )
- Where
- 101 sites in United States, Belgium and 9 more
- Volunteers
- 1,105 people
- Sponsor
- Shire
Ischemia, Stress, Mental
Neurocardiac Interactions Evaluated by Anatomic and Physiologic MRI Assessment
The purpose of project is to answer fundamental questions about the mechanisms underlying mental stress ischemia in patients with coronary artery disease, mood disorders, or both, and to identify potential biomarkers and…
- Trial name
- NIRVANA (NCT02962154)
- Testing
- Coronary CT Angiography, Mood Symptom Scale, Anxiety Symptom Scale
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Depressive Disorder, Treatment-Resistant
Proof of Concept Study Evaluating the Efficacy and Safety of MIJ821 in Patients With Treatment-resistant Depression
This study evaluated the efficacy and safety of the compound MIJ821 compared to placebo in patients aged from 18 to 65 years diagnosed with treatment-resistant depression. The study was conducted in the US and in Europe (Spain).
- Trial name
- NCT03756129
- Testing
- MIJ821, Ketamine
- Where
- 12 sites in United States, Spain
- Volunteers
- 70 people
- Sponsor
- Novartis Pharmaceuticals
Schizophrenia, Psychotic Disorders
Recovery Therapy Trial
This project will systematically apply a specialist version of Cognitive Behaviour Therapy (CBT), known as Recovery Therapy, to a random sample of patients with psychotic disorders.
- Conditions
- Schizophrenia, Psychotic Disorders, Mood Disorders
- Trial name
- NCT00239122
- Testing
- Recovery Therapy (Cognitive Behaviour Therapy for psychosis)
- Where
- 2 sites in Australia
- Volunteers
- 94 people
- Sponsor
- Melbourne Health
Depression, Anxiety, Self-Injurious Behavior
Brief App-based Mood Monitoring and Mindfulness Intervention for First-year College Students
The investigators examined whether brief, app-based interventions were helpful in alleviating mental health symptoms during the transition to college.
- Trial name
- NCT06348277
- Testing
- Mindfulness plus mood monitoring, Mood monitoring
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Lawrence University
Common Mental Disorder
Definitive Selection of Neuroimaging Biomarkers for the Diagnosis and Treatment to Common Mental Disorders
To explore the whole-brain anatomical and functional abnormalities in drug-naive patients with schizophrenia ,drug-naive patients with BD, drug-naive patients with MDD and healthy controls by using a combination of…
- Trial name
- NCT04218981
- Testing
- Antipsychotic drugs, Mood stabilizer, Paroxetine
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Central South University
Bipolar Disorder
Transcranial Photobiomodulation for Executive Function in Bipolar Disorder
Transcranial light therapy, or transcranial photobiomodulation (tPBM), is a treatment that stimulates the brain by applying near-infrared light to the forehead.
- Trial name
- TPEB (NCT05408637)
- Testing
- Transcranial Phoobiomodulation (tPBM)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Paolo Cassano